Agency Forms Undergoing Paperwork Reduction Act Review, 52334-52335 [2012-21323]
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Federal Register / Vol. 77, No. 168 / Wednesday, August 29, 2012 / Notices
Several in vitro assays have been
developed, or are currently under
development, with the aim of finding an
alternative method to the HIST for
monitoring residual PTx activity in aP
vaccines. The International Working
Group for Alternatives to HIST is
coordinating the acquisition and
distribution of aP vaccine samples from
manufacturers to research laboratories
for generation of data using in vitro
methods to evaluate vaccines spiked
with a known amount of PTx. Data from
the various alternative assays will be
presented at the upcoming workshop
and will form the basis for identifying
in vitro methods for future assessment
in the next international collaborative
study.
The following methods will be
evaluated and may be used to generate
data to be presented at the upcoming
workshop:
1. Binding assay: used to assess the
amount of PTx/toxoid binding activity
to the glycoprotein fetuin
2. Enzymatic assay: monitors the
residual ADP-ribosylation of the PTx/
toxoid
3. Cell-based assays: monitor the
generation of cAMP or decrease in
cellular ATP following exposure to
PTx
4. Genetic assays: determine potential
genomic markers of PTx activity
This workshop will provide a forum
to discuss and review the in vitro
protocols and available data from the
International Working Group for
Alternatives to HIST study and will
suggest future collaborative projects
using prepared materials. The workshop
will also review additional new
methods and approaches for aP vaccine
safety testing that should improve test
accuracy, precision, and efficiency
while also reducing or replacing the use
of animals in vaccine safety testing.
Finally, the workshop will address the
path toward global validation,
acceptance, and implementation of
scientifically valid alternative methods
for aP vaccines.
TKELLEY on DSK3SPTVN1PROD with NOTICES
Registration information, draft
agenda, and additional meeting
information are available on the
NICEATM–ICCVAM Web site (https://
iccvam.niehs.nih.gov/meetings/
HISTWksp-2012/HISTWksp.htm) and
upon request from NICEATM (see FOR
FURTHER INFORMATION CONTACT).
NICEATM and ICCVAM invite the
submission of abstracts for scientific
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Background Information on NICEATM
and ICCVAM
ICCVAM is an interagency committee
composed of representatives from 15
Federal regulatory and research agencies
that require, use, generate, or
disseminate toxicological and safety
testing information. ICCVAM conducts
technical evaluations of new, revised,
and alternative safety testing methods
and integrated testing strategies with
regulatory applicability and promotes
the scientific validation and regulatory
acceptance of testing methods that more
accurately assess the safety and hazards
of chemicals and products and that
reduce, refine, or replace animal use.
The ICCVAM Authorization Act of 2000
(42 U.S.C. 285l¥3) established ICCVAM
as a permanent interagency committee
of the NIEHS under NICEATM.
NICEATM administers ICCVAM,
provides scientific and operational
support for ICCVAM-related activities,
and conducts independent validation
studies to assess the usefulness and
limitations of new, revised, and
alternative test methods and strategies.
NICEATM and ICCVAM welcome the
public nomination of new, revised, and
alternative test methods and strategies
applicable to the needs of U.S. Federal
agencies. Additional information about
ICCVAM and NICEATM can be found
on the NICEATM–ICCVAM Web site
(https://iccvam.niehs.nih.gov).
2011. The International Workshop on
Alternative Methods to Reduce, Refine
and Replace the Use of Animals in
Vaccine Potency and Safety Testing—
Introduction and Summary. In:
International Workshop on Alternative
Methods to Reduce, Refine, and Replace
the Use of Animals in Vaccine Potency
and Safety Testing: State of the Science
and Future Directions (Kulpa-Eddy J,
McFarland R, Stokes WS, eds). Procedia
Vaccinol 5: 1–15.
Dated: August 20, 2012.
John R. Bucher,
Associate Director, National Toxicology
Program.
[FR Doc. 2012–21368 Filed 8–28–12; 8:45 am]
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DEPARTMENT OF HEALTH AND
HUMAN SERVICES
Centers for Disease Control and
Prevention
[30Day–12–12EK]
Agency Forms Undergoing Paperwork
Reduction Act Review
The Centers for Disease Control and
Prevention (CDC) publishes a list of
information collection requests under
review by the Office of Management and
Budget (OMB) in compliance with the
Paperwork Reduction Act (44 U.S.C.
chapter 35). To request a copy of these
requests, call the CDC Reports Clearance
Officer at (404) 639–7570 or send an
email to omb@cdc.gov. Send written
comments to CDC Desk Officer, Office of
Management and Budget, Washington,
DC or by fax to (202) 395–5806. Written
comments should be received within 30
days of this notice.
References
Preliminary Workshop Agenda and
Registration
Call for Abstract Submissions
posters to be displayed during this
workshop. Guidelines for the
submission of abstracts are available at
https://iccvam.niehs.nih.gov/meetings/
HISTWksp-2012/HISTWkspAbstractSubmit-508.pdf. Abstracts must
be submitted by email to
niceatm@niehs.nih.gov. The deadline
for abstract submission is October 12,
2012. The corresponding author will be
notified regarding the abstract’s
acceptance within 21 working days of
the submission deadline. Guidelines for
poster presentations will be sent to the
corresponding author with notification
of acceptance.
Proposed Project
Process and Intermediate Outcome
Evaluation of ‘‘Teenage Pregnancy
Prevention: Integrating Services,
Programs, and Strategies through
Community-Wide Initiatives’’—New—
National Center for Chronic Disease
Prevention and Health Promotion
(NCCDPHP), Centers for Disease Control
and Prevention (CDC).
Bache C, Hoonakker M, Hendriksen C,
Buchheit K–H, Spreitzer I, Montag T.
2012. Workshop on Animal Free
Detection of Pertussis Toxin in
Vaccines—Alternatives to the Histamine
Sensitization Test. Biologicals 40: 309–
311.
Corbel MJ, Xing DK–L. 2004. Toxicity and
potency evaluation of pertussis vaccines.
Exp Rev Vaccines 3: 89–101.
Isbrucker R. 2011. Alternative safety testing
strategies for acellular pertussis vaccines.
ALTEX Proceedings, 1/12, Proceedings
of WC8; 77–80.
Stokes WS, Kulpa-Eddy J, McFarland RM.
Background and Brief Description
CDC is currently providing funding to
nine state and community awardees,
and five national organizations, to
examine innovative, evidence-based
teenage pregnancy prevention programs.
Efforts are focused in communities with
high rates of teen pregnancy in underserved African American and Latino
youth. Components of these efforts
include (1) implementing evidencebased or evidence-informed prevention
programs; (2) linking teens to quality
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Federal Register / Vol. 77, No. 168 / Wednesday, August 29, 2012 / Notices
health services; (3) educating
stakeholders (parents, community
leaders, and other constituents) about
relevant evidence-based or evidenceinformed strategies to reduce teen
pregnancy; and (4) supporting the
sustainability of the community-wide
teen pregnancy prevention effort
through capacity building and improved
coordination of services.
CDC proposes to collect the
information needed to conduct a
process and intermediate outcome
evaluation of these efforts. The
information collection and evaluation
plan will systematically document
capacity building within funded
communities and the extent to which
communities implement multicomponent, community-wide initiative
activities. Respondents for the nine state
and community awardees will include
the project director/coordinator for each
site, evaluators, and other program staff.
In addition, to gain a variety of
perspectives, information will be
requested from multiple community and
clinical partners associated with each
state or community awardee (e.g.,
program implementers and core
advisory group members). Information
collected from these respondents will
include needs assessments. Finally,
CDC will collect information about the
training and technical assistance needs
of state and community awardees, and
national organizations, which have been
funded to support community-wide teen
pregnancy prevention (TPP) activities.
The training and technical assistance
reporting forms will be submitted to
CDC electronically through an
interactive web-based system. The
remaining information collection forms
will initially be fielded in hardcopy, but
respondents may submit the completed
forms to CDC via electronic mail. To
allow flexibility based on awardee
preferences, web-based reporting
options may be implemented for all
forms. Assessment and performance
information will be reported to CDC
annually. Training and technical
assistance needs will be reported
monthly so that CDC can provide
immediate, targeted technical assistance
as needed.
The assessment information,
performance measures and training and
technical assistance information to be
collected are critical to understanding
(1) the teen pregnancy prevention needs
of each target community, (2) quality
implementation practices associated
with evidence-based programs and
contraceptive access, and (3) the impact
of implemented strategies.
OMB approval is requested for three
years. There are no costs to respondents
other than their time. The total
estimated annualized burden hours are
1,150.
ESTIMATED ANNUALIZED BURDEN HOURS
Type of respondent
State and Community Awardees.
National Organization Awardees.
Community and Clinical Partners.
(Pub. L. 92–463), and pursuant to the
requirements of 42 CFR 83.15(a), the
Centers for Disease Control and
Prevention (CDC), announces the
following meeting of the
aforementioned committee:
[FR Doc. 2012–21323 Filed 8–28–12; 8:45 am]
Times and Dates (All Times are
Mountain Time)
8:15 a.m.–5:45 p.m., September 18,
2012.
8:15 a.m.–5:45 p.m., September 19,
2012.
8:15 a.m.–12:00 p.m., September 20,
2012.
BILLING CODE 4163–18–P
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
TKELLEY on DSK3SPTVN1PROD with NOTICES
Centers for Disease Control and
Prevention
Advisory Board on Radiation and
Worker Health (ABRWH or Advisory
Board), National Institute for
Occupational Safety and Health
(NIOSH)
In accordance with section 10(a)(2) of
the Federal Advisory Committee Act
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Public Comment Times and Dates (All
Times are Mountain Time)
6:00 p.m.–7:00 p.m.*, September 18,
2012.
6:00 p.m.–7:00 p.m.*, September 19,
2012.
*Please note that the public comment
periods may end before the times
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Average
burden per
response
(in hr)
9
1
45/60
50
1
4
50
50
1
12
45/60
1
15
12
1
50
1
1
100
State and Community Awardee Project Director/Project Coordinator Needs Assessment.
State and Community Awardee Performance Measure Reporting Tool.
State and Community Awardee Staff Needs Assessment .......
State and Community Awardee Training and Technical Assistance Reporting Tool.
National Organization Awardee Training and Technical Assistance Reporting Tool.
Community and Clinical Partner Clinical Partner Needs Assessment.
Community and Clinical Partner Program Implementation
Partner Needs Assessment.
Dated: August 23,2012.
Ron A. Otten,
Director, Office of Scientific Integrity (OSI),
Office of the Associate Director for Science,
Office of the Directors, Centers for Disease
Control and Prevention.
Number of
responses per
respondent
1
45/60
Number of
respondents
Form name
Sfmt 4703
indicated, following the last call for
comments. Members of the public who
wish to provide public comments
should plan to attend public comment
sessions at the start times listed.
Place: Denver Marriott Tech Center,
4900 South Syracuse Street, Denver,
Colorado 80237; Telephone: 303–779–
1100; Fax: 303–740–2523. Audio
Conference Call via FTS Conferencing:
The USA toll-free, dial-in number is 1–
866–659–0537 with a pass code of
9933701.
Status: Open to the public, limited
only by the space available. The meeting
space accommodates approximately 150
people.
Background: The Advisory Board was
established under the Energy Employees
Occupational Illness Compensation
Program Act of 2000 to advise the
President on a variety of policy and
technical functions required to
E:\FR\FM\29AUN1.SGM
29AUN1
Agencies
[Federal Register Volume 77, Number 168 (Wednesday, August 29, 2012)]
[Notices]
[Pages 52334-52335]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: 2012-21323]
-----------------------------------------------------------------------
DEPARTMENT OF HEALTH AND HUMAN SERVICES
Centers for Disease Control and Prevention
[30Day-12-12EK]
Agency Forms Undergoing Paperwork Reduction Act Review
The Centers for Disease Control and Prevention (CDC) publishes a
list of information collection requests under review by the Office of
Management and Budget (OMB) in compliance with the Paperwork Reduction
Act (44 U.S.C. chapter 35). To request a copy of these requests, call
the CDC Reports Clearance Officer at (404) 639-7570 or send an email to
omb@cdc.gov. Send written comments to CDC Desk Officer, Office of
Management and Budget, Washington, DC or by fax to (202) 395-5806.
Written comments should be received within 30 days of this notice.
Proposed Project
Process and Intermediate Outcome Evaluation of ``Teenage Pregnancy
Prevention: Integrating Services, Programs, and Strategies through
Community-Wide Initiatives''--New--National Center for Chronic Disease
Prevention and Health Promotion (NCCDPHP), Centers for Disease Control
and Prevention (CDC).
Background and Brief Description
CDC is currently providing funding to nine state and community
awardees, and five national organizations, to examine innovative,
evidence-based teenage pregnancy prevention programs. Efforts are
focused in communities with high rates of teen pregnancy in under-
served African American and Latino youth. Components of these efforts
include (1) implementing evidence-based or evidence-informed prevention
programs; (2) linking teens to quality
[[Page 52335]]
health services; (3) educating stakeholders (parents, community
leaders, and other constituents) about relevant evidence-based or
evidence-informed strategies to reduce teen pregnancy; and (4)
supporting the sustainability of the community-wide teen pregnancy
prevention effort through capacity building and improved coordination
of services.
CDC proposes to collect the information needed to conduct a process
and intermediate outcome evaluation of these efforts. The information
collection and evaluation plan will systematically document capacity
building within funded communities and the extent to which communities
implement multi-component, community-wide initiative activities.
Respondents for the nine state and community awardees will include the
project director/coordinator for each site, evaluators, and other
program staff. In addition, to gain a variety of perspectives,
information will be requested from multiple community and clinical
partners associated with each state or community awardee (e.g., program
implementers and core advisory group members). Information collected
from these respondents will include needs assessments. Finally, CDC
will collect information about the training and technical assistance
needs of state and community awardees, and national organizations,
which have been funded to support community-wide teen pregnancy
prevention (TPP) activities.
The training and technical assistance reporting forms will be
submitted to CDC electronically through an interactive web-based
system. The remaining information collection forms will initially be
fielded in hardcopy, but respondents may submit the completed forms to
CDC via electronic mail. To allow flexibility based on awardee
preferences, web-based reporting options may be implemented for all
forms. Assessment and performance information will be reported to CDC
annually. Training and technical assistance needs will be reported
monthly so that CDC can provide immediate, targeted technical
assistance as needed.
The assessment information, performance measures and training and
technical assistance information to be collected are critical to
understanding (1) the teen pregnancy prevention needs of each target
community, (2) quality implementation practices associated with
evidence-based programs and contraceptive access, and (3) the impact of
implemented strategies.
OMB approval is requested for three years. There are no costs to
respondents other than their time. The total estimated annualized
burden hours are 1,150.
Estimated Annualized Burden Hours
----------------------------------------------------------------------------------------------------------------
Average
Number of Number of burden per
Type of respondent Form name respondents responses per response
respondent (in hr)
----------------------------------------------------------------------------------------------------------------
State and Community Awardees......... State and Community Awardee 9 1 45/60
Project Director/Project
Coordinator Needs
Assessment.
State and Community Awardee 50 1 4
Performance Measure
Reporting Tool.
State and Community Awardee 50 1 45/60
Staff Needs Assessment.
State and Community Awardee 50 12 1
Training and Technical
Assistance Reporting Tool.
National Organization Awardees....... National Organization 15 12 1
Awardee Training and
Technical Assistance
Reporting Tool.
Community and Clinical Partners...... Community and Clinical 50 1 1
Partner Clinical Partner
Needs Assessment.
Community and Clinical 100 1 45/60
Partner Program
Implementation Partner
Needs Assessment.
----------------------------------------------------------------------------------------------------------------
Dated: August 23,2012.
Ron A. Otten,
Director, Office of Scientific Integrity (OSI), Office of the Associate
Director for Science, Office of the Directors, Centers for Disease
Control and Prevention.
[FR Doc. 2012-21323 Filed 8-28-12; 8:45 am]
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