Draft National Toxicology Program (NTP) Monograph on Developmental Effects and Pregnancy Outcomes Associated With Cancer Chemotherapy Use During Pregnancy; Request for Comments; Peer Review Panel Meeting, 48995-48997 [2012-20044]

Download as PDF 48995 Federal Register / Vol. 77, No. 158 / Wednesday, August 15, 2012 / Notices implementation, and evaluation of tobacco-product regulations in the U.S. Frequency of Response: Annually. Affected Public: Individuals or households. Type of Respondents: Youth (ages 12–17) and Adults (ages 18+). The annual reporting burden for the field test is presented in Table 1, and the annual reporting burden for the baseline data collection is presented in Table 2. The annualized cost to respondents for the field test is estimated at: $22,993; and the annualized cost to respondents for the baseline data collection is: $1,792,156. There are no capital, operating, or maintenance costs. TABLE 1—PATH STUDY FIELD TEST HOUR BURDEN ESTIMATES Estimated number of respondents Type of respondents Estimated number of responses per respondent Average burden hours per response Estimated total annual burden hours requested Adults—Household Screener .......................................................................... Adults—Individual Screener ............................................................................ Adults—Extended Interview ............................................................................. Adults—Biospecimen Collection Forms ........................................................... Adults—Tobacco Use Form ............................................................................ Adults—Followup/Tracking Participant Information Form ............................... Youth—Extended Interview ............................................................................. Adult—Parent Interview ................................................................................... Adults—Followup/Tracking Participant Information Form for Youth (completed by parents) ........................................................................................ 1,295 840 590 590 590 590 100 100 1 1 1 1 1 2 1 1 ⁄ ⁄ 19⁄60 9⁄60 2⁄60 6⁄60 35⁄60 19⁄60 367 84 679 89 20 118 58 32 100 2 8 60 ⁄ 27 Total .......................................................................................................... ........................ ........................ ........................ 1,446 Estimated number of responses per respondent Average burden hours per response Estimated total annual burden hours requested 17 60 6 60 TABLE 2—PATH STUDY BASELINE HOUR BURDEN ESTIMATES Estimated number of respondents Type of respondents 100,983 63,000 42,730 42,730 42,730 42,730 16,857 16,857 1 1 1 1 1 2 1 1 ⁄ ⁄ 19⁄60 9⁄60 2⁄60 6⁄60 35⁄60 19⁄60 28,612 6,300 49,140 6,410 1,424 8,546 9,833 5,338 16,857 2 8 60 ⁄ 4,495 Total .......................................................................................................... srobinson on DSK4SPTVN1PROD with NOTICES Adults—Household Screener .......................................................................... Adults—Individual Screener ............................................................................ Adults—Extended Interview ............................................................................. Adults—Biospecimen Collection Forms ........................................................... Adults—Tobacco Use Form ............................................................................ Adults—Followup/Tracking Participant Information Form ............................... Youth—Extended Interview ............................................................................. Adult—Parent Interview ................................................................................... Adults—Followup/Tracking Participant Information Form for Youth (completed by parents) ........................................................................................ ........................ ........................ ........................ 115,602 Request for Comments: Written comments and/or suggestions from the public and affected agencies are invited on one or more of the following points: (1) Whether the proposed collection of information is necessary for the proper performance of the function of the agency, including whether the information will have practical utility; (2) The accuracy of the agency’s estimate of the burden of the proposed collection of information, including the validity of the methodology and assumptions used; (3) Ways to enhance the quality, utility, and clarity of the information to be collected; and (4) Ways to minimize the burden of the collection of information on those who are to respond, including the use of appropriate automated, electronic, mechanical, or other technological collection techniques or other forms of information technology. VerDate Mar<15>2010 17:49 Aug 14, 2012 Jkt 226001 Direct Comments to OMB: Written comments and/or suggestions regarding the item(s) contained in this notice, especially regarding the estimated public burden and associated response time, should be directed to the: Office of Management and Budget, Office of Regulatory Affairs, OIRA_submission@omb.eop.gov or by fax to 202–395–6974, Attention: Desk Officer for NIH. To request more information on the proposed project or to obtain a copy of the data collection plans and instruments, contact: Kevin P. Conway, Ph.D., Deputy Director, Division of Epidemiology, Services, and Prevention Research, National Institute on Drug Abuse, 6001 Executive Blvd., Room 5185; 301–443–8755; email PATHprojectofficer@mail.nih.gov. Comments Due Date: Comments regarding this information collection are best assured of having their full effect if PO 00000 Frm 00048 Fmt 4703 Sfmt 4703 17 60 6 60 received within 30-days of the date of this publication. Dated: August 7, 2012. Glenda J. Conroy, Executive Officer (OM Director) NIDA. [FR Doc. 2012–20068 Filed 8–14–12; 8:45 am] BILLING CODE 4140–01–P DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Draft National Toxicology Program (NTP) Monograph on Developmental Effects and Pregnancy Outcomes Associated With Cancer Chemotherapy Use During Pregnancy; Request for Comments; Peer Review Panel Meeting Division of the National Toxicology Program (DNTP), National AGENCY: E:\FR\FM\15AUN1.SGM 15AUN1 48996 Federal Register / Vol. 77, No. 158 / Wednesday, August 15, 2012 / Notices Institute of Environmental Health Sciences (NIEHS), National Institutes of Health. ACTION: Notice. The peer review meeting will take place October 1, 2012, 1:00 to 5:00 p.m. Eastern Daylight Time (EDT) and October 2, 2012, from 8:30 a.m. until adjournment, approximately 5 p.m. Two days are set aside for the meeting; however, it may adjourn sooner if the panel completes its peer review of the draft monograph. Topic: Peer review of the draft NTP Monograph on Developmental Effects and Pregnancy Outcomes Associated with Cancer Chemotherapy Use during Pregnancy (available by August 14, 2012, at https://ntp.niehs.nih.gov/go/ 36639). Place: Rodbell Auditorium, Rall Building, NIEHS, 111 T.W. Alexander Drive, Research Triangle Park, NC 27709. The meeting is open to the public with attendance limited only by the space available. Webcast of the meeting will be available at https:// www.niehs.nih.gov/news/video/ index.cfm. Contact Person: Dr. Mary S. Wolfe, NTP Designated Federal Official, Office of Liaison, Policy and Review, DNTP, NIEHS, P.O. Box 12233, MD K2–03, Research Triangle Park, NC 27709, Phone: (919) 541–7539, Fax: (919) 541– 0295, or wolfe@niehs.nih.gov. Courier address: 530 Davis Drive, Room 2142, Morrisville, NC 27560. Request for Comments and Registration: The meeting is open to the public with time scheduled for oral public comment. The NTP also invites written comments on the draft monograph, submission deadline is September 14, 2012, and the deadline for pre-registration to attend the meeting and/or provide oral comments is September 24, 2012, online registration is available at https://ntp.niehs.nih.gov/ go/36639. Visitor and security information is available at https:// www.niehs.nih.gov/about/visiting/ index.cfm. Public comments and any other correspondence on the draft monograph should be sent to the Contact Person. Individuals with disabilities who need accommodation to participate in this event should contact Danica Andrews at phone: (919) 541– 2595 or email: andrewsda@niehs.nih.gov. TTY users should contact the Federal TTY Relay Service at 800–877–8339. Requests should be made at least five business days in advance of the event. SUPPLEMENTARY INFORMATION: srobinson on DSK4SPTVN1PROD with NOTICES DATES: VerDate Mar<15>2010 17:49 Aug 14, 2012 Jkt 226001 Background The panel will peer review the Draft NTP Monograph on Developmental Effects and Pregnancy Outcomes Associated with Cancer Chemotherapy Use during Pregnancy, prepared by the Office of Health Assessment and Translation (OHAT), DNTP. Cancer diagnosed during pregnancy affects approximately 1/6000 to 1/1000 women. Treatment for cancer frequently involves chemotherapy, and nearly all chemotherapeutic agents are known developmental toxicants in laboratory animals. OHAT has prepared a comprehensive draft NTP Monograph that summarizes the effects on development and pregnancy outcomes of gestational exposure to 52 cancer chemotherapeutic agents, individually and/or in combination therapy as reported in the peer-reviewed literature. The draft monograph also provides information on seven frequently diagnosed cancers in pregnant women and on mechanism of action, placental and breast milk transport, and laboratory animal developmental toxicology for the more frequently used chemotherapeutic agents. The overall goal of the monograph is to serve as a resource for the medical communities and their patients. Preliminary Topic and Availability of Meeting Materials The preliminary agenda and draft monograph should be posted on the NTP Web site (https://ntp.niehs.nih.gov/ go/36639) by August 14, 2012. Additional information, when available, will be posted on the NTP Web site or may be requested in hardcopy from the Contact Person. Following the meeting, a report of the peer review will be prepared and made available on the NTP Web site. Registered attendees are encouraged to access the meeting page to stay abreast of the most current information regarding the meeting. Request for Comments The NTP invites written comments on the draft monograph, which should be received by September 14, 2012, to enable review by the peer review panel and NTP staff prior to the meeting. Persons submitting written comments should include their name, affiliation, mailing address, phone, email, and sponsoring organization (if any) with the document. Written comments received in response to this notice will be posted on the NTP Web site, and the submitter will be identified by name, affiliation, and/or sponsoring organization. PO 00000 Frm 00049 Fmt 4703 Sfmt 4703 Public input at this meeting is also invited, and time is set aside for the presentation of oral comments on the draft monograph. In addition to inperson oral comments at the meeting at the NIEHS, public comments can be presented by teleconference line. There will be 50 lines for this call; availability will be on a first-come, first-served basis. The available lines will be open from 1–5 p.m. EDT on October 1 and from 8:30 until adjournment on October 2, although oral comments will be received only during the formal public comment period indicated on the preliminary agenda. Each organization is allowed one time slot. At least 7 minutes will be allotted to each speaker, and if time permits, may be extended to 10 minutes at the discretion of the chair. Persons wishing to make an oral presentation are asked to register online at https://ntp.niehs.nih.gov/go/36639 by September 24, 2012, and if possible, to send a copy of their slides and/or statement or talking points at that time. Written statements can supplement and may expand the oral presentation. Registration for oral comments will also be available at the meeting, although time allowed for presentation by on-site registrants may be less than that for preregistered speakers and will be determined by the number of persons who register on-site. Background Information on OHAT and NTP Peer Review Panels The NIEHS/DNTP established OHAT to serve as an environmental health resource to the public and to regulatory and health agencies. This office conducts evaluations to assess the evidence that environmental chemicals, physical substances, or mixtures (collectively referred to as ‘‘substances’’) cause adverse health effects and provides opinions on whether these substances may be of concern given what is known about current human exposure levels. OHAT also organizes workshops or state-of-the-science evaluations to address issues of importance in environmental health sciences. OHAT assessments are published as NTP Monographs. Information about OHAT is found at https://ntp.niehs.nih.gov/go/ohat. NTP panels are technical, scientific advisory bodies established on an ‘‘as needed’’ basis to provide independent scientific peer review and advise the NTP on agents of public health concern, new/revised toxicological test methods, or other issues. These panels help ensure transparent, unbiased, and scientifically rigorous input to the program for its use in making credible decisions about human hazard, setting E:\FR\FM\15AUN1.SGM 15AUN1 Federal Register / Vol. 77, No. 158 / Wednesday, August 15, 2012 / Notices research and testing priorities, and providing information to regulatory agencies about alternative methods for toxicity screening. The NTP welcomes nominations of scientific experts for upcoming panels. Scientists interested in serving on an NTP panel should provide a current curriculum vitae to the Contact Person. The authority for NTP panels is provided by 42 U.S.C. 217a; section 222 of the Public Health Service (PHS) Act, as amended. The panel is governed by the Federal Advisory Committee Act, as amended (5 U.S.C. Appendix 2), which sets forth standards for the formation and use of advisory committees. Dated: August 8, 2012. John R. Bucher, Associate Director, National Toxicology Program. [FR Doc. 2012–20044 Filed 8–14–12; 8:45 am] BILLING CODE 4140–01–P DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Government-Owned Inventions; Availability for Licensing National Institutes of Health, Public Health Service, HHS. ACTION: Notice. AGENCY: The inventions listed below are owned by an agency of the U.S. Government and are available for licensing in the U.S. in accordance with 35 U.S.C. 207 to achieve expeditious commercialization of results of federally-funded research and development. Foreign patent applications are filed on selected inventions to extend market coverage for companies and may also be available for licensing. FOR FURTHER INFORMATION CONTACT: Licensing information and copies of the U.S. patent applications listed below may be obtained by writing to the indicated licensing contact at the Office of Technology Transfer, National Institutes of Health, 6011 Executive Boulevard, Suite 325, Rockville, Maryland 20852–3804; telephone: 301– 496–7057; fax: 301–402–0220. A signed Confidential Disclosure Agreement will be required to receive copies of the patent applications. srobinson on DSK4SPTVN1PROD with NOTICES SUMMARY: Quick2Insight: 3D Biological Tissue Image Rendering Software Description of Technology: Available for licensing for commercialization or internal use is software providing automatic visualization of features VerDate Mar<15>2010 17:49 Aug 14, 2012 Jkt 226001 inside biological image volumes in 3D. The software provides a simple and interactive visualization for the exploration of biological datasets through dataset-specific transfer functions and direct volume rendering. The method employs a K–Means++ clustering algorithm to classify a twodimensional histogram created from the input volume. The classification process utilizes spatial and data properties from the volume. Then using properties derived from the classified clusters the software automatically generates color and opacity transfer functions and presents the user with a high quality initial rendering of the volume data. User input can be incorporated through the simple yet intuitive interface for transfer function manipulation included in our framework. Our new interface helps users focus on feature space exploration instead of the usual effort intensive, low-level widget manipulation. Potential Commercial Applications: • Biological tissue visualization in 3D • Research uses Competitive Advantages: • User friendly • Intuitive interface Development Stage: Prototype Inventors: Yanling Liu, Jack Collins, Curtis Lisle (all of FCRDC/SAIC) Publications: 1. Maciejewski R, et al. Structuring feature space: a non-parametric method for volumetric transfer function generation. IEEE Trans Vis Comput Graphics. 2009 Nov– Dec;15(6):1473–80. [PMID 19834223] 2. Zhou J, Takatsuka M. Automatic transfer function generation using contour tree controlled residue flow model and color harmonics. IEEE Trans Vis Comput Graphics. 2009 Nov–Dec;15(6):1481–8. [PMID 19834224] ¨ 3. Rottger S, et al. Spatialized Transfer Functions. In: Brodlie K, Duke DJ, and Joy KI (eds.) EuroVis05 Joint Eurographics—IEEE VGTC Symposium on Visualization 1–3 June 2005, Leeds, United Kingdom, pp. 271–278. [doi: 10.2312/VisSym/EuroVis05/271–278] Intellectual Property: HHS Reference No. E–254–2012/0 — Software Research Tool. Patent protection is not being pursued for this technology. Licensing Contact: Michael Shmilovich; 301–435–5019; shmilovm@mail.nih.gov. Collaborative Research Opportunity: The National Cancer Institute is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate or commercialize automatic 3D visualization of biological image volumes. For collaboration opportunities, please contact John Hewes, Ph.D. at hewesj@mail.nih.gov. PO 00000 Frm 00050 Fmt 4703 Sfmt 4703 48997 Human Renal Epithelial Tubular Cells for Studies of Cystinosis Description of Technology: Cystinosis is a rare lysosomal storage disease, affecting about 500 people (mostly children) in the United States and about 2000 people worldwide. It is an autosomal recessive disorder, wherein patients have a defect in the CTNS gene, which codes for the lysosomal cystine transporter. In this disorder, cystine (an amino acid) is not properly transported out of the lysosome and accumulates in the cells, forming damaging crystals. As a result, cystinosis slowly destroys various organs in the body, including kidneys, liver, muscles, eyes, and brain. Currently, the only treatment for cystinosis is cysteamine, a drug that reduces intracellular cystine levels, although this treatment requires frequent dosing. Available from NHGRI are human renal epithelial tubular cells isolated from cystinosis patient samples. These cells may be useful for studying the biology of cystinosis, as well as the metabolic role of the lysosomal cystine transporter; they may also be useful for the development of screening assays for potential therapeutic agents for cystinosis. Potential Commercial Applications: • Use in studies focused on cystinosis and lysosomal metabolism • Use in assays for high throughput screening of potential therapeutic agents Competitive Advantages: These cell lines were derived from cystinosis patient samples, and studies performed using these cells are expected to correlate well to the initiation, progression and treatment of cystinosis in patients. Development Stage: Early-stage Inventor: William A. Gahl (NHGRI) Intellectual Property: HHS Reference No. E–204–2012/0—Research Tool. Patent protection is not being pursued for this technology. Licensing Contact: Tara L. Kirby, Ph.D.; 301–435–4426; tarak@mail.nih.gov. Context Aware Mobile Device Software for Substance Abuse Interventions and Behavioral Modification Description of Technology: Available for licensing for commercial development is software that provides personalized feedback for treating drug dependence and associated risky behaviors. The tool is designed for both healthcare providers at the point-of-care and for self-help. Many people who could benefit from treatment do not receive it because of its low availability and high cost. The available software E:\FR\FM\15AUN1.SGM 15AUN1

Agencies

[Federal Register Volume 77, Number 158 (Wednesday, August 15, 2012)]
[Notices]
[Pages 48995-48997]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: 2012-20044]


-----------------------------------------------------------------------

DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Draft National Toxicology Program (NTP) Monograph on 
Developmental Effects and Pregnancy Outcomes Associated With Cancer 
Chemotherapy Use During Pregnancy; Request for Comments; Peer Review 
Panel Meeting

AGENCY: Division of the National Toxicology Program (DNTP), National

[[Page 48996]]

Institute of Environmental Health Sciences (NIEHS), National Institutes 
of Health.

ACTION: Notice.

-----------------------------------------------------------------------

DATES: The peer review meeting will take place October 1, 2012, 1:00 to 
5:00 p.m. Eastern Daylight Time (EDT) and October 2, 2012, from 8:30 
a.m. until adjournment, approximately 5 p.m. Two days are set aside for 
the meeting; however, it may adjourn sooner if the panel completes its 
peer review of the draft monograph.
    Topic: Peer review of the draft NTP Monograph on Developmental 
Effects and Pregnancy Outcomes Associated with Cancer Chemotherapy Use 
during Pregnancy (available by August 14, 2012, at https://ntp.niehs.nih.gov/go/36639).
    Place: Rodbell Auditorium, Rall Building, NIEHS, 111 T.W. Alexander 
Drive, Research Triangle Park, NC 27709. The meeting is open to the 
public with attendance limited only by the space available. Webcast of 
the meeting will be available at https://www.niehs.nih.gov/news/video/index.cfm.
    Contact Person: Dr. Mary S. Wolfe, NTP Designated Federal Official, 
Office of Liaison, Policy and Review, DNTP, NIEHS, P.O. Box 12233, MD 
K2-03, Research Triangle Park, NC 27709, Phone: (919) 541-7539, Fax: 
(919) 541-0295, or wolfe@niehs.nih.gov. Courier address: 530 Davis 
Drive, Room 2142, Morrisville, NC 27560.
    Request for Comments and Registration: The meeting is open to the 
public with time scheduled for oral public comment. The NTP also 
invites written comments on the draft monograph, submission deadline is 
September 14, 2012, and the deadline for pre-registration to attend the 
meeting and/or provide oral comments is September 24, 2012, online 
registration is available at https://ntp.niehs.nih.gov/go/36639. Visitor 
and security information is available at https://www.niehs.nih.gov/about/visiting/index.cfm. Public comments and any other correspondence 
on the draft monograph should be sent to the Contact Person. 
Individuals with disabilities who need accommodation to participate in 
this event should contact Danica Andrews at phone: (919) 541-2595 or 
email: andrewsda@niehs.nih.gov. TTY users should contact the Federal 
TTY Relay Service at 800-877-8339. Requests should be made at least 
five business days in advance of the event.

SUPPLEMENTARY INFORMATION:

Background

    The panel will peer review the Draft NTP Monograph on Developmental 
Effects and Pregnancy Outcomes Associated with Cancer Chemotherapy Use 
during Pregnancy, prepared by the Office of Health Assessment and 
Translation (OHAT), DNTP. Cancer diagnosed during pregnancy affects 
approximately 1/6000 to 1/1000 women. Treatment for cancer frequently 
involves chemotherapy, and nearly all chemotherapeutic agents are known 
developmental toxicants in laboratory animals. OHAT has prepared a 
comprehensive draft NTP Monograph that summarizes the effects on 
development and pregnancy outcomes of gestational exposure to 52 cancer 
chemotherapeutic agents, individually and/or in combination therapy as 
reported in the peer-reviewed literature. The draft monograph also 
provides information on seven frequently diagnosed cancers in pregnant 
women and on mechanism of action, placental and breast milk transport, 
and laboratory animal developmental toxicology for the more frequently 
used chemotherapeutic agents. The overall goal of the monograph is to 
serve as a resource for the medical communities and their patients.

Preliminary Topic and Availability of Meeting Materials

    The preliminary agenda and draft monograph should be posted on the 
NTP Web site (https://ntp.niehs.nih.gov/go/36639) by August 14, 2012. 
Additional information, when available, will be posted on the NTP Web 
site or may be requested in hardcopy from the Contact Person. Following 
the meeting, a report of the peer review will be prepared and made 
available on the NTP Web site. Registered attendees are encouraged to 
access the meeting page to stay abreast of the most current information 
regarding the meeting.

Request for Comments

    The NTP invites written comments on the draft monograph, which 
should be received by September 14, 2012, to enable review by the peer 
review panel and NTP staff prior to the meeting. Persons submitting 
written comments should include their name, affiliation, mailing 
address, phone, email, and sponsoring organization (if any) with the 
document. Written comments received in response to this notice will be 
posted on the NTP Web site, and the submitter will be identified by 
name, affiliation, and/or sponsoring organization.
    Public input at this meeting is also invited, and time is set aside 
for the presentation of oral comments on the draft monograph. In 
addition to in-person oral comments at the meeting at the NIEHS, public 
comments can be presented by teleconference line. There will be 50 
lines for this call; availability will be on a first-come, first-served 
basis. The available lines will be open from 1-5 p.m. EDT on October 1 
and from 8:30 until adjournment on October 2, although oral comments 
will be received only during the formal public comment period indicated 
on the preliminary agenda. Each organization is allowed one time slot. 
At least 7 minutes will be allotted to each speaker, and if time 
permits, may be extended to 10 minutes at the discretion of the chair. 
Persons wishing to make an oral presentation are asked to register 
online at https://ntp.niehs.nih.gov/go/36639 by September 24, 2012, and 
if possible, to send a copy of their slides and/or statement or talking 
points at that time. Written statements can supplement and may expand 
the oral presentation. Registration for oral comments will also be 
available at the meeting, although time allowed for presentation by on-
site registrants may be less than that for pre-registered speakers and 
will be determined by the number of persons who register on-site.

Background Information on OHAT and NTP Peer Review Panels

    The NIEHS/DNTP established OHAT to serve as an environmental health 
resource to the public and to regulatory and health agencies. This 
office conducts evaluations to assess the evidence that environmental 
chemicals, physical substances, or mixtures (collectively referred to 
as ``substances'') cause adverse health effects and provides opinions 
on whether these substances may be of concern given what is known about 
current human exposure levels. OHAT also organizes workshops or state-
of-the-science evaluations to address issues of importance in 
environmental health sciences. OHAT assessments are published as NTP 
Monographs. Information about OHAT is found at https://ntp.niehs.nih.gov/go/ohat.
    NTP panels are technical, scientific advisory bodies established on 
an ``as needed'' basis to provide independent scientific peer review 
and advise the NTP on agents of public health concern, new/revised 
toxicological test methods, or other issues. These panels help ensure 
transparent, unbiased, and scientifically rigorous input to the program 
for its use in making credible decisions about human hazard, setting

[[Page 48997]]

research and testing priorities, and providing information to 
regulatory agencies about alternative methods for toxicity screening. 
The NTP welcomes nominations of scientific experts for upcoming panels. 
Scientists interested in serving on an NTP panel should provide a 
current curriculum vitae to the Contact Person. The authority for NTP 
panels is provided by 42 U.S.C. 217a; section 222 of the Public Health 
Service (PHS) Act, as amended. The panel is governed by the Federal 
Advisory Committee Act, as amended (5 U.S.C. Appendix 2), which sets 
forth standards for the formation and use of advisory committees.

    Dated: August 8, 2012.
John R. Bucher,
Associate Director, National Toxicology Program.
[FR Doc. 2012-20044 Filed 8-14-12; 8:45 am]
BILLING CODE 4140-01-P
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.