Kentucky; Amendment No. 5 to Notice of a Major Disaster Declaration, 18834-18835 [2012-7396]
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tkelley on DSK3SPTVN1PROD with NOTICES
18834
Federal Register / Vol. 77, No. 60 / Wednesday, March 28, 2012 / Notices
inventors designed a rapid mass
spectrometry device using direct impact
spark ionization source for microbial
analytes identification via spectral
pattern recognition. The device design
includes a rapid mass spectrometer
suitable for analyzing microbiological
samples that was earlier used to analyze
low volatile organic compounds. The
device employs a solid needle for
electrode discharge. It includes a gear
plate that introduces stainless steel pins
carrying bacterial samples. The pins
also act as counter electrodes and are
targeted by controlled arcs. The small
custom-made glass cylinder that is
meant to shut out oxygen and prevent
the introduction of ambient moisture
into the analyte is unique from other
DISI device. The examination revealed
enormous peak intensity and spectral
information with normal ionization
mode on the same instrument. This
device can be employed in fields such
as pathogen determination in clinical
settings, QA/QC (of drugs, food or
cosmetic ingredients), continuous
monitoring of (airborne) Biological
Warfare Agents and the like.
Potential Commercial Applications:
• Pathogen detection,
• QA/QC (of drugs, food or cosmetic
ingredients),
• Continuous monitoring of (airborne)
Biological Warfare Agents and the like.
Competitive Advantages:
• Rapid, specific, sensitive and
reproducible identification of
microbiological analytes.
• Systematic acquisition of
reproducible spectra among same
bacterial species.
• Whole cell analysis of food-borne
pathogens is rapid, safer and microreliable.
• Characteristic mass spectra
obtained and reproduced for food-borne
pathogens.
• Unique DISI device with gas
cylinder chamber.
Development Stage:
• Prototype.
• In vitro data available.
Inventors: Peter Alusta, Cameron
Dorey, Ryan Parker, Dan A. Buzatu, Jon
G. Wilkes (all of FDA/NCTR).
Intellectual Property: HHS Reference
No. E–258–2011/0—U.S. Patent
Application No. 13/271,182 filed 11 Oct
2011.
Related Technologies:
• HHS Reference No. E–169–2000/
0—U.S. Patent Application No. 09/
975,530 filed 10 Oct 2001.
• HHS Reference No. E–259–2011/
0—U.S. Provision Application No. 61/
564,926 filed 30 Nov 2011.
Licensing Contact: Michael A.
Shmilovich, Esq., CLP; 301–435–5019;
shmilovm@mail.nih.gov.
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17:29 Mar 27, 2012
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Collaborative Research Opportunity:
The NCTR/FDA inventors are seeking
statements of capability or interest from
parties interested in collaborative
research to further develop, evaluate or
commercialize this device. For
collaboration opportunities, please
contact Alice Y. Welch, Ph.D. at
Alice.Welch@fda.hhs.gov.
Method of Treating Hepatitis C Virus
Infection With a Small Molecule CHK2
Inhibitor
Description of Technology: DNA
damage sensors such as Checkpoint
Kinase 2 (Chk2) are key regulators of the
cellular DNA damage response that
limits cell-cycle progression in response
to DNA damage. It has been reported
that these DNA damage sensors also
play a key role in Hepatitis C virus
(HCV) replication. The subject
technology are small molecule CHK2
kinase inhibitors that have been shown
to have promising activity against HCV
replication. The compounds were
discovered by high throughput
screening of chemical libraries with
more than 150,000 compounds. These
novel compounds can potentially be
used in combination with other antiHCV drugs or interferon and represent
a novel target for treating HCV. In vitro
antiviral assay data, as well as
preliminary in vitro and in vivo
pharmokinetic data are available upon
request.
Potential Commercial Applications:
The subject technology can potentially
be developed into anti-HCV
therapeutics, particularly in
combination with other anti-HCV
therapeutics.
Competitive Advantages: The subject
technology represents a novel and
promising target for treating HCV
infection and thus, has the potential to
increase the efficacy of other HCV
antivirals that directly target HCV in a
multi-drug formulation. Furthermore,
since the subject technology targets a
cellular protein necessary for HCV
replication and not the virus itself, the
emergence of viral resistance against the
subject technology could be low or more
delayed.
Development Stage:
• Early-stage.
• Pre-clinical.
• In vitro data available.
• In vivo data available (animal).
Inventors: Yves G. Pommier, Robert H.
Shoemaker, Dominic A. Scudiero,
Andrew G. Jobson, David S. Waugh,
George T. Lountos (all of NCI)
Publications:
1. Jobson AG, et al. Identification of
a Bis-guanylhydrazone [4,4′Diacetyldiphenylurea-
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bis(guanylhydrazone); NSC 109555] as a
novel chemotype for inhibition of Chk2
kinase. Mol Pharmacol 2007
Oct;72(4):876–884. [PMID 17616632]
2. Jobson AG, et al. Cellular inhibition
of checkpoint kinase 2 (Chk2) and
potentiation of camptothecins and
radiation by the novel Chk2 inhibitor
PV1019 [7-nitro-1H-indole-2-carboxylic
acid {4-[1-(guanidinohydrazone)-ethyl]phenyl}-amide]. J Pharmacol Exp Ther.
2009 Dec;331(3):816–826. [PMID
19741151]
3. Lountos GT, et al. Crystal structure
of checkpoint kinase 2 in complex with
NSC 109555, a potent and selective
inhibitor. Protein Sci. 2009
Jan;18(1):92–100. [PMID 19177354]
4. Lountos GT, et al. X-ray structures
of checkpoint kinase 2 in complex with
inhibitors that target its gatekeeperdependent hydrophobic pocket. FEBS
Lett. 2011Oct 20;585(20):3245–3249.
[PMID 21907711]
5. Lountos GT, et al. Structural
characterization of inhibitor complexes
with checkpoint kinase 2 (Chk2), a drug
target for cancer therapy. J Struct Biol.
2011 Dec;176(3):292–301. [PMID
21963792]
Intellectual Property: HHS Reference
No. E–224–2011/0—U.S. Provisional
Patent Application No. 61/551,742 filed
26 Oct 2011.
Related Technology: HHS Reference
No. E–211–2005/0—U.S. Patent
Application No. 11/989,737 filed 29 Jan
2008, with corresponding applications
in Europe, Canada, and Australia.
Licensing Contact: Kevin W. Chang,
Ph.D.; 301–435–5018;
changke@mail.nih.gov.
Dated: March 22, 2012.
Richard U. Rodriguez,
Director, Division of Technology Development
and Transfer, Office of Technology Transfer,
National Institutes of Health.
[FR Doc. 2012–7419 Filed 3–27–12; 8:45 am]
BILLING CODE 4140–01–P
DEPARTMENT OF HOMELAND
SECURITY
Federal Emergency Management
Agency
[Internal Agency Docket No. FEMA–4057–
DR; Docket ID FEMA–2012–0002]
Kentucky; Amendment No. 5 to Notice
of a Major Disaster Declaration
Federal Emergency
Management Agency, DHS.
ACTION: Notice.
AGENCY:
This notice amends the notice
of a major disaster declaration for the
SUMMARY:
E:\FR\FM\28MRN1.SGM
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Federal Register / Vol. 77, No. 60 / Wednesday, March 28, 2012 / Notices
Commonwealth of Kentucky (FEMA–
4057–DR), dated March 6, 2012, and
related determinations.
DATES: Effective Date: March 20, 2012.
FOR FURTHER INFORMATION CONTACT:
Peggy Miller, Office of Response and
Recovery, Federal Emergency
Management Agency, 500 C Street SW.,
Washington, DC 20472, (202) 646–3886.
SUPPLEMENTARY INFORMATION: The notice
of a major disaster declaration for the
Commonwealth of Kentucky is hereby
amended to include the following areas
among those areas determined to have
been adversely affected by the event
declared a major disaster by the
President in his declaration of March 6,
2012.
Ballard County for Public Assistance.
Johnson, Kenton, Larue, Pendleton,
Trimble, and Wolfe Counties for Public
Assistance (already designated for Individual
Assistance).
The following Catalog of Federal Domestic
Assistance Numbers (CFDA) are to be used
for reporting and drawing funds: 97.030,
Community Disaster Loans; 97.031, Cora
Brown Fund; 97.032, Crisis Counseling;
97.033, Disaster Legal Services; 97.034,
Disaster Unemployment Assistance (DUA);
97.046, Fire Management Assistance Grant;
97.048, Disaster Housing Assistance to
Individuals and Households in Presidentially
Declared Disaster Areas; 97.049,
Presidentially Declared Disaster Assistance—
Disaster Housing Operations for Individuals
and Households; 97.050, Presidentially
Declared Disaster Assistance to Individuals
and Households—Other Needs; 97.036,
Disaster Grants—Public Assistance
(Presidentially Declared Disasters); 97.039,
Hazard Mitigation Grant.
FOR FURTHER INFORMATION CONTACT:
Peggy Miller, Office of Response and
Recovery, Federal Emergency
Management Agency, 500 C Street SW.,
Washington, DC 20472, (202) 646–3886.
SUPPLEMENTARY INFORMATION: The notice
of a major disaster declaration for the
Commonwealth of Kentucky is hereby
amended to include the Public
Assistance program for the following
areas among those areas determined to
have been adversely affected by the
event declared a major disaster by the
President in his declaration of March 6,
2012.
Grant, Laurel, Lawrence, Magoffin, Martin,
Menifee, and Morgan Counties for Public
Assistance (already designated for Individual
Assistance).
The following Catalog of Federal Domestic
Assistance Numbers (CFDA) are to be used
for reporting and drawing funds: 97.030,
Community Disaster Loans; 97.031, Cora
Brown Fund; 97.032, Crisis Counseling;
97.033, Disaster Legal Services; 97.034,
Disaster Unemployment Assistance (DUA);
97.046, Fire Management Assistance Grant;
97.048, Disaster Housing Assistance to
Individuals and Households in Presidentially
Declared Disaster Areas; 97.049,
Presidentially Declared Disaster Assistance—
Disaster Housing Operations for Individuals
and Households; 97.050, Presidentially
Declared Disaster Assistance to Individuals
and Households—Other Needs; 97.036,
Disaster Grants—Public Assistance
(Presidentially Declared Disasters); 97.039,
Hazard Mitigation Grant.
W. Craig Fugate,
Administrator, Federal Emergency
Management Agency.
[FR Doc. 2012–7399 Filed 3–27–12; 8:45 am]
W. Craig Fugate,
Administrator, Federal Emergency
Management Agency.
BILLING CODE 9111–23–P
[FR Doc. 2012–7396 Filed 3–27–12; 8:45 am]
DEPARTMENT OF HOMELAND
SECURITY
BILLING CODE 9111–23–P
Federal Emergency Management
Agency
DEPARTMENT OF HOMELAND
SECURITY
[Docket ID FEMA–2012–0003; Internal
Agency Docket No. FEMA–B–1246]
Federal Emergency Management
Agency
[Internal Agency Docket No. FEMA–4057–
DR; Docket ID FEMA–2011–0001]
Kentucky; Amendment No. 4 to Notice
of a Major Disaster Declaration
tkelley on DSK3SPTVN1PROD with NOTICES
This notice amends the notice
of a major disaster declaration for the
Commonwealth of Kentucky (FEMA–
4057–DR), dated March 6, 2012, and
related determinations.
DATES: Effective Date: March 16, 2012.
SUMMARY:
17:29 Mar 27, 2012
Federal Emergency
Management Agency, DHS.
ACTION: Notice.
AGENCY:
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Flood Insurance Study (FIS) reports for
the communities listed in the table
below. The purpose of this notice is to
seek general information and comment
regarding the preliminary FIRM, and
where applicable, the FIS report that the
Federal Emergency Management Agency
(FEMA) has provided to the affected
communities. The FIRM and FIS report
are the basis of the floodplain
management measures that the
community is required either to adopt
or to show evidence of having in effect
in order to qualify or remain qualified
for participation in the National Flood
Insurance Program (NFIP). In addition,
the FIRM and FIS report, once effective,
will be used by insurance agents and
others to calculate appropriate flood
insurance premium rates for new
buildings and the contents of those
buildings.
Comments are to be submitted
on or before June 26, 2012.
ADDRESSES: The Preliminary FIRM, and
where applicable, the FIS report for
each community are available for
inspection at both the online location
and the respective Community Map
Repository address listed in the tables
below. Additionally, the current
effective FIRM and FIS report for each
community are accessible online
through the FEMA Map Service Center
at www.msc.fema.gov for comparison.
You may submit comments, identified
by Docket No. FEMA–B–1246, to Luis
Rodriguez, Chief, Engineering
Management Branch, Federal Insurance
and Mitigation Administration, FEMA,
500 C Street SW., Washington, DC
20472, (202) 646–4064, or (email)
Luis.Rodriguez3@fema.dhs.gov.
DATES:
Luis
Rodriguez, Chief, Engineering
Management Branch, Federal Insurance
and Mitigation Administration, FEMA,
500 C Street SW., Washington, DC
20472, (202) 646–4064, or (email)
Luis.Rodriguez3@fema.dhs.gov; or visit
the FEMA Map Information eXchange
(FMIX) online at
www.floodmaps.fema.gov/fhm/
fmx_main.html.
FOR FURTHER INFORMATION CONTACT:
FEMA
proposes to make flood hazard
determinations for each community
listed below, in accordance with section
110 of the Flood Disaster Protection Act
of 1973, 42 U.S.C. 4104, and 44 CFR
67.4(a).
These proposed flood hazard
determinations, together with the
floodplain management criteria required
by 44 CFR 60.3, are the minimum that
are required. They should not be
construed to mean that the community
SUPPLEMENTARY INFORMATION:
Comments are requested on
proposed flood hazard determinations,
which may include additions or
modifications of any Base Flood
Elevation (BFE), base flood depth,
Special Flood Hazard Area (SFHA)
boundary or zone designation, or
regulatory floodway on the Flood
Insurance Rate Maps (FIRMs), and
where applicable, in the supporting
SUMMARY:
Federal Emergency
Management Agency, DHS.
ACTION: Notice.
AGENCY:
VerDate Mar<15>2010
Proposed Flood Hazard
Determinations
18835
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28MRN1
]]>Agencies
[Federal Register Volume 77, Number 60 (Wednesday, March 28, 2012)]
[Notices]
[Pages 18834-18835]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: 2012-7396]
=======================================================================
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DEPARTMENT OF HOMELAND SECURITY
Federal Emergency Management Agency
[Internal Agency Docket No. FEMA-4057-DR; Docket ID FEMA-2012-0002]
Kentucky; Amendment No. 5 to Notice of a Major Disaster
Declaration
AGENCY: Federal Emergency Management Agency, DHS.
ACTION: Notice.
-----------------------------------------------------------------------
SUMMARY: This notice amends the notice of a major disaster declaration
for the
[[Page 18835]]
Commonwealth of Kentucky (FEMA-4057-DR), dated March 6, 2012, and
related determinations.
DATES: Effective Date: March 20, 2012.
FOR FURTHER INFORMATION CONTACT: Peggy Miller, Office of Response and
Recovery, Federal Emergency Management Agency, 500 C Street SW.,
Washington, DC 20472, (202) 646-3886.
SUPPLEMENTARY INFORMATION: The notice of a major disaster declaration
for the Commonwealth of Kentucky is hereby amended to include the
following areas among those areas determined to have been adversely
affected by the event declared a major disaster by the President in his
declaration of March 6, 2012.
Ballard County for Public Assistance.
Johnson, Kenton, Larue, Pendleton, Trimble, and Wolfe Counties
for Public Assistance (already designated for Individual
Assistance).
The following Catalog of Federal Domestic Assistance Numbers
(CFDA) are to be used for reporting and drawing funds: 97.030,
Community Disaster Loans; 97.031, Cora Brown Fund; 97.032, Crisis
Counseling; 97.033, Disaster Legal Services; 97.034, Disaster
Unemployment Assistance (DUA); 97.046, Fire Management Assistance
Grant; 97.048, Disaster Housing Assistance to Individuals and
Households in Presidentially Declared Disaster Areas; 97.049,
Presidentially Declared Disaster Assistance--Disaster Housing
Operations for Individuals and Households; 97.050, Presidentially
Declared Disaster Assistance to Individuals and Households--Other
Needs; 97.036, Disaster Grants--Public Assistance (Presidentially
Declared Disasters); 97.039, Hazard Mitigation Grant.
W. Craig Fugate,
Administrator, Federal Emergency Management Agency.
[FR Doc. 2012-7396 Filed 3-27-12; 8:45 am]
BILLING CODE 9111-23-P
