National Institutes of Health, 40383-40384 [2011-17227]

Download as PDF Federal Register / Vol. 76, No. 131 / Friday, July 8, 2011 / Notices generated using the rat growth hormone gene promoter (rGH) to target ffLuceGFP fusion gene expression to the pituitary gland, restricting any resulting interfering reporter signal within the head. This allows the tracking of cancer progression throughout the body, where the reporter activity of introduced ffLuc/ eGFP-labeled tumors is maintained, despite normal immune function. These immunocompetent rGH-ffLuc-eGFP transgenic mice can be used as hosts in cancer models, allowing long-term in vivo monitoring of the progression of ffLuc/eGFP-labeled tumor cells in the body, which may lead to more clinically relevant insights into cancer progression, metastases and response to therapies. Applications • In vivo model for studying tumor progression and testing anti-cancer therapeutics using ffLuc or eGFP labeling for bioimaging. • Since rGH-ffLuc-eGFP is also a growth hormone-responsive reporter, these rGH–Luc-GFP mice may also be used to screen growth-hormone stimulating drugs for treating Achondroplasia (dwarf syndrome) or as a test for illegal performance-enhancing drugs. Advantages • This technology represents a more clinically relevant in vivo model of cancer progression for testing anticancer therapeutics. • This immunocompetent mouse model is more desirable as a pre-clinical model over the currently used immunodeficient mouse models as immune function is crucial for tumor development and progression. • Early-stage. • Pre-clinical. • In vitro data available. • In vivo data available (animal). Inventors: Chi-Ping Day and Glenn Merlino (NCI). mstockstill on DSK4VPTVN1PROD with NOTICES Jkt 223001 Patent Status: HHS Reference No. E– 173–2010/0—Research Tool. Patent protection is not being pursued for this technology. Licensing Status: Available for licensing. Licensing Contact: Sabarni K. Chatterjee, PhD; 301–435–5587; chatterjeesa@mail.nih.gov. Collaborative Research Opportunity: The National Cancer Institute Center for Cancer Research is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize immunocompetent rGHffLuc-eGFP transgenic mice. Please contact John Hewes, PhD at 301–435– 3121 or hewesj@mail.nih.gov for more information. Description of Technology: Embryonic stem cells (ESCs) are pluripotent cells that can be cultured indefinitely, and maintain their capability to differentiate into all cell lineages. To maintain these cells as well as various types of related induced stem cells and progenitor cells in culture, Mouse Embryonic Fibroblasts (MEFs) are routinely used as feeder cells, largely to serve as a source of Leukemia Inhibitory Factor (LIF). ESCs can also be cultured without feeders if the medium is supplemented with recombinant LIF and other factors. However, these methods of culturing ESCs suffer from certain drawbacks, such as limited proliferation capacity and variability of primary MEFs. Therefore, finding improved conditions that maintain ESC pluripotency is an area of great interest. Scientists at NIEHS have now developed a knock-in (KI) mouse model in which LIF is overproduced from its endogenous locus because of increased stability of its mRNA. MEFs and presumably other cells derived from the homozygous mice hypersecrete LIF protein; lesser degrees of overexpression would be expected from heterozygous mice. These mice can be used to study LIF function, including how LIF contributes to various physiological and pathological states. Cells derived from these mice can be used to culture ESCs, as well as other progenitor cells. Cells or genetic material derived from these mice can also be used as sources of LIF for isolation and purification. Dated: July 1, 2011. Richard U. Rodriguez, Director, Division of Technology Development and Transfer, Office of Technology Transfer, National Institutes of Health. [FR Doc. 2011–17228 Filed 7–7–11; 8:45 am] BILLING CODE 4140–01–P Government-Owned Inventions; Availability for Licensing Public Health Service, National Institutes of Health, HHS. ACTION: Notice. AGENCY: 1. Day C.P., et al. Preclinical therapeutic response of residual metastatic disease is distinct from its primary tumor of origin. Int J Cancer. 2011 Feb 10, doi: 10.1002/ijc.25978. [Epub ahead of print]. 2. Day C.P., et al. Lentivirus-mediated bifunctional cell labeling for in vivo melanoma study. Pigment Cell Melanoma Res. 2009 Jun;22(3):283–295. [PMID: 19175523]. 3. Luque R.M., et al. Reporter expression, induced by a growth hormone promoterdriven Cre recombinase (rGHp-Cre) transgene, questions the developmental relationship between somatotropes and 17:52 Jul 07, 2011 ADDRESSES: National Institutes of Health Relevant Publications VerDate Mar<15>2010 lactotropes in the adult mouse pituitary gland. Endocrinology. 2007 May;148(5):1946–1953. [PMID: 17289844]. 4. Latta-Mahieu M., et al. Gene transfer of a chimeric trans-activator is immunogenic and results in short-lived transgene expression. Hum Gene Ther. 2002 Sep 1;13(13):1611–1620. [PMID: 12228016]. 5. Stripecke R., et al. Immune response to green fluorescent protein: implications for gene therapy. Gene Ther. 1999 Jul;6(7):1305– 1312. [PMID: 10455440]. 6. Liao C.P., et al. Mouse models of prostate adenocarcinoma with the capacity to monitor spontaneous carcinogenesis by bioluminescence or fluorescence. Cancer Res. 2007 Aug 1;67(15):7525–7533. [PMID: 17671224]. DEPARTMENT OF HEALTH AND HUMAN SERVICES Development Status 40383 The inventions listed below are owned by an agency of the U.S. Government and are available for licensing in the U.S. in accordance with 35 U.S.C. 207 to achieve expeditious commercialization of results of Federally-funded research and development. Foreign patent applications are filed on selected inventions to extend market coverage for companies and may also be available for licensing. SUMMARY: PO 00000 Frm 00062 Fmt 4703 Sfmt 4703 Licensing information and copies of the U.S. patent applications listed below may be obtained by writing to the indicated licensing contact at the Office of Technology Transfer, National Institutes of Health, 6011 Executive Boulevard, Suite 325, Rockville, Maryland 20852–3804; telephone: 301– 496–7057; fax: 301–402–0220. A signed Confidential Disclosure Agreement will be required to receive copies of the patent applications. Mouse Model and Derived Cells That Hypersecrete Leukemia Inhibitory Factor (LIF) Applications • Maintenance of ESCs and progenitor cells. • In vivo, cellular and cell-free sources of LIF. • Sources of LIF for isolation and purification. • Studies of LIF function in mice, such as contribution of LIF to tumor growth. Inventors: Dr. Perry Blackshear (NIEHS), et al. E:\FR\FM\08JYN1.SGM 08JYN1 40384 Federal Register / Vol. 76, No. 131 / Friday, July 8, 2011 / Notices mstockstill on DSK4VPTVN1PROD with NOTICES Patent Status: HHS Reference No. E– 175–2011/0 —Research Tool. Patent protection is not being pursued for this technology. Licensing Status: Available for licensing under a Biological Materials License Agreement. Licensing Contact: Betty B. Tong, PhD; 301–594–6565; tongb@mail.nih.gov. Collaborative Research Opportunity: The NIEHS Laboratory of Signal Transduction is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize these mice or other strains derived from them, or cells or other reagents derived from them. Please contact Dr. Elizabeth Denholm (denholme@niehs.nih.gov) in the NIEHS Office of Technology Transfer, or the Inventor Dr. Perry Blackshear (black009@niehs.nih.gov) for more information. Inhibitors of Human Apurinic/ Apyrimidinic Endonuclease 1 (APE1), an Anticancer Drug Target Description of Technology: APE1 is the primary mammalian enzyme responsible for the removal of abasic (AP sites) in DNA and functions as part of the base excision DNA repair pathway (BER). BER is instrumental in the repair of DNA damage caused by DNA alkylating agents (e.g. many cancer chemotherapeutics). APE1 has been shown to be overexpressed in cancer cells. It has been postulated that APE1 would be an attractive target in anticancer treatment paradigms; preclinical and clinical data confirm that APE1 is a valid anticancer drug target. To date, only one APE1 small molecule inhibitor has progressed to clinical trials (methoxyamine hydrochloride), and this compound inhibits a wide range of repair processes, which could result in undesired side-effects. The NIH inventors now report the discovery of a novel APE1 small molecule inhibitor, which exhibits potent in vitro activity, potentiates the cytotoxicity of DNA damaging agents (alkylators methylmethane sulfonate and Temozolomide), results in the accumulation of AP sites, and has favorable pharmacokinetic properties. The inventors plan to carry out further studies in mouse tumor xenograft models. Applications: Cancer therapeutics as single agent as well as in combination therapy. Development Status: In vivo pharmacokinetics data on lead compounds available. VerDate Mar<15>2010 17:52 Jul 07, 2011 Jkt 223001 Inventors: David J. Maloney, et al. (NHGRI). Publication: Manuscript submitted. Patent Status: U.S. Provisional Patent Application No. 61/480,145 filed April 28, 2011 (HHS Reference No. E–094– 2011/0–US–01). Licensing Status: Available for licensing. Licensing Contact: Betty B. Tong, PhD; 301–594–6565; tongb@mail.nih.gov. Collaborative Research Opportunity: The NIH Center for Translational Therapeutics, NHGRI is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize the above technology. Please contact Lili Portilla, Acting Director of Technology Transfer and Partnerships, NCTT at Lilip@nih.gov for more information. Dated: July 1, 2011. Richard U. Rodriguez, Director, Division of Technology Development and Transfer, Office of Technology Transfer, National Institutes of Health. Bethesda, MD 20892. (301) 496–3996. netteyr@mail.nih.gov. This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. Name of Committee: National Center on Minority Health and Health Disparities Special Emphasis Panel, R13 Review. Date: July 13, 2011. Time: 8 a.m. to 5 p.m. Agenda: To review and evaluate grant applications. Place: National Institutes of Health, 6707 Democracy Boulevard, Suite 800, Bethesda, MD 20892. (Virtual Meeting.) Contact Person: Robert Nettey, M.D., Chief, Scientific Review Officer, National Institute on Minority Health and Health Disparities, 6707 Democracy Boulevard, Suite 800, Bethesda, MD 20892. (301) 496–3996. netteyr@mail.nih.gov. This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. Dated: July 1, 2011. Jennifer S. Spaeth, Director, Office of Federal Advisory Committee Policy. [FR Doc. 2011–17227 Filed 7–7–11; 8:45 am] [FR Doc. 2011–17225 Filed 7–7–11; 8:45 am] BILLING CODE 4140–01–P BILLING CODE 4140–01–P DEPARTMENT OF HEALTH AND HUMAN SERVICES DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Institutes of Health National Center on Minority and Health Disparities; Notice of Closed Meeting National Center for Research Resources; Notice of Closed Meetings Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App), notice is hereby given of the following meeting. The meeting will be closed to the public in accordance with the provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The grant applications and the discussions could disclose confidential trade secrets or commercial property such as patentable materials, and personal information concerning individuals associated with the grant applications, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is hereby given of the following meetings. The meetings will be closed to the public in accordance with the provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The grant applications and the discussions could disclose confidential trade secrets or commercial property such as patentable material, and personal information concerning individuals associated with the grant applications, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. Name of Committee: National Center on Minority Health and Health Disparities Special, Emphasis Panel, U24 Grant Review. Date: July 11–12, 2011. Time: 8 a.m. to 5 p.m. Agenda: To review and evaluate grant applications. Place: Hilton Washington/Rockville, 1750 Rockville Pike, Rockville, MD 20852. Contact Person: Robert Nettey, M.D., Chief, Scientific Review Officer, National Institute on Minority Health and Health Disparities, 6707 Democracy Boulevard, Suite 800, Name of Committee: National Center for Research Resources Special Emphasis Panel, NCRR Animal Resource. Date: July 28, 2011. Time: 1 to 2 p.m. Agenda: To review and evaluate grant applications, Place: National Institutes of Health/NCRR/ OR, Democracy 1, 6701 Democracy Blvd., 1078, Bethesda, MD 20892. Contact Person: Lee Warren Slice, PhD, Scientific Review Officer, Office of Review, National Center for Research Resources, 6701 PO 00000 Frm 00063 Fmt 4703 Sfmt 4703 E:\FR\FM\08JYN1.SGM 08JYN1

Agencies

[Federal Register Volume 76, Number 131 (Friday, July 8, 2011)]
[Notices]
[Pages 40383-40384]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: 2011-17227]


-----------------------------------------------------------------------

DEPARTMENT OF HEALTH AND HUMAN SERVICES


National Institutes of Health

Government-Owned Inventions; Availability for Licensing

AGENCY: Public Health Service, National Institutes of Health, HHS.

ACTION: Notice.

-----------------------------------------------------------------------

SUMMARY: The inventions listed below are owned by an agency of the U.S. 
Government and are available for licensing in the U.S. in accordance 
with 35 U.S.C. 207 to achieve expeditious commercialization of results 
of Federally-funded research and development. Foreign patent 
applications are filed on selected inventions to extend market coverage 
for companies and may also be available for licensing.

ADDRESSES: Licensing information and copies of the U.S. patent 
applications listed below may be obtained by writing to the indicated 
licensing contact at the Office of Technology Transfer, National 
Institutes of Health, 6011 Executive Boulevard, Suite 325, Rockville, 
Maryland 20852-3804; telephone: 301-496-7057; fax: 301-402-0220. A 
signed Confidential Disclosure Agreement will be required to receive 
copies of the patent applications.

Mouse Model and Derived Cells That Hypersecrete Leukemia Inhibitory 
Factor (LIF)

    Description of Technology: Embryonic stem cells (ESCs) are 
pluripotent cells that can be cultured indefinitely, and maintain their 
capability to differentiate into all cell lineages. To maintain these 
cells as well as various types of related induced stem cells and 
progenitor cells in culture, Mouse Embryonic Fibroblasts (MEFs) are 
routinely used as feeder cells, largely to serve as a source of 
Leukemia Inhibitory Factor (LIF). ESCs can also be cultured without 
feeders if the medium is supplemented with recombinant LIF and other 
factors. However, these methods of culturing ESCs suffer from certain 
drawbacks, such as limited proliferation capacity and variability of 
primary MEFs. Therefore, finding improved conditions that maintain ESC 
pluripotency is an area of great interest.
    Scientists at NIEHS have now developed a knock-in (KI) mouse model 
in which LIF is overproduced from its endogenous locus because of 
increased stability of its mRNA. MEFs and presumably other cells 
derived from the homozygous mice hypersecrete LIF protein; lesser 
degrees of overexpression would be expected from heterozygous mice. 
These mice can be used to study LIF function, including how LIF 
contributes to various physiological and pathological states. Cells 
derived from these mice can be used to culture ESCs, as well as other 
progenitor cells. Cells or genetic material derived from these mice can 
also be used as sources of LIF for isolation and purification.

Applications

     Maintenance of ESCs and progenitor cells.
     In vivo, cellular and cell-free sources of LIF.
     Sources of LIF for isolation and purification.
     Studies of LIF function in mice, such as contribution of 
LIF to tumor growth.
    Inventors: Dr. Perry Blackshear (NIEHS), et al.

[[Page 40384]]

    Patent Status: HHS Reference No. E-175-2011/0 --Research Tool. 
Patent protection is not being pursued for this technology.
    Licensing Status: Available for licensing under a Biological 
Materials License Agreement.
    Licensing Contact: Betty B. Tong, PhD; 301-594-6565; 
tongb@mail.nih.gov.
    Collaborative Research Opportunity: The NIEHS Laboratory of Signal 
Transduction is seeking statements of capability or interest from 
parties interested in collaborative research to further develop, 
evaluate, or commercialize these mice or other strains derived from 
them, or cells or other reagents derived from them. Please contact Dr. 
Elizabeth Denholm (denholme@niehs.nih.gov) in the NIEHS Office of 
Technology Transfer, or the Inventor Dr. Perry Blackshear 
(black009@niehs.nih.gov) for more information.

Inhibitors of Human Apurinic/Apyrimidinic Endonuclease 1 (APE1), an 
Anticancer Drug Target

    Description of Technology: APE1 is the primary mammalian enzyme 
responsible for the removal of abasic (AP sites) in DNA and functions 
as part of the base excision DNA repair pathway (BER). BER is 
instrumental in the repair of DNA damage caused by DNA alkylating 
agents (e.g. many cancer chemotherapeutics). APE1 has been shown to be 
overexpressed in cancer cells. It has been postulated that APE1 would 
be an attractive target in anti-cancer treatment paradigms; preclinical 
and clinical data confirm that APE1 is a valid anticancer drug target.
    To date, only one APE1 small molecule inhibitor has progressed to 
clinical trials (methoxyamine hydrochloride), and this compound 
inhibits a wide range of repair processes, which could result in 
undesired side-effects. The NIH inventors now report the discovery of a 
novel APE1 small molecule inhibitor, which exhibits potent in vitro 
activity, potentiates the cytotoxicity of DNA damaging agents 
(alkylators methylmethane sulfonate and Temozolomide), results in the 
accumulation of AP sites, and has favorable pharmacokinetic properties. 
The inventors plan to carry out further studies in mouse tumor 
xenograft models.
    Applications: Cancer therapeutics as single agent as well as in 
combination therapy.
    Development Status: In vivo pharmacokinetics data on lead compounds 
available.
    Inventors: David J. Maloney, et al. (NHGRI).
    Publication: Manuscript submitted.
    Patent Status: U.S. Provisional Patent Application No. 61/480,145 
filed April 28, 2011 (HHS Reference No. E-094-2011/0-US-01).
    Licensing Status: Available for licensing.
    Licensing Contact: Betty B. Tong, PhD; 301-594-6565; 
tongb@mail.nih.gov.
    Collaborative Research Opportunity: The NIH Center for 
Translational Therapeutics, NHGRI is seeking statements of capability 
or interest from parties interested in collaborative research to 
further develop, evaluate, or commercialize the above technology. 
Please contact Lili Portilla, Acting Director of Technology Transfer 
and Partnerships, NCTT at Lilip@nih.gov for more information.

    Dated: July 1, 2011.
Richard U. Rodriguez,
Director, Division of Technology Development and Transfer, Office of 
Technology Transfer, National Institutes of Health.
[FR Doc. 2011-17227 Filed 7-7-11; 8:45 am]
BILLING CODE 4140-01-P
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