National Heart, Lung, and Blood Institute; Notice of Closed Meeting, 31617 [2011-13523]
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Federal Register / Vol. 76, No. 105 / Wednesday, June 1, 2011 / Notices
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system for the treatment of solid tumors.
Adv Drug Deliv Rev. 2001 Dec
31;53(3):285–305. [PMID: 11744173]
6. Frenkel V, Oberoi J, Stone MJ, et al.
Pulsed-high intensity focused
ultrasound enhances thrombolysis in an
in vitro model. Radiology 2006
Apr;239(1);86–93. [PMID: 16493016]
Licensing Status: Available for
licensing.
Licensing Contacts:
• Uri Reichman, PhD, MBA; 301–
435–4616; UR7a@nih.gov.
• Michael Shmilovich, Esq.; 301–
435–5019; shmilovm@mail.nih.gov.
Collaborative Research Opportunity:
The NIH Clinical Center, Interventional
Radiology Section & Center for
Interventional Oncology is seeking
statements of capability or interest from
parties interested in collaborative
research to further develop, evaluate, or
commercialize this novel approach to
thrombolysis. Please contact Ken Rose,
PhD at 301–435–3132 or
rosek@mail.nih.gov for more
information.
Methods and Devices for Transcatheter
Cerclage Annuloplasty
Description of Technology: The
invention relates to techniques and
devices for cardiovascular valve repair,
particularly annuloplasty techniques
and devices in which tensioning
elements are positioned to treat
regurgitation of the mitral valve or
tricuspid valve. More specifically, the
technology pertains to a new device for
myocardial septal traversal (‘‘cerclage
reentry’’) that also serves to capture
(ensnare) and externalize the traversing
guidewire. The focus of the invention is
to avoid a phenomenon in cardiac
surgery known as ‘‘trabecular
entrapment.’’ The device features an
expandable and collapsible mesh
deployed in the right ventricle to
simplify capture of a reentering
guidewire during transcatheter cerclage
annuloplasty. The wire mesh exerts
pressure against trabecular-papillary
elements of the tricuspid valve to
displace them against the right
ventricular septal wall. By abutting the
right ventricular reentry site of the
cercalge guidewire, trabecular
entrapment is avoided. The device
comprises a shaft having a distal loop
which provides a target in the
interventrical myocardial septum
through which a catheter-delivered
tensioning system is guided. The loop
ensnares the catheter-delivered
tensioning system as it reenters the right
ventricle or right atrium. The
expandable and collapsible mesh is
disposed within the right ventricle such
that the catheter-delivered tensioning
VerDate Mar<15>2010
18:48 May 31, 2011
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system is directed from the ventricular
septum into the right ventricular cavity
through only a suitable opening in the
mesh and such that the catheter
delivered tensioning system is captured
or ensnared within the mesh opening.
Applications: Cardiovascular valve
repair surgeries.
Features and Advantages:
• The device avoids trabecular
entrapment of the cerclage guidewire
during septal-perforator-to-rightventricular myocardial guidewire
traversal
• The device allows ensnarement of
reentering guidewire.
• The device provides an X-ray target
for guidewire reentry from the septal
perforator veins.
• Collapsible transcatheter device
that can be introduced from a cephalad
(typically transjugular or transaxillary)
or caudad (typically transfemoral)
approach.
• The device is intended to allow
straightforward removal from the same
vascular sheath as the cerclage
retrograde traversal guidewire, to allow
both free ends of the guidewire to be
externalized through the same sheath.
Development Status:
• Practical usefulness of the
technology has been demonstrated.
• Preclinical testing of extant
prototype is planned.
• Clinical development is planned.
Inventors: Robert J. Lederman and
Ozgur Kocaturk (NHLBI).
Relevant Publication: Kim JH, et al.
Mitral cerelage annuloplasty, a novel
transcatheter treatment for secondary
mitral valve regurgitation: initial results
in swine. J Am Coll Cardiol. 2009 Aug
11;54(7):638–651. [PMID: 19660696].
Patent Status: U.S. Provisional
Application No. 61/383,061 filed 15 Sep
2010 (HHS Reference No. E–108–2010/
0–US–01).
Licensing Status: Available for
licensing.
Licensing Contacts:
• Uri Reichman, PhD, MBA; 301–
435–4616; UR7a@nih.gov.
• Michael Shmilovich, Esq.; 301–
435–5019; shmilovm@mail.nih.gov.
Collaborative Research Opportunity:
The National Heart, Lung, and Blood
Institute is seeking statements of
capability or interest from parties
interested in collaborative research to
further develop, evaluate, or
commercialize this technology. Please
contact Peg Koelble at
koelblep@nhlbi.nih.gov for more
information.
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31617
Dated: May 25, 2011
Richard U. Rodriguez,
Director, Division of Technology Development
and Transfer, Office of Technology Transfer,
National Institutes of Health.
[FR Doc. 2011–13521 Filed 5–31–11; 8:45 am]
BILLING CODE 4140–01–P
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
National Heart, Lung, and Blood
Institute; Notice of Closed Meeting
Pursuant to section 10(d) of the
Federal Advisory Committee Act, as
amended (5 U.S.C. App.), notice is
hereby given of the following meeting.
The meeting will be closed to the
public in accordance with the
provisions set forth in sections
552b(c)(4) and 552b(c)(6), Title 5 U.S.C.,
as amended. The grant applications and
the discussions could disclose
confidential trade secrets or commercial
property such as patentable material,
and personal information concerning
individuals associated with the grant
applications, the disclosure of which
would constitute a clearly unwarranted
invasion of personal privacy.
Name of Committee: National Heart, Lung,
and Blood Institute Special Emphasis Panel,
Utilization of a Human Lung Tissue Resource
for Vascular Research.
Date: June 23, 2011.
Time: 8 a.m. to 5 p.m.
Agenda: To review and evaluate grant
applications.
Place: Hyatt Regency Bethesda, One
Bethesda Metro Center, 7400 Wisconsin
Avenue, Bethesda, MD 20814.
Contact Person: Susan Wohler Sunnarborg,
PhD, Scientific Review Officer, Review
Branch/DERA, National Heart, Lung, and
Blood Institute, 6701 Rockledge Drive, Room
7185, Bethesda, MD 20892.
(Catalogue of Federal Domestic Assistance
Program Nos. 93.233, National Center for
Sleep Disorders Research; 93.837, Heart and
Vascular Diseases Research; 93.838, Lung
Diseases Research; 93.839, Blood Diseases
and Resources Research, National Institutes
of Health, HHS)
Dated: May 25, 2011.
Jennifer S. Spaeth,
Director, Office of Federal Advisory
Committee Policy.
[FR Doc. 2011–13523 Filed 5–31–11; 8:45 am]
BILLING CODE 4140–01–P
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]]>Agencies
[Federal Register Volume 76, Number 105 (Wednesday, June 1, 2011)]
[Notices]
[Page 31617]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: 2011-13523]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health
National Heart, Lung, and Blood Institute; Notice of Closed
Meeting
Pursuant to section 10(d) of the Federal Advisory Committee Act, as
amended (5 U.S.C. App.), notice is hereby given of the following
meeting.
The meeting will be closed to the public in accordance with the
provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5
U.S.C., as amended. The grant applications and the discussions could
disclose confidential trade secrets or commercial property such as
patentable material, and personal information concerning individuals
associated with the grant applications, the disclosure of which would
constitute a clearly unwarranted invasion of personal privacy.
Name of Committee: National Heart, Lung, and Blood Institute
Special Emphasis Panel, Utilization of a Human Lung Tissue Resource
for Vascular Research.
Date: June 23, 2011.
Time: 8 a.m. to 5 p.m.
Agenda: To review and evaluate grant applications.
Place: Hyatt Regency Bethesda, One Bethesda Metro Center, 7400
Wisconsin Avenue, Bethesda, MD 20814.
Contact Person: Susan Wohler Sunnarborg, PhD, Scientific Review
Officer, Review Branch/DERA, National Heart, Lung, and Blood
Institute, 6701 Rockledge Drive, Room 7185, Bethesda, MD 20892.
(Catalogue of Federal Domestic Assistance Program Nos. 93.233,
National Center for Sleep Disorders Research; 93.837, Heart and
Vascular Diseases Research; 93.838, Lung Diseases Research; 93.839,
Blood Diseases and Resources Research, National Institutes of
Health, HHS)
Dated: May 25, 2011.
Jennifer S. Spaeth,
Director, Office of Federal Advisory Committee Policy.
[FR Doc. 2011-13523 Filed 5-31-11; 8:45 am]
BILLING CODE 4140-01-P
