Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Meeting, 25699-25700 [2011-11034]
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Federal Register / Vol. 76, No. 87 / Thursday, May 5, 2011 / Notices
Imidazoacridones With Anti-Tumor
Activity
Description of Invention: The present
invention relates to novel bifunctional
molecules with potent and selective
activity against colon, liver and
pancreatic tumors. Compounds have
low animal toxicity, excellent PK/PD
characteristics and proved to be very
effective in several preclinical animal
models of cancer. Extensive mechanistic
studies have demonstrated that
compounds inhibit tumor growth
through a novel mechanism. These
agents are composed of an
imidazoacridone moiety linked by a
nitrogen containing aliphatic chain of
various length and rigidity to another
aromatic ring system capable of
intercalation to DNA.
Previous studies on related
symmetrical bis-imidazoacridones
revealed that only one planar
imidazoacridone moiety intercalates
into DNA. The second aromatic moiety,
which is crucial for biological activity,
along with the linker resides in DNA
minor groove, and is believed to interact
with DNA-binding proteins (most likely,
transcription factors and/or repair
proteins). The symmetrical bisimidazoacridones arrest the growth of
sensitive cancers (especially colon
cancers) but do not kill the tumors. It
was hypothesized that the growth arrest
was due to the inability of the affected
tumor cells to repair DNA damage
caused by the compounds. Remarkably,
bis-imidazoacridones are very well
tolerated, are very tissue selective and
do not appear to damage normal tissues.
Since the binding of the symmetrical
bis-imidazoacridones to DNA was
unsymmetrical, the inventors have
developed unsymmetrical compounds
in which one imidazoacridone moieties
was replaced by other intercalating
groups, with the expectation that this
would enhance biological activity while
retaining the remarkable tissue
selectivity and low systemic toxicity.
The new compounds contain
intercalating moieties such as 3-chloro7-methoxyacridine or naphthalimide
along with the original
imidazoacridones.
These new compounds, especially
those containing naphthalimide moiety,
are extremely cytotoxic against a variety
of tumor cells in vitro (IC50 at low
nanomolar range) and kill tumor cells
by inducing apoptosis. In vivo, in nude
mice xenografted with human tumors,
the compounds significantly inhibited
the growth of such tumors as colon
tumor HCT116 and Colo205 as well as
pancreatic tumors (lines 6.03 and 10.05
freshly established from a patient).
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These compounds are extremely potent
agents against hepatocellular carcinoma
as evidenced by their ability to eradicate
liver cancer in an orthotopic liver
cancer model in rats. Remarkably, no
toxicity was observed at the therapeutic
doses. These are among the most potent
agents known against cancers of the GI
tract and appear to be tolerated very
well.
Inventors: Wieslaw M. Cholody et al.
(NCI)
Patent Status:
• U.S. Patent 6,664,263 issued 16 Dec
2003 (HHS Reference No. E–289–1999/
0–US–07) and related international
patents/patent applications.
• U.S. Patent 6,541,483 issued 01 Apr
2003 (HHS Reference No. E–065–1996/
2–US–25) and related international
patents/patent applications.
Licensing Status: Available for
licensing.
Licensing Contact: Betty B. Tong,
PhD; 301–594–6565;
tongb@mail.nih.gov.
Collaborative Research Opportunity:
The National Cancer Institute, Center for
Cancer Research, is seeking statements
of capability or interest from parties
interested in collaborative research to
further develop, evaluate, or
commercialize imidazoacridones as
therapeutic agents for cancer treatment.
Please contact John Hewes, PhD at 301–
435–3121 or hewesj@mail.nih.gov for
more information.
Dated: April 29, 2011.
Richard U. Rodriguez,
Director, Division of Technology Development
and Transfer, Office of Technology Transfer,
National Institutes of Health.
[FR Doc. 2011–11055 Filed 5–4–11; 8:45 am]
BILLING CODE 4140–01–P
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
Eunice Kennedy Shriver National
Institute of Child Health & Human
Development; Notice of Meeting
Pursuant to section 10(d) of the
Federal Advisory Committee Act, as
amended (5 U.S.C. App.), notice is
hereby given of a meeting of the
National Advisory Child Health and
Human Development Council.
The meeting will be open to the
public, with attendance limited to space
available. Individuals who plan to
attend and need special assistance, such
as sign language interpretation or other
reasonable accommodations, should
notify the Contact Person listed below
in advance of the meeting.
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The meeting will be closed to the
public in accordance with the
provisions set forth in sections
552b(c)(4) and 552b(c)(6), Title 5 U.S.C.,
as amended. The grant applications
and/or contract proposals and the
discussions could disclose confidential
trade secrets or commercial property
such as patentable material, and
personal information concerning
individuals associated with the grant
applications and/or contract proposals,
the disclosure of which would
constitute a clearly unwarranted
invasion of personal privacy.
Name of Committee: National Advisory
Child Health and Human Development
Council.
Date: June 2, 2011.
Open: 8 a.m. to 12:20 p.m.
Agenda: (1) A report by the Director,
NICHD; (2) Report of the Subcommittee on
Planning and Policy; (3) NICHD Scientific
Visioning update; and other business of the
Council.
Place: National Institutes of Health,
Building 31, 31 Center Drive, C-Wing,
Conference Room 6, Bethesda, MD 20892.
Closed: 12:20 p.m. to 5 p.m.
Agenda: To review and evaluate grant
applications and/or proposals.
Place: National Institutes of Health,
Building 31, 31 Center Drive, C-Wing,
Conference Room 6, Bethesda, MD 20892.
Contact Person: Yvonne T. Maddox, PhD,
Deputy Director, National Institute of Child
Health, and Human Development, NIH, 9000
Rockville Pike MSC 7510, Building 31, Room
2A03, Bethesda, MD 20892, (301) 496–1848.
Any interested person may file written
comments with the committee by forwarding
the statement to the Contact Person listed on
this notice. The statement should include the
name, address, telephone number and when
applicable, the business or professional
affiliation of the interested person.
In the interest of security, NIH has
instituted stringent procedures for entrance
onto the NIH campus. All visitor vehicles,
including taxis, hotel, and airport shuttles
will be inspected before being allowed on
campus. Visitors will be asked to show one
form of identification (for example, a
government-issued photo ID, driver’s license,
or passport) and to state the purpose of their
visit.
Information is also available on the
Institute’s/Center’s home page: https://
ww.nichd.nih.gov/about/nachhd.htm, where
an agenda and any additional information for
the meeting will be posted when available.
In order to facilitate public attendance at
the open session of Council, reserve seating
will be made available to the first five
individuals reserving seats in the main
meeting room, Conference Room 6. Please
contact Ms. Lisa Kaeser, Program and Public
Liaison Office, NICHD, at 301–496–0536 to
make your reservation. Additional seating
will be available in the meeting overflow
rooms, Conference Rooms 7 and 8.
Individuals will also be able to view the
meeting via NIH Videocast. Please go to the
following link for Videocast access
E:\FR\FM\05MYN1.SGM
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25700
Federal Register / Vol. 76, No. 87 / Thursday, May 5, 2011 / Notices
instructions at: https://www.nichd.nih.gov/
about/overview/advisory/nachhd/virtualmeeting.cfm The meeting is partially closed
to the public.
(Catalogue of Federal Domestic Assistance
Program Nos. 93.864, Population Research;
93.865, Research for Mothers and Children;
93.929, Center for Medical Rehabilitation
Research; 93.209, Contraception and
Infertility Loan Repayment program, National
Institutes of Health, HHS)
Dated: April 29, 2011.
Jennifer S. Spaeth,
Director, Office of Federal Advisory
Committee Policy.
[FR Doc. 2011–11034 Filed 5–4–11; 8:45 am]
BILLING CODE 4140–01–P
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
National Institute of Diabetes and
Digestive and Kidney Diseases; Notice
of Closed Meetings
jlentini on DSKJ8SOYB1PROD with NOTICES
Pursuant to section 10(d) of the
Federal Advisory Committee Act, as
amended (5 U.S.C. App.), notice is
hereby given of the following meetings.
The meetings will be closed to the
public in accordance with the
provisions set forth in sections
552b(c)(4) and 552b(c)(6), Title 5 U.S.C.,
as amended. The grant applications and
the discussions could disclose
confidential trade secrets or commercial
property such as patentable material,
and personal information concerning
individuals associated with the grant
applications, the disclosure of which
would constitute a clearly unwarranted
invasion of personal privacy.
Name of Committee: National Institute of
Diabetes and Digestive and Kidney Diseases
Special Emphasis Panel, PAR–09–247:
NIDDK Ancillary Studies to Major Ongoing
Clinical Research Studies in CKD (R01).
Date: May 27, 2011.
Time: 2 p.m. to 5 p.m.
Agenda: To review and evaluate grant
applications.
Place: National Institutes of Health, Two
Democracy Plaza, 6707 Democracy
Boulevard, Bethesda, MD 20892. (Telephone
Conference Call.)
Contact Person: Najma Begum, PhD,
Scientific Review Officer, Review Branch,
DEA, NIDDK, National Institutes of Health,
Room 749, 6707 Democracy Boulevard,
Bethesda, MD 20892–5452. (301) 594–8894.
begumn@niddk.nih.gov.
Name of Committee: National Institute of
Diabetes and Digestive and Kidney Diseases
Special Emphasis Panel, Periodontitis and
Glycemic Control.
Date: June 15, 2011.
Time: 2 p.m. to 4 p.m.
Agenda: To review and evaluate grant
applications.
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Place: National Institutes of Health, Two
Democracy Plaza, 6707 Democracy
Boulevard, Bethesda, MD 20892. (Telephone
Conference Call.)
Contact Person: D. G. Patel, PhD, Scientific
Review Officer, Review Branch, DEA,
NIDDK, National Institutes of Health, Room
756, 6707 Democracy Boulevard, Bethesda,
MD 20892–5452. (301) 594–7682.
pateldg@niddk.nih.gov.
Name of Committee: National Institute of
Diabetes and Digestive and Kidney Diseases
Special Emphasis Panel, Studies Related to
Diabetes.
Date: June 17, 2011.
Time: 2 p.m. to 4 p.m.
Agenda: To review and evaluate grant
applications.
Place: National Institutes of Health, Two
Democracy Plaza, 6707 Democracy
Boulevard, Bethesda, MD 20892. (Telephone
Conference Call.)
Contact Person: D. G. Patel, PhD, Scientific
Review Officer, Review Branch, DEA,
NIDDK, National Institutes of Health, Room
756, 6707 Democracy Boulevard, Bethesda,
MD 20892–5452. (301) 594–7682.
pateldg@niddk.nih.gov.
(Catalogue of Federal Domestic Assistance
Program Nos. 93.847, Diabetes,
Endocrinology and Metabolic Research;
93.848, Digestive Diseases and Nutrition
Research; 93.849, Kidney Diseases, Urology
and Hematology Research, National Institutes
of Health, HHS)
Dated: April 29, 2011.
Jennifer S. Spaeth,
Director, Office of Federal Advisory
Committee Policy.
[FR Doc. 2011–11037 Filed 5–4–11; 8:45 am]
BILLING CODE 4140–01–P
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
National Center for Research
Resources; Notice of Closed Meeting
Pursuant to section 10(d) of the
Federal Advisory Committee Act, as
amended (5 U.S.C. App.), notice is
hereby given of the following meeting.
The meeting will be closed to the
public in accordance with the
provisions set forth in sections
552b(c)(4) and 552b(c)(6), Title 5 U.S.C.,
as amended. The grant applications and
the discussions could disclose
confidential trade secrets or commercial
property such as patentable material,
and personal information concerning
individuals associated with the grant
applications, the disclosure of which
would constitute a clearly unwarranted
invasion of personal privacy.
Name of Committee: National Center for
Research Resources Initial Review Group,
Comparative Medicine Review Committee.
Date: June 7–8, 2011.
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Time: 8 a.m. to 12 p.m.
Agenda: To review and evaluate grant
applications.
Place: Residence Inn Marriott, 7335
Wisconsin Avenue, Bethesda, MD 20814.
Contact Person: Bonnie B. Dunn, PhD,
Scientific Review Officer, National Center
For Research Resources, or National
Institutes of Health, 6701 Democracy Blvd.,
1 Democracy Plaza, Room 1074, MSC 4874,
Bethesda, Md 20892–4874, 301–435–0824,
dunnbo@mail.nih.gov.
(Catalogue of Federal Domestic Assistance
Program Nos. 93.306, Comparative Medicine;
93.333, Clinical Research; 93.371, Biomedical
Technology; 93.389, Research Infrastructure,
93.306, 93.333; 93.702, ARRA Related
Construction Awards., National Institutes of
Health, HHS)
Dated: April 29, 2011.
Jennifer S. Spaeth,
Director, Office of Federal Advisory
Committee Policy.
[FR Doc. 2011–11040 Filed 5–4–11; 8:45 am]
BILLING CODE 4140–01–P
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
National Institute of Allergy and
Infectious Diseases; Notice of Meeting
Pursuant to section 10(a) of the
Federal Advisory Committee Act, as
amended (5 U.S.C. App.), notice is
hereby given of a meeting of the AIDS
Research Advisory Committee, NIAID.
The meeting will be open to the
public, with attendance limited to space
available. Individuals who plan to
attend and need special assistance, such
as sign language interpretation or other
reasonable accommodations, should
notify the Contact Person listed below
in advance of the meeting.
Name of Committee: AIDS Research
Advisory Committee, NIAID, AIDS Vaccine
Research Subcommittee.
Date: May 24–25, 2011.
Time: 8:30 a.m. to 5 p.m.
Agenda: Presenting and discussing data on
recombinant chimpanzee adenovirus vectors
for malaria and AIDS vaccines and
discussing future clinical trial plans for AIDS
vaccine testing.
Place: National Institutes of Health,
Natcher Building, 45 Center Drive,
Conference Rooms E1 and E2, Bethesda, MD
20892.
Contact Person: James A. Bradac, PhD,
Program Official, Preclinical Research and
Development Branch, Division of AIDS,
Room 5116, National Institutes of Health/
NIAID, 6700B Rockledge Drive, Bethesda,
MD 20892–7628, 301–435–3754,
jbradac@mail.nih.gov.
(Catalogue of Federal Domestic Assistance
Program Nos. 93.855, Allergy, Immunology,
and Transplantation Research; 93.856,
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Agencies
[Federal Register Volume 76, Number 87 (Thursday, May 5, 2011)]
[Notices]
[Pages 25699-25700]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: 2011-11034]
-----------------------------------------------------------------------
DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health
Eunice Kennedy Shriver National Institute of Child Health & Human
Development; Notice of Meeting
Pursuant to section 10(d) of the Federal Advisory Committee Act, as
amended (5 U.S.C. App.), notice is hereby given of a meeting of the
National Advisory Child Health and Human Development Council.
The meeting will be open to the public, with attendance limited to
space available. Individuals who plan to attend and need special
assistance, such as sign language interpretation or other reasonable
accommodations, should notify the Contact Person listed below in
advance of the meeting.
The meeting will be closed to the public in accordance with the
provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5
U.S.C., as amended. The grant applications and/or contract proposals
and the discussions could disclose confidential trade secrets or
commercial property such as patentable material, and personal
information concerning individuals associated with the grant
applications and/or contract proposals, the disclosure of which would
constitute a clearly unwarranted invasion of personal privacy.
Name of Committee: National Advisory Child Health and Human
Development Council.
Date: June 2, 2011.
Open: 8 a.m. to 12:20 p.m.
Agenda: (1) A report by the Director, NICHD; (2) Report of the
Subcommittee on Planning and Policy; (3) NICHD Scientific Visioning
update; and other business of the Council.
Place: National Institutes of Health, Building 31, 31 Center
Drive, C-Wing, Conference Room 6, Bethesda, MD 20892.
Closed: 12:20 p.m. to 5 p.m.
Agenda: To review and evaluate grant applications and/or
proposals.
Place: National Institutes of Health, Building 31, 31 Center
Drive, C-Wing, Conference Room 6, Bethesda, MD 20892.
Contact Person: Yvonne T. Maddox, PhD, Deputy Director, National
Institute of Child Health, and Human Development, NIH, 9000
Rockville Pike MSC 7510, Building 31, Room 2A03, Bethesda, MD 20892,
(301) 496-1848.
Any interested person may file written comments with the
committee by forwarding the statement to the Contact Person listed
on this notice. The statement should include the name, address,
telephone number and when applicable, the business or professional
affiliation of the interested person.
In the interest of security, NIH has instituted stringent
procedures for entrance onto the NIH campus. All visitor vehicles,
including taxis, hotel, and airport shuttles will be inspected
before being allowed on campus. Visitors will be asked to show one
form of identification (for example, a government-issued photo ID,
driver's license, or passport) and to state the purpose of their
visit.
Information is also available on the Institute's/Center's home
page: https://ww.nichd.nih.gov/about/nachhd.htm, where an agenda and
any additional information for the meeting will be posted when
available.
In order to facilitate public attendance at the open session of
Council, reserve seating will be made available to the first five
individuals reserving seats in the main meeting room, Conference
Room 6. Please contact Ms. Lisa Kaeser, Program and Public Liaison
Office, NICHD, at 301-496-0536 to make your reservation. Additional
seating will be available in the meeting overflow rooms, Conference
Rooms 7 and 8. Individuals will also be able to view the meeting via
NIH Videocast. Please go to the following link for Videocast access
[[Page 25700]]
instructions at: https://www.nichd.nih.gov/about/overview/advisory/nachhd/virtual-meeting.cfm The meeting is partially closed to the
public.
(Catalogue of Federal Domestic Assistance Program Nos. 93.864,
Population Research; 93.865, Research for Mothers and Children;
93.929, Center for Medical Rehabilitation Research; 93.209,
Contraception and Infertility Loan Repayment program, National
Institutes of Health, HHS)
Dated: April 29, 2011.
Jennifer S. Spaeth,
Director, Office of Federal Advisory Committee Policy.
[FR Doc. 2011-11034 Filed 5-4-11; 8:45 am]
BILLING CODE 4140-01-P