National Institute of Environmental Health Sciences; Amended Notice of Meeting, 22110 [2011-9492]
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Federal Register / Vol. 76, No. 76 / Wednesday, April 20, 2011 / Notices
targeting could have therapeutic
potential. Inactivation of TSLP
expression or its receptor signaling can
effectively control cancer progression
and metastasis (1).
Applications:
• In treatments to control cancer
invasion and spreading
• Cancer treatment that circumvents
cancer-induced immune suppression
• As a means to augment anti-tumor
immune responses
• For the development of prognostic
markers for disease outcome in cancer
patients
Inventors: Arya Biragyn (NIA), Warren
J. Leonard (NHLBI)
Relevant Publications:
1. Olkhanud PB, Rochman Y, Bodogai
M, Malchinkhuu E, Wejksza K, Xu M,
Gress RE, Hesdorffer C, Leonard WJ,
Biragyn A. Thymic stromal
lymphopoietin is a key mediator of
breast cancer progression. J Immunol.
2011;V:186, In Press.
2. De Monte L, Reni M, Tassi E,
Clavenna D, Papa I, Recalde H, Braga M,
Di Carlo V, Doglioni C, Protti MP.
Intratumor T helper type 2 cell infiltrate
correlates with cancer-associated
fibroblast thymic stromal lymphopoietin
production and reduced survival in
pancreatic cancer. J Exp Med. 2011 Mar
14;208(3):469–478. [PubMed: 21339327]
3. Pedroza-Gonzalez A, Xu K, Wu TC,
Aspord C, Tindle S, Marches F, Gallegos
M, Burton EC, Savino D, Hori T, Tanaka
Y, Zurawski S, Zurawski G, Bover L, Liu
YJ, Banchereau J, Palucka AK. Thymic
stromal lymphopoietin fosters human
breast tumor growth by promoting type
2 inflammation. J Exp Med. 2011 Mar
14;208(3):479–490. [PubMed: 21339324]
Patent Status: U.S. Provisional
Application No. 61/416,619 filed
November 23, 2010 (HHS Reference No.
E–019–2011/0–US–01)
Licensing Status: Available for
licensing.
Licensing Contact: Patrick P. McCue,
PhD; 301–435–5560;
mccuepat@mail.nih.gov
Collaborative Research Opportunity:
The National Institute on Aging,
Immunotherapeutics Unit, is seeking
statements of capability or interest from
parties interested in collaborative
research to further develop, evaluate, or
commercialize clinical application of
TSLP in cancers. Please contact Nicole
Guyton, PhD at 301–435–3101 or
darackn@mail.nih.gov for more
information.
System and Method for Producing
Nondiffracting Light Sheets That
Improves the Performance of Selective
Plane Illumination Microscopy (SPIM)
Description of Technology: The
technology offered for licensing relates
VerDate Mar<15>2010
17:52 Apr 19, 2011
Jkt 223001
to a system and method of producing
nondiffracting beams of light that
spatially overlap, but do not interfere
with each other when intersecting the
detection plane of an optical
arrangement. The system includes an
illumination source (i.e., ultrafast laser)
for transmitting a beam of light through
the optical arrangement that includes a
diffraction grating for diffracting the
light beam to produce beams of light
having different wavelengths, which are
then passed through an annular aperture
that transforms the beams of light into
nondiffracting beams having different
wavelengths. The method can be readily
utilized in Selective Plane Illumination
Microscopy (SPIM), a system that
provides optical sectioning of a sample
that is labeled with fluorescent dyes.
SPIM can provide quantitative threedimensional maps of the distribution of
a flurophore within the sample with
high spatiotemporal resolution and an
excellent signal-to-noise ratio. The
standard SPIM technique however
produces nonuniform axial resolution,
which is caused by the diffraction of the
laser beam through the sample, causing
degradation in the optical sectioning,
and forcing a compromise between field
of view and axial resolution.
Techniques for decoupling field of view
and axial resolution have previously
utilized nondiffracting beams (e.g.,
Bessel beams) for sample illumination.
The resulting interference from multiple
nondiffracting beams degrades the
quality of optical sectioning and the
quality of the image. The present
technology utilizing nondiffracting
noninterfering beams is intended to
alleviate the problems associated with
the currently used SPIM techniques.
Applications: In Selective Plane
Illumination Microscopy (SPIM) used
for optical sectioning and imaging of
biological samples.
Development Status: Proof of concept
has been demonstrated.
Inventors: Andrew York, Yicong Wu,
Hari Shroff (NIBIB)
Relevant Publications:
1. Durnin J, Micheli J Jr, Eberly JH.
Diffraction-free beams. Phys Rev Lett.
1987 Apr 13;58(15):1499–1501.
2. Greger K, Swoger J, Stelzer EH. Basic
building units and properties of a
fluorescence single plane illumination
microscope. Rev Sci Instrum. 2007
Feb;78(2):023705. [PubMed: 17578115]
3. Fahrbach F, Rohrbach A. Microscopy with
Non-diffracting Beams. Abstract at 2009
Focus on Microscopy Conference, https://
www.focusonmicroscopy.org/2009/PDF/
28l_Fahrbach.pdf.
4. Rohrbach A. Artifacts resulting from
imaging in scattering media: a theoretical
prediction. Opt Lett. 2009 Oct
1;34(19):3041–3043. [PubMed:
PO 00000
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Patent Status: U.S. Provisional
Application No. 61/360,352 filed 30 Jun
2010, entitled ‘‘System and Method of
Producing Nondiffracting Light Sheets
by a Multiplicity of Spatially
Overlapping, Minimally Interfering
Nondiffracting Optical Beams’’ (HHS
Reference No. E–118–2010/0–US–01)
Licensing Status: Available for
licensing.
Licensing Contacts:
• Uri Reichman, PhD, MBA; 301–
435–4616; UR7a@nih.gov
• Michael Shmilovich, Esq.; 301–
435–5019; shmilovm@mail.nih.gov
Collaborative Research Opportunity:
The NIBIB Section on High Resolution
Optical Imaging is seeking statements of
capability or interest from parties
interested in collaborative research to
further develop, evaluate, or
commercialize the nondiffracting Light
Sheets for SPIM. Please contact Hari
Shroff at 301–435–1995 or
hari.shroff@nih.gov for more
information.
Dated: April 14, 2011.
Richard U. Rodriguez,
Director, Division of Technology Development
and Transfer, Office of Technology Transfer,
National Institutes of Health.
[FR Doc. 2011–9571 Filed 4–19–11; 8:45 am]
BILLING CODE 4140–01–P
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
National Institute of Environmental
Health Sciences; Amended Notice of
Meeting
Notice is hereby given of a change in
the meeting of the Board of Scientific
Counselors, NIEHS, March 20, 2011, 7
p.m. to March 22, 2011, 12:30 p.m.,
Doubletree Guest Suites, 2515 Meridian
Parkway, Research Triangle Park, NC,
27713 which was published in the
Federal Register on February 23, 2011,
76 FR 36.
This Federal Register Notice has been
amended to change the meeting date.
The meeting will be held Sunday, May
22, 2011 at 7 p.m. through Tuesday,
May 24, 2011 at 12:30 p.m. The meeting
is partially Closed to the public.
Dated: April 12, 2011.
Jennifer S. Spaeth,
Director, Office of Federal Advisory
Committee Policy.
[FR Doc. 2011–9492 Filed 4–19–11; 8:45 am]
BILLING CODE 4140–01–P
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[Federal Register Volume 76, Number 76 (Wednesday, April 20, 2011)]
[Notices]
[Page 22110]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: 2011-9492]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health
National Institute of Environmental Health Sciences; Amended
Notice of Meeting
Notice is hereby given of a change in the meeting of the Board of
Scientific Counselors, NIEHS, March 20, 2011, 7 p.m. to March 22, 2011,
12:30 p.m., Doubletree Guest Suites, 2515 Meridian Parkway, Research
Triangle Park, NC, 27713 which was published in the Federal Register on
February 23, 2011, 76 FR 36.
This Federal Register Notice has been amended to change the meeting
date. The meeting will be held Sunday, May 22, 2011 at 7 p.m. through
Tuesday, May 24, 2011 at 12:30 p.m. The meeting is partially Closed to
the public.
Dated: April 12, 2011.
Jennifer S. Spaeth,
Director, Office of Federal Advisory Committee Policy.
[FR Doc. 2011-9492 Filed 4-19-11; 8:45 am]
BILLING CODE 4140-01-P
