National Institute on Drug Abuse; Notice of Closed Meetings, 15328-15329 [2011-6584]

Download as PDF 15328 Federal Register / Vol. 76, No. 54 / Monday, March 21, 2011 / Notices mstockstill on DSKH9S0YB1PROD with NOTICES • Tiopronin does not inhibit the activity of ABC transporters, thereby reducing the chance of undesired sideeffects during treatment • The effects of Tiopronin correlates with the level of ABC transporter expression, allowing healthy cells to better survive treatments • Tiopronin can also improve the effectiveness of chemotherapy by resensitizing resistant cells that were previously considered impervious to treatment • Tiopronin has already been approved for use in humans for the treatment of cytinuria, facilitating the pathway for use in humans as a treatment for cancer Development Status: Preclinical stage of development, in vitro data Inventors: Andrew S. Goldsborough et al. (NCI) US Patent Status: US Provisional Application 61/407,948 (E–227–2010/0– US–01) Licensing Status: The technology is available for exclusive licensing. Licensing Contact: David Lambertson, PhD; 301–435–4632; lambertsond@mail.nih.gov. Collaborative Research Opportunity: The National Cancer Institute, Multidrug Resistance Section, is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize this technology. Please contact John Hewes, PhD at 301–435– 3121 or hewesj@mail.nih.gov for more information. Identification of EGFR as a Receptor for AAV6 Transduction Description of Technology: AAV vectors offer unique advantages in gene therapy applications. Studies have shown that these replication deficient parvovirus vectors can deliver DNA to specific tissues and confer long-term transgene expression in a variety of systems. Although many studies have looked at the tissue-specific expression elicited by each of the AAV serotypes, a true understanding of how AAV transduces these tissues is still unclear. Of the large AAV family, only a few receptors or co-receptors have been identified. The ability to better target transduction to specific tissues on the basis of the receptors that each serotype uses for entry is essential for selecting a serotype given the receptor expression in specific tissue, or to exploit altered receptor expression under disease conditions. AAV6 has been reported to effectively transduce muscle, lung, brain, and multiple types of tumors, including gliomas and lung adenocarcinomas. By VerDate Mar<15>2010 17:50 Mar 18, 2011 Jkt 223001 using a bioinformatics based screen approach, the NIH investigators discovered that the epidermal growth factor receptor (EGFR) is a co-receptor for AAV6 infection in mammalian cells, and is necessary for efficient vector internalization. Applications and Market: Improved gene therapy applications. Development Status: Pre-clinical stage of development. Inventors: John A. Chiorini, Melodie L. Weller, Michael Schmidt (NIDCR) Publication: Weller ML, Amornphimoltham P, Schmidt M, Wilson PA, Gutkind JS, Chiorini JA. Epidermal growth factor receptor is a co-receptor for adeno-associated virus serotype 6. Nat Med. 2010 Jun;16(6):662–664. [PubMed: 20473307] Patent Status: U.S. Utility Patent Application No. 12/879,142 filed 10 Sep 2010 (HHS Reference No. E–194–2010/ 0–US–01) Licensing Status: Available for licensing. Licensing Contact: Betty B. Tong, PhD; 301–594–6565; tongb@mail.nih.gov. Therapeutic Approach to Neurodegenerative Disorders Using a TFP5-Peptide Description of Technology: This invention discloses methods for treating neurodegenerative diseases by administering cyclin dependent kinase 5 (Cdk5) inhibitory peptides derived from P35, the activator of Cdk5. Abnormally hyperactive Cdk5 has been shown to be associated with a variety of neurodegenerative disorders. Disclosed in this invention are isolated peptide fragments, pharmaceutical compositions and methods for use of such for treating subjects with a neurodegenerative disease, such as Alzheimer’s disease (AD), Amyotrophic Lateral Sclerosis (ALS) and Parkinson’s disease (PD). An inhibitory fragment, TFP5, disclosed in this invention, has been shown to ameliorate symptoms of AD in disease animal models without any evidence of toxicity. In particular, TFP5 treatment of rat cortical neurons reduced hyperactivation of Cdk5 upon neuronal stress and insults. Following intraperitoneal (ip) injection, TFP5 was capable of crossing the BBB and localizing within the brain where it was found to rescue memory deficits and pathology in a double transgenic mouse (APP/PS1) AD model. Applications: Therapeutic developments (AD, PD, ALS) Advantages: The products are small peptides that pass the blood brain barrier. PO 00000 Frm 00051 Fmt 4703 Sfmt 4703 Market: Development for AD, PD, and ALS. Development Status: Pre-clinical; some animal data Inventors: Harish C. Pant (NINDS) Patent Status: U.S. Provisional Application No. 61/387,839 filed 29 Sep 2010 (HHS Reference No. E–144–2010/ 0–US–01) Licensing Status: Available for licensing. Licensing Contact: Steven H. Standley, PhD; 301–435–4074; sstand@mail.nih.gov. Collaborative Research Opportunity: The National Institute of Neurological Disorders and Stroke, Neuronal Cytoskeletal Protein Regulation Section, is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize topic of invention or related laboratory interests. Please contact Heather Gunas, J.D., M.P.H., at 301–451–3944 or gunash@mail.nih.gov for more information. Dated: March 15, 2011. Richard U. Rodriguez, Director, Division of Technology Development and Transfer, Office of Technology Transfer, National Institutes of Health. [FR Doc. 2011–6569 Filed 3–18–11; 8:45 am] BILLING CODE 4140–01–P DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Institute on Drug Abuse; Notice of Closed Meetings Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App), notice is hereby given of the following meetings. The meetings will be closed to the public in accordance with the provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The contract proposals and the discussions could disclose confidential trade secrets or commercial property such as patentable materials, and personal information concerning individuals associated with the contract proposals, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. Name of Committee: National Institute on Drug Abuse Special Emphasis Panel; GISTE, the Geospatial Information Systems Tool (5558). Date: April 18, 2011. Time: 1:30 p.m. to 3 p.m. Agenda: To review and evaluate contract proposals. E:\FR\FM\21MRN1.SGM 21MRN1 mstockstill on DSKH9S0YB1PROD with NOTICES Federal Register / Vol. 76, No. 54 / Monday, March 21, 2011 / Notices Place: National Institutes of Health, Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852 (Telephone Conference Call). Contact Person: Gerald L. McLaughlin, PhD, Scientific Review Administrator, Office of Extramural Affairs, National Institute on Drug Abuse, NIH, DHHS, Room 4238, MSC 9550, 6001 Executive Blvd., Bethesda, MD 20892–9550, 301–402–6626, gm145a@nih.gov. Name of Committee: National Institute on Drug Abuse Special Emphasis Panel; Research Works: Enrollment Workflow (2219). Date: April 28, 2011. Time: 9:30 a.m. to 12 p.m. Agenda: To review and evaluate contract proposals. Place: National Institutes of Health, Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852 (Telephone Conference Call). Contact Person: Lyle Furr, Contract Review Specialist, Office of Extramural Affairs, National Institute on Drug Abuse, NIH, DHHS, Room 4227, MSC 9550, 6001 Executive Boulevard, Bethesda, MD 20892– 9550, (301) 435–1439, lf33c@nih.gov. Name of Committee: National Institute on Drug Abuse Special Emphasis Panel; NIDA’s Science Meetings Logistical Support (1144). Date: May 3–4, 2011. Time: 9 a.m. to 5 p.m. Agenda: To review and evaluate contract proposals. Place: Courtyard by Marriott Rockville, 2500 Research Boulevard, Rockville, MD 20850. Contact Person: Lyle Furr, Contract Review Specialist, Office of Extramural Affairs, National Institute on Drug Abuse, NIH, DHHS, Room 4227, MSC 9550, 6001 Executive Boulevard, Bethesda, MD 20892– 9550, (301) 435–1439, lf33c@nih.gov. Name of Committee: National Institute on Drug Abuse Special Emphasis Panel; Research Support Services for NIDA AIDS Research Program (1207). Date: May 5, 2011. Time: 9:30 a.m. to 12 p.m. Agenda: To review and evaluate contract proposals. Place: National Institutes of Health, Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852 (Telephone Conference Call). Contact Person: Lyle Furr, Contract Review Specialist, Office of Extramural Affairs, National Institute on Drug Abuse, NIH, DHHS, Room 4227, MSC 9550, 6001 Executive Boulevard, Bethesda, MD 20892– 9550, (301) 435–1439, lf33c@nih.gov. Name of Committee: National Institute on Drug Abuse Special Emphasis Panel; Development & Manufacture of Pharmaceutical Products/Addiction Treatment (8899). Date: May 24, 2011. Time: 9 a.m. to 5 p.m. Agenda: To review and evaluate contract proposals. Place: Courtyard by Marriott Rockville, 2500 Research Boulevard, Rockville, MD 20850. VerDate Mar<15>2010 17:50 Mar 18, 2011 Jkt 223001 15329 Contact Person: Lyle Furr, Contract Review Specialist, Office of Extramural Affairs, National Institute on Drug Abuse, NIH, DHHS, Room 4227, MSC 9550, 6001 Executive Boulevard, Bethesda, MD 20892– 9550, (301) 435–1439, lf33c@nih.gov. (Catalogue of Federal Domestic Assistance Program Nos.: 93.279, Drug Abuse and Addiction Research Programs, National Institutes of Health, HHS) [FR Doc. 2011–6578 Filed 3–18–11; 8:45 am] Dated: March 15, 2011. Jennifer Spaeth, Director, Office of Federal Advisory Committee Policy. National Institutes of Health [FR Doc. 2011–6584 Filed 3–18–11; 8:45 am] BILLING CODE 4140–01–P DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Institute on Drug Abuse; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App), notice is hereby given of the following meeting. The meeting will be closed to the public in accordance with the provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 USC, as amended. The grant applications and the discussions could disclose confidential trade secrets or commercial property such as patentable materials, and personal information concerning individuals associated with the grant applications, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. Name of Committee: National Institute on Drug Abuse Special Emphasis Panel, R25 Summer Programs. Date: March 30, 2011. Time: 11 a.m. to 1 p.m. Agenda: To review and evaluate grant applications. Place: National Institutes of Health, Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852 (Telephone Conference Call). Contact Person: Gerald L. McLaughlin, PhD, Scientific Review Officer, Office of Extramural Affairs, National Institute on Drug Abuse, NIH, DHHS, Room 4238, MSC 9550, 6001 Executive Blvd., Bethesda, MD 20892–9550, 301–402–6626, gm145a@nih.gov. This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. (Catalogue of Federal Domestic Assistance Program Nos.: 93.279, Drug Abuse and Addiction Research Programs, National Institutes of Health, HHS) PO 00000 Frm 00052 Fmt 4703 Sfmt 9990 Dated: March 15, 2011. Jennifer Spaeth, Director, Office of Federal Advisory Committee Policy. BILLING CODE 4140–01–P DEPARTMENT OF HEALTH AND HUMAN SERVICES Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is hereby given of the following meeting. The meeting will be closed to the public in accordance with the provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The grant applications and the discussions could disclose confidential trade secrets or commercial property such as patentable material, and personal information concerning individuals associated with the grant applications, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. Name of Committee: National Institute of Child Health and Human Development Special Emphasis Panel, Functional Development of the Mammary Gland. Date: April 14, 2011. Time: 2 p.m. to 4 p.m. Agenda: To review and evaluate grant applications. Place: National Institutes of Health, 6100 Executive Boulevard, Rockville, MD 20852 (Telephone Conference Call). Contact Person: Peter Zelazowski, PhD, Scientific Review Officer, Division of Scientific Review, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, 6100 Executive Blvd., Room 5B01, Bethesda, MD 20892, 301–435–6902, peter.zelazowski@nih.gov. (Catalogue of Federal Domestic Assistance Program Nos. 93.864, Population Research; 93.865, Research for Mothers and Children; 93.929, Center for Medical Rehabilitation Research; 93.209, Contraception and Infertility Loan Repayment Program, National Institutes of Health, HHS) Dated: March 15, 2011. Jennifer S. Spaeth, Director, Office of Federal Advisory Committee Policy. [FR Doc. 2011–6575 Filed 3–18–11; 8:45 am] BILLING CODE 4140–01–P E:\FR\FM\21MRN1.SGM 21MRN1

Agencies

[Federal Register Volume 76, Number 54 (Monday, March 21, 2011)]
[Notices]
[Pages 15328-15329]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: 2011-6584]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


National Institute on Drug Abuse; Notice of Closed Meetings

    Pursuant to section 10(d) of the Federal Advisory Committee Act, as 
amended (5 U.S.C. App), notice is hereby given of the following 
meetings.
    The meetings will be closed to the public in accordance with the 
provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 
U.S.C., as amended. The contract proposals and the discussions could 
disclose confidential trade secrets or commercial property such as 
patentable materials, and personal information concerning individuals 
associated with the contract proposals, the disclosure of which would 
constitute a clearly unwarranted invasion of personal privacy.

    Name of Committee: National Institute on Drug Abuse Special 
Emphasis Panel; GISTE, the Geospatial Information Systems Tool 
(5558).
    Date: April 18, 2011.
    Time: 1:30 p.m. to 3 p.m.
    Agenda: To review and evaluate contract proposals.

[[Page 15329]]

    Place: National Institutes of Health, Neuroscience Center, 6001 
Executive Boulevard, Rockville, MD 20852 (Telephone Conference 
Call).
    Contact Person: Gerald L. McLaughlin, PhD, Scientific Review 
Administrator, Office of Extramural Affairs, National Institute on 
Drug Abuse, NIH, DHHS, Room 4238, MSC 9550, 6001 Executive Blvd., 
Bethesda, MD 20892-9550, 301-402-6626, gm145a@nih.gov.

    Name of Committee: National Institute on Drug Abuse Special 
Emphasis Panel; Research Works: Enrollment Workflow (2219).
    Date: April 28, 2011.
    Time: 9:30 a.m. to 12 p.m.
    Agenda: To review and evaluate contract proposals.
    Place: National Institutes of Health, Neuroscience Center, 6001 
Executive Boulevard, Rockville, MD 20852 (Telephone Conference 
Call).
    Contact Person: Lyle Furr, Contract Review Specialist, Office of 
Extramural Affairs, National Institute on Drug Abuse, NIH, DHHS, 
Room 4227, MSC 9550, 6001 Executive Boulevard, Bethesda, MD 20892-
9550, (301) 435-1439, lf33c@nih.gov.

    Name of Committee: National Institute on Drug Abuse Special 
Emphasis Panel; NIDA's Science Meetings Logistical Support (1144).
    Date: May 3-4, 2011.
    Time: 9 a.m. to 5 p.m.
    Agenda: To review and evaluate contract proposals.
    Place: Courtyard by Marriott Rockville, 2500 Research Boulevard, 
Rockville, MD 20850.
    Contact Person: Lyle Furr, Contract Review Specialist, Office of 
Extramural Affairs, National Institute on Drug Abuse, NIH, DHHS, 
Room 4227, MSC 9550, 6001 Executive Boulevard, Bethesda, MD 20892-
9550, (301) 435-1439, lf33c@nih.gov.

    Name of Committee: National Institute on Drug Abuse Special 
Emphasis Panel; Research Support Services for NIDA AIDS Research 
Program (1207).
    Date: May 5, 2011.
    Time: 9:30 a.m. to 12 p.m.
    Agenda: To review and evaluate contract proposals.
    Place: National Institutes of Health, Neuroscience Center, 6001 
Executive Boulevard, Rockville, MD 20852 (Telephone Conference 
Call).
    Contact Person: Lyle Furr, Contract Review Specialist, Office of 
Extramural Affairs, National Institute on Drug Abuse, NIH, DHHS, 
Room 4227, MSC 9550, 6001 Executive Boulevard, Bethesda, MD 20892-
9550, (301) 435-1439, lf33c@nih.gov.

    Name of Committee: National Institute on Drug Abuse Special 
Emphasis Panel; Development & Manufacture of Pharmaceutical 
Products/Addiction Treatment (8899).
    Date: May 24, 2011.
    Time: 9 a.m. to 5 p.m.
    Agenda: To review and evaluate contract proposals.
    Place: Courtyard by Marriott Rockville, 2500 Research Boulevard, 
Rockville, MD 20850.
    Contact Person: Lyle Furr, Contract Review Specialist, Office of 
Extramural Affairs, National Institute on Drug Abuse, NIH, DHHS, 
Room 4227, MSC 9550, 6001 Executive Boulevard, Bethesda, MD 20892-
9550, (301) 435-1439, lf33c@nih.gov.
(Catalogue of Federal Domestic Assistance Program Nos.: 93.279, Drug 
Abuse and Addiction Research Programs, National Institutes of 
Health, HHS)


    Dated: March 15, 2011.
Jennifer Spaeth,
Director, Office of Federal Advisory Committee Policy.
[FR Doc. 2011-6584 Filed 3-18-11; 8:45 am]
BILLING CODE 4140-01-P
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