Government-Owned Inventions; Availability for Licensing, 13193-13195 [2011-5511]
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Federal Register / Vol. 76, No. 47 / Thursday, March 10, 2011 / Notices
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
Government-Owned Inventions;
Availability for Licensing
National Institutes of Health,
Public Health Service, HHS.
ACTION: Notice.
AGENCY:
The inventions listed below
are owned by an agency of the U.S.
Government and are available for
licensing in the U.S. in accordance with
35 U.S.C. 207 to achieve expeditious
commercialization of results of
federally-funded research and
development. Foreign patent
applications are filed on selected
inventions to extend market coverage
for companies and may also be available
for licensing.
ADDRESSES: Licensing information and
copies of the U.S. patent applications
listed below may be obtained by writing
to the indicated licensing contact at the
Office of Technology Transfer, National
Institutes of Health, 6011 Executive
Boulevard, Suite 325, Rockville,
Maryland 20852–3804; telephone: 301/
496–7057; fax: 301/402–0220. A signed
Confidential Disclosure Agreement will
be required to receive copies of the
patent applications.
SUMMARY:
jdjones on DSK8KYBLC1PROD with NOTICES
System and Method for Automatic
Speed Adaptation Control of a
Treadmill
Description of Invention: The
invention offered for further commercial
development relates to the coupling of
virtual reality technology with a
treadmill to implement goal-oriented
walking practices effectively and to
promote improved learning skills during
gait training. The technology will be
useful in rehabilitation of individuals
with gait impairments resulting from
Parkinson’s disease, Traumatic Brain
Injury, Stroke, Cerebral Palsy, and
Spinal Cord Injury. In order to allow
patients practice (e.g., voluntary change
of walking speed in a natural way),
software has been developed that
automatically updates the velocity of a
treadmill following the intention of the
person walking on the treadmill. The
invention uses a swing foot velocity
measurement to control the velocity of
the treadmill which can quickly and
precisely detect the user’s intention of
changing walking velocity. Swing foot
velocity measurement allows users to
voluntarily change walking velocity
while they have a realistic feel of
walking (such as over-ground walking).
We are seeking a CRADA collaborator to
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Jkt 223001
expand implementation of the invention
into a fully integrated system that can
control treadmill velocity in real time
and can be reliably adapted to typical
commercial treadmills.
Applications:
• Rehabilitation of individuals with
gait impairments as a complication of
Parkinson’s disease, traumatic brain
injury, stroke, cerebral palsy, or spinal
cord injury.
• The technology can also be used for
walking through architectural models,
for educational purposes (student walk
through historical sites or geological
surfaces), military or law enforcement
training, gaming, motor and sensory
rehabilitation, and exercise and
recreation.
Development Status: Development
partner with experience designing
virtual reality environments is sought
for a CRADA collaboration.
Inventors: Hyung S. Park (NIH/CC)
and Jung Won Yoon.
Relevant Publications:
1. Lichtenstein L, Barabas J, Woods RL, Peli
E. A feedback control interface for
treadmill locomotion in virtual
environments. ACM Trans Appl Percept.
2007 Jan;4(1):Article No. 7; doi
10.1145//1227134.1227141.
2. Souman JL, Giordano PR, Frissen I, De
Luca A, Ernst MO. Making virtual
walking real: Perceptual evaluation of a
new treadmill control algorithm. ACM
Trans Appl Percept. 2010
Feb;7(2):Article No. 11; doi 10.1145//
1670671.1670675.
3. Christensen RR, Hollerbach JM, Xu Y,
Meek SG. Inertial force feedback for the
treadport locomotion interface. Presence:
Teleoperators and Virtual Environments.
2000 Feb;9(1):1–14; doi:10.1162/
105474600566574.
4. von Zitzewitz J, Bernhardt M, Riener R. A
novel method for automatic treadmill
speed adaptation. IEEE Trans Neural
Syst Rehabil Eng. 2007 Sep;15(3):401–
409. [PubMed: 17894272]
5. Farnet MG. Treadmill having an automatic
speed control system. U.S. Patent
5,368,532 issued November 29, 1994.
6. Potash RL, Jentges CJ, Burns SK, Potash RJ.
Adaptive treadmill. U.S. Patent
5,314,391 issued May 24, 1994.
7. Minetti AE, Boldrini L, Brusamolin L,
Zamparo P, McKee T. A feedbackcontrolled treadmill (treadmill-ondemand) and the spontaneous speed of
walking and running in humans. J Appl
Physiol. 2003 Aug;95(2):838–843.
[PubMed: 12692130]
Patent Status: HHS Reference No. E–
046–2011/0—One aspect of the overall
invention currently exists in software
form, for which the U.S. Government
will not be seeking patent protection.
Licensing Status: Available for
licensing.
Licensing Contacts:
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13193
• Uri Reichman, PhD, MBA; 301–
435–4616; UR7a@nih.gov.
• Michael Shmilovich, Esq.; 301–
435–5019; ShmilovichM@mail.nih.gov.
Collaborative Research Opportunity:
The National Institutes of Health
Clinical Center is seeking statements of
capability or interest from parties
interested in collaborative research to
further develop, evaluate, or
commercialize ‘‘A system and method
for automatic speed adaptation control
of a treadmill for patients.’’ Please
contact Dr. Hyung S. Park at 301–451–
7533 for more information.
Method for the Detection of a Subdural
Hematoma Using a Handheld
Hematoma Detector and Discriminator
Description of Invention: The
invention offered for licensing and
further development is a device and
method for detecting hematomas. The
device is based on near infrared light
emitted perpendicularly into a tissue
from a non-stationary emitter and on
continuous detection of the reflected
light with a non-stationary probe. The
device is designed as a handheld
detector that can be used either in an ER
or at the scene of an accident, which
will allow the Doctor or EMT to
diagnose hematoma for patients with a
Traumatic Brain Injury at the scene.
Furthermore, this device can be utilized
to discriminate between subdural and
epidural hematoma. The invention also
discloses a novel method of data
analysis. The specific combination and
sequences of data analysis are
performed to discriminate healthy tissue
from tissue perfused with blood. In
addition, an interface to a laptop will be
provided that creates a 3D surface image
of the location of the hematoma is
displayed. This invention will result in
a better triage and treatment for patients
with Traumatic Brain Injury (TBI) and
fills a must filled gap in TBI health care.
Applications:
• Diagnosis for hematoma
• Early screening and triage for
diagnosis of hemorrhage from head
trauma
• At-the-scene diagnostic
• On-going patient monitoring
• Neurosurgical procedure
preparation
• The device will be useful in combat
critical care and/or third world care
where CT may not be readily available
• Potential use of the device in a field
deployable sense
Advantages:
• Improved capabilities of accurately
diagnosing hematoma
• At-the-scene detection capabilities
• The device is inexpensive, simple
in its design and easy to operate
E:\FR\FM\10MRN1.SGM
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13194
Federal Register / Vol. 76, No. 47 / Thursday, March 10, 2011 / Notices
• Potential improvement in medical
procedures
Development Status:
• The invention is fully developed
• May need to develop a prototype for
testing on phantoms
Inventors: Jason D. Riley (NICHD) et
al.
Patent Status:
• U.S. Provisional Application No.
61/286, 626 filed 15 Dec 2009 (HHS
Reference No. E–010–2010/0–US–01)
• PCT Application No. PCT/US2010/
060506 filed 15 Dec 2010 (HHS
Reference No. E–010–2010/0–PCT–02)
Licensing Status: Available for
licensing.
Licensing Contacts:
• Uri Reichman, PhD, MBA; 301–
435–4616; UR7a@nih.gov.
• Michael Shmilovich, Esq.; 301–
435–5019; ShmilovichM@mail.nih.gov.
Collaborative Research Opportunity:
The National Institute of Child Health
and Human Development, Section on
Biomedical Stochastic Physics, is
seeking statements of capability or
interest from parties interested in
collaborative research to further
develop, evaluate, or commercialize the
topic of this invention or related
laboratory interests. Please contact Alan
Hubbs, PhD at 301–594–4263 or
hubbsa@mail.nih.gov for more
information.
jdjones on DSK8KYBLC1PROD with NOTICES
System and Method for Monitoring and
Controlling Radio Frequency Signals in
Interventional Devices
Description of Invention: The
invention offered for licensing and
commercial development is in the field
of Interventional Magnetic Resonance
Imaging (‘‘iMRI’’). More specifically the
invention discloses interventional
devices in which the heat generated at
the device during the imaging process
can be controlled to not exceed
acceptable levels.
Interventional devices may heat up
significantly during an interventional
MRI procedure as a result of an RF
induced current on the device. The RF
induced current is caused by the
coupling between the interventional
device and RF electrical fields generated
by the MRI. As the magnitude of the
induced RF signal increases, the amount
of heat that is generated also increases.
The system of the present invention
measures the induced RF signal and
changes a decoupling capacitor value by
using a varactor and a control circuit to
adjust the impedance of the device and
thus controls the magnitude of the RF
signal. This unique design renders the
device and the procedures done with it
safe.
Applications:
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• Interventional cardiology
• MRI guided surgery
Advantages: The device may
fundamentally enable any ‘‘active’’ MRI
catheter device to be safe during realtime MRI guided interventional
procedures. Automated feedback loops
between RF power applied by the MRI
scanner and measured power detected
inside the MRI catheter coil can be used
to assure safety of ‘‘active’’ MRI catheter
devices.
Development Status: In development.
Prototype is being built.
Inventors: Ozgur Kocaturk and
Merdim Sonmez (NHLBI).
Relevant Publication: Overall WR,
Pauly JM, Stang PP, Scott GC. Ensuring
safety of implanted devices under MRI
using reversed RF polarization. Magn
Reson Med. 2010 Sep;64(3):823–833.
[PubMed: 20593374]
Patent Status: U.S. Provisional
Application No. 61/430,311 filed 07 Jan
2011 (HHS Reference No. E–034–2011/
0–US–01)
Licensing Status: Available for
licensing.
Licensing Contact:
• Uri Reichman, PhD, MBA; 301–
435–4616; UR7a@nih.gov.
• Michael Shmilovich, Esq.; 301–
435–5019; ShmilovichM@mail.nih.gov.
Collaborative Research Opportunity:
The National Heart, Lung, and Blood
Institute is seeking statements of
capability or interest from parties
interested in collaborative research to
further develop, evaluate, or
commercialize safety interventional
devices during iMRI procedures. Please
contact Peg Koelble at
koelblep@nhlbi.nih.gov for more
information.
Single Channel MRI Guidewire
Description of Invention: The
invention offered for licensing and
commercial development is in the field
of Interventional Magnetic Resonance
Imaging (‘‘iMRI’’). More specifically the
invention discloses a guidewire for
magnetic resonance imaging with a
single channel design to reduce
complexity and to provide conspicuous
tip visibility under MRI. In the design
of the present device, the guidewire
body includes an antenna formed from
a rod and a helical coil coupled
together. The helical coil can have
multiple windings without a gap
between the windings. The rod passes
through the windings of the helical coil
and is coupled to the helical coil using
a conductive joint positioned at an end
of the rod and at an end of the helical
coil. Insulation can be positioned
between the rod and the windings of the
helical coil. The configuration allows
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visibility of the antenna along the length
of a rod, except where it enters the
windings of the coil. Thus, the tip
visibility is enhanced as being separated
from the rod.
Applications:
• Interventional cardiology
• MRI guided surgery
Advantages:
• The unique design of the device
and its dipole antenna, provide a lower
profile guidewire (such as coronary
0.014: guidewire) and it is therefore
safer and more convenient to use
compared with existing guidewires.
• The modified dipole antenna of the
device can combine the distinct tip
signal profile typical of loop antennae
with the whole-shaft visibility of dipole
antennae, all operating on a single
receiver channel. This overcomes
challenges both of conspicuity and of
undesirable coupling of comparable
two-channel devices that causes
heating.
Development Status: In development.
Prototype is being built.
Inventors: Merdim Sonmez, Ozgur
Kocaturk, and Christina E. Saikus
(NHLBI)
Relevant Publications:
1. Kocaturk O, Kim AH, Saikus CE, Guttman
MA, Faranesh AZ, Ozturk C, Lederman
RJ. Active two-channel 0.035’’ guidewire
for interventional cardiovascular MRI. J
Magn Reson Imaging. 2009
Aug;30(2):461–465. [PubMed: 19629968]
2. Qian D, El-Sharkawy AM, Atalar E,
Bottomley PA. Interventional MRI:
tapering improves the distal sensitivity
of the loopless antenna. Magn Reson
Med. 2010 Mar;63(3):797–802. [PubMed:
20187186]
Patent Status: U.S. Provisional
Application No. 61/429,833 filed 05 Jan
2011 (HHS Reference No. E–274–2010/
0–US–01)
Related Technology: U.S. Patent
Application No. 12/810,481 filed 24 Jun
2010 (HHS Reference No. E–209–2007/
0–US–03), entitled ‘‘Active 0.035
Guidewire with Two Separate
Channels’’
Licensing Status: Available for
licensing.
Licensing Contact:
• Uri Reichman, PhD, MBA; 301–
435–4616; UR7a@nih.gov.
• Michael Shmilovich, Esq.; 301–
435–5019; ShmilovichM@mail.nih.gov.
Collaborative Research Opportunity:
The National Heart, Lung, and Blood
Institute is seeking statements of
capability or interest from parties
interested in collaborative research to
further develop, evaluate, or
commercialize technology involving
single channel MRI guidewires. Please
contact Peg Koelble at
E:\FR\FM\10MRN1.SGM
10MRN1
Federal Register / Vol. 76, No. 47 / Thursday, March 10, 2011 / Notices
koelblep@nhlbi.nih.gov for more
information.
jdjones on DSK8KYBLC1PROD with NOTICES
Active Adaptive Detuning Systems To
Improve Safety of Interventional
Devices
Description of Invention: The
invention offered for licensing and
commercial development is in the field
of Interventional Magnetic Resonance
Imaging (‘‘iMRI’’). More specifically the
invention discloses interventional
devices in which the heat generated at
the device during the imaging process
can be controlled to not exceed
acceptable levels.
Active MRI compatible intravascular
devices contain RF antenna so that they
are visible under MRI. However, these
metallic structures may heat up
significantly during interventional MRI
procedures due to eddy current
formation over the conductive
transmission lines. The electrical field
coupling between interventional devices
and RF transmission coils strongly
depend on the device position and
orientation within the bore and
insertion length of the device. Currently,
conventional detuning circuit is used to
decouple the conductive intravascular
device during RF transmission phase of
the MRI by activating the circuit with a
PIN diode. However, conventional
passive techniques do not adapt for each
possible orientation or insertion length
of the device. The current invention
provides for a new active detuning
system that adapts its circuit component
to limit heating for every possible
orientation and insertion length. The
system reads out the received current
signal value during RF transmission
phase and changes the decoupling
capacitor value by using varactor and
integrated circuit components to reach
new resonant condition (very high
impedance).
Applications:
• Interventional cardiology
• MRI guided surgery
Advantages: The device may
fundamentally enable any ‘‘active’’ MRI
catheter device (independent of the
orientation and insertion length of the
device) to be safe during real-time MRI
guided interventional procedures.
Development Status: In development.
Prototype is being built.
Inventors: Ozgur Kocaturk (NHLBI).
Patent Status: U.S. Provisional
Application No. 61/360,998 filed 07 Jul
2010 (HHS Reference No. E–114–2010/
0–US–01)
Relevant Publication: Overall WR,
Pauly JM, Stang PP, Scott GC. Ensuring
safety of implanted devices under MRI
using reversed RF polarization. Magn
VerDate Mar<15>2010
14:43 Mar 09, 2011
Jkt 223001
Reson Med. 2010 Sep;64(3):823–833.
[PubMed: 20593374]
Licensing Status: Available for
licensing.
Licensing Contact:
• Uri Reichman, PhD, MBA; 301–
435–4616; UR7a@nih.gov.
• Michael Shmilovich, Esq.; 301–
435–5019; ShmilovichM@mail.nih.gov.
Collaborative Research Opportunity:
The National Heart, Lung, and Blood
Institute is seeking statements of
capability or interest from parties
interested in collaborative research to
further develop, evaluate, or
commercialize this technology. Please
contact Peg Koelble at
koelblep@nhlbi.nih.gov for more
information.
Dated: March 4, 2011.
Richard U. Rodriguez,
Director, Division of Technology Development
and Transfer, Office of Technology Transfer,
National Institutes of Health.
[FR Doc. 2011–5511 Filed 3–9–11; 8:45 am]
BILLING CODE 4140–01–P
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
National Institute of Allergy and
Infectious Diseases; Notice of Closed
Meeting
Pursuant to section 10(d) of the
Federal Advisory Committee Act, as
amended (5 U.S.C. App.), notice is
hereby given of the following meeting.
The meeting will be closed to the
public in accordance with the
provisions set forth in sections
552b(c)(4) and 552b(c)(6), Title 5 U.S.C.,
as amended. The grant applications and
the discussions could disclose
confidential trade secrets or commercial
property such as patentable material,
and personal information concerning
individuals associated with the grant
applications, the disclosure of which
would constitute a clearly unwarranted
invasion of personal privacy.
Name of Committee: National Institute of
Allergy and Infectious Diseases Special
Emphasis Panel; Mouse Models of Host
Responses.
Date: April 5, 2011.
Time: 1 p.m. to 5 p.m.
Agenda: To review and evaluate grant
applications.
Place: National Institutes of Health, 6700B
Rockledge Drive, Bethesda, MD 20817.
Contact Person: Brandt Randall Burgess,
PhD, Scientific Review Officer, Scientific
Review Program, Division of Extramural
Activities, DHHS/NIH/NIAID, 6700B
Rockledge Drive, MSC 7616, Bethdesda, MD
20892, 301–451–2584,
bburgess@niaid.nih.gov.
PO 00000
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13195
(Catalogue of Federal Domestic Assistance
Program Nos. 93.855, Allergy, Immunology,
and Transplantation Research; 93.856,
Microbiology and Infectious Diseases
Research, National Institutes of Health, HHS)
Dated: March 4, 2011.
Jennifer S. Spaeth,
Director, Office of Federal Advisory
Committee Policy.
[FR Doc. 2011–5505 Filed 3–9–11; 8:45 am]
BILLING CODE 4140–01–P
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
Center for Scientific Review; Notice of
Closed Meetings
Pursuant to section 10(d) of the
Federal Advisory Committee Act, as
amended (5 U.S.C. App.), notice is
hereby given of the following meetings.
The meetings will be closed to the
public in accordance with the
provisions set forth in sections
552b(c)(4) and 552b(c)(6), Title 5 U.S.C.,
as amended. The grant applications and
the discussions could disclose
confidential trade secrets or commercial
property such as patentable material,
and personal information concerning
individuals associated with the grant
applications, the disclosure of which
would constitute a clearly unwarranted
invasion of personal privacy.
Name of Committee: Center for Scientific
Review Special Emphasis Panel;
Fellowships: AIDS Predoctoral and
Postdoctoral.
Date: March 29, 2011.
Time: 11 a.m. to 7 p.m.
Agenda: To review and evaluate grant
applications.
Place: New York Marriott East Side, 525
Lexington Avenue at 49th Street, New York,
NY 10017.
Contact Person: Shiv A Prasad, PhD,
Scientific Review Officer, Center for
Scientific Review, National Institutes of
Health, 6701 Rockledge Drive, Room 5220,
MSC 7852, Bethesda, MD 20892, 301–443–
5779, prasads@csr.nih.gov.
Name of Committee: Center for Scientific
Review Special Emphasis Panel; Member
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Genomics.
Date: March 29, 2011.
Time: 3 p.m. to 5 p.m.
Agenda: To review and evaluate grant
applications.
Place: National Institutes of Health, 6701
Rockledge Drive, Bethesda, MD 20892
(Telephone Conference Call).
Contact Person: Malgorzata Klosek, PhD,
Scientific Review Officer, Center for
Scientific Review, National Institutes of
Health, 6701 Rockledge Drive, Room 4188,
MSC 7849, Bethesda, MD 20892, (301) 435–
2211, klosekm@csr.nih.gov.
E:\FR\FM\10MRN1.SGM
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]]>Agencies
[Federal Register Volume 76, Number 47 (Thursday, March 10, 2011)]
[Notices]
[Pages 13193-13195]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: 2011-5511]
[[Page 13193]]
-----------------------------------------------------------------------
DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health
Government-Owned Inventions; Availability for Licensing
AGENCY: National Institutes of Health, Public Health Service, HHS.
ACTION: Notice.
-----------------------------------------------------------------------
SUMMARY: The inventions listed below are owned by an agency of the U.S.
Government and are available for licensing in the U.S. in accordance
with 35 U.S.C. 207 to achieve expeditious commercialization of results
of federally-funded research and development. Foreign patent
applications are filed on selected inventions to extend market coverage
for companies and may also be available for licensing.
ADDRESSES: Licensing information and copies of the U.S. patent
applications listed below may be obtained by writing to the indicated
licensing contact at the Office of Technology Transfer, National
Institutes of Health, 6011 Executive Boulevard, Suite 325, Rockville,
Maryland 20852-3804; telephone: 301/496-7057; fax: 301/402-0220. A
signed Confidential Disclosure Agreement will be required to receive
copies of the patent applications.
System and Method for Automatic Speed Adaptation Control of a Treadmill
Description of Invention: The invention offered for further
commercial development relates to the coupling of virtual reality
technology with a treadmill to implement goal-oriented walking
practices effectively and to promote improved learning skills during
gait training. The technology will be useful in rehabilitation of
individuals with gait impairments resulting from Parkinson's disease,
Traumatic Brain Injury, Stroke, Cerebral Palsy, and Spinal Cord Injury.
In order to allow patients practice (e.g., voluntary change of walking
speed in a natural way), software has been developed that automatically
updates the velocity of a treadmill following the intention of the
person walking on the treadmill. The invention uses a swing foot
velocity measurement to control the velocity of the treadmill which can
quickly and precisely detect the user's intention of changing walking
velocity. Swing foot velocity measurement allows users to voluntarily
change walking velocity while they have a realistic feel of walking
(such as over-ground walking). We are seeking a CRADA collaborator to
expand implementation of the invention into a fully integrated system
that can control treadmill velocity in real time and can be reliably
adapted to typical commercial treadmills.
Applications:
Rehabilitation of individuals with gait impairments as a
complication of Parkinson's disease, traumatic brain injury, stroke,
cerebral palsy, or spinal cord injury.
The technology can also be used for walking through
architectural models, for educational purposes (student walk through
historical sites or geological surfaces), military or law enforcement
training, gaming, motor and sensory rehabilitation, and exercise and
recreation.
Development Status: Development partner with experience designing
virtual reality environments is sought for a CRADA collaboration.
Inventors: Hyung S. Park (NIH/CC) and Jung Won Yoon.
Relevant Publications:
1. Lichtenstein L, Barabas J, Woods RL, Peli E. A feedback control
interface for treadmill locomotion in virtual environments. ACM
Trans Appl Percept. 2007 Jan;4(1):Article No. 7; doi 10.1145//
1227134.1227141.
2. Souman JL, Giordano PR, Frissen I, De Luca A, Ernst MO. Making
virtual walking real: Perceptual evaluation of a new treadmill
control algorithm. ACM Trans Appl Percept. 2010 Feb;7(2):Article No.
11; doi 10.1145//1670671.1670675.
3. Christensen RR, Hollerbach JM, Xu Y, Meek SG. Inertial force
feedback for the treadport locomotion interface. Presence:
Teleoperators and Virtual Environments. 2000 Feb;9(1):1-14;
doi:10.1162/105474600566574.
4. von Zitzewitz J, Bernhardt M, Riener R. A novel method for
automatic treadmill speed adaptation. IEEE Trans Neural Syst Rehabil
Eng. 2007 Sep;15(3):401-409. [PubMed: 17894272]
5. Farnet MG. Treadmill having an automatic speed control system.
U.S. Patent 5,368,532 issued November 29, 1994.
6. Potash RL, Jentges CJ, Burns SK, Potash RJ. Adaptive treadmill.
U.S. Patent 5,314,391 issued May 24, 1994.
7. Minetti AE, Boldrini L, Brusamolin L, Zamparo P, McKee T. A
feedback-controlled treadmill (treadmill-on-demand) and the
spontaneous speed of walking and running in humans. J Appl Physiol.
2003 Aug;95(2):838-843. [PubMed: 12692130]
Patent Status: HHS Reference No. E-046-2011/0--One aspect of the
overall invention currently exists in software form, for which the U.S.
Government will not be seeking patent protection.
Licensing Status: Available for licensing.
Licensing Contacts:
Uri Reichman, PhD, MBA; 301-435-4616; UR7a@nih.gov.
Michael Shmilovich, Esq.; 301-435-5019;
ShmilovichM@mail.nih.gov.
Collaborative Research Opportunity: The National Institutes of
Health Clinical Center is seeking statements of capability or interest
from parties interested in collaborative research to further develop,
evaluate, or commercialize ``A system and method for automatic speed
adaptation control of a treadmill for patients.'' Please contact Dr.
Hyung S. Park at 301-451-7533 for more information.
Method for the Detection of a Subdural Hematoma Using a Handheld
Hematoma Detector and Discriminator
Description of Invention: The invention offered for licensing and
further development is a device and method for detecting hematomas. The
device is based on near infrared light emitted perpendicularly into a
tissue from a non-stationary emitter and on continuous detection of the
reflected light with a non-stationary probe. The device is designed as
a handheld detector that can be used either in an ER or at the scene of
an accident, which will allow the Doctor or EMT to diagnose hematoma
for patients with a Traumatic Brain Injury at the scene. Furthermore,
this device can be utilized to discriminate between subdural and
epidural hematoma. The invention also discloses a novel method of data
analysis. The specific combination and sequences of data analysis are
performed to discriminate healthy tissue from tissue perfused with
blood. In addition, an interface to a laptop will be provided that
creates a 3D surface image of the location of the hematoma is
displayed. This invention will result in a better triage and treatment
for patients with Traumatic Brain Injury (TBI) and fills a must filled
gap in TBI health care.
Applications:
Diagnosis for hematoma
Early screening and triage for diagnosis of hemorrhage
from head trauma
At-the-scene diagnostic
On-going patient monitoring
Neurosurgical procedure preparation
The device will be useful in combat critical care and/or
third world care where CT may not be readily available
Potential use of the device in a field deployable sense
Advantages:
Improved capabilities of accurately diagnosing hematoma
At-the-scene detection capabilities
The device is inexpensive, simple in its design and easy
to operate
[[Page 13194]]
Potential improvement in medical procedures
Development Status:
The invention is fully developed
May need to develop a prototype for testing on phantoms
Inventors: Jason D. Riley (NICHD) et al.
Patent Status:
U.S. Provisional Application No. 61/286, 626 filed 15 Dec
2009 (HHS Reference No. E-010-2010/0-US-01)
PCT Application No. PCT/US2010/060506 filed 15 Dec 2010
(HHS Reference No. E-010-2010/0-PCT-02)
Licensing Status: Available for licensing.
Licensing Contacts:
Uri Reichman, PhD, MBA; 301-435-4616; UR7a@nih.gov.
Michael Shmilovich, Esq.; 301-435-5019;
ShmilovichM@mail.nih.gov.
Collaborative Research Opportunity: The National Institute of Child
Health and Human Development, Section on Biomedical Stochastic Physics,
is seeking statements of capability or interest from parties interested
in collaborative research to further develop, evaluate, or
commercialize the topic of this invention or related laboratory
interests. Please contact Alan Hubbs, PhD at 301-594-4263 or
hubbsa@mail.nih.gov for more information.
System and Method for Monitoring and Controlling Radio Frequency
Signals in Interventional Devices
Description of Invention: The invention offered for licensing and
commercial development is in the field of Interventional Magnetic
Resonance Imaging (``iMRI''). More specifically the invention discloses
interventional devices in which the heat generated at the device during
the imaging process can be controlled to not exceed acceptable levels.
Interventional devices may heat up significantly during an
interventional MRI procedure as a result of an RF induced current on
the device. The RF induced current is caused by the coupling between
the interventional device and RF electrical fields generated by the
MRI. As the magnitude of the induced RF signal increases, the amount of
heat that is generated also increases. The system of the present
invention measures the induced RF signal and changes a decoupling
capacitor value by using a varactor and a control circuit to adjust the
impedance of the device and thus controls the magnitude of the RF
signal. This unique design renders the device and the procedures done
with it safe.
Applications:
Interventional cardiology
MRI guided surgery
Advantages: The device may fundamentally enable any ``active'' MRI
catheter device to be safe during real-time MRI guided interventional
procedures. Automated feedback loops between RF power applied by the
MRI scanner and measured power detected inside the MRI catheter coil
can be used to assure safety of ``active'' MRI catheter devices.
Development Status: In development. Prototype is being built.
Inventors: Ozgur Kocaturk and Merdim Sonmez (NHLBI).
Relevant Publication: Overall WR, Pauly JM, Stang PP, Scott GC.
Ensuring safety of implanted devices under MRI using reversed RF
polarization. Magn Reson Med. 2010 Sep;64(3):823-833. [PubMed:
20593374]
Patent Status: U.S. Provisional Application No. 61/430,311 filed 07
Jan 2011 (HHS Reference No. E-034-2011/0-US-01)
Licensing Status: Available for licensing.
Licensing Contact:
Uri Reichman, PhD, MBA; 301-435-4616; UR7a@nih.gov.
Michael Shmilovich, Esq.; 301-435-5019;
ShmilovichM@mail.nih.gov.
Collaborative Research Opportunity: The National Heart, Lung, and
Blood Institute is seeking statements of capability or interest from
parties interested in collaborative research to further develop,
evaluate, or commercialize safety interventional devices during iMRI
procedures. Please contact Peg Koelble at koelblep@nhlbi.nih.gov for
more information.
Single Channel MRI Guidewire
Description of Invention: The invention offered for licensing and
commercial development is in the field of Interventional Magnetic
Resonance Imaging (``iMRI''). More specifically the invention discloses
a guidewire for magnetic resonance imaging with a single channel design
to reduce complexity and to provide conspicuous tip visibility under
MRI. In the design of the present device, the guidewire body includes
an antenna formed from a rod and a helical coil coupled together. The
helical coil can have multiple windings without a gap between the
windings. The rod passes through the windings of the helical coil and
is coupled to the helical coil using a conductive joint positioned at
an end of the rod and at an end of the helical coil. Insulation can be
positioned between the rod and the windings of the helical coil. The
configuration allows visibility of the antenna along the length of a
rod, except where it enters the windings of the coil. Thus, the tip
visibility is enhanced as being separated from the rod.
Applications:
Interventional cardiology
MRI guided surgery
Advantages:
The unique design of the device and its dipole antenna,
provide a lower profile guidewire (such as coronary 0.014: guidewire)
and it is therefore safer and more convenient to use compared with
existing guidewires.
The modified dipole antenna of the device can combine the
distinct tip signal profile typical of loop antennae with the whole-
shaft visibility of dipole antennae, all operating on a single receiver
channel. This overcomes challenges both of conspicuity and of
undesirable coupling of comparable two-channel devices that causes
heating.
Development Status: In development. Prototype is being built.
Inventors: Merdim Sonmez, Ozgur Kocaturk, and Christina E. Saikus
(NHLBI)
Relevant Publications:
1. Kocaturk O, Kim AH, Saikus CE, Guttman MA, Faranesh AZ, Ozturk C,
Lederman RJ. Active two-channel 0.035'' guidewire for interventional
cardiovascular MRI. J Magn Reson Imaging. 2009 Aug;30(2):461-465.
[PubMed: 19629968]
2. Qian D, El-Sharkawy AM, Atalar E, Bottomley PA. Interventional
MRI: tapering improves the distal sensitivity of the loopless
antenna. Magn Reson Med. 2010 Mar;63(3):797-802. [PubMed: 20187186]
Patent Status: U.S. Provisional Application No. 61/429,833 filed 05
Jan 2011 (HHS Reference No. E-274-2010/0-US-01)
Related Technology: U.S. Patent Application No. 12/810,481 filed 24
Jun 2010 (HHS Reference No. E-209-2007/0-US-03), entitled ``Active
0.035 Guidewire with Two Separate Channels''
Licensing Status: Available for licensing.
Licensing Contact:
Uri Reichman, PhD, MBA; 301-435-4616; UR7a@nih.gov.
Michael Shmilovich, Esq.; 301-435-5019;
ShmilovichM@mail.nih.gov.
Collaborative Research Opportunity: The National Heart, Lung, and
Blood Institute is seeking statements of capability or interest from
parties interested in collaborative research to further develop,
evaluate, or commercialize technology involving single channel MRI
guidewires. Please contact Peg Koelble at
[[Page 13195]]
koelblep@nhlbi.nih.gov for more information.
Active Adaptive Detuning Systems To Improve Safety of Interventional
Devices
Description of Invention: The invention offered for licensing and
commercial development is in the field of Interventional Magnetic
Resonance Imaging (``iMRI''). More specifically the invention discloses
interventional devices in which the heat generated at the device during
the imaging process can be controlled to not exceed acceptable levels.
Active MRI compatible intravascular devices contain RF antenna so
that they are visible under MRI. However, these metallic structures may
heat up significantly during interventional MRI procedures due to eddy
current formation over the conductive transmission lines. The
electrical field coupling between interventional devices and RF
transmission coils strongly depend on the device position and
orientation within the bore and insertion length of the device.
Currently, conventional detuning circuit is used to decouple the
conductive intravascular device during RF transmission phase of the MRI
by activating the circuit with a PIN diode. However, conventional
passive techniques do not adapt for each possible orientation or
insertion length of the device. The current invention provides for a
new active detuning system that adapts its circuit component to limit
heating for every possible orientation and insertion length. The system
reads out the received current signal value during RF transmission
phase and changes the decoupling capacitor value by using varactor and
integrated circuit components to reach new resonant condition (very
high impedance).
Applications:
Interventional cardiology
MRI guided surgery
Advantages: The device may fundamentally enable any ``active'' MRI
catheter device (independent of the orientation and insertion length of
the device) to be safe during real-time MRI guided interventional
procedures.
Development Status: In development. Prototype is being built.
Inventors: Ozgur Kocaturk (NHLBI).
Patent Status: U.S. Provisional Application No. 61/360,998 filed 07
Jul 2010 (HHS Reference No. E-114-2010/0-US-01)
Relevant Publication: Overall WR, Pauly JM, Stang PP, Scott GC.
Ensuring safety of implanted devices under MRI using reversed RF
polarization. Magn Reson Med. 2010 Sep;64(3):823-833. [PubMed:
20593374]
Licensing Status: Available for licensing.
Licensing Contact:
Uri Reichman, PhD, MBA; 301-435-4616; UR7a@nih.gov.
Michael Shmilovich, Esq.; 301-435-5019;
ShmilovichM@mail.nih.gov.
Collaborative Research Opportunity: The National Heart, Lung, and
Blood Institute is seeking statements of capability or interest from
parties interested in collaborative research to further develop,
evaluate, or commercialize this technology. Please contact Peg Koelble
at koelblep@nhlbi.nih.gov for more information.
Dated: March 4, 2011.
Richard U. Rodriguez,
Director, Division of Technology Development and Transfer, Office of
Technology Transfer, National Institutes of Health.
[FR Doc. 2011-5511 Filed 3-9-11; 8:45 am]
BILLING CODE 4140-01-P
