Lymphohematopoietic Cancers Induced by Chemicals and Other Agents: Overview and Implications for Risk Assessment, 76460-76461 [2010-30848]

Download as PDF 76460 Federal Register / Vol. 75, No. 235 / Wednesday, December 8, 2010 / Notices approach may allow estimation of dataderived uncertainty factors that consider use of toxicokinetic and toxicodynamic data to inform quantitative extrapolations for interspecies differences and human variability in dose response assessment. The topics to be covered in the February 2011 SAP are consistent with EPA’s Office of Pesticide Programs continuing efforts to improve the scientific basis for risk assessment by broadening the application of probabilistic exposure techniques and PBPK models. The Agency has a conceptually similar effort on-going to link PBPK models for pyrethroids with Stochastic Human Exposure and Dose Simulator (SHEDS) exposure software, a probabilistic exposure model developed by the EPA’s Office of Research and Development, which was reviewed by the SAP in July 2010. The current effort by Dow AgroSciences is a research effort which may, if sufficiently robust, inform future risk assessments; the February meeting is a key milestone in this research. The Agency will solicit feedback from the Panel on technical issues related to PBPK/PD model, the proposed approach for merging the PBPK/PD model with CARES, and the use of such merged models in risk assessment. jlentini on DSKJ8SOYB1PROD with NOTICES C. FIFRA SAP Documents and Meeting Minutes EPA’s background paper, related supporting materials, charge/questions to FIFRA SAP, FIFRA SAP composition (i.e., members and ad hoc members for this meeting), and the meeting agenda will be available by late January 2011. In addition, the Agency may provide additional background documents as the materials become available. You may obtain electronic copies of these documents, and certain other related documents that might be available electronically, at https:// www.regulations.gov and the FIFRA SAP homepage at https://www.epa.gov/ scipoly/sap. FIFRA SAP will prepare meeting minutes summarizing its recommendations to the Agency approximately 90 days after the meeting. The meeting minutes will be posted on the FIFRA SAP Web site or may be obtained from the OPP Regulatory Public Docket at https:// www.regulations.gov. List of Subjects Environmental protection, Pesticides and pests. VerDate Mar<15>2010 18:23 Dec 07, 2010 Jkt 223001 Dated: November 23, 2010. Frank Sanders, Director, Office of Science Coordination and Policy. [FR Doc. 2010–30630 Filed 12–7–10; 8:45 am] BILLING CODE 6560–50–P ENVIRONMENTAL PROTECTION AGENCY [FRL–9236–6; Docket ID No. EPA–HQ–ORD– 2010–0991] Lymphohematopoietic Cancers Induced by Chemicals and Other Agents: Overview and Implications for Risk Assessment Environmental Protection Agency (EPA). ACTION: Notice of public comment period. AGENCY: EPA is announcing a 45-day public comment period for the draft document titled, ‘‘Lymphohematopoietic Cancers Induced by Chemicals and Other Agents: Overview and Implications for Risk Assessment’’ (EPA/600/R–10/ 095A). The draft document was prepared by the National Center for Environmental Assessment within EPA’s Office of Research and Development. The draft document provides an overview of the types and mechanisms underlying the lymphohematopoietic cancers induced by chemical agents and radiation in humans, with a primary emphasis on leukemia and leukemia-inducing agents. In addition, the document also focuses on how mechanistic information on human leukemia-inducing agents can inform risk assessment. EPA is releasing this draft document solely for the purpose of predissemination peer review under applicable information quality guidelines. This draft document has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency policy or determination. All public comments received will be provided to the peer reviewers at the beginning of the review process. DATES: The 45-day public comment period begins December 8, 2010, and ends January 24, 2011. Technical comments should be in writing and must be received by EPA by January 24, 2011. ADDRESSES: The draft ‘‘Lymphohematopoietic Cancers Induced by Chemicals and Other Agents: Overview and Implications for Risk Assessment’’ is available primarily SUMMARY: PO 00000 Frm 00068 Fmt 4703 Sfmt 4703 via the Internet on the National Center for Environmental Assessment’s home page under the Recent Additions and the Data and Publications menus at https://www.epa.gov/ncea. A limited number of paper copies are available from the Information Management Team, NCEA; telephone: 703–347–8561; facsimile: 703–347–8691. If you are requesting a paper copy, please provide your name, your mailing address, and the draft document title, ‘‘Lymphohematopoietic Cancers Induced by Chemicals and Other Agents: Overview and Implications for Risk Assessment.’’ Comments may be submitted electronically via https:// www.regulations.gov, by mail, by facsimile, or by hand delivery/courier. Please follow the detailed instructions provided in the SUPPLEMENTARY INFORMATION section of this notice. FOR FURTHER INFORMATION CONTACT: For information on the public comment period, contact the Office of Environmental Information Docket; telephone: 202–566–1752; facsimile: 202–566–1753; or e-mail: ORD.Docket@epa.gov. For technical information, contact Nagu Keshava, NCEA; telephone: 919– 541–3047; facsimile: 919–541–0245; or e-mail: keshava.nagu@epa.gov. SUPPLEMENTARY INFORMATION: I. Information About the Project/ Document This project was initiated to better understand the mechanisms underlying the lymphohematopoietic cancers induced by chemical agents in humans. A draft report was developed that provides an overview of types and mechanisms underlying the lymphohematopoietic cancers induced by both chemical agents and radiation in humans, with a primary emphasis on leukemia and leukemia-inducing agents. II. How to Submit Technical Comments to the Docket at https:// www.regulations.gov Submit your comments, identified by Docket ID No. EPA–HQ–ORD–2010– 0991, by one of the following methods: • https://www.regulations.gov: Follow the on-line instructions for submitting comments. • E-mail: ORD.Docket@epa.gov. • Fax: 202–566–1753. • Mail: Office of Environmental Information (OEI) Docket (Mail Code: 2822T), U.S. Environmental Protection Agency, 1200 Pennsylvania Ave., NW., Washington, DC 20460. The phone number is 202–566–1752. • Hand Delivery: The OEI Docket is located in the EPA Headquarters Docket E:\FR\FM\08DEN1.SGM 08DEN1 jlentini on DSKJ8SOYB1PROD with NOTICES Federal Register / Vol. 75, No. 235 / Wednesday, December 8, 2010 / Notices Center, Room 3334 EPA West Building, 1301 Constitution Ave., NW., Washington, DC. The EPA Docket Center Public Reading Room is open from 8:30 a.m. to 4:30 p.m., Monday through Friday, excluding legal holidays. The telephone number for the Public Reading Room is 202–566–1744. Such deliveries are only accepted during the docket’s normal hours of operation, and special arrangements should be made for deliveries of boxed information. If you provide comments by mail or hand delivery, please submit three copies of the comments. For attachments, provide an index, number pages consecutively with the comments, and submit an unbound original and three copies. Instructions: Direct your comments to Docket ID No. EPA–HQ–ORD–2010– 0991. Please ensure that your comments are submitted within the specified comment period. Comments received after the closing date will be marked ‘‘late,’’ and may only be considered if time permits. It is EPA’s policy to include all comments it receives in the public docket without change and to make the comments available online at https://www.regulations.gov, including any personal information provided, unless a comment includes information claimed to be Confidential Business Information (CBI) or other information whose disclosure is restricted by statute. Do not submit information that you consider to be CBI or otherwise protected through https:// www.regulations.gov or e-mail. The https://www.regulations.gov Web site is an ‘‘anonymous access’’ system, which means EPA will not know your identity or contact information unless you provide it in the body of your comment. If you send an e-mail comment directly to EPA without going through https:// www.regulations.gov, your e-mail address will be automatically captured and included as part of the comment that is placed in the public docket and made available on the Internet. If you submit an electronic comment, EPA recommends that you include your name and other contact information in the body of your comment and with any disk or CD–ROM you submit. If EPA cannot read your comment due to technical difficulties and cannot contact you for clarification, EPA may not be able to consider your comment. Electronic files should avoid the use of special characters, any form of encryption, and be free of any defects or viruses. For additional information about EPA’s public docket visit the EPA Docket Center homepage at https:// www.epa.gov/epahome/dockets.htm. VerDate Mar<15>2010 18:23 Dec 07, 2010 Jkt 223001 Docket: Documents in the docket are listed in the https://www.regulations.gov index. Although listed in the index, some information is not publicly available, e.g., CBI or other information whose disclosure is restricted by statute. Certain other materials, such as copyrighted material, are publicly available only in hard copy. Publicly available docket materials are available either electronically in https:// www.regulations.gov or in hard copy at the OEI Docket in the EPA Headquarters Docket Center. Dated: December 2, 2010. Darrell A. Winner, Acting Director, National Center for Environmental Assessment. [FR Doc. 2010–30848 Filed 12–7–10; 8:45 am] BILLING CODE 6560–50–P ENVIRONMENTAL PROTECTION AGENCY [EPA–HQ–OPP–2010–0548; FRL–8852–8] Petition for a Ban on Triclosan; Notice of Availability Environmental Protection Agency (EPA). ACTION: Notice. AGENCY: This notice makes available for review and public comment a petition submitted by Beyond Pesticides, and Food & Water Watch (hereafter referred to as ‘‘the petitioners’’) to the Environmental Protection Agency (hereafter referred to as ‘‘EPA’’ or ‘‘the Agency’’), asking EPA to use its authority under various statutes to regulate triclosan. Triclosan is an antimicrobial substance used in pesticide products, hand sanitizers, toothpaste, and other consumer products. The petitioners claim that the ‘‘pervasive and widespread use’’ of triclosan poses significant risks to human health and the environment. In addition, the petitioners claim that the agency failed to address the impacts posed by triclosan’s degradation products on human health and the environment, failed to conduct separate assessments for triclosan residues in contaminated drinking water and food, and is complacent in seriously addressing concerns related to antibacterial resistance and endocrine disruption. EPA has established a public docket, which contains a copy of the petition and will contain all comments received in response to this notice. The docket may be accessed as described in this notice. DATES: Comments must be received on or before February 7, 2011. SUMMARY: PO 00000 Frm 00069 Fmt 4703 Sfmt 4703 76461 Submit your comments, identified by docket identification (ID) number EPA–HQ–OPP–2010–0548, by one of the following methods: • Federal eRulemaking Portal: https:// www.regulations.gov. Follow the on-line instructions for submitting comments. • Mail: Office of Pesticide Programs (OPP) Regulatory Public Docket (7502P), Environmental Protection Agency, 1200 Pennsylvania Ave., NW., Washington, DC 20460–0001. • Delivery: OPP Regulatory Public Docket (7502P), Environmental Protection Agency, Rm. S–4400, One Potomac Yard (South Bldg.), 2777 S. Crystal Dr., Arlington, VA. Deliveries are only accepted during the Docket Facility’s normal hours of operation (8:30 a.m. to 4 p.m., Monday through Friday, excluding legal holidays). Special arrangements should be made for deliveries of boxed information. The Docket Facility telephone number is (703) 305–5805. Instructions: Direct your comments to docket ID number EPA–HQ–OPP–2010– 0548. When commenting, please specify the statute to which your comments refer (FIFRA, FFDCA, SDWA, CWA, or ESA) and the specific issue(s) raised in the petition regarding that statute on which you are commenting. EPA’s policy is that all comments received will be included in the docket without change and may be made available online at https://www.regulations.gov, including any personal information provided, unless the comment includes information claimed to be Confidential Business Information (CBI) or other information whose disclosure is restricted by statute. Do not submit information that you consider to be CBI or otherwise protected through regulations.gov or e-mail. The regulations.gov Web site is an ‘‘anonymous access’’ system, which means EPA will not know your identity or contact information unless you provide it in the body of your comment. If you send an e-mail comment directly to EPA without going through regulations.gov, your e-mail address will be automatically captured and included as part of the comment that is placed in the docket and made available on the Internet. If you submit an electronic comment, EPA recommends that you include your name and other contact information in the body of your comment and with any disk or CD–ROM you submit. If EPA cannot read your comment due to technical difficulties and cannot contact you for clarification, EPA may not be able to consider your comment. Electronic files should avoid the use of special characters, any form ADDRESSES: E:\FR\FM\08DEN1.SGM 08DEN1

Agencies

[Federal Register Volume 75, Number 235 (Wednesday, December 8, 2010)]
[Notices]
[Pages 76460-76461]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: 2010-30848]


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ENVIRONMENTAL PROTECTION AGENCY

[FRL-9236-6; Docket ID No. EPA-HQ-ORD-2010-0991]


Lymphohematopoietic Cancers Induced by Chemicals and Other 
Agents: Overview and Implications for Risk Assessment

AGENCY: Environmental Protection Agency (EPA).

ACTION: Notice of public comment period.

-----------------------------------------------------------------------

SUMMARY: EPA is announcing a 45-day public comment period for the draft 
document titled, ``Lymphohematopoietic Cancers Induced by Chemicals and 
Other Agents: Overview and Implications for Risk Assessment'' (EPA/600/
R-10/095A). The draft document was prepared by the National Center for 
Environmental Assessment within EPA's Office of Research and 
Development. The draft document provides an overview of the types and 
mechanisms underlying the lymphohematopoietic cancers induced by 
chemical agents and radiation in humans, with a primary emphasis on 
leukemia and leukemia-inducing agents. In addition, the document also 
focuses on how mechanistic information on human leukemia-inducing 
agents can inform risk assessment.
    EPA is releasing this draft document solely for the purpose of pre-
dissemination peer review under applicable information quality 
guidelines. This draft document has not been formally disseminated by 
EPA. It does not represent and should not be construed to represent any 
Agency policy or determination. All public comments received will be 
provided to the peer reviewers at the beginning of the review process.

DATES: The 45-day public comment period begins December 8, 2010, and 
ends January 24, 2011. Technical comments should be in writing and must 
be received by EPA by January 24, 2011.

ADDRESSES: The draft ``Lymphohematopoietic Cancers Induced by Chemicals 
and Other Agents: Overview and Implications for Risk Assessment'' is 
available primarily via the Internet on the National Center for 
Environmental Assessment's home page under the Recent Additions and the 
Data and Publications menus at https://www.epa.gov/ncea. A limited 
number of paper copies are available from the Information Management 
Team, NCEA; telephone: 703-347-8561; facsimile: 703-347-8691. If you 
are requesting a paper copy, please provide your name, your mailing 
address, and the draft document title, ``Lymphohematopoietic Cancers 
Induced by Chemicals and Other Agents: Overview and Implications for 
Risk Assessment.''
    Comments may be submitted electronically via https://www.regulations.gov, by mail, by facsimile, or by hand delivery/
courier. Please follow the detailed instructions provided in the 
SUPPLEMENTARY INFORMATION section of this notice.

FOR FURTHER INFORMATION CONTACT: For information on the public comment 
period, contact the Office of Environmental Information Docket; 
telephone: 202-566-1752; facsimile: 202-566-1753; or e-mail: 
ORD.Docket@epa.gov.
    For technical information, contact Nagu Keshava, NCEA; telephone: 
919-541-3047; facsimile: 919-541-0245; or e-mail: keshava.nagu@epa.gov.

SUPPLEMENTARY INFORMATION:

I. Information About the Project/Document

    This project was initiated to better understand the mechanisms 
underlying the lymphohematopoietic cancers induced by chemical agents 
in humans. A draft report was developed that provides an overview of 
types and mechanisms underlying the lymphohematopoietic cancers induced 
by both chemical agents and radiation in humans, with a primary 
emphasis on leukemia and leukemia-inducing agents.

II. How to Submit Technical Comments to the Docket at https://www.regulations.gov

    Submit your comments, identified by Docket ID No. EPA-HQ-ORD-2010-
0991, by one of the following methods:
     https://www.regulations.gov: Follow the on-line 
instructions for submitting comments.
     E-mail: ORD.Docket@epa.gov.
     Fax: 202-566-1753.
     Mail: Office of Environmental Information (OEI) Docket 
(Mail Code: 2822T), U.S. Environmental Protection Agency, 1200 
Pennsylvania Ave., NW., Washington, DC 20460. The phone number is 202-
566-1752.
     Hand Delivery: The OEI Docket is located in the EPA 
Headquarters Docket

[[Page 76461]]

Center, Room 3334 EPA West Building, 1301 Constitution Ave., NW., 
Washington, DC. The EPA Docket Center Public Reading Room is open from 
8:30 a.m. to 4:30 p.m., Monday through Friday, excluding legal 
holidays. The telephone number for the Public Reading Room is 202-566-
1744. Such deliveries are only accepted during the docket's normal 
hours of operation, and special arrangements should be made for 
deliveries of boxed information. If you provide comments by mail or 
hand delivery, please submit three copies of the comments. For 
attachments, provide an index, number pages consecutively with the 
comments, and submit an unbound original and three copies.
    Instructions: Direct your comments to Docket ID No. EPA-HQ-ORD-
2010-0991. Please ensure that your comments are submitted within the 
specified comment period. Comments received after the closing date will 
be marked ``late,'' and may only be considered if time permits. It is 
EPA's policy to include all comments it receives in the public docket 
without change and to make the comments available online at https://www.regulations.gov, including any personal information provided, 
unless a comment includes information claimed to be Confidential 
Business Information (CBI) or other information whose disclosure is 
restricted by statute. Do not submit information that you consider to 
be CBI or otherwise protected through https://www.regulations.gov or e-
mail. The https://www.regulations.gov Web site is an ``anonymous 
access'' system, which means EPA will not know your identity or contact 
information unless you provide it in the body of your comment. If you 
send an e-mail comment directly to EPA without going through https://www.regulations.gov, your e-mail address will be automatically captured 
and included as part of the comment that is placed in the public docket 
and made available on the Internet. If you submit an electronic 
comment, EPA recommends that you include your name and other contact 
information in the body of your comment and with any disk or CD-ROM you 
submit. If EPA cannot read your comment due to technical difficulties 
and cannot contact you for clarification, EPA may not be able to 
consider your comment. Electronic files should avoid the use of special 
characters, any form of encryption, and be free of any defects or 
viruses. For additional information about EPA's public docket visit the 
EPA Docket Center homepage at https://www.epa.gov/epahome/dockets.htm.
    Docket: Documents in the docket are listed in the https://www.regulations.gov index. Although listed in the index, some 
information is not publicly available, e.g., CBI or other information 
whose disclosure is restricted by statute. Certain other materials, 
such as copyrighted material, are publicly available only in hard copy. 
Publicly available docket materials are available either electronically 
in https://www.regulations.gov or in hard copy at the OEI Docket in the 
EPA Headquarters Docket Center.

    Dated: December 2, 2010.
Darrell A. Winner,
Acting Director, National Center for Environmental Assessment.
[FR Doc. 2010-30848 Filed 12-7-10; 8:45 am]
BILLING CODE 6560-50-P
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