Agency Information Collection Activities: Form I-914, Extension of a Currently Approved Information Collection; Comment Request, 75182-75183 [2010-30150]
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75182
Federal Register / Vol. 75, No. 231 / Thursday, December 2, 2010 / Notices
WReier-Aviles on DSKGBLS3C1PROD with NOTICES
peptide analogs via on resin click
chemistry. In preparation.
Patent Status: U.S. Provisional
Application No. 61/347,038 filed 21
May 2010 (HHS Reference No. E–130–
2010/0–US–01).
Licensing Status: Available for
licensing.
Licensing Contact: Whitney Hastings;
301–451–7337; hastingw@mail.nih.gov.
Novel Therapeutic Compounds for
Treatment of Cancer and Immune
Disorders
Description of Invention: The global
market for cancer therapeutics is over
$40 billion and is anticipated to
continue to rise in the future. There
remains a significant unmet need for
therapeutics for cancers that affect
blood, bone marrow, and lymph nodes
and the immune system, such as
leukemia, multiple myeloma, and
lymphoma. The proteasome inhibitor
bortezomib, which may prevent
degradation of pro-apoptotic factors
permitting activation of programmed
cell death in neoplastic cells dependent
upon suppression of pro-apoptotic
pathways, has been a successful mode
of treatment for such cancers. However,
some patient’s cancers have been found
to be resistant to the drug.
Researchers at the National Institutes
of Health have developed novel
hydrazone and diacyl hydrazine
compounds that are inhibitors of the
endoplasmic reticulum-associated
protein degradation (ERAD) pathway.
These compounds preferentially target
the proteasome assistant ATPase p97/
VCP at a site independent of nucleotide
binding. The researchers have shown
that these ERAD inhibitors can induce
cancer cell death and can also synergize
with bortezomib in cytotoxic activity. In
addition to treating diseases or disorders
in which inhibition of the ERAD
pathway is an effective therapy, these
novel compounds may also be useful in
the study of protein degradation.
Advantages:
• Development of therapies against
tumors that are resistant to bortezomib.
• Use in therapies in combination
with proteasome inhibitors.
• Development of
immunosuppressive therapies that
target the ubiquitin proteasome system.
• Studies of the mechanism of protein
degradation and other biological
processes that involve the p97 ATPase.
• Bioprobes to detect endoplasmic
reticulum (ER) structures in live cells.
Advantages:
• Potent anti-tumor activity.
• Simpler chemical structure makes
synthesis easier and more cost-effective
than previous ERAD inhibitors.
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15:28 Dec 01, 2010
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• Retain activity against bortezomibresistant cells and can synergize with
bortezomib.
• Fluorescent.
• High affinity for the ER.
Development Status: Pre-clinical.
Inventors: Adrian Wiestner (NHLBI),
William Trenkle (NIDDK), Yihong Ye
(NIDDK) et al.
Relevant Publications:
1. Qiuyan Wang et al. ERAD inhibitors
integrate ER stress with an
epigenetic mechanism to activate
BH3-only protein NOXA in cancer
cells. Proc Natl Acad Sci USA 2009
Feb 17;106(7):2200–2205. [PubMed:
19164757]
2. Qiuyan Wang et al. The ERAD
inhibitor Eeyarestatin I is a
bifunctional compound with a
membrane-binding domain and a
p97/VCP inhibitory group. PloS
ONE 2010, in press.
Patent Status: U.S. Provisional
Application No. 61/266,760 filed 04 Dec
2009 (HHS Reference No. E–291–2009/
0–US–01).
Licensing Status: Available for
licensing.
Licensing Contact: Surekha Vathyam,
Ph.D.; 301–435–4076;
vathyams@mail.nih.gov.
Targeted Anti-Cancer Compounds for
Treating Chromosomal Instability
Syndromes
Description of Invention: At $47
billion, cancer is one of the largest,
fastest growing markets in the
pharmaceutical industry. There remains
a significant unmet need for new
therapeutics that target cancer cells
while sparing normal cells. Cancer cells
show higher levels of DNA damage than
normal cells, and therefore rely more
heavily than normal cells on DNA repair
mechanisms for survival. There is a
particular need for cancer therapies for
cancer-prone chromosomal instability
syndromes such as Ataxia
Telangiectasia, Nijmegen Breakage,
Bloom, and Fanconi’s anemia, which
result from dysfunctional DNA repair
systems.
Researchers at Columbia University
and the National Cancer Institute (NCI)
have developed compositions and
methods of useful in the treatment of
cancer and in the sensitization of cancer
cells to cancer therapy. The
compositions target the MRE11–
RAD50–NBS1 (MRN) complex, a DNA
repair complex essential for sensing and
responding to DNA damage.
Given the dependency of cancer cells
on DNA repair systems, they are
susceptible to compositions that inhibit
DNA damage repair. Thus, cancers that
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already have one or more defects in
DNA repair systems, such as those from
patients with chromosomal instability
syndromes, are effectively treated with
the present compositions.
Applications: Development of
treatments for cancer.
Development Status: Pre-clinical.
Inventors: Levy Kopelovich (NCI)
et al.
´
Relevant Publication: A Dupre et al. A
forward chemical genetic screen reveals
an inhibitor of the Mre11–Rad50–Nbs1
complex. Nat Chem Biol. 2008;4(2):119–
125. [PubMed: 18176557]
Patent Status:
• U.S. Provisional Application No.
61/203,377 filed 22 Dec 2008 (HHS
Reference No. E–154–2009/0–US–01).
• International Application No. PCT/
US09/69171 filed 22 Dec 2009, which
published as WO 2010/075372 on 01 Jul
2010 (HHS Reference No. E–154–2009/
0–PCT–02).
Licensing Status: Available for
licensing.
Licensing Contact: Patrick P. McCue,
Ph.D.; 301–435–5560;
mccuepat@mail.nih.gov.
Collaborative Research Opportunity:
The National Cancer Institute, Division
of Cancer Prevention, Chemopreventive
Agent Development Research Group, is
seeking statements of capability or
interest from parties interested in
collaborative research to further
develop, evaluate, or commercialize
agents for the prevention and treatment
of cancer. Please contact John Hewes,
Ph.D. at 301–435–3121 or
hewesj@mail.nih.gov for more
information.
Dated: November 24, 2010.
Richard U. Rodriguez,
Director, Division of Technology Development
and Transfer, Office of Technology Transfer,
National Institutes of Health.
[FR Doc. 2010–30278 Filed 12–1–10; 8:45 am]
BILLING CODE 4140–01–P
DEPARTMENT OF HOMELAND
SECURITY
U.S. Citizenship and Immigration
Services
Agency Information Collection
Activities: Form I–914, Extension of a
Currently Approved Information
Collection; Comment Request
30-Day Notice of Information
Collection under Review: Form I–914
and Supplements A and B, Application
for T Nonimmigrant Status; Application
for Immediate Family Member of T–1
Recipient; and Declaration of Law
Enforcement Officer for Victim of
ACTION:
E:\FR\FM\02DEN1.SGM
02DEN1
Federal Register / Vol. 75, No. 231 / Thursday, December 2, 2010 / Notices
WReier-Aviles on DSKGBLS3C1PROD with NOTICES
Trafficking in Persons; OMB Control No.
1615–0099.
The Department of Homeland
Security, U.S. Citizenship and
Immigration Services (USCIS) will be
submitting the following information
collection request to the Office of
Management and Budget (OMB) for
review and clearance in accordance
with the Paperwork Reduction Act of
1995. The information collection was
previously published in the Federal
Register on September 8, 2010, at 75 FR
54646, allowing for a 60-day public
comment period. USCIS did not receive
any comments for this information
collection.
The purpose of this notice is to allow
an additional 30 days for public
comments. Comments are encouraged
and will be accepted until January 3,
2011. This process is conducted in
accordance with 5 CFR 1320.10.
Written comments and/or suggestions
regarding the item(s) contained in this
notice, especially regarding the
estimated public burden and associated
response time, should be directed to the
Department of Homeland Security
(DHS), and to the Office of Management
and Budget (OMB) USCIS Desk Officer.
Comments may be submitted to: USCIS,
Chief, Regulatory Products Division, 20
Massachusetts Avenue, Washington, DC
20529–2020. Comments may also be
submitted to DHS via facsimile to 202–
272–0997 or via e-mail at
rfs.regs@dhs.gov, and to the OMB USCIS
Desk Officer via facsimile at 202–395–
5806 or via e-mail at
oira_submission@omb.eop.gov. When
submitting comments by e-mail please
make sure to add OMB Control Number
1615–0099 in the subject box. Written
comments and suggestions from the
public and affected agencies should
address one or more of the following
four points:
(1) Evaluate whether the proposed
collection of information is necessary
for the proper performance of the
functions of the agency, including
whether the information will have
practical utility;
(2) Evaluate the accuracy of the
agencies estimate of the burden of the
proposed collection of information,
including the validity of the
methodology and assumptions used;
(3) Enhance the quality, utility, and
clarity of the information to be
collected; and
(4) Minimize the burden of the
collection of information on those who
are to respond, including through the
use of appropriate automated,
electronic, mechanical, or other
technological collection techniques or
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75183
other forms of information technology,
e.g., permitting electronic submission of
responses.
DEPARTMENT OF THE INTERIOR
Overview of This Information
Collection
[IDI–36712]
(1) Type of Information Collection:
Extension of a currently approved
information collection.
(2) Title of the Form/Collection:
Application for T Nonimmigrant Status;
Supplement A: Application for
Immediate Family Member of T–1
Recipient; and Supplement B:
Declaration of Law Enforcement Officer
for Victim of Trafficking in Persons.
(3) Agency form number, if any, and
the applicable component of the
Department of Homeland Security
sponsoring the collection: Form I–914;
U.S. Citizenship and Immigration
Services (USCIS).
(4) Affected public who will be asked
or required to respond, as well as a brief
abstract: Primary: Individuals or
Households. Form I–914 permits
victims of severe forms of trafficking
and their immediate family members to
demonstrate that they qualify for
temporary nonimmigrant status
pursuant to the Victims of Trafficking
and Violence Protection Act of 2000
(VTVPA), and to receive temporary
immigration benefits.
(5) An estimate of the total number of
respondents and the amount of time
estimated for an average respondent to
respond: Form I–914, 500 responses at
2.25 hours per response; Supplement A,
500 responses at 1 hour per response;
Supplement B, 200 responses at .50
hours per response.
(6) An estimate of the total public
burden (in hours) associated with the
collection: 1,725 annual burden hours.
If you need a copy of the information
collection instrument, please visit the
Web site at: https://www.regulations.gov.
We may also be contacted at: USCIS,
Regulatory Products Division, 20
Massachusetts Avenue, NW.,
Washington, DC 20529–2020;
Telephone 202–272–8377.
Dated: November 24, 2010.
Sunday Aigbe,
Chief, Regulatory Products Division, U.S.
Citizenship and Immigration Services,
Department of Homeland Security.
[FR Doc. 2010–30150 Filed 12–1–10; 8:45 am]
BILLING CODE 9111–97–P
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Bureau of Land Management
Notice of Proposed Withdrawal and
Opportunity for Public Meeting; Idaho
Bureau of Land Management,
Interior.
ACTION: Notice.
AGENCY:
The Forest Service (FS) has
filed an application with the Bureau of
Land Management (BLM) requesting the
Assistant Secretary of the Interior for
Land and Minerals Management to
withdraw 10 acres of public land
adjacent to the Clearwater National
Forest from mining to protect the Lenore
Tree Improvement Area near Orofino,
Idaho and adjacent to the Clearwater
River. This notice segregates the land for
up to 2 years from settlement, sale,
location or entry under the United
States mining laws. The land will
remain open to mineral leasing and to
all activities currently consistent with
applicable Forest plans and those
related to the exercise of valid existing
rights. This parcel of land has been
withdrawn for FS use since 1990 for
genetic seedling testing purposes. This
proposed withdrawal covers the same
10 acres that were withdrawn for FS use
under Public Land Order (PLO) No.
6799, BLM Serial Number IDI–26701,
published on Friday, September 14,
1990 in the Federal Register (55 FR
37878). Due to an administrative
oversight on the part of the FS, PLO
6799 expired before an extension of the
withdrawal can be processed. Therefore,
the FS is requesting a new 20-year
withdrawal covering the same area.
DATES: Comments and request for a
public meeting must be received by
March 2, 2011.
ADDRESSES: Comments and meeting
requests should be sent to the Forest
Supervisor, Clearwater National Forest,
12730 Highway 12, Orofino, Idaho
83544.
SUMMARY:
FOR FURTHER INFORMATION CONTACT:
Laura Summers, BLM Idaho State
Office, 208–373–3866 or Scott Bixler,
Forest Service, (406) 329–3655.
SUPPLEMENTARY INFORMATION: The FS
has filed an application to withdraw the
following described public land from
settlement, sale, location and entry
under the United States mining laws,
subject to valid existing rights:
Boise Meridian
Clearwater National Forest
T. 37 N., R. 1 W.,
Sec. 32, N1⁄2S1⁄2NW1⁄4SW1⁄4.
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]]>Agencies
[Federal Register Volume 75, Number 231 (Thursday, December 2, 2010)]
[Notices]
[Pages 75182-75183]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: 2010-30150]
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DEPARTMENT OF HOMELAND SECURITY
U.S. Citizenship and Immigration Services
Agency Information Collection Activities: Form I-914, Extension
of a Currently Approved Information Collection; Comment Request
ACTION: 30-Day Notice of Information Collection under Review: Form I-
914 and Supplements A and B, Application for T Nonimmigrant Status;
Application for Immediate Family Member of T-1 Recipient; and
Declaration of Law Enforcement Officer for Victim of
[[Page 75183]]
Trafficking in Persons; OMB Control No. 1615-0099.
-----------------------------------------------------------------------
The Department of Homeland Security, U.S. Citizenship and
Immigration Services (USCIS) will be submitting the following
information collection request to the Office of Management and Budget
(OMB) for review and clearance in accordance with the Paperwork
Reduction Act of 1995. The information collection was previously
published in the Federal Register on September 8, 2010, at 75 FR 54646,
allowing for a 60-day public comment period. USCIS did not receive any
comments for this information collection.
The purpose of this notice is to allow an additional 30 days for
public comments. Comments are encouraged and will be accepted until
January 3, 2011. This process is conducted in accordance with 5 CFR
1320.10.
Written comments and/or suggestions regarding the item(s) contained
in this notice, especially regarding the estimated public burden and
associated response time, should be directed to the Department of
Homeland Security (DHS), and to the Office of Management and Budget
(OMB) USCIS Desk Officer. Comments may be submitted to: USCIS, Chief,
Regulatory Products Division, 20 Massachusetts Avenue, Washington, DC
20529-2020. Comments may also be submitted to DHS via facsimile to 202-
272-0997 or via e-mail at rfs.regs@dhs.gov, and to the OMB USCIS Desk
Officer via facsimile at 202-395-5806 or via e-mail at oira_submission@omb.eop.gov. When submitting comments by e-mail please make
sure to add OMB Control Number 1615-0099 in the subject box. Written
comments and suggestions from the public and affected agencies should
address one or more of the following four points:
(1) Evaluate whether the proposed collection of information is
necessary for the proper performance of the functions of the agency,
including whether the information will have practical utility;
(2) Evaluate the accuracy of the agencies estimate of the burden of
the proposed collection of information, including the validity of the
methodology and assumptions used;
(3) Enhance the quality, utility, and clarity of the information to
be collected; and
(4) Minimize the burden of the collection of information on those
who are to respond, including through the use of appropriate automated,
electronic, mechanical, or other technological collection techniques or
other forms of information technology, e.g., permitting electronic
submission of responses.
Overview of This Information Collection
(1) Type of Information Collection: Extension of a currently
approved information collection.
(2) Title of the Form/Collection: Application for T Nonimmigrant
Status; Supplement A: Application for Immediate Family Member of T-1
Recipient; and Supplement B: Declaration of Law Enforcement Officer for
Victim of Trafficking in Persons.
(3) Agency form number, if any, and the applicable component of the
Department of Homeland Security sponsoring the collection: Form I-914;
U.S. Citizenship and Immigration Services (USCIS).
(4) Affected public who will be asked or required to respond, as
well as a brief abstract: Primary: Individuals or Households. Form I-
914 permits victims of severe forms of trafficking and their immediate
family members to demonstrate that they qualify for temporary
nonimmigrant status pursuant to the Victims of Trafficking and Violence
Protection Act of 2000 (VTVPA), and to receive temporary immigration
benefits.
(5) An estimate of the total number of respondents and the amount
of time estimated for an average respondent to respond: Form I-914, 500
responses at 2.25 hours per response; Supplement A, 500 responses at 1
hour per response; Supplement B, 200 responses at .50 hours per
response.
(6) An estimate of the total public burden (in hours) associated
with the collection: 1,725 annual burden hours.
If you need a copy of the information collection instrument, please
visit the Web site at: https://www.regulations.gov.
We may also be contacted at: USCIS, Regulatory Products Division,
20 Massachusetts Avenue, NW., Washington, DC 20529-2020; Telephone 202-
272-8377.
Dated: November 24, 2010.
Sunday Aigbe,
Chief, Regulatory Products Division, U.S. Citizenship and Immigration
Services, Department of Homeland Security.
[FR Doc. 2010-30150 Filed 12-1-10; 8:45 am]
BILLING CODE 9111-97-P
