National Cancer Institute; Notice of Closed Meetings, 60130-60131 [2010-24414]
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Federal Register / Vol. 75, No. 188 / Wednesday, September 29, 2010 / Notices
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Reporting Requirements for
Bioavailability and Bioequivalence
Studies in Humans,’’ published
elsewhere in this issue of the Federal
Register.
DATES: Although you can comment on
any guidance at any time (see 21 CFR
10.115(g)(5)), to ensure that the agency
considers your comment on this draft
guidance before it begins work on the
final version of the guidance, submit
either electronic or written comments
on the draft guidance by December 28,
2010.
ADDRESSES: Submit written requests for
single copies of the draft guidance to the
Division of Drug Information, Center for
Drug Evaluation and Research, Food
and Drug Administration, 10903 New
Hampshire Ave., Bldg. 51, rm. 2201,
Silver Spring, MD 20993–0002; or the
Office of Communication, Outreach, and
Development (HFM–40), Center for
Biologics Evaluation and Research,
Food and Drug Administration, 1401
Rockville Pike, suite 200N, Rockville,
MD 20852–1448. Send one selfaddressed adhesive label to assist that
office in processing your requests. See
the SUPPLEMENTARY INFORMATION section
for electronic access to the draft
guidance document.
Submit written comments to the
Division of Dockets Management (HFA–
305), Food and Drug Administration,
5630 Fishers Lane, rm. 1061, Rockville,
MD 20852. Submit electronic comments
on the draft guidance to https://
www.regulations.gov.
FOR FURTHER INFORMATION CONTACT:
Janet Norden, Center for Drug
Evaluation and Research, Food and
Drug Administration, 10903 New
Hampshire Ave., Bldg. 51, rm. 6324,
Silver Spring, MD 20993–0002, 301–
796–2500; or Laura Rich, Center for
Biologics Evaluation and Research,
Food and Drug Administration, 1401
Rockville Pike, suite 200N, Rockville,
MD 20852–1448, 301–827–6210.
SUPPLEMENTARY INFORMATION:
I. Background
FDA is announcing the availability of
a draft guidance for industry and
investigators entitled ‘‘Safety Reporting
Requirements for INDs and BA/BE
Studies.’’ This draft guidance is
intended to help sponsors and
investigators comply with the new
requirements for investigational new
drug applications (IND) safety reporting
and safety reporting for bioavailability
(BA) and bioequivalence (BE) studies.
In the Federal Register of March 14,
2003 (68 FR 12406), FDA published a
proposed rule to revise its regulations
governing pre- and postmarket safety
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reporting for human drug and biological
products. To make rulemaking more
manageable, the Agency decided to
issue revisions to the pre- and
postmarket safety reporting regulations
in two separate rulemakings. The final
rule, entitled ‘‘Investigational New Drug
Safety Reporting Requirements for
Human Drug and Biological Products
and Safety Reporting Requirements for
Bioavailability and Bioequivalence
Studies in Humans,’’ published
elsewhere in this issue of the Federal
Register, revises the premarket
regulations. The revisions in the final
rule will improve the utility and quality
of safety reports, expedite and
strengthen FDA’s ability to review
critical safety information, improve
safety monitoring of human drug and
biological products, better protect
human subjects enrolled in clinical
trials, and harmonize safety reporting
internationally. The new requirements
revise the definitions used for IND
safety reporting, make clear when to
submit IND safety reports, and subject
BA and BE studies to safety reporting
requirements.
The draft guidance was developed to
accompany the publication of the final
rule. The draft guidance provides
examples and explanations of the
definitions used for IND safety
reporting, makes recommendations for
determining when and how to submit a
safety report, and provides advice on
other safety reporting issues that have
generated questions from sponsors and
investigators.
The draft guidance is being issued
consistent with FDA’s good guidance
practices regulation (21 CFR 10.115).
The draft guidance, when finalized, will
represent the Agency’s current thinking
on safety reporting requirements for
INDs and BA/BE studies. It does not
create or confer any rights for or on any
person and does not operate to bind
FDA or the public. An alternative
approach may be used if such approach
satisfies the requirements of the
applicable statutes and regulations.
II. Comments
Interested persons may submit to the
Division of Dockets Management (see
ADDRESSES) either electronic or written
comments regarding this document. It is
only necessary to send one set of
comments. It is no longer necessary to
send two copies of mailed comments.
Identify comments with the docket
number found in brackets in the
heading of this document. Received
comments may be seen in the Division
of Dockets Management between 9 a.m.
and 4 p.m., Monday through Friday.
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III. Paperwork Reduction Act of 1995
This draft guidance contains
information collection provisions that
are subject to review by the Office of
Management and Budget (OMB) under
the Paperwork Reduction Act of 1995
(44 U.S.C. 3501–3520). The collection(s)
of information in the draft guidance are
estimated in section ‘‘VII. Paperwork
Reduction Act of 1995’’ of the final rule
entitled, ‘‘Investigational New Drug
Safety Reporting Requirements for
Human Drug and Biological Products
and Safety Reporting Requirements for
Bioavailability and Bioequivalence
Studies in Humans’’ published
elsewhere in this issue of the Federal
Register.
IV. Electronic Access
Persons with access to the Internet
may obtain the document at either
https://www.fda.gov/Drugs/Guidance
ComplianceRegulatoryInformation/
Guidances/default.htm or https://
www.regulations.gov.
Dated: September 23, 2010.
Leslie Kux,
Acting Assistant Commissioner for Policy.
[FR Doc. 2010–24295 Filed 9–28–10; 8:45 am]
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DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
National Cancer Institute; Notice of
Closed Meetings
Pursuant to section 10(d) of the
Federal Advisory Committee Act, as
amended (5 U.S.C. App.), notice is
hereby given of the following meetings.
The meetings will be closed to the
public in accordance with the
provisions set forth in sections
552b(c)(4) and 552b(c)(6), Title 5 U.S.C.,
as amended. The grant applications and
the discussions could disclose
confidential trade secrets or commercial
property such as patentable material,
and personal information concerning
individuals associated with the grant
applications, the disclosure of which
would constitute a clearly unwarranted
invasion of personal privacy.
Name of Committee: National Cancer
Institute Special Emphasis Panel; Basic and
Translational Oncology P01.
Date: September 30–October 1, 2010.
Time: 8 a.m. to 5 p.m.
Agenda: To review and evaluate grant
applications.
Place: Bethesda North Marriott Hotel &
Conference Center, 5701 Marinelli Road,
Bethesda, MD 20852.
Contact Person: Shakeel Ahmad, PhD,
Scientific Review Officer, Research Programs
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Federal Register / Vol. 75, No. 188 / Wednesday, September 29, 2010 / Notices
Review Branch, Division of Extramural
Activities, National Cancer Institute, NIH,
6116 Executive Boulevard, Room 8137,
Bethesda, MD 20892–8328, (301) 594–0114,
ahmads@mail.nih.gov.
This notice is being published less than 15
days prior to the meeting due to scheduling
conflicts.
Name of Committee: National Cancer
Institute Special Emphasis Panel; Cancer
Prevention Research Small Grant Program
(R03).
Date: October 28–29, 2010.
Time: 8 a.m. to 5 p.m.
Agenda: To review and evaluate grant
applications.
Place: Renaissance Washington, DC
DuPont Circle Hotel, 1143 New Hampshire
Avenue, NW., Washington, DC 20037.
Contact Person: Irina Gordienko, PhD,
Scientific Review Officer, Scientific Review
and Logistics Branch, Division of Extramural
Activities, National Cancer Institute, NIH,
6116 Executive Blvd., Rm. 7073, Bethesda,
MD 20892, 301–594–1566,
gordienkoiv@mail.nih.gov.
(Catalogue of Federal Domestic Assistance
Program Nos. 93.392, Cancer Construction;
93.393, Cancer Cause and Prevention
Research; 93.394, Cancer Detection and
Diagnosis Research; 93.395, Cancer
Treatment Research; 93.396, Cancer Biology
Research; 93.397, Cancer Centers Support;
93.398, Cancer Research Manpower; 93.399,
Cancer Control, National Institutes of Health,
HHS)
Dated: September 22, 2010.
Jennifer S. Spaeth,
Director, Office of Federal Advisory
Committee Policy.
[FR Doc. 2010–24414 Filed 9–28–10; 8:45 am]
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DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
erowe on DSK5CLS3C1PROD with NOTICES
National Institute of Mental Health;
Notice of Meeting
Pursuant to section 10(a) of the
Federal Advisory Committee Act, as
amended (5 U.S.C. App.), notice is
hereby given of an Interagency Autism
Coordinating Committee (IACC)
meeting.
The purpose of the IACC meeting is
to listen to presentations on various
aspects of autism spectrum disorder
research and services and to discuss
plans for the annual update of the IACC
Strategic Plan for Autism Spectrum
Disorders Research. The meeting will be
open to the public and will be
accessible by webcast and conference
call.
Name of Committee: Interagency Autism
Coordinating Committee (IACC).
Type of meeting: Open meeting.
Date: October 22, 2010.
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Time: 10 a.m. to 5 p.m.* Eastern Time *—
Approximate end time.
Agenda: Invited speakers will give
presentations on various aspects of autism
spectrum disorder research and services and
the IACC will discuss plans for the annual
update of the IACC Strategic Plan for Autism
Spectrum Disorder Research.
Place: The National Institutes of Health,
Main Campus, William H. Natcher
Conference Center, 45 Center Drive,
Conference Rooms E1/E2, Bethesda, MD
20892.
Webcast Live: https://videocast.nih.gov/.
Conference Call Access: Dial: 1–888–577–
8995; Access code: 1991506.
Cost: The meeting is free and open to the
public.
Registration: https://
www.acclaroresearch.com/oarc/10-2210_IACC. Pre-registration is recommended to
expedite check-in. Seating in the meeting
room is limited to room capacity and on a
first come, first served basis.
Deadlines: Notification of intent to present
oral comments: October 14th by 5 p.m. ET.
Submission of written/electronic statement
for oral comments: October 15th by 5 p.m.
ET.
Submission of written comments: October
18th by 5 p.m. ET.
Access: Metro accessible—Medical Center
Metro (Red Line).
Contact Person: Ms. Lina Perez, Office of
Autism Research Coordination, National
Institute of Mental Health, NIH, 6001
Executive Boulevard, Room 8200, Bethesda,
MD 20892–9669. Phone: 301–443–6040. Email: IACCPublicInquiries@mail.nih.gov.
Please Note: Any member of the public
interested in presenting oral comments to the
Committee must notify the Contact Person
listed on this notice by 5 p.m. ET on
Thursday, October 14, 2010 with their
request to present oral comments at the
meeting. Interested individuals and
representatives of organizations must submit
a written/electronic copy of the oral
statement/comments including a brief
description of the organization represented
by 5 p.m. ET on Friday, October 15, 2010.
Statements submitted will become a part of
the public record. Only one representative of
an organization will be allowed to present
oral comments and presentations will be
limited to three to five minutes per speaker,
depending on number of speakers to be
accommodated within the allotted time.
Speakers will be assigned a time to speak in
the order of the date and time when their
request to speak is received, along with the
required submission of the written/electronic
statement by the specified deadline.
In addition, any interested person may
submit written comments to the IACC prior
to the meeting by sending the comments to
the Contact Person listed on this notice by 5
p.m. ET, Monday, October 18, 2010. The
comments should include the name and
when applicable, the business or professional
affiliation of the interested person. All
written comments received by the deadlines
for both oral and written public comments
will be provided to the IACC for their
consideration and will become part of the
public record.
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60131
The meeting will be open to the public
through a conference call phone number and
webcast live on the Internet. Members of the
public who participate using the conference
call phone number will be able to listen to
the meeting but will not be heard. If you
experience any technical problems with the
webcast live or conference call, please e-mail
IACCTechSupport@acclaroresearch.com.
Individuals who participate in person or by
using these electronic services and who need
special assistance, such as captioning of the
conference call or other reasonable
accommodations, should submit a request to
the Contact Person listed on this notice at
least 7 days prior to the meeting.
To access the webcast live on the Internet
the following computer capabilities are
required: (A) Internet Explorer 5.0 or later,
Netscape Navigator 6.0 or later or Mozilla
Firefox 1.0 or later; (B) Windows® 2000, XP
Home, XP Pro, 2003 Server or Vista; (C)
Stable 56k, cable modem, ISDN, DSL or
better Internet connection; (D) Minimum of
Pentium 400 with 256 MB of RAM
(Recommended); (E) Java Virtual Machine
enabled (Recommended).
NIH has instituted stringent security
procedures for entrance onto the NIH
campus. All visitors must enter through the
NIH Gateway Center. This center combines
visitor parking, non-commercial vehicle
inspection and visitor ID processing, all in
one location. The NIH will process all
visitors in vehicles or as pedestrians. You
will be asked to submit to a vehicle or
personal inspection and will be asked to state
the purpose of your visit. Visitors over 15
years of age must provide a form of
government-issued ID such as a driver’s
license or passport. All visitors should be
prepared to have their personal belongings
inspected and to go through metal detection
inspection.
When driving to NIH, plan some extra time
to get through the security checkpoints. Be
aware that visitor parking lots on the NIH
campus can fill up quickly. The NIH campus
is also accessible via the metro Red Line,
Medical Center Station. The William H.
Natcher Conference Center is a 5-minute
walk from the Medical Center Metro Station.
Additional NIH campus visitor information
is available at: https://www.nih.gov/about/
visitor/index.htm.
As a part of security procedures, attendees
should be prepared to present a photo ID at
the meeting registration desk during the
check-in process. Pre-registration is
recommended. Seating will be limited to the
room capacity and seats will be on a first
come, first served basis, with expedited
check-in for those who are pre-registered.
Meeting schedule subject to change.
Information about the IACC is available on
the website: https://www.iacc.hhs.gov.
Dated: September 22, 2010.
Jennifer S. Spaeth,
Director, Office of Federal Advisory
Committee Policy.
[FR Doc. 2010–24403 Filed 9–28–10; 8:45 am]
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Agencies
[Federal Register Volume 75, Number 188 (Wednesday, September 29, 2010)]
[Notices]
[Pages 60130-60131]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: 2010-24414]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health
National Cancer Institute; Notice of Closed Meetings
Pursuant to section 10(d) of the Federal Advisory Committee Act, as
amended (5 U.S.C. App.), notice is hereby given of the following
meetings.
The meetings will be closed to the public in accordance with the
provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5
U.S.C., as amended. The grant applications and the discussions could
disclose confidential trade secrets or commercial property such as
patentable material, and personal information concerning individuals
associated with the grant applications, the disclosure of which would
constitute a clearly unwarranted invasion of personal privacy.
Name of Committee: National Cancer Institute Special Emphasis
Panel; Basic and Translational Oncology P01.
Date: September 30-October 1, 2010.
Time: 8 a.m. to 5 p.m.
Agenda: To review and evaluate grant applications.
Place: Bethesda North Marriott Hotel & Conference Center, 5701
Marinelli Road, Bethesda, MD 20852.
Contact Person: Shakeel Ahmad, PhD, Scientific Review Officer,
Research Programs
[[Page 60131]]
Review Branch, Division of Extramural Activities, National Cancer
Institute, NIH, 6116 Executive Boulevard, Room 8137, Bethesda, MD
20892-8328, (301) 594-0114, ahmads@mail.nih.gov.
This notice is being published less than 15 days prior to the
meeting due to scheduling conflicts.
Name of Committee: National Cancer Institute Special Emphasis
Panel; Cancer Prevention Research Small Grant Program (R03).
Date: October 28-29, 2010.
Time: 8 a.m. to 5 p.m.
Agenda: To review and evaluate grant applications.
Place: Renaissance Washington, DC DuPont Circle Hotel, 1143 New
Hampshire Avenue, NW., Washington, DC 20037.
Contact Person: Irina Gordienko, PhD, Scientific Review Officer,
Scientific Review and Logistics Branch, Division of Extramural
Activities, National Cancer Institute, NIH, 6116 Executive Blvd.,
Rm. 7073, Bethesda, MD 20892, 301-594-1566,
gordienkoiv@mail.nih.gov.
(Catalogue of Federal Domestic Assistance Program Nos. 93.392,
Cancer Construction; 93.393, Cancer Cause and Prevention Research;
93.394, Cancer Detection and Diagnosis Research; 93.395, Cancer
Treatment Research; 93.396, Cancer Biology Research; 93.397, Cancer
Centers Support; 93.398, Cancer Research Manpower; 93.399, Cancer
Control, National Institutes of Health, HHS)
Dated: September 22, 2010.
Jennifer S. Spaeth,
Director, Office of Federal Advisory Committee Policy.
[FR Doc. 2010-24414 Filed 9-28-10; 8:45 am]
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