Government-Owned Inventions; Availability for Licensing, 44270-44271 [2010-18490]

Download as PDF sroberts on DSKD5P82C1PROD with NOTICES 44270 Federal Register / Vol. 75, No. 144 / Wednesday, July 28, 2010 / Notices melanoma patients. Diagnostic tests specifically directed at NUAK2 are anticipated to be highly predictive of the aggression level and course of disease in individual patients. Gaining information about melanoma before late-stage symptoms are observed should give clinicians more opportunity to treat patients before the cancer metastasizes out of control. • Few therapies exist for melanoma and the treatments utilized by clinicians are prone to toxic side effects. Targeted therapies, such as shRNAs directed against NUAK2 could combine more effective inhibition of melanoma with fewer harsh side effects. Development Status: This technology is in a preclinical stage of development. Market: There remains a long-felt public health need to develop new therapeutics and diagnostics for treating melanoma. Melanoma is the most serious type of skin cancer, accounting the majority of skin cancer deaths, and the percentage of people who develop melanoma has more than doubled in the past 30 years. With the increase in Hispanic and Asian populations in the United States, the incidence of acral melanoma has risen to become a major public health problem as it accounts for between 30%–70% of melanoma cases in dark-skinned individuals. In the United States alone in 2009, it is estimated that 68,720 new cases of melanoma were diagnosed and 8,650 people were expected to die of the disease. In 2005, the American Academy of Dermatology and the Society for Investigative Dermatology released a comprehensive study that quantified the estimated total direct cost associated with the treatment of melanoma in 2004 at $291 million in the United States. Currently, there are more than 200 therapeutics in active development to target melanoma—from early pre-clinical to marketed drugs. Clearly, a sizable portion of the melanoma diagnostic and therapeutic markets is available, since no one course of treatment is effective for all patients and very few diagnostic tools exist to identify melanoma at early stages. Inventors: Vincent J. Hearing (NCI) and Takeshi Namiki (formerly NCI). Publications: 1. T Namiki, et al. Genomic alterations in primary cutaneous melanomas detected by metaphase comparative genomic hybridization with laser capture or manual microdissection: 6p gains may predict poor outcome. Cancer Genet Cytogenet. 2005 Feb;157(1):1–11. [PubMed: 15676140]. 2. JH Kim, et al. SNARK, a novel downstream molecule of EBV latent VerDate Mar<15>2010 19:05 Jul 27, 2010 Jkt 220001 membrane protein 1, is associated with resistance to cancer cell death. Leuk Lymphoma. 2008 Jul;49(7):1392–1398. [PubMed: 18452098]. Patent Status: U.S. Provisional Application No. 61/321,136 filed 05 April 2010 (HHS Reference No. E–281– 2009/0–US–01). Licensing Status: Available for licensing. Licensing Contact: Samuel E. Bish, PhD; 301–435–5282; bishse@mail.nih.gov. Collaborative Research Opportunity: The Center for Cancer Research, Laboratory of Cell Biology, is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize Prolonging Survival in Melanoma Patients. Please contact John Hewes, PhD, at 301–435–3121 or hewesj@mail.nih.gov for more information. Immortalized Human Bronchial Epithelial Cell Line Description of Invention: Normal cells can be cultured in vitro for a limited period of time before they exhibit a ‘‘crisis’’ or senescence, wherein they display abnormal cell morphology and significant reduction or cessation of cell proliferation. Investigators at the National Cancer Institute developed immortalized cell line by isolating bronchial epithelial cells from noncancerous individuals and subsequent infection with an adenovirus 12–SV40 virus hybrid. Unlike normal cells, the immortalized cells be cultured continuously in vitro in suitable medium and retain features of normal human bronchial epithelial cells, including the absence of invasive behavior in vitro or in vivo. These cells can also be transfected with oncogenes and used as a model for multistage carcinogenesis, or employed to assay a biological or chemical agent’s ability to induce differentiation and carcinogenesis as well as test potential chemotherapeutic agents. Applications: • Model to study multistage bronchial carcinogenesis. • Identification of potential chemotherapeutic drugs. • Identification of carcinogenic agents. Advantages: Immortalized cells that retain normal human bronchial characteristics. Market: • Global cancer market is worth more than eight percent of total global pharmaceutical sales. • Cancer industry is predicted to expand to $85.3 billion by 2010. PO 00000 Frm 00057 Fmt 4703 Sfmt 4703 Inventors: Curtis C. Harris (NCI) et al. Relevant Publication: RR Reddel et al. Transformation of human bronchial epithelial cells by infection with SV40 or adenovirus-12 SV40 hybrid virus, or transfection via stronium phosphate coprecipitation with a plasmid containing SV40 early region genes. Cancer Res. 1988 Apr 1;48(7):1904– 1909. [PubMed: 2450641]. Patent Status: HHS Reference No. E– 287–1987/0—Research Material. Patent protection is not being pursued for this technology. Licensing Status: Available for licensing. Licensing Contact: Jennifer Wong; 301–435–4633; wongje@mail.nih.gov. Collaborative Research Opportunity: The Center for Cancer Research, Laboratory of Human Carcinogenesis, is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize Immortalized Human Bronchial Epithelial Cell Line. Please contact John Hewes, PhD, at 301–435–3121 or hewesj@mail.nih.gov for more information. Dated: July 22, 2010. Richard U. Rodriguez, Director, Division of Technology Development and Transfer, Office of Technology Transfer, National Institutes of Health. [FR Doc. 2010–18487 Filed 7–27–10; 8:45 am] BILLING CODE 4140–01–P DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Government-Owned Inventions; Availability for Licensing National Institutes of Health, Public Health Service, HHS. ACTION: Notice. AGENCY: The inventions listed below are owned by an agency of the U.S. Government and are available for licensing in the U.S. in accordance with 35 U.S.C. 207 to achieve expeditious commercialization of results of federally-funded research and development. Foreign patent applications are filed on selected inventions to extend market coverage for companies and may also be available for licensing. ADDRESSES: Licensing information and copies of the U.S. patent applications listed below may be obtained by writing to the indicated licensing contact at the Office of Technology Transfer, National Institutes of Health, 6011 Executive SUMMARY: E:\FR\FM\28JYN1.SGM 28JYN1 Federal Register / Vol. 75, No. 144 / Wednesday, July 28, 2010 / Notices Boulevard, Suite 325, Rockville, Maryland 20852–3804; telephone: 301/ 496–7057; fax: 301/402–0220. A signed Confidential Disclosure Agreement will be required to receive copies of the patent applications. sroberts on DSKD5P82C1PROD with NOTICES Therapeutics for the Treatment and Prevention of Atherosclerosis and Cardiovascular Disease Description of Invention: This technology consists of peptides and peptide-analogues that enhance clearance of excess cholesterol in cells and do not exhibit the cytotoxicity that has hampered development of similar potential therapeutics. Briefly, apolipoprotein A–1 (ApoA–1) promotes cholesterol efflux from cells and its concentration is inversely correlated with atherosclerotic events. The isolated peptidic component of ApoA–1 that acts within the cholesterol secretion pathway is therapeutic towards atherosclerosis but exhibits cytotoxic effects. In contrast, our inventors have derivatized that ApoA– 1 peptide which is both less cytotoxic and more active than the underivatized component in initial studies. This potential therapeutic is similar to high density lipoprotein (HDL) therapy and may complement statin-mediated reduction of pro-atherogenic lipoproteins. Potential Applications: • Treatment and prevention of atherosclerosis • Treatment and prevention of cardiovascular disease, coronary artery disease, heart attack, stroke, and inflammation • Therapeutic or preventative coating for a heart or vascular implant • Alternative to HDL therapy Potential Advantages: • Enhanced cytotoxicity profile • Enhanced hydrophilicity profile • Complements statin-based therapies • Oral delivery approaches in development Development Status: Early stage with in vitro proof of concept data. Market: The CDC indicates that heart attacks account for 26% of deaths in the United States of which atherosclerosis is a significant contributing factor or cause. Global sales for cardiovascular therapeutics are expected to exceed $50b in 2010. Inventors: Amar A. Sethi (NHLBI) et al. Patent Status: U.S. Provisional Application No. 61/265,291 filed 30 Nov 2009 (HHS Reference No. E–047– 2009/0–US–01). Licensing Status: Available for licensing. VerDate Mar<15>2010 19:05 Jul 27, 2010 Jkt 220001 Licensing Contact: Fatima Sayyid, M.H.P.M.; 301–435–4521; Fatima.Sayyid@nih.hhs.gov. Use of Immunosuppressive Agents for Treatment of Age-related Macular Degeneration (AMD) and Diabetic Retinopathy Description of Invention: AMD belongs to a group of disorders in which the immune system may play an important role. This invention discloses that patients with AMD gain additional therapeutic benefit from combination treatment of immunosuppressive agents and standard-of-care in comparison to standard-of-care alone. This invention slows the progression of choroidal neovascularization (CNV) and may have implications for related pathologies, including diabetic retinopathy. Clinical data from a small, randomized pilot clinical trial are available. Applications: • A method of treatment for AMD. • A method of treatment for diabetic retinopathy. • A method of treatment for diseases associated with CNV. Advantages: • Likely to be synergistic with existing therapeutics. • May enable repurposing of some exiting immunosuppressive agents. Development Status: In clinical trials. Market: An estimated three million individuals in the United States will have an advanced form of AMD by 2020 (Klein R et al. The epidemiology of agerelated macular degeneration. Am J Ophthalmol. 2004;137(3):486–95). Inventors: Robert B. Nussenblatt and Frederick L. Ferris (NEI). Publication: In preparation. Patent Status: U.S. Provisional Application No. 61/254,439 filed 23 Oct 2009 (HHS Reference No. E–198–2008/ 0–US–01). Licensing Status: Available for licensing. Licensing Contact: Norbert Pontzer, J.D., Ph.D.; 301–435–5502; pontzern@mail.nih.gov. Collaborative Research Opportunity: The National Eye Institute, Laboratory of Immunology, is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize the use of immunosuppressive agents in the treatment of age related macular degeneration. This is in light of new findings that immune mechanisms appear to be central to the expression of the clinical disease we know as AMD. Please contact Alan Hubbs, Ph.D. at 301–594–4263 or hubbsa@mail.nih.gov for more information. PO 00000 Frm 00058 Fmt 4703 Sfmt 9990 44271 Dated: July 22, 2010. Richard U. Rodriguez, Director, Division of Technology Development and Transfer, Office of Technology Transfer, National Institutes of Health. [FR Doc. 2010–18490 Filed 7–27–10; 8:45 am] BILLING CODE 4140–01–P DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Office of the Director; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App), notice is hereby given of the following meeting. The meeting will be closed to the public in accordance with the provisions set forth in sections 552b(c)(4) and 552b(c)(6), title 5 U.S.C., as amended. The grant applications and the discussions could disclose confidential trade secrets or commercial property such as patentable materials, and personal information concerning individuals associated with the grant applications, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. Name of Committee: Advisory Committee to the Director, NIH. Date: August 9, 2010. Time: 2 p.m. to 3 p.m. e.s.t. Agenda: To review and evaluate grant applications (Telephone Conference Call). Place: National Institutes of Health, Building 31, Conference Room 6, 9000 Rockville Pike, Bethesda, MD 20892. Contact Person: Lawrence A. Tabak, PhD, DDS, Acting Director, Division of Program Coordination, Planning, and Strategic Initiatives, Office of the Director, National Institutes of Health, 31 Center Drive, Building 31, Room 2C39, Bethesda, MD 20892, 301–496–3571, lawrence_tabak@nih.gov. This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. Any interested person may file written comments with the committee by forwarding the statement to the Contact Person listed on this notice. The statement should include the name, address, telephone number and when applicable, the business or professional affiliation of the interested person. Dated: July 22, 2010. Jennifer Spaeth, Director, Office of Federal Advisory Committee Policy. [FR Doc. 2010–18496 Filed 7–27–10; 8:45 am] BILLING CODE 4140–01–P E:\FR\FM\28JYN1.SGM 28JYN1

Agencies

[Federal Register Volume 75, Number 144 (Wednesday, July 28, 2010)]
[Notices]
[Pages 44270-44271]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: 2010-18490]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Government-Owned Inventions; Availability for Licensing

AGENCY: National Institutes of Health, Public Health Service, HHS.

ACTION: Notice.

-----------------------------------------------------------------------

SUMMARY: The inventions listed below are owned by an agency of the U.S. 
Government and are available for licensing in the U.S. in accordance 
with 35 U.S.C. 207 to achieve expeditious commercialization of results 
of federally-funded research and development. Foreign patent 
applications are filed on selected inventions to extend market coverage 
for companies and may also be available for licensing.

ADDRESSES: Licensing information and copies of the U.S. patent 
applications listed below may be obtained by writing to the indicated 
licensing contact at the Office of Technology Transfer, National 
Institutes of Health, 6011 Executive

[[Page 44271]]

Boulevard, Suite 325, Rockville, Maryland 20852-3804; telephone: 301/
496-7057; fax: 301/402-0220. A signed Confidential Disclosure Agreement 
will be required to receive copies of the patent applications.

Therapeutics for the Treatment and Prevention of Atherosclerosis and 
Cardiovascular Disease

    Description of Invention: This technology consists of peptides and 
peptide-analogues that enhance clearance of excess cholesterol in cells 
and do not exhibit the cytotoxicity that has hampered development of 
similar potential therapeutics.
    Briefly, apolipoprotein A-1 (ApoA-1) promotes cholesterol efflux 
from cells and its concentration is inversely correlated with 
atherosclerotic events. The isolated peptidic component of ApoA-1 that 
acts within the cholesterol secretion pathway is therapeutic towards 
atherosclerosis but exhibits cytotoxic effects. In contrast, our 
inventors have derivatized that ApoA-1 peptide which is both less 
cytotoxic and more active than the underivatized component in initial 
studies. This potential therapeutic is similar to high density 
lipoprotein (HDL) therapy and may complement statin-mediated reduction 
of pro-atherogenic lipoproteins.
    Potential Applications:
     Treatment and prevention of atherosclerosis
     Treatment and prevention of cardiovascular disease, 
coronary artery disease, heart attack, stroke, and inflammation
     Therapeutic or preventative coating for a heart or 
vascular implant
     Alternative to HDL therapy
    Potential Advantages:
     Enhanced cytotoxicity profile
     Enhanced hydrophilicity profile
     Complements statin-based therapies
     Oral delivery approaches in development
    Development Status: Early stage with in vitro proof of concept 
data.
    Market: The CDC indicates that heart attacks account for 26% of 
deaths in the United States of which atherosclerosis is a significant 
contributing factor or cause. Global sales for cardiovascular 
therapeutics are expected to exceed $50b in 2010.
    Inventors: Amar A. Sethi (NHLBI) et al.
    Patent Status: U.S. Provisional Application No. 61/265,291 filed 30 
Nov 2009 (HHS Reference No. E-047-2009/0-US-01).
    Licensing Status: Available for licensing.
    Licensing Contact: Fatima Sayyid, M.H.P.M.; 301-435-4521; 
Fatima.Sayyid@nih.hhs.gov.

Use of Immunosuppressive Agents for Treatment of Age-related Macular 
Degeneration (AMD) and Diabetic Retinopathy

    Description of Invention: AMD belongs to a group of disorders in 
which the immune system may play an important role. This invention 
discloses that patients with AMD gain additional therapeutic benefit 
from combination treatment of immunosuppressive agents and standard-of-
care in comparison to standard-of-care alone. This invention slows the 
progression of choroidal neovascularization (CNV) and may have 
implications for related pathologies, including diabetic retinopathy. 
Clinical data from a small, randomized pilot clinical trial are 
available.
    Applications:
     A method of treatment for AMD.
     A method of treatment for diabetic retinopathy.
     A method of treatment for diseases associated with CNV.
    Advantages:
     Likely to be synergistic with existing therapeutics.
     May enable repurposing of some exiting immunosuppressive 
agents.
    Development Status: In clinical trials.
    Market: An estimated three million individuals in the United States 
will have an advanced form of AMD by 2020 (Klein R et al. The 
epidemiology of age-related macular degeneration. Am J Ophthalmol. 
2004;137(3):486-95).
    Inventors: Robert B. Nussenblatt and Frederick L. Ferris (NEI).
    Publication: In preparation.
    Patent Status: U.S. Provisional Application No. 61/254,439 filed 23 
Oct 2009 (HHS Reference No. E-198-2008/0-US-01).
    Licensing Status: Available for licensing.
    Licensing Contact: Norbert Pontzer, J.D., Ph.D.; 301-435-5502; 
pontzern@mail.nih.gov.
    Collaborative Research Opportunity: The National Eye Institute, 
Laboratory of Immunology, is seeking statements of capability or 
interest from parties interested in collaborative research to further 
develop, evaluate, or commercialize the use of immunosuppressive agents 
in the treatment of age related macular degeneration. This is in light 
of new findings that immune mechanisms appear to be central to the 
expression of the clinical disease we know as AMD. Please contact Alan 
Hubbs, Ph.D. at 301-594-4263 or hubbsa@mail.nih.gov for more 
information.

    Dated: July 22, 2010.
Richard U. Rodriguez,
Director, Division of Technology Development and Transfer, Office of 
Technology Transfer, National Institutes of Health.
[FR Doc. 2010-18490 Filed 7-27-10; 8:45 am]
BILLING CODE 4140-01-P
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