HHS Intent To Publish Grant and Contract Solicitations for Comparative Effectiveness Research (CER) Projects With Funds Allocated to the Office of the Secretary From the American Recovery and Reinvestment Act (ARRA), 990-991 [E9-31340]
Download as PDF
<![CDATA[
990
Federal Register / Vol. 75, No. 4 / Thursday, January 7, 2010 / Notices
Camptothecins are effective
Topoisomerase I (Top1) inhibitors, and
two derivatives (Topotecan® and
Camptosar®) are currently approved for
treatment of ovarian and colorectal
cancer. Camptothecins damage DNA by
trapping covalent complexes between
the Top1 catalytic tyrosine and the 3′end of the broken DNA. Tdp1 repairs
Top1–DNA covalent complexes by
hydrolyzing the tyrosyl-DNA bond.
Thus, the presence and activity of Tdp1
can reduce the effectiveness of
camptothecins as anticancer agents. In
addition, Tpd1 repairs free-radicalmediated DNA breaks.
Inhibition of Tpd1 using diamidine or
its derivatives. may reduce repair of
DNA breaks and increase the rate of
apoptosis in cancer cells. In addition.
diamidine derivatives have the potential
to enhance the anti-neoplastic activity
of Top1 inhibitors, by reducing repair of
Top1–DNA lesions through inhibition of
Tdp1.
Development Status: Pre-clinical
stage.
Inventors: Yves G. Pommier and
Christoph Marchand (NCI).
Publications
WReier-Aviles on DSKGBLS3C1PROD with NOTICES
1. Z Liao et al. Inhibition of human tyrosylDNA phosphodiesterase by aminoglycoside
antibiotics and ribosome inhibitors. Mol
Pharmacol. 2006 Jul:70(1):366–372.
2. Y Pommier. Camptothecins and
topoisomerase I: a foot in the door. Targeting
the genome beyond topoisomerase I with
camptothecins and novel anticancer drugs:
importance of DNA replication, repair and
cell cycle checkpoints. Curr Med Chem
Anticancer Agents. 2004 Sep; 4(5):429–434.
Review.
3. Y Pommier et al. Repair of and
checkpoint response to topoisomerase I
mediated DNA damage. Mutat Res. 2003 Nov
27;532(1–2):173–203. Review.
Patent Status: U.S. Patent Application
No. 12/225,672 filed 26 Sep 2008 (HHS
Reference No. E–165–2006/0–US–04).
Licensing Status: Available for
licensing.
Licensing Contact: Betty Tong, PhD;
301–594–6565; tongb@mail.nih.gov.
Collaborative Research Opportunity:
The Laboratory of Molecular
Pharmacology is seeking statements of
capability or interest from parties
interested in collaborative research to
further develop, evaluate, or
commercialize Tdp1 inhibitors for the
treatment of cancers. Please contact
John D. Hewes, PhD at 301–435–3121 or
hewesj@mail.nih.gov for more
information.
VerDate Nov<24>2008
14:42 Jan 06, 2010
Jkt 220001
Dated: December 23, 2009.
Richard U. Rodriguez,
Director, Division of Technology Development
and Transfer, Office of Technology Transfer,
National Institutes of Health.
[FR Doc. E9–31284 Filed 1–6–10; 8:45 am]
BILLING CODE 4140–01–M
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
Agency for Healthcare Research and
Quality
HHS Intent To Publish Grant and
Contract Solicitations for Comparative
Effectiveness Research (CER) Projects
With Funds Allocated to the Office of
the Secretary From the American
Recovery and Reinvestment Act
(ARRA)
AGENCY: Agency for Healthcare Research
and Quality (AHRQ), HHS.
ACTION:
Notice of intent.
The Department of Health and
Human Services announces its intention
to support new CER projects with funds
allocated by the American Recovery and
Reinvestment Act (ARRA). The ARRA
appropriated $400 million to the Office
of the Secretary for support of CER.
AHRQ has been designated point of
contact for management of these funds.
Prioritization of the OS ARRA CER
allocation was determined by several
factors: public input, the Comparative
Effectiveness Research-Coordination
Implementation Team, the Federal
Coordinating Council for Comparative
Effectiveness Research (FCC), and the
Institute of Medicine Report on CER. OS
ARRA CER projects will focus, initially,
on either (1) one of the 14 priority
conditions established by the Secretary
of the Department of Health and Human
Services under Section 1013 of the
Medicare Prescription Drug,
Improvement, and Modernization Act of
2003, (2) 100 Institute of Medicine topic
recommendations, or (3) topics that fall
into one of the AHRQ identified
evidence gaps or are identified in the
FCC report. An additional integral focus
for these OS ARRA CER funds are the
priority populations, which include low
income groups; minority groups;
women; children; the elderly; and
individuals with special health care
needs, including individuals with
disabilities and individuals who need
chronic care or end-of-life health care.
The CER solicitations will come from a
diverse set of divisions and agencies
across the Department of Health and
Human Services.
SUMMARY:
PO 00000
Frm 00023
Fmt 4703
Sfmt 4703
DATES: HHS anticipates grant and
contract solicitations to be published
over the next several months.
ADDRESSES: The future CER funding
opportunity announcements will be
published in the NIH Guide: https://
grants.nih.gov/grants/guide/
and on Grants.gov.: https://
www.grants.gov/. Contract solicitations
can be found on the Federal Business
Opportunity site at https://www.fbo.gov/
index?cck=1&au=&ck=.
FOR FURTHER INFORMATION CONTACT:
Until the solicitations are published,
AHRQ cannot provide information on
their contents.
Direct any general comments
regarding the OS ARRA CER program
to: Kathleen Kendrick, Deputy Director,
Office of the Director, Agency for
Healthcare Research and Quality, 540
Gaither Road, Rockville, MD 20850,
Telephone: 301–427–1200, e-mail
address: ARRA
Support@AHRQ.HHS.gov.
SUPPLEMENTARY INFORMATION:
Background
The American Recovery and
Reinvestment Act (ARRA) provided $1.1
billion for comparative effectiveness
research (CER). The Act allocated $300
million to the Agency for Healthcare
Research and Quality (AHRQ), $400
million to the National Institutes of
Health (NIH), and $400 million to the
Office of the Secretary (OS) of the
Department of Health and Human
Services (HHS). These funds are
dedicated specifically towards CER and
must be obligated by the end of fiscal
year 2010.
Comparative Effectiveness Research
Initiative Description
The Department of Health and Human
Service’s overall goal for the investment
in comparative effectiveness research is
to promote high quality care through
broad availability of information that
helps clinicians and patients match the
best science to individual needs and
preferences. Moreover, the investment
can build a sustainable foundation for
CER so that it will enable—now and in
the future the United States healthcare
system to deliver the highest quality and
best value care to all Americans.
Funding Opportunity
Announcements soliciting grant
applications and Requests for Contracts
for CER will provide $210.5 million for
data infrastructure and related research,
$89.5 million for dissemination and
translation, $71 million for research,
$7.6 million for inventory and
evaluation projects and $4 million for
E:\FR\FM\07JAN1.SGM
07JAN1
Federal Register / Vol. 75, No. 4 / Thursday, January 7, 2010 / Notices
salary and benefits for ARRA-related
staff and administrative support.
An additional, $17.4 million will be
allocated to projects that address any
gaps within the new and existing CER
programs.
Notice of Meeting; National
Commission on Children and Disasters
The
National Commission on Children and
Disasters is an independent Commission
that shall conduct a comprehensive
study to examine and assess the needs
of children as they relate to preparation
for, response to, and recovery from all
hazards, building upon the evaluations
of other entities and avoiding
unnecessary duplication by reviewing
the findings, conclusions, and
recommendations of these entities. The
Commission shall then submit a report
to the President and the Congress on the
Commission’s independent and specific
findings, conclusions, and
recommendations to address the needs
of children as they relate to preparation
for, response to, and recovery from all
hazards, including major disasters and
emergencies.
Administration for Children
and Families, Department of Health and
Human Services.
ACTION: Notice of Meeting.
Dated: December 28, 2009.
David A. Hansell,
Principal Deputy Assistant Secretary for
Children and Families.
[FR Doc. E9–31402 Filed 1–6–10; 8:45 am]
DATES: The meeting will be held on
Monday, February 1, 2010, from 9 a.m.
to 5:30 p.m.
ADDRESSES: The meeting will be held at
the Renaissance Mayflower Hotel, 1127
Connecticut Avenue, NW., Washington,
DC 20036. To attend in person, please
register by 5 p.m. Eastern Time, January
28, 2010. To register, please visit
https://
www.childrenanddisasters.acf.hhs.gov.
If you experience technical difficulties,
please contact
NCCDregister@theambitgroup.com. If
you require a sign language interpreter
or other special assistance, please call
Jacqueline Haye at (202) 205–9560 or email jacqueline.haye@acf.hhs.gov as
soon as possible and no later than 5
p.m. Eastern Time, January 19, 2010.
Agenda: The National Commission on
Children and Disasters is hosting a
Long-Term Disaster Recovery Workshop
to explore challenges and solutions that
impact the unique needs of children.
This one day forum provides an
opportunity for Federal, State, Tribal,
local and non-governmental partners to
inform the Commission as it prepares its
Final Report to the President and the
Congress, due October 2010. Key issues
that will be discussed at the workshop
include children’s access to medical
care, the provision of mental health
services to children, and barriers to
information and data sharing.
Additional Information: Contacts:
Roberta Lavin, Office of Human Services
Emergency Preparedness and Response,
e-mail Roberta.lavin@acf.hhs.gov or
(202) 401–9306.
BILLING CODE 4184–01–M
Dated: December 30, 2009.
Carolyn M. Clancy,
AHRQ, Director.
[FR Doc. E9–31340 Filed 1–6–10; 8:45 am]
BILLING CODE 4160–90–M
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
Administration for Children and
Families
WReier-Aviles on DSKGBLS3C1PROD with NOTICES
AGENCY:
VerDate Nov<24>2008
14:42 Jan 06, 2010
Jkt 220001
SUPPLEMENTARY INFORMATION:
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
National Institute of Mental Health;
Notice of Meeting
Pursuant to section 10(d) of the
Federal Advisory Committee Act, as
amended (5 U.S.C. App.), notice is
hereby given of a meeting of the
National Advisory Mental Health
Council.
The meeting will be open to the
public as indicated below, with
attendance limited to space available.
Individuals who plan to attend and
need special assistance, such as sign
language interpretation or other
reasonable accommodations, should
notify the Contact Person listed below
in advance of the meeting.
The meeting will be closed to the
public in accordance with the
provisions set forth in sections
552b(c)(4) and 552b(c)(6), Title 5 U.S.C.,
as amended. The grant applications and
the discussions could disclose
confidential trade secrets or commercial
property such as patentable material,
and personal information concerning
individuals associated with the grant
applications, the disclosure of which
would constitute a clearly unwarranted
invasion of personal privacy.
Name of Committee: National Advisory
Mental Health Council.
Date: February 11–12, 2010.
PO 00000
Frm 00024
Fmt 4703
Sfmt 4703
991
Closed: February 11, 2010, 10 a.m. to 5
p.m.
Agenda: To review and evaluate grant
applications and review the activities of the
NIMH Intramural Research Programs.
Place: National Institutes of Health,
Neuroscience Center, 6001 Executive
Boulevard, Conference Room C/D/E,
Rockville, MD 20852.
Open: February 12, 2010, 8:30 a.m. to 12:30
p.m.
Agenda: Presentation of NIMH Director’s
report and discussion on NIMH program and
policy issues.
Place: National Institutes of Health,
Building 31, C Wing, 31 Center Drive, 6th
Floor, Conference Room 6, Bethesda, MD
20892
Contact Person: Jane A. Steinberg, PhD,
Director, Division of Extramural Activities,
National Institute of Mental Health, NIH,
Neuroscience Center, 6001 Executive Blvd.,
Room 6154, MSC 9609, Bethesda, MD 20892–
9609, 301–443–5047.
Any member of the public interested in
presenting oral comments to the committee
may notify the Contact Person listed on this
notice at least 10 days in advance of the
meeting. Interested individuals and
representatives of organizations may submit
a letter of intent, a brief description of the
organization represented, and a short
description of the oral presentation. Only one
representative of an organization may be
allowed to present oral comments and if
accepted by the committee, presentations
may be limited to five minutes. Both printed
and electronic copies are requested for the
record. In addition, any interested person
may file written comments with the
committee by forwarding their statement to
the Contact Person listed on this notice. The
statement should include the name, address,
telephone number and when applicable, the
business or professional affiliation of the
interested person.
In the interest of security, NIH has
instituted stringent procedures for entrance
onto the NIH campus. All visitor vehicles,
including taxicabs, hotel, and airport shuttles
will be inspected before being allowed on
campus. Visitors will be asked to show one
form of identification (for example, a
government-issued photo ID, driver’s license,
or passport) and to state the purpose of their
visit.
Information is also available on the
Institute’s/Center’s home page: https://
www.nimh.nih.gov/about/advisory-boardsand-groups/namhc/index.shtml where an
agenda and any additional information for
the meeting will be posted when available.
(Catalogue of Federal Domestic Assistance
Program Nos. 93.242, Mental Health Research
Grants; 93.281, Scientist Development
Award, Scientist Development Award for
Clinicians, and Research Scientist Award;
93.282, Mental Health National Research
Service Awards for Research Training,
National Institutes of Health, HHS)
E:\FR\FM\07JAN1.SGM
07JAN1
]]>Agencies
[Federal Register Volume 75, Number 4 (Thursday, January 7, 2010)]
[Notices]
[Pages 990-991]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: E9-31340]
-----------------------------------------------------------------------
DEPARTMENT OF HEALTH AND HUMAN SERVICES
Agency for Healthcare Research and Quality
HHS Intent To Publish Grant and Contract Solicitations for
Comparative Effectiveness Research (CER) Projects With Funds Allocated
to the Office of the Secretary From the American Recovery and
Reinvestment Act (ARRA)
AGENCY: Agency for Healthcare Research and Quality (AHRQ), HHS.
ACTION: Notice of intent.
-----------------------------------------------------------------------
SUMMARY: The Department of Health and Human Services announces its
intention to support new CER projects with funds allocated by the
American Recovery and Reinvestment Act (ARRA). The ARRA appropriated
$400 million to the Office of the Secretary for support of CER. AHRQ
has been designated point of contact for management of these funds.
Prioritization of the OS ARRA CER allocation was determined by
several factors: public input, the Comparative Effectiveness Research-
Coordination Implementation Team, the Federal Coordinating Council for
Comparative Effectiveness Research (FCC), and the Institute of Medicine
Report on CER. OS ARRA CER projects will focus, initially, on either
(1) one of the 14 priority conditions established by the Secretary of
the Department of Health and Human Services under Section 1013 of the
Medicare Prescription Drug, Improvement, and Modernization Act of 2003,
(2) 100 Institute of Medicine topic recommendations, or (3) topics that
fall into one of the AHRQ identified evidence gaps or are identified in
the FCC report. An additional integral focus for these OS ARRA CER
funds are the priority populations, which include low income groups;
minority groups; women; children; the elderly; and individuals with
special health care needs, including individuals with disabilities and
individuals who need chronic care or end-of-life health care. The CER
solicitations will come from a diverse set of divisions and agencies
across the Department of Health and Human Services.
DATES: HHS anticipates grant and contract solicitations to be published
over the next several months.
ADDRESSES: The future CER funding opportunity announcements will be
published in the NIH Guide: https://grants.nih.gov/grants/guide/ and on Grants.gov.: https://www.grants.gov/. Contract
solicitations can be found on the Federal Business Opportunity site at
https://www.fbo.gov/index?cck=1&au=&ck=.
FOR FURTHER INFORMATION CONTACT: Until the solicitations are published,
AHRQ cannot provide information on their contents.
Direct any general comments regarding the OS ARRA CER program to:
Kathleen Kendrick, Deputy Director, Office of the Director, Agency for
Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850,
Telephone: 301-427-1200, e-mail address: ARRA Support@AHRQ.HHS.gov.
SUPPLEMENTARY INFORMATION:
Background
The American Recovery and Reinvestment Act (ARRA) provided $1.1
billion for comparative effectiveness research (CER). The Act allocated
$300 million to the Agency for Healthcare Research and Quality (AHRQ),
$400 million to the National Institutes of Health (NIH), and $400
million to the Office of the Secretary (OS) of the Department of Health
and Human Services (HHS). These funds are dedicated specifically
towards CER and must be obligated by the end of fiscal year 2010.
Comparative Effectiveness Research Initiative Description
The Department of Health and Human Service's overall goal for the
investment in comparative effectiveness research is to promote high
quality care through broad availability of information that helps
clinicians and patients match the best science to individual needs and
preferences. Moreover, the investment can build a sustainable
foundation for CER so that it will enable--now and in the future the
United States healthcare system to deliver the highest quality and best
value care to all Americans.
Funding Opportunity Announcements soliciting grant applications and
Requests for Contracts for CER will provide $210.5 million for data
infrastructure and related research, $89.5 million for dissemination
and translation, $71 million for research, $7.6 million for inventory
and evaluation projects and $4 million for
[[Page 991]]
salary and benefits for ARRA-related staff and administrative support.
An additional, $17.4 million will be allocated to projects that
address any gaps within the new and existing CER programs.
Dated: December 30, 2009.
Carolyn M. Clancy,
AHRQ, Director.
[FR Doc. E9-31340 Filed 1-6-10; 8:45 am]
BILLING CODE 4160-90-M
