Government-Owned Inventions; Availability for Licensing, 989-990 [E9-31284]

Download as PDF Federal Register / Vol. 75, No. 4 / Thursday, January 7, 2010 / Notices 989 TRANSACTION GRANTED EARLY TERMINATION—Continued ET date Trans No. 25–NOV–09 .............................................................. 20100088 20100089 20100117 27–NOV–09 .............................................................. For Further Information Contact: Sandra M. Peay, Contact Representative or Renee Hallman, Contact Representative, Federal Trade Commission, Premerger Notification Office, Bureau of Competition, Room H– 303, Washington, DC 20580, (202) 326– 3100. By Direction of the Commission. Donald S. Clark, Secretary. [FR Doc. E9–31208 Filed 1–6–10; 8:45 am] BILLING CODE 6750–01–M DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Government-Owned Inventions; Availability for Licensing WReier-Aviles on DSKGBLS3C1PROD with NOTICES AGENCY: National Institutes of Health, Public Health Service, HHS. ACTION: Notice. SUMMARY: The inventions listed below are owned by an agency of the U.S. Government and are available for licensing in the U.S. in accordance with 35 U.S.C. 207 to achieve expeditious commercialization of results of federally-funded research and development. Foreign patent applications are filed on selected inventions to extend market coverage for companies and may also be available for licensing. ADDRESSES: Licensing information and copies of the U.S. patent applications listed below may be obtained by writing to the indicated licensing contact at the Office of Technology Transfer, National Institutes of Health, 6011 Executive Boulevard, Suite 325, Rockville, Maryland 20852–3804: telephone: 301– VerDate Nov<24>2008 14:42 Jan 06, 2010 Jkt 220001 20100154 ET req status G G G G G G G G G G G G G G G G Party name International Business Machines Corporation. International Business Machines Corporation. The Southern Company. Broadway Generating Company, LLC. West Georgia Generating Company, LLC. Broadway Generating Company, LLC. Southern Power Company. DeSoto County Generating Company, LLC. Ameriprise Financial, Inc. Bank of America Corporation. Bank of America, N.A. Columbia Wanger Asset Management, L.P. WAM Acquisition GP, Inc. ACS Actividades de Construccion y Servicios, S.A. William R. Pulice. Pulice Construction, Inc. 496–7057 fax: 301/402–0220. A signed Confidential Disclosure Agreement will be required to receive copies of the patent applications. Method of Preventing and Treating Metastatic Disease Description of Technology: Cancer that recurs as metastatic disease many years after primary tumor resection and adjuvant therapy appears to arise from tumor cells that disseminated early in the course of disease but did not develop into clinically apparent lesions. These long-term surviving, disseminated tumor cells maintain a state of dormancy, but may be triggered to proliferate through largely unknown factors. Inventors at the National Institutes of Health have discovered agents that prevent or treat recurrent metastatic cancer by inhibiting type I collagen production and downstream signaling through beta 1 integrin activation. Blocking activation of beta-1 integrin signaling using pharmacological approaches or using RNA interference was found to prevent reorganization of the cytoskeleton that is associated with proliferation of the dormant tumor cells. The technology provides compositions and methods for modulating the switch from tumor cell dormancy to proliferation clinical metastatic disease in a patient by administering beta-1 integrin signaling inhibitors. Applications • Method of treating metastatic disease by targeting components of the beta-1 integrin signaling pathway. • Method of preventing metastatic disease after removal of primary tumors. Advantage: Discovery of beta-1 integrin signaling pathway involvement provides a number of therapeutic targets PO 00000 Frm 00022 Fmt 4703 Sfmt 4703 for development of novel cancer therapeutics. Market: In the U.S., it is estimated that 192,370 women will be diagnosed with and 40,170 women will die of cancer of the breast in 2009. Although improved detection and treatment of primary tumors has raised the rate of survival there remains a high probability of recurrence of metastatic disease leading to mortality. Inventors: Dalit Barkan and Jeffrey E. Green (NCI). Publications: None related to this technology. Patent Status: U.S. Provisional Application No. 61/179,641 filed 19 May 2009 (HHS Reference No. E–192– 2009/0–US–01). Licensing Status: Available for licensing. Licensing Contact: Surekha Vathyam, PhD, 301–435–4076; vathyams@mail.nih.gov. Collaborative Research Opportunity: The Center for Cancer Research, Laboratory of Cancer Biology and Genetics, is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize this technology. Please contact John D. Hewes, PhD at 301–435– 3121 or hewesj@mail.nih.gov for more information. Diamidine Inhibitors of Tdp1 as AntiCancer Agents Description of Technology: Available for licensing and commercial development are methods and compositions for treating cancer, using novel compounds derived from diamidine. Diamidine and its derivatives are potent inhibitors of tyrosyl-DNA-phosphodiesterase (Tdp1). which may be useful in chemotherapy. E:\FR\FM\07JAN1.SGM 07JAN1 990 Federal Register / Vol. 75, No. 4 / Thursday, January 7, 2010 / Notices Camptothecins are effective Topoisomerase I (Top1) inhibitors, and two derivatives (Topotecan® and Camptosar®) are currently approved for treatment of ovarian and colorectal cancer. Camptothecins damage DNA by trapping covalent complexes between the Top1 catalytic tyrosine and the 3′end of the broken DNA. Tdp1 repairs Top1–DNA covalent complexes by hydrolyzing the tyrosyl-DNA bond. Thus, the presence and activity of Tdp1 can reduce the effectiveness of camptothecins as anticancer agents. In addition, Tpd1 repairs free-radicalmediated DNA breaks. Inhibition of Tpd1 using diamidine or its derivatives. may reduce repair of DNA breaks and increase the rate of apoptosis in cancer cells. In addition. diamidine derivatives have the potential to enhance the anti-neoplastic activity of Top1 inhibitors, by reducing repair of Top1–DNA lesions through inhibition of Tdp1. Development Status: Pre-clinical stage. Inventors: Yves G. Pommier and Christoph Marchand (NCI). Publications WReier-Aviles on DSKGBLS3C1PROD with NOTICES 1. Z Liao et al. Inhibition of human tyrosylDNA phosphodiesterase by aminoglycoside antibiotics and ribosome inhibitors. Mol Pharmacol. 2006 Jul:70(1):366–372. 2. Y Pommier. Camptothecins and topoisomerase I: a foot in the door. Targeting the genome beyond topoisomerase I with camptothecins and novel anticancer drugs: importance of DNA replication, repair and cell cycle checkpoints. Curr Med Chem Anticancer Agents. 2004 Sep; 4(5):429–434. Review. 3. Y Pommier et al. Repair of and checkpoint response to topoisomerase I mediated DNA damage. Mutat Res. 2003 Nov 27;532(1–2):173–203. Review. Patent Status: U.S. Patent Application No. 12/225,672 filed 26 Sep 2008 (HHS Reference No. E–165–2006/0–US–04). Licensing Status: Available for licensing. Licensing Contact: Betty Tong, PhD; 301–594–6565; tongb@mail.nih.gov. Collaborative Research Opportunity: The Laboratory of Molecular Pharmacology is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize Tdp1 inhibitors for the treatment of cancers. Please contact John D. Hewes, PhD at 301–435–3121 or hewesj@mail.nih.gov for more information. VerDate Nov<24>2008 14:42 Jan 06, 2010 Jkt 220001 Dated: December 23, 2009. Richard U. Rodriguez, Director, Division of Technology Development and Transfer, Office of Technology Transfer, National Institutes of Health. [FR Doc. E9–31284 Filed 1–6–10; 8:45 am] BILLING CODE 4140–01–M DEPARTMENT OF HEALTH AND HUMAN SERVICES Agency for Healthcare Research and Quality HHS Intent To Publish Grant and Contract Solicitations for Comparative Effectiveness Research (CER) Projects With Funds Allocated to the Office of the Secretary From the American Recovery and Reinvestment Act (ARRA) AGENCY: Agency for Healthcare Research and Quality (AHRQ), HHS. ACTION: Notice of intent. The Department of Health and Human Services announces its intention to support new CER projects with funds allocated by the American Recovery and Reinvestment Act (ARRA). The ARRA appropriated $400 million to the Office of the Secretary for support of CER. AHRQ has been designated point of contact for management of these funds. Prioritization of the OS ARRA CER allocation was determined by several factors: public input, the Comparative Effectiveness Research-Coordination Implementation Team, the Federal Coordinating Council for Comparative Effectiveness Research (FCC), and the Institute of Medicine Report on CER. OS ARRA CER projects will focus, initially, on either (1) one of the 14 priority conditions established by the Secretary of the Department of Health and Human Services under Section 1013 of the Medicare Prescription Drug, Improvement, and Modernization Act of 2003, (2) 100 Institute of Medicine topic recommendations, or (3) topics that fall into one of the AHRQ identified evidence gaps or are identified in the FCC report. An additional integral focus for these OS ARRA CER funds are the priority populations, which include low income groups; minority groups; women; children; the elderly; and individuals with special health care needs, including individuals with disabilities and individuals who need chronic care or end-of-life health care. The CER solicitations will come from a diverse set of divisions and agencies across the Department of Health and Human Services. SUMMARY: PO 00000 Frm 00023 Fmt 4703 Sfmt 4703 DATES: HHS anticipates grant and contract solicitations to be published over the next several months. ADDRESSES: The future CER funding opportunity announcements will be published in the NIH Guide: https:// grants.nih.gov/grants/guide/ and on Grants.gov.: https:// www.grants.gov/. Contract solicitations can be found on the Federal Business Opportunity site at https://www.fbo.gov/ index?cck=1&au=&ck=. FOR FURTHER INFORMATION CONTACT: Until the solicitations are published, AHRQ cannot provide information on their contents. Direct any general comments regarding the OS ARRA CER program to: Kathleen Kendrick, Deputy Director, Office of the Director, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850, Telephone: 301–427–1200, e-mail address: ARRA Support@AHRQ.HHS.gov. SUPPLEMENTARY INFORMATION: Background The American Recovery and Reinvestment Act (ARRA) provided $1.1 billion for comparative effectiveness research (CER). The Act allocated $300 million to the Agency for Healthcare Research and Quality (AHRQ), $400 million to the National Institutes of Health (NIH), and $400 million to the Office of the Secretary (OS) of the Department of Health and Human Services (HHS). These funds are dedicated specifically towards CER and must be obligated by the end of fiscal year 2010. Comparative Effectiveness Research Initiative Description The Department of Health and Human Service’s overall goal for the investment in comparative effectiveness research is to promote high quality care through broad availability of information that helps clinicians and patients match the best science to individual needs and preferences. Moreover, the investment can build a sustainable foundation for CER so that it will enable—now and in the future the United States healthcare system to deliver the highest quality and best value care to all Americans. Funding Opportunity Announcements soliciting grant applications and Requests for Contracts for CER will provide $210.5 million for data infrastructure and related research, $89.5 million for dissemination and translation, $71 million for research, $7.6 million for inventory and evaluation projects and $4 million for E:\FR\FM\07JAN1.SGM 07JAN1

Agencies

[Federal Register Volume 75, Number 4 (Thursday, January 7, 2010)]
[Notices]
[Pages 989-990]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: E9-31284]


=======================================================================
-----------------------------------------------------------------------

DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Government-Owned Inventions; Availability for Licensing

AGENCY: National Institutes of Health, Public Health Service, HHS.

ACTION: Notice.

-----------------------------------------------------------------------

SUMMARY: The inventions listed below are owned by an agency of the U.S. 
Government and are available for licensing in the U.S. in accordance 
with 35 U.S.C. 207 to achieve expeditious commercialization of results 
of federally-funded research and development. Foreign patent 
applications are filed on selected inventions to extend market coverage 
for companies and may also be available for licensing.

ADDRESSES: Licensing information and copies of the U.S. patent 
applications listed below may be obtained by writing to the indicated 
licensing contact at the Office of Technology Transfer, National 
Institutes of Health, 6011 Executive Boulevard, Suite 325, Rockville, 
Maryland 20852-3804: telephone: 301-496-7057 fax: 301/402-0220. A 
signed Confidential Disclosure Agreement will be required to receive 
copies of the patent applications.

Method of Preventing and Treating Metastatic Disease

    Description of Technology: Cancer that recurs as metastatic disease 
many years after primary tumor resection and adjuvant therapy appears 
to arise from tumor cells that disseminated early in the course of 
disease but did not develop into clinically apparent lesions. These 
long-term surviving, disseminated tumor cells maintain a state of 
dormancy, but may be triggered to proliferate through largely unknown 
factors. Inventors at the National Institutes of Health have discovered 
agents that prevent or treat recurrent metastatic cancer by inhibiting 
type I collagen production and downstream signaling through beta 1 
integrin activation. Blocking activation of beta-1 integrin signaling 
using pharmacological approaches or using RNA interference was found to 
prevent reorganization of the cytoskeleton that is associated with 
proliferation of the dormant tumor cells. The technology provides 
compositions and methods for modulating the switch from tumor cell 
dormancy to proliferation clinical metastatic disease in a patient by 
administering beta-1 integrin signaling inhibitors.

Applications

     Method of treating metastatic disease by targeting 
components of the beta-1 integrin signaling pathway.
     Method of preventing metastatic disease after removal of 
primary tumors.
    Advantage: Discovery of beta-1 integrin signaling pathway 
involvement provides a number of therapeutic targets for development of 
novel cancer therapeutics.
    Market: In the U.S., it is estimated that 192,370 women will be 
diagnosed with and 40,170 women will die of cancer of the breast in 
2009. Although improved detection and treatment of primary tumors has 
raised the rate of survival there remains a high probability of 
recurrence of metastatic disease leading to mortality.
    Inventors: Dalit Barkan and Jeffrey E. Green (NCI).
    Publications: None related to this technology.
    Patent Status: U.S. Provisional Application No. 61/179,641 filed 19 
May 2009 (HHS Reference No. E-192-2009/0-US-01).
    Licensing Status: Available for licensing.
    Licensing Contact: Surekha Vathyam, PhD, 301-435-4076; 
vathyams@mail.nih.gov.
    Collaborative Research Opportunity: The Center for Cancer Research, 
Laboratory of Cancer Biology and Genetics, is seeking statements of 
capability or interest from parties interested in collaborative 
research to further develop, evaluate, or commercialize this 
technology. Please contact John D. Hewes, PhD at 301-435-3121 or 
hewesj@mail.nih.gov for more information.

Diamidine Inhibitors of Tdp1 as Anti-Cancer Agents

    Description of Technology: Available for licensing and commercial 
development are methods and compositions for treating cancer, using 
novel compounds derived from diamidine. Diamidine and its derivatives 
are potent inhibitors of tyrosyl-DNA-phosphodiesterase (Tdp1). which 
may be useful in chemotherapy.

[[Page 990]]

    Camptothecins are effective Topoisomerase I (Top1) inhibitors, and 
two derivatives (Topotecan[supreg] and Camptosar[supreg]) are currently 
approved for treatment of ovarian and colorectal cancer. Camptothecins 
damage DNA by trapping covalent complexes between the Top1 catalytic 
tyrosine and the 3'-end of the broken DNA. Tdp1 repairs Top1-DNA 
covalent complexes by hydrolyzing the tyrosyl-DNA bond. Thus, the 
presence and activity of Tdp1 can reduce the effectiveness of 
camptothecins as anticancer agents. In addition, Tpd1 repairs free-
radical-mediated DNA breaks.
    Inhibition of Tpd1 using diamidine or its derivatives. may reduce 
repair of DNA breaks and increase the rate of apoptosis in cancer 
cells. In addition. diamidine derivatives have the potential to enhance 
the anti-neoplastic activity of Top1 inhibitors, by reducing repair of 
Top1-DNA lesions through inhibition of Tdp1.
    Development Status: Pre-clinical stage.
    Inventors: Yves G. Pommier and Christoph Marchand (NCI).

Publications

    1. Z Liao et al. Inhibition of human tyrosyl-DNA 
phosphodiesterase by aminoglycoside antibiotics and ribosome 
inhibitors. Mol Pharmacol. 2006 Jul:70(1):366-372.
    2. Y Pommier. Camptothecins and topoisomerase I: a foot in the 
door. Targeting the genome beyond topoisomerase I with camptothecins 
and novel anticancer drugs: importance of DNA replication, repair 
and cell cycle checkpoints. Curr Med Chem Anticancer Agents. 2004 
Sep; 4(5):429-434. Review.
    3. Y Pommier et al. Repair of and checkpoint response to 
topoisomerase I mediated DNA damage. Mutat Res. 2003 Nov 27;532(1-
2):173-203. Review.
    Patent Status: U.S. Patent Application No. 12/225,672 filed 26 Sep 
2008 (HHS Reference No. E-165-2006/0-US-04).
    Licensing Status: Available for licensing.
    Licensing Contact: Betty Tong, PhD; 301-594-6565; 
tongb@mail.nih.gov.
    Collaborative Research Opportunity: The Laboratory of Molecular 
Pharmacology is seeking statements of capability or interest from 
parties interested in collaborative research to further develop, 
evaluate, or commercialize Tdp1 inhibitors for the treatment of 
cancers. Please contact John D. Hewes, PhD at 301-435-3121 or 
hewesj@mail.nih.gov for more information.

    Dated: December 23, 2009.
Richard U. Rodriguez,
Director, Division of Technology Development and Transfer, Office of 
Technology Transfer, National Institutes of Health.
[FR Doc. E9-31284 Filed 1-6-10; 8:45 am]
BILLING CODE 4140-01-M

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.