Government-Owned Inventions; Availability for Licensing, 59560-59561 [E9-27633]

Download as PDF 59560 Federal Register / Vol. 74, No. 221 / Wednesday, November 18, 2009 / Notices Dated: November 12, 2009. David Horowitz, Assistant Commissioner for Policy. [FR Doc. E9–27659 Filed 11–17–09; 8:45 am] DEPARTMENT OF HEALTH AND HUMAN SERVICES DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration National Institutes of Health [Docket No. FDA–2009–C–0543] Government-Owned Inventions; Availability for Licensing BILLING CODE 4160–01–S DEPARTMENT OF HEALTH AND HUMAN SERVICES Sauflon Pharmaceuticals Ltd.; Filing of Color Additive Petition Administration for Children and Families HHS. AGENCY: Administration on Children, Youth and Families; Notice To Award One Expansion Supplement Grant AGENCY: Family and Youth Services Bureau, ACYF, ACF, HHS. ACTION: Notice to award one expansion supplement grant. mstockstill on DSKH9S0YB1PROD with NOTICES CFDA Number: 93.592. Legislative Authority: The Family Violence Prevention and Services Act, 42 U.S.C. 10401 through 10421, as extended by the Department of Health and Human Services Appropriations Act, 2009, Public Law 111–8. Total Amount of Award: $225,000. Project Period: September 30, 2009– September 29, 2010. SUMMARY: This notice announces the award of an expansion supplement grant to one grantee under the Family and Youth Services Bureau (FYSB)/ Family Violence Prevention and Services Program. The expansion supplement award is made to the Pennsylvania Coalition Against Domestic Violence, Harrisburg, PA, a technical assistance provider, to support their capacity to provide technical support and training to State and local domestic violence advocates and social service agencies. These efforts will allow FYSB to support collaborative work to enhance the capacity of Temporary Assistance to Needy Families (TANF) and other Federal programs to provide assistance to eligible victims of domestic violence. FOR FURTHER INFORMATION CONTACT: Marylouise Kelley, Ph.D., Director, Family Violence Prevention and Services Program, 1250 Maryland Avenue, SW., Suite 8216, Washington, DC 20024. Telephone: 202–104–5756 Email: Marylouise.kelley@acf.hhs.gov. Dated: November 10, 2009. Maiso L. Bryant, Acting Commissioner, Administration on Children, Youth and Families. [FR Doc. E9–27667 Filed 11–17–09; 8:45 am] BILLING CODE 4184–32–P VerDate Nov<24>2008 16:30 Nov 17, 2009 Jkt 220001 ACTION: Food and Drug Administration, Notice. SUMMARY: The Food and Drug Administration (FDA) is announcing that Sauflon Pharmaceuticals Ltd. has filed a petition proposing that the color additive regulations be amended to provide for the safe use of disodium 1amino-4-[[4-[(2-bromo-1oxoallyl)amino]-2sulfonatophenyl]amino]-9,10-dihydro9,10-dioxoanthracene-2-sulfonate (CAS Reg. No. 70209–99–3) as a color additive in contact lenses. FOR FURTHER INFORMATION CONTACT: Raphael A. Davy, Center for Food Safety and Applied Nutrition (HFS–265), Food and Drug Administration, 5100 Paint Branch Pkwy., College Park, MD 20740– 3835, 301–436–1272. Under the Federal Food, Drug, and Cosmetic Act (sec. 721(d)(1) (21 U.S.C. 379e(d)(1))), notice is given that a color additive petition (CAP 8C0287) has been filed by Sauflon Pharmaceuticals Ltd., 49–53 York St., Twickenham, Middlesex, TW1 3LP, United Kingdom. The petition proposes to amend the color additive regulations in 21 CFR part 73, subpart D, Medical Devices to provide for the safe use of disodium 1-amino-4-[[4-[(2bromo-1-oxoallyl)amino]-2sulfonatophenyl]amino]-9,10-dihydro9,10-dioxoanthracene-2-sulfonate (CAS Reg. No. 70209–99–3) as a color additive in contact lenses. The agency has determined under 21 CFR 25.32(l) that this action is of a type that does not individually or cumulatively have a significant effect on the human environment. Therefore, neither an environmental assessment nor an environmental impact statement is required. SUPPLEMENTARY INFORMATION: Dated: November 10, 2009. Laura M. Tarantino, Director, Office of Food Additive Safety, Center for Food Safety and Applied Nutrition. [FR Doc. E9–27629 Filed 11–17–09; 8:45 am] BILLING CODE 4160–01–S PO 00000 Frm 00041 Fmt 4703 Sfmt 4703 AGENCY: National Institutes of Health, Public Health Service, HHS. ACTION: Notice. SUMMARY: The inventions listed below are owned by an agency of the U.S. Government and are available for licensing in the U.S. in accordance with 35 U.S.C. 207 to achieve expeditious commercialization of results of federally-funded research and development. Foreign patent applications are filed on selected inventions to extend market coverage for companies and may also be available for licensing. ADDRESSES: Licensing information and copies of the U.S. patent applications listed below may be obtained by writing to the indicated licensing contact at the Office of Technology Transfer, National Institutes of Health, 6011 Executive Boulevard, Suite 325, Rockville, Maryland 20852–3804; telephone: 301/ 496–7057; fax: 301/402–0220. A signed Confidential Disclosure Agreement will be required to receive copies of the patent applications. A Novel Treatment for Malarial Infections Description of Invention: The inventions described herein are antimalarial small molecule inhibitors of the plasmodial surface anion channel (PSAC), an essential nutrient acquisition ion channel expressed on human erythrocytes infected with malaria parasites. These inhibitors were discovered by high-throughput screening of chemical libraries and analysis of their ability to kill malaria parasites in culture. Two separate classes of inhibitors were found to work synergistically in combination against PSAC and killed malaria cultures at markedly lower concentrations than separately. These inhibitors have high affinity and specificity for PSAC and have acceptable cytotoxicity profiles. Preliminary in vivo testing of these compounds in a mouse malaria model is currently ongoing. Applications: Treatment of malarial infections. Advantages: Novel drug treatment for malarial infections; Synergistic effect of these compounds on PSAC. Development Status: In vitro and in vivo data can be provided upon request. Market: Treatment of malarial infection. E:\FR\FM\18NON1.SGM 18NON1 Federal Register / Vol. 74, No. 221 / Wednesday, November 18, 2009 / Notices Inventor: Sanjay A. Desai (NIAID) mstockstill on DSKH9S0YB1PROD with NOTICES Publications 1. M Kang, G Lisk, S Hollingworth, SM Baylor, SA Desai. Malaria parasites are rapidly killed by dantrolene derivatives specific for the plasmodial surface anion channel. Mol. Pharmacol. 2005 Jul;68(1):34–40. 2. SA Desai, SM Bezrukov, J Zimmerberg. A voltage-dependent channel involved in nutrient uptake by red blood cells infected with the malaria parasite. Nature. 2000 Aug 31;406(6799):1001–1005. Patent Status: International Patent Application No. PCT/US09/50637 (HHS Reference No. E–202–2008/0–PCT–02) filed 15 Jul 2009. Licensing Status: Available for licensing. Licensing Contact: Kevin W. Chang; 301–435–5018; changke@mail.nih.gov. Collaborative Research Opportunity: The NIAID Office of Technology Development is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize antimalarial drugs that target PSAC or other parasite-specific transporters. Please contact Dana Hsu at 301–496–2644 for more information. Optimized Expression of IL–12 Cytokine Family Description of Invention: The IL–12 family of cytokines (IL–12, IL–23, and IL–27) has an important role in inflammation and autoimmune diseases. IL–12 is produced by macrophages and dendritic cells in response to certain bacterial and parasitic infections and is a powerful inducer of IFN-gamma production. IL–23 is proposed to stimulate a subset of T cells to produce IL–17, which in turn induce the production of proinflammatory cytokines that lead to a protective response during infection. IL–27 appears to have duel functions as an initiator of TH1-type (cellular immunity) immune responses and as an attenuator of immune/inflammatory responses. The present inventions provide methods for improved expression of multimeric proteins by engineering different ratios of the subunit expression units in a cell or upon expression from a multi-promoter plasmid having different strength promoters. The inventors have improved the levels and efficiency of expression of the IL–12 family of cytokines, which includes IL– 12, IL–23, and IL–27, by adjusting the transcription and translation of the alpha and beta subunits that comprise the heterodimeric proteins. Optimal VerDate Nov<24>2008 16:30 Nov 17, 2009 Jkt 220001 ratios of expression for the two (2) subunits were determined for IL–12, IL– 23, and IL–27. Applications: Tumor treatment; Antiviral therapy; Anti-inflammatory therapy. Advantages: Increased expression and stability of in vitro expressed IL–12, IL– 23 and IL–27 cytokines. Development Status: In vitro data and data in animal models can be provided upon request. Market: Infectious Diseases; Cancer; Inflammatory Diseases. Inventors: George N. Pavlakis and Barbara K. Felber (NCI). Patent Status: International PCT Patent Application No. PCT/US09/ 043481 filed 11 May 2009 (HHS Reference No. E–192–2008/1–PCT–02). Licensing Status: Available for licensing. Licensing Contact: Kevin W. Chang, Ph.D.; 301–435–5018; changke@mail.nih.gov. Collaborative Research Opportunity: The Center for Cancer Research, Human Retrovirus Section, is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize delivery of cytokines of the IL–12 family in cancer and other indications. Please contact John D. Hewes, Ph.D. at 301–435–3121 or hewesj@mail.nih.gov for more information. Dated: November 9, 2009. Richard U. Rodriguez, Director, Division of Technology Development and Transfer, Office of Technology Transfer, National Institutes of Health. [FR Doc. E9–27633 Filed 11–17–09; 8:45 am] BILLING CODE 4140–01–P DEPARTMENT OF HEALTH AND HUMAN SERVICES Indian Health Service Loan Repayment Program for Repayment of Health Professions Educational Loans Announcement Type: Initial. CFDA Number: 93.164. Key Dates: January 15, 2010 first award cycle deadline date, September 30, 2010 entry on duty deadline date. I. Funding Opportunity Description The Indian Health Service (IHS) estimated budget request for Fiscal Year (FY) 2010 includes $17,488,854 for the IHS Loan Repayment Program (LRP) for health professional educational loans (undergraduate and graduate) in return for full-time clinical service in Indian health programs. PO 00000 Frm 00042 Fmt 4703 Sfmt 4703 59561 This program announcement is subject to the appropriation of funds. This notice is being published early to coincide with the recruitment activity of the IHS, which competes with other Government and private health management organizations to employ qualified health professionals. This program is authorized by Section 108 of the Indian Health Care Improvement Act (IHCIA) as amended, 25 U.S.C. 1601 et seq. The IHS invites potential applicants to request an application for participation in the LRP. II . Award Information The estimated amount available is approximately $17,488,854 to support approximately 391 competing awards averaging $44,740 per award for a two year contract. One year contract continuations will receive priority consideration in any award cycle. Applicants selected for participation in the FY 2010 program cycle will be expected to begin their service period no later than September 30, 2010. III. Eligibility Information 1. Eligible Applicants Pursuant to Section 108(b), to be eligible to participate in the LRP, an individual must: (1) (A) Be enrolled— (i) In a course of study or program in an accredited institution, as determined by the Secretary, within any State and be scheduled to complete such course of study in the same year such individual applies to participate in such program; or (ii) In an approved graduate training program in a health profession; or (B) Have a degree in a health profession and a license to practice in a state; and (2) (A) Be eligible for, or hold an appointment as a Commissioned Officer in the Regular or Reserve Corps of the Public Health Service (PHS); or (B) Be eligible for selection for service in the Regular or Reserve Corps of the PHS; or (C) Meet the professional standards for civil service employment in the IHS; or (D) Be employed in an Indian health program without service obligation; and (E) Submit to the Secretary an application for a contract to the LRP. The Secretary must approve the contract before the disbursement of loan repayments can be made to the participant. Participants will be required to fulfill their contract service agreements through full-time clinical practice at an Indian health program site determined by the Secretary. Loan E:\FR\FM\18NON1.SGM 18NON1

Agencies

[Federal Register Volume 74, Number 221 (Wednesday, November 18, 2009)]
[Notices]
[Pages 59560-59561]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: E9-27633]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Government-Owned Inventions; Availability for Licensing

AGENCY: National Institutes of Health, Public Health Service, HHS.

ACTION: Notice.

-----------------------------------------------------------------------

SUMMARY: The inventions listed below are owned by an agency of the U.S. 
Government and are available for licensing in the U.S. in accordance 
with 35 U.S.C. 207 to achieve expeditious commercialization of results 
of federally-funded research and development. Foreign patent 
applications are filed on selected inventions to extend market coverage 
for companies and may also be available for licensing.

ADDRESSES: Licensing information and copies of the U.S. patent 
applications listed below may be obtained by writing to the indicated 
licensing contact at the Office of Technology Transfer, National 
Institutes of Health, 6011 Executive Boulevard, Suite 325, Rockville, 
Maryland 20852-3804; telephone: 301/496-7057; fax: 301/402-0220. A 
signed Confidential Disclosure Agreement will be required to receive 
copies of the patent applications.

A Novel Treatment for Malarial Infections

    Description of Invention: The inventions described herein are 
antimalarial small molecule inhibitors of the plasmodial surface anion 
channel (PSAC), an essential nutrient acquisition ion channel expressed 
on human erythrocytes infected with malaria parasites. These inhibitors 
were discovered by high-throughput screening of chemical libraries and 
analysis of their ability to kill malaria parasites in culture. Two 
separate classes of inhibitors were found to work synergistically in 
combination against PSAC and killed malaria cultures at markedly lower 
concentrations than separately. These inhibitors have high affinity and 
specificity for PSAC and have acceptable cytotoxicity profiles. 
Preliminary in vivo testing of these compounds in a mouse malaria model 
is currently ongoing.
    Applications: Treatment of malarial infections.
    Advantages: Novel drug treatment for malarial infections; 
Synergistic effect of these compounds on PSAC.
    Development Status: In vitro and in vivo data can be provided upon 
request.
    Market: Treatment of malarial infection.

[[Page 59561]]

    Inventor: Sanjay A. Desai (NIAID)

Publications

    1. M Kang, G Lisk, S Hollingworth, SM Baylor, SA Desai. Malaria 
parasites are rapidly killed by dantrolene derivatives specific for the 
plasmodial surface anion channel. Mol. Pharmacol. 2005 Jul;68(1):34-40.
    2. SA Desai, SM Bezrukov, J Zimmerberg. A voltage-dependent channel 
involved in nutrient uptake by red blood cells infected with the 
malaria parasite. Nature. 2000 Aug 31;406(6799):1001-1005.
    Patent Status: International Patent Application No. PCT/US09/50637 
(HHS Reference No. E-202-2008/0-PCT-02) filed 15 Jul 2009.
    Licensing Status: Available for licensing.
    Licensing Contact: Kevin W. Chang; 301-435-5018; 
changke@mail.nih.gov.
    Collaborative Research Opportunity: The NIAID Office of Technology 
Development is seeking statements of capability or interest from 
parties interested in collaborative research to further develop, 
evaluate, or commercialize antimalarial drugs that target PSAC or other 
parasite-specific transporters. Please contact Dana Hsu at 301-496-2644 
for more information.

Optimized Expression of IL-12 Cytokine Family

    Description of Invention: The IL-12 family of cytokines (IL-12, IL-
23, and IL-27) has an important role in inflammation and autoimmune 
diseases. IL-12 is produced by macrophages and dendritic cells in 
response to certain bacterial and parasitic infections and is a 
powerful inducer of IFN-gamma production. IL-23 is proposed to 
stimulate a subset of T cells to produce IL-17, which in turn induce 
the production of proinflammatory cytokines that lead to a protective 
response during infection. IL-27 appears to have duel functions as an 
initiator of TH1-type (cellular immunity) immune responses and as an 
attenuator of immune/inflammatory responses.
    The present inventions provide methods for improved expression of 
multimeric proteins by engineering different ratios of the subunit 
expression units in a cell or upon expression from a multi-promoter 
plasmid having different strength promoters. The inventors have 
improved the levels and efficiency of expression of the IL-12 family of 
cytokines, which includes IL-12, IL-23, and IL-27, by adjusting the 
transcription and translation of the alpha and beta subunits that 
comprise the heterodimeric proteins. Optimal ratios of expression for 
the two (2) subunits were determined for IL-12, IL-23, and IL-27.
    Applications: Tumor treatment; Anti-viral therapy; Anti-
inflammatory therapy.
    Advantages: Increased expression and stability of in vitro 
expressed IL-12, IL-23 and IL-27 cytokines.
    Development Status: In vitro data and data in animal models can be 
provided upon request.
    Market: Infectious Diseases; Cancer; Inflammatory Diseases.
    Inventors: George N. Pavlakis and Barbara K. Felber (NCI).
    Patent Status: International PCT Patent Application No. PCT/US09/
043481 filed 11 May 2009 (HHS Reference No. E-192-2008/1-PCT-02).
    Licensing Status: Available for licensing.
    Licensing Contact: Kevin W. Chang, Ph.D.; 301-435-5018; 
changke@mail.nih.gov.
    Collaborative Research Opportunity: The Center for Cancer Research, 
Human Retrovirus Section, is seeking statements of capability or 
interest from parties interested in collaborative research to further 
develop, evaluate, or commercialize delivery of cytokines of the IL-12 
family in cancer and other indications. Please contact John D. Hewes, 
Ph.D. at 301-435-3121 or hewesj@mail.nih.gov for more information.

    Dated: November 9, 2009.
Richard U. Rodriguez,
Director, Division of Technology Development and Transfer, Office of 
Technology Transfer, National Institutes of Health.
[FR Doc. E9-27633 Filed 11-17-09; 8:45 am]
BILLING CODE 4140-01-P
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