Importer of Controlled Substances; Notice of Registration, 46230-46231 [E9-21534]
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46230
Federal Register / Vol. 74, No. 172 / Tuesday, September 8, 2009 / Notices
manufacture bulk controlled substance
intermediates for sale to its customers.
No comments or objections have been
received. DEA has considered the
factors in 21 U.S.C. 823(a) and § 952(a)
and determined that the registration of
Penick Corporation to import the basic
classes of controlled substances is
consistent with the public interest and
with United States obligations under
international treaties, conventions, or
protocols in effect on May 1, 1971, at
this time. DEA has investigated Penick
Corporation to ensure that the
company’s registration is consistent
with the public interest. The
investigation has included inspection
and testing of the company’s physical
security systems, verification of the
company’s compliance with state and
local laws, and a review of the
company’s background and history.
Therefore, pursuant to 21 U.S.C. 952(a)
and § 958(a), and in accordance with 21
CFR 1301.34, the above named company
is granted registration as an importer of
the basic classes of controlled
substances listed.
Dated: August 21, 2009.
Joseph T. Rannazzisi,
Deputy Assistant Administrator, Office of
Diversion Control, Drug Enforcement
Administration.
[FR Doc. E9–21536 Filed 9–4–09; 8:45 am]
BILLING CODE 4410–09–P
DEPARTMENT OF JUSTICE
Drug Enforcement Administration
Importer of Controlled Substances;
Notice of Registration
By Notice dated June 3, 2009, and
published in the Federal Register on
June 9, 2009, (74 FR 27347), Research
Triangle Institute, Kenneth H. Davis Jr.,
Hermann Building, East Institute Drive,
P.O. Box 12194, Research Triangle,
North Carolina 27709, made application
by renewal to the Drug Enforcement
Administration (DEA) to be registered as
an importer of the basic classes of
controlled substances listed in
schedules I and II:
jlentini on DSKJ8SOYB1PROD with NOTICES
Drug
1-(1-Phenylcyclohexyl)pyrrolidine
(7458).
1-[1-(2Thienyl)cyclohexy]piperidine
(7470).
1-[1-(2Thienyl)cyclohexyl]pyrrolidine
(7473).
1-Methyl-4-phenyl-4propionoxypiperidine (9661).
VerDate Nov<24>2008
17:32 Sep 04, 2009
Schedule
I
I
I
I
Jkt 217001
Drug
Schedule
1-(2-Phenylethyl)-4-phenyl-4acetoxypiperidine (9663).
2,5-Dimethoxy-4-(n)propylthiophenethylamine
(7348).
2,5-Dimethoxy-4ethylamphetamine (7399).
2,5-Dimethoxyamphetamine
(7396).
3,4,5-Trimethoxyamphetamine
(7390).
3,4-Methylenedioxyamphetamine
(7400).
3,4Methylenedioxymethamphetamine (7405).
3,4-Methylenedioxy-Nethylamphetamine (7404).
3-Methylfentanyl (9813) ................
3-Methylthiofentanyl (9833) ..........
4-Bromo-2,5dimethoxyamphetamine (7391).
4-Bromo-2,5dimethoxyphenethylamine
(7392).
4-Methyl-2,5dimethoxyamphetamine (7395).
4-Methylaminorex (cis isomer)
(1590).
4-Methoxyamphetamine (7411) ...
5-Methoxy-3,4methylenedioxyamphetamine
(7401).
5-Methoxy-N,Ndiisopropyltryptamine (7439).
Acetorphine (9319) .......................
Acetyl-alpha-methylfentanyl
(9815).
Acetyldihydrocodeine (9051) ........
Acetylmethadol (9601) .................
Allylprodine (9602) .......................
Alphacetylmethadol except levoalphacetylmethadol (9603).
Alpha-ethyltryptamine (7249) .......
Alphameprodine (9604) ................
Alphamethadol (9605) ..................
Alpha-methylfentanyl (9814) ........
Alpha-methylthiofentanyl (9832) ...
Alpha-methyltryptamine (7432) ....
Aminorex (1585) ...........................
Benzethidine (9606) .....................
Benzylmorphine (9052) ................
Betacetylmethadol (9607) ............
Beta-hydroxy-3-methylfentanyl
(9831).
Beta-hydroxyfentanyl (9830) ........
Betameprodine (9608) ..................
Betamethadol (9609) ....................
Betaprodine (9611) .......................
Bufotenine (7433) .........................
Cathinone (1235) ..........................
Clonitazene (9612) .......................
Codeine methylbromide (9070) ....
Codeine-N-Oxide (9053) ..............
Cyprenorphine (9054) ..................
Desomorphine (9055) ...................
Dextromoramide (9613) ...............
Diampromide (9615) .....................
Diethylthiambutene (9616) ...........
Diethyltryptamine (7434) ..............
Difenoxin (9168) ...........................
Dihydromorphine (9145) ...............
Dimenoxadol (9617) .....................
Dimepheptanol (9618) ..................
PO 00000
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Sfmt 4703
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Drug
Dimethylthiambutene (9619) ........
Dimethyltryptamine (7435) ...........
Dioxaphetyl butyrate (9621) .........
Dipipanone (9622) ........................
Drotebanol (9335) ........................
Ethylmethylthiambutene (9623) ....
Etonitazene (9624) .......................
Etorphine except HCl (9056) ........
Etoxeridine (9625) ........................
Fenethylline (1503) .......................
Furethidine (9626) ........................
Gamma
Hydroxybutyric
Acid
(2010).
Heroin (9200) ...............................
Hydromorphinol (9301) .................
Hydroxypethidine (9627) ..............
Ibogaine (7260) ............................
Ketobemidone (9628) ...................
Levomoramide (9629) ..................
Levophenacylmorphan (9631) ......
Lysergic acid diethylamide (7315)
Marihuana (7360) .........................
Mecloqualone (2572) ....................
Mescaline (7381) ..........................
Methaqualone (2565) ...................
Methcathinone (1237) ..................
Methyldesorphine (9302) ..............
Methyldihydromorphine (9304) .....
Morpheridine (9632) .....................
Morphine methylbromide (9305) ..
Morphine methylsulfonate (9306)
Morphine-N-Oxide (9307) .............
Myrophine (9308) .........................
N,N-Dimethylamphetamine (1480)
N-[1-(2-thienyl)methyl-4-piperidyl]N-phenylpropanamide (9834).
N-[1-benzyl-4-piperidyl]-Nphenylpropanamide (9818).
N-Benzylpiperazine (7493) ...........
N-Ethyl-3-piperidyl
benzilate
(7482).
N-Ethylamphetamine (1475) ........
N-Ethyl-l-phenylcyclohexylamine
(7455).
N-Hydroxy-3,4methylenedioxyamphetamine
(7402).
Nicocodeine (9309) ......................
Nicomorphine (9312) ....................
N-Methyl-3-piperidyl
benzilate
(7484).
Noracymethadol (9633) ................
Norlevorphanol (9634) ..................
Normethadone (9635) ..................
Normorphine (9313) .....................
Norpipanone (9636) .....................
Para-Fluorofentanyl (9812) ..........
Parahexyl (7374) ..........................
Peyote (7415) ...............................
Phenadoxone (9637) ....................
Phenampromide (9638) ................
Phenomorphan (9647) .................
Phenoperidine (9641) ...................
Pholcodine (9314) ........................
Piritramide (9642) .........................
Proheptazine (9643) .....................
Properidine (9644) ........................
Propiram (9649) ...........................
Psilocybin (7437) ..........................
Psilocyn (7438) .............................
Racemoramide (9645) ..................
Tetrahydrocannabinols (7370) .....
Thebacon (9315) ..........................
Thiofentanyl (9835) ......................
E:\FR\FM\08SEN1.SGM
08SEN1
Schedule
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46231
Federal Register / Vol. 74, No. 172 / Tuesday, September 8, 2009 / Notices
Drug
Schedule
jlentini on DSKJ8SOYB1PROD with NOTICES
Tilidine (9750) ...............................
Trimeperidine (9646) ....................
1-Phenylcyclohexylamine (7460)
1Piperidinocyclohexanecarbonitrile (8603).
Alfentanil (9737) ...........................
Alphaprodine (9010) .....................
Amobarbital (2125) .......................
Amphetamine (1100) ....................
Anileridine (9020) .........................
Bezitramide (9800) .......................
Carfentanil (9743) .........................
Coca Leaves (9040) .....................
Cocaine (9041) .............................
Codeine (9050) .............................
Dextropropoxyphene, bulk (nondosage forms) (9273).
Dihydrocodeine (9120) .................
Dihydroetorphine (9334) ...............
Diphenoxylate (9170) ...................
Ethylmorphine (9190) ...................
Etorphine Hcl (9059) ....................
Fentanyl (9801) ............................
Glutethimide (2550) ......................
Hydrocodone (9193) .....................
Hydromorphone (9150) ................
Isomethadone (9226) ...................
Levo-alphacetylmethadol (9648) ..
Levomethorphan (9210) ...............
Levorphanol (9220) ......................
Lisdexamfetamine (1205) .............
Meperidine (9230) ........................
Meperidine intermediate-A (9232)
Meperidine intermediate-B (9233)
Meperidine intermediate-C (9234)
Metazocine (9240) ........................
Methadone (9250) ........................
Methadone intermediate (9254) ...
Methamphetamine (1105) ............
Methylphenidate (1724) ................
Metopon (9260) ............................
Moramide intermediate (9802) .....
Morphine (9300) ...........................
Nabilone (7379) ............................
Opium, raw (9600) .......................
Opium extracts (9610) ..................
Opium fluid extract (9620) ............
Opium tincture (9630) ..................
Opium, granulated (9640) ............
Oxycodone (9143) ........................
Oxymorphone (9652) ...................
Pentobarbital (2270) .....................
Phenazocine (9715) .....................
Phencyclidine (7471) ....................
Phenmetrazine (1631) ..................
Phenylacetone (8501) ..................
Piminodine (9730) ........................
Powdered opium (9639) ...............
Racemethorphan (9732) ..............
Racemorphan (9733) ...................
Remifentanil (9739) ......................
Secobarbital (2315) ......................
Sufentanil (9740) ..........................
Thebaine (9333) ...........................
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Dated: August 28, 2009.
Joseph T. Rannazzisi,
Deputy Assistant Administrator, Office of
Diversion Control, Drug Enforcement
Administration.
[FR Doc. E9–21534 Filed 9–4–09; 8:45 am]
BILLING CODE 4410–09–M
DEPARTMENT OF JUSTICE
Drug Enforcement Administration
Manufacturer of Controlled
Substances; Notice of Application
The company plans to import small
quantities of the listed controlled
substances for the National Institute on
Drug Abuse (NIDA) for research
activities.
No comments or objections have been
received. DEA has considered the
VerDate Nov<24>2008
17:32 Sep 04, 2009
Jkt 217001
factors in 21 U.S.C. 823(a) and 952(a)
and determined that the registration of
Research Triangle Institute to import the
basic class of controlled substance is
consistent with the public interest and
with United States obligations under
international treaties, conventions, or
protocols in effect on May 1, 1971, at
this time. DEA has investigated
Research Triangle Institute to ensure
that the company’s registration is
consistent with the public interest. The
investigation has included inspection
and testing of the company’s physical
security systems, verification of the
company’s compliance with state and
local laws, and a review of the
company’s background and history.
Therefore, pursuant to 21 U.S.C. 952(a)
and 958(a), and in accordance with 21
CFR 1301.34, the above named company
is granted registration as an importer of
the basic classes of controlled
substances listed.
Pursuant to § 1301.33(a) of Title 21 of
the Code of Federal Regulations (CFR),
this is notice that on July 21, 2009,
Chemic Laboratories, Inc., 480 Neponset
Street, Building 7, Canton,
Massachusetts 02021, made application
by renewal to the Drug Enforcement
Administration (DEA) as a bulk
manufacturer of Cocaine (9041), a basic
class of controlled substance listed in
schedule II.
The company plans to manufacture
small quantities of the above listed
controlled substance for distribution to
its customers for the purpose of
research.
Any other such applicant, and any
person who is presently registered with
DEA to manufacture such substance,
may file comments or objections to the
issuance of the proposed registration
pursuant to 21 CFR 1301.33(a).
Any such written comments or
objections should be addressed, in
quintuplicate, to the Drug Enforcement
Administration, Office of Diversion
Control, Federal Register Representative
(ODL), 8701 Morrissette Drive,
PO 00000
Frm 00152
Fmt 4703
Sfmt 4703
Springfield, Virginia 22152; and must be
filed no later than November 9, 2009.
Dated: August 28, 2009.
Joseph T. Rannazzisi,
Deputy Assistant Administrator, Office of
Diversion Control, Drug Enforcement
Administration.
[FR Doc. E9–21521 Filed 9–4–09; 8:45 am]
BILLING CODE 4410–09–P
DEPARTMENT OF JUSTICE
Drug Enforcement Administration
Manufacturer of Controlled
Substances; Notice of Application
Pursuant to § 1301.33(a) of Title 21 of
the Code of Federal Regulations (CFR),
this is notice that on July 8, 2009, Cody
Laboratories, 601 Yellowstone Avenue,
Cody, Wyoming 82414, made
application by renewal to the Drug
Enforcement Administration (DEA) to
be registered as a bulk manufacturer of
the basic classes of controlled
substances listed in schedules I and II:
Drug
Dihydromorphine (9145) ...............
Amphetamine (1100) ....................
Methamphetamine (1105) ............
Amobarbital (2125) .......................
Pentobarbital (2270) .....................
Secobarbital (2315) ......................
Phenylacetone (8501) ..................
Cocaine (9041) .............................
Codeine (9050) .............................
Dihydrocodeine (9120) .................
Oxycodone (9143) ........................
Hydromorphone (9150) ................
Diphenoxylate (9170) ...................
Ecgonine (9180) ...........................
Hydrocodone (9193) .....................
Meperidine (9230) ........................
Methadone (9250) ........................
Morphine (9300) ...........................
Oxymorphone (9652) ...................
Alfentanil (9737) ...........................
Remifentanil (9739) ......................
Sufentanil (9740) ..........................
Fentanyl (9801) ............................
Schedule
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The company plans on manufacturing
the listed controlled substances in bulk
for sale to its customers.
Any other such applicant, and any
person who is presently registered with
DEA to manufacture such substances,
may file comments or objections to the
issuance of the proposed registration
pursuant to 21 CFR 1301.33(a).
Any such written comments or
objections should be addressed, in
quintuplicate, to the Drug Enforcement
Administration, Office of Diversion
Control, Federal Register Representative
(ODL), 8701 Morrissette Drive,
Springfield, Virginia 22152; and must be
filed no later than November 9, 2009.
E:\FR\FM\08SEN1.SGM
08SEN1
Agencies
[Federal Register Volume 74, Number 172 (Tuesday, September 8, 2009)]
[Notices]
[Pages 46230-46231]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: E9-21534]
-----------------------------------------------------------------------
DEPARTMENT OF JUSTICE
Drug Enforcement Administration
Importer of Controlled Substances; Notice of Registration
By Notice dated June 3, 2009, and published in the Federal Register
on June 9, 2009, (74 FR 27347), Research Triangle Institute, Kenneth H.
Davis Jr., Hermann Building, East Institute Drive, P.O. Box 12194,
Research Triangle, North Carolina 27709, made application by renewal to
the Drug Enforcement Administration (DEA) to be registered as an
importer of the basic classes of controlled substances listed in
schedules I and II:
------------------------------------------------------------------------
Drug Schedule
------------------------------------------------------------------------
1-(1-Phenylcyclohexyl)pyrrolidine (7458)... I
1-[1-(2-Thienyl)cyclohexy]piperidine (7470) I
1-[1-(2-Thienyl)cyclohexyl]pyrrolidine I
(7473).
1-Methyl-4-phenyl-4-propionoxypiperidine I
(9661).
1-(2-Phenylethyl)-4-phenyl-4- I
acetoxypiperidine (9663).
2,5-Dimethoxy-4-(n)- I
propylthiophenethylamine (7348).
2,5-Dimethoxy-4-ethylamphetamine (7399).... I
2,5-Dimethoxyamphetamine (7396)............ I
3,4,5-Trimethoxyamphetamine (7390)......... I
3,4-Methylenedioxyamphetamine (7400)....... I
3,4-Methylenedioxymethamphetamine (7405)... I
3,4-Methylenedioxy-N-ethylamphetamine I
(7404).
3-Methylfentanyl (9813).................... I
3-Methylthiofentanyl (9833)................ I
4-Bromo-2,5-dimethoxyamphetamine (7391).... I
4-Bromo-2,5-dimethoxyphenethylamine (7392). I
4-Methyl-2,5-dimethoxyamphetamine (7395)... I
4-Methylaminorex (cis isomer) (1590)....... I
4-Methoxyamphetamine (7411)................ I
5-Methoxy-3,4-methylenedioxyamphetamine I
(7401).
5-Methoxy-N,N-diisopropyltryptamine (7439). I
Acetorphine (9319)......................... I
Acetyl-alpha-methylfentanyl (9815)......... I
Acetyldihydrocodeine (9051)................ I
Acetylmethadol (9601)...................... I
Allylprodine (9602)........................ I
Alphacetylmethadol except levo- I
alphacetylmethadol (9603).
Alpha-ethyltryptamine (7249)............... I
Alphameprodine (9604)...................... I
Alphamethadol (9605)....................... I
Alpha-methylfentanyl (9814)................ I
Alpha-methylthiofentanyl (9832)............ I
Alpha-methyltryptamine (7432).............. I
Aminorex (1585)............................ I
Benzethidine (9606)........................ I
Benzylmorphine (9052)...................... I
Betacetylmethadol (9607)................... I
Beta-hydroxy-3-methylfentanyl (9831)....... I
Beta-hydroxyfentanyl (9830)................ I
Betameprodine (9608)....................... I
Betamethadol (9609)........................ I
Betaprodine (9611)......................... I
Bufotenine (7433).......................... I
Cathinone (1235)........................... I
Clonitazene (9612)......................... I
Codeine methylbromide (9070)............... I
Codeine-N-Oxide (9053)..................... I
Cyprenorphine (9054)....................... I
Desomorphine (9055)........................ I
Dextromoramide (9613)...................... I
Diampromide (9615)......................... I
Diethylthiambutene (9616).................. I
Diethyltryptamine (7434)................... I
Difenoxin (9168)........................... I
Dihydromorphine (9145)..................... I
Dimenoxadol (9617)......................... I
Dimepheptanol (9618)....................... I
Dimethylthiambutene (9619)................. I
Dimethyltryptamine (7435).................. I
Dioxaphetyl butyrate (9621)................ I
Dipipanone (9622).......................... I
Drotebanol (9335).......................... I
Ethylmethylthiambutene (9623).............. I
Etonitazene (9624)......................... I
Etorphine except HCl (9056)................ I
Etoxeridine (9625)......................... I
Fenethylline (1503)........................ I
Furethidine (9626)......................... I
Gamma Hydroxybutyric Acid (2010)........... I
Heroin (9200).............................. I
Hydromorphinol (9301)...................... I
Hydroxypethidine (9627).................... I
Ibogaine (7260)............................ I
Ketobemidone (9628)........................ I
Levomoramide (9629)........................ I
Levophenacylmorphan (9631)................. I
Lysergic acid diethylamide (7315).......... I
Marihuana (7360)........................... I
Mecloqualone (2572)........................ I
Mescaline (7381)........................... I
Methaqualone (2565)........................ I
Methcathinone (1237)....................... I
Methyldesorphine (9302).................... I
Methyldihydromorphine (9304)............... I
Morpheridine (9632)........................ I
Morphine methylbromide (9305).............. I
Morphine methylsulfonate (9306)............ I
Morphine-N-Oxide (9307).................... I
Myrophine (9308)........................... I
N,N-Dimethylamphetamine (1480)............. I
N-[1-(2-thienyl)methyl-4-piperidyl]-N- I
phenylpropanamide (9834).
N-[1-benzyl-4-piperidyl]-N- I
phenylpropanamide (9818).
N-Benzylpiperazine (7493).................. I
N-Ethyl-3-piperidyl benzilate (7482)....... I
N-Ethylamphetamine (1475).................. I
N-Ethyl-l-phenylcyclohexylamine (7455)..... I
N-Hydroxy-3,4-methylenedioxyamphetamine I
(7402).
Nicocodeine (9309)......................... I
Nicomorphine (9312)........................ I
N-Methyl-3-piperidyl benzilate (7484)...... I
Noracymethadol (9633)...................... I
Norlevorphanol (9634)...................... I
Normethadone (9635)........................ I
Normorphine (9313)......................... I
Norpipanone (9636)......................... I
Para-Fluorofentanyl (9812)................. I
Parahexyl (7374)........................... I
Peyote (7415).............................. I
Phenadoxone (9637)......................... I
Phenampromide (9638)....................... I
Phenomorphan (9647)........................ I
Phenoperidine (9641)....................... I
Pholcodine (9314).......................... I
Piritramide (9642)......................... I
Proheptazine (9643)........................ I
Properidine (9644)......................... I
Propiram (9649)............................ I
Psilocybin (7437).......................... I
Psilocyn (7438)............................ I
Racemoramide (9645)........................ I
Tetrahydrocannabinols (7370)............... I
Thebacon (9315)............................ I
Thiofentanyl (9835)........................ I
[[Page 46231]]
Tilidine (9750)............................ I
Trimeperidine (9646)....................... I
1-Phenylcyclohexylamine (7460)............. II
1-Piperidinocyclohexanecarbonitrile (8603). II
Alfentanil (9737).......................... II
Alphaprodine (9010)........................ II
Amobarbital (2125)......................... II
Amphetamine (1100)......................... II
Anileridine (9020)......................... II
Bezitramide (9800)......................... II
Carfentanil (9743)......................... II
Coca Leaves (9040)......................... II
Cocaine (9041)............................. II
Codeine (9050)............................. II
Dextropropoxyphene, bulk (non-dosage forms) II
(9273).
Dihydrocodeine (9120)...................... II
Dihydroetorphine (9334).................... II
Diphenoxylate (9170)....................... II
Ethylmorphine (9190)....................... II
Etorphine Hcl (9059)....................... II
Fentanyl (9801)............................ II
Glutethimide (2550)........................ II
Hydrocodone (9193)......................... II
Hydromorphone (9150)....................... II
Isomethadone (9226)........................ II
Levo-alphacetylmethadol (9648)............. II
Levomethorphan (9210)...................... II
Levorphanol (9220)......................... II
Lisdexamfetamine (1205).................... II
Meperidine (9230).......................... II
Meperidine intermediate-A (9232)........... II
Meperidine intermediate-B (9233)........... II
Meperidine intermediate-C (9234)........... II
Metazocine (9240).......................... II
Methadone (9250)........................... II
Methadone intermediate (9254).............. II
Methamphetamine (1105)..................... II
Methylphenidate (1724)..................... II
Metopon (9260)............................. II
Moramide intermediate (9802)............... II
Morphine (9300)............................ II
Nabilone (7379)............................ II
Opium, raw (9600).......................... II
Opium extracts (9610)...................... II
Opium fluid extract (9620)................. II
Opium tincture (9630)...................... II
Opium, granulated (9640)................... II
Oxycodone (9143)........................... II
Oxymorphone (9652)......................... II
Pentobarbital (2270)....................... II
Phenazocine (9715)......................... II
Phencyclidine (7471)....................... II
Phenmetrazine (1631)....................... II
Phenylacetone (8501)....................... II
Piminodine (9730).......................... II
Powdered opium (9639)...................... II
Racemethorphan (9732)...................... II
Racemorphan (9733)......................... II
Remifentanil (9739)........................ II
Secobarbital (2315)........................ II
Sufentanil (9740).......................... II
Thebaine (9333)............................ II
------------------------------------------------------------------------
The company plans to import small quantities of the listed
controlled substances for the National Institute on Drug Abuse (NIDA)
for research activities.
No comments or objections have been received. DEA has considered
the factors in 21 U.S.C. 823(a) and 952(a) and determined that the
registration of Research Triangle Institute to import the basic class
of controlled substance is consistent with the public interest and with
United States obligations under international treaties, conventions, or
protocols in effect on May 1, 1971, at this time. DEA has investigated
Research Triangle Institute to ensure that the company's registration
is consistent with the public interest. The investigation has included
inspection and testing of the company's physical security systems,
verification of the company's compliance with state and local laws, and
a review of the company's background and history. Therefore, pursuant
to 21 U.S.C. 952(a) and 958(a), and in accordance with 21 CFR 1301.34,
the above named company is granted registration as an importer of the
basic classes of controlled substances listed.
Dated: August 28, 2009.
Joseph T. Rannazzisi,
Deputy Assistant Administrator, Office of Diversion Control, Drug
Enforcement Administration.
[FR Doc. E9-21534 Filed 9-4-09; 8:45 am]
BILLING CODE 4410-09-M