Availability of Draft Toxicological Profile for Perfluoroalkyls, 36492-36493 [E9-17529]

Download as PDF 36492 Federal Register / Vol. 74, No. 140 / Thursday, July 23, 2009 / Notices social networking sites (without parental consent) for surveys. The Academy for Educational Development will be conducting the research. There is no cost to respondents other than their time. The total estimated annual burden hours are 481. ESTIMATED ANNUALIZED BURDEN HOURS Number of respondents Type of respondent Form name Parents of 15–17 yr old .................................. Females (15–17 yr old) ................................... Female (18–25 yr old) .................................... Female (15–25 yr old) .................................... Female (15–25 yr old) .................................... Focus Group Screener for Parents of Minors Focus Group Screener for Minors ................. Focus Group Screener for Adult Women ...... Focus Group Moderator Guide (15–25) ........ Mall Intercept Screener & Moderator Guide (15–25). Online Screener and Survey (15–25) ............ Female (15–25 yr old) .................................... Dated: July 16, 2009. Marilyn S. Radke, Reports Clearance Officer, Centers for Disease Control and Prevention. [FR Doc. E9–17525 Filed 7–22–09; 8:45 am] BILLING CODE 4163–18–P DEPARTMENT OF HEALTH AND HUMAN SERVICES Agency for Toxic Substances and Disease Registry [ATSDR–253] Availability of Draft Toxicological Profile for Perfluoroalkyls erowe on DSK5CLS3C1PROD with NOTICES AGENCY: Agency for Toxic Substances and Disease Registry (ATSDR), Department of Health and Human Services (HHS). ACTION: Notice of availability. SUMMARY: This notice announces the availability of the draft toxicological profile for perfluoroalkyls, prepared by ATSDR, for review and comment. DATES: In order to be considered, comments on this draft toxicological profile must be received on or before October 30, 2009. Comments received after the public comment period will be considered at the discretion of ATSDR on the basis of what is deemed to be in the best interest of the general public. ADDRESSES: Requests for a printed copy of the draft toxicological profile should be sent to the attention of Ms. Olga Dawkins, Division of Toxicology and Environmental Medicine, Agency for Toxic Substances and Disease Registry, Mailstop F–32, 1600 Clifton Road, NE., Atlanta, Georgia 30333. Electronic access to the document is also available at the ATSDR Web site: http:// www.atsdr.cdc.gov/toxpro2.html. Requests for printed copies of the draft toxicological profile must be in writing and must specifically identify VerDate Nov<24>2008 15:01 Jul 22, 2009 Jkt 217001 the toxicological profile that you wish to receive. ATSDR reserves the right to provide free of charge only one copy of each profile requested. In case of extended distribution delays, requestors will be notified. Comments regarding the draft toxicological profile for perfluoroalkyls should be sent to the attention of Ms. Nickolette Roney, Division of Toxicology and Environmental Medicine, Agency for Toxic Substances and Disease Registry, Mailstop F–62, 1600 Clifton Road, NE., Atlanta, Georgia 30333. Electronic comments may be sent to TPPublicComments@cdc.gov. All comments sent electronically should contain the docket control number ATSDR–253 in the subject line. Written comments and other data submitted in response to this notice and the draft toxicological profile should bear the docket control number ATSDR– 253. Send one copy of all comments and three copies of all supporting documents to Ms. Roney at the above address by the end of the comment period. Because all public comments regarding ATSDR toxicological profiles are available for public inspection, no confidential information should be submitted in response to this notice. FOR FURTHER INFORMATION CONTACT: Ms. Olga Dawkins, Division of Toxicology and Environmental Medicine, Agency for Toxic Substances and Disease Registry, Mailstop F–62, 1600 Clifton Road, NE., Atlanta, Georgia 30333; telephone number (800) 232–4636 or (770) 488–3315. SUPPLEMENTARY INFORMATION: This draft toxicological profile for perfluoroalkyls was prepared in accordance with guidelines developed by the Agency for Toxic Substances and Disease Registry and the Environmental Protection Agency (EPA) for the preparation of toxicological profiles. The original guidelines were published in the Federal Register on April 17, 1987. PO 00000 Frm 00045 Fmt 4703 Sfmt 4703 Number of responses per respondent Average burden per response (in hours) 54 54 126 180 200 1 1 1 1 1 5/60 5/60 5/60 2 10/60 500 1 8/60 While perfluoroalkyls are not found on the ATSDR Priority List of Hazardous Substances, ATSDR has determined that a profile for these substances was necessary because data indicate that some perfluoroalkyls are found in the blood of the United States general population and in the environment. The agency also determined that it was important to characterize the current available information regarding the health effects from exposure to perfluoroalkyls in order to support and inform public health responses and activities by ATSDR and others. This profile will be revised and republished as necessary. Section 104(i)(3) of the Comprehensive Environmental Response, Compensation, and Liability Act [42 U.S.C. 9604(i)(3)] outlines the content of the toxicological profiles. Each profile includes an examination, a summary, and an interpretation of available toxicological information and epidemiologic evaluations. This information and these data are to be used to identify the levels of significant human exposure to a substance and the associated health effects. The profiles must also include a determination of whether adequate information on the health effects of each substance is available or in the process of development. When adequate information is not available, ATSDR, in cooperation with the National Toxicology Program (NTP), will initiate a research program to determine these health effects. Although key studies for this substance were considered during the profile development process, this Federal Register notice solicits any additional studies, particularly unpublished data and ongoing studies, which will be evaluated for possible addition to the profile now or in the future. E:\FR\FM\23JYN1.SGM 23JYN1 36493 Federal Register / Vol. 74, No. 140 / Thursday, July 23, 2009 / Notices The following draft toxicological profile will be made available to the public on or about July 6, 2009. Document Toxicological profile CAS No. 1 ................................................................. PERFLUOROALKYLS .................................................................................................. 000375–22–4 000335–67–1 001763–23–1 All profiles issued as ‘‘Draft for Public Comment’’ represent ATSDR’s best efforts to provide important toxicological information on priority substances. We are seeking public comments and additional information that may be used to supplement this profile. ATSDR remains committed to providing a public comment period for these documents as the best means to serve public health and our clients. Ken Rose, Director, Office of Policy, Planning, and Evaluation, National Center for Environmental Health/Agency for Toxic Substances and Disease Registry. [FR Doc. E9–17529 Filed 7–22–09; 8:45 am] BILLING CODE 4163–70–P DEPARTMENT OF HEALTH AND HUMAN SERVICES Agency for Toxic Substances and Disease Registry [ATSDR–254] Notice of Development of Set 23 Toxicological Profiles AGENCY: Agency for Toxic Substances and Disease Registry (ATSDR), Department of Health and Human Services (HHS). ACTION: Notice. consists of three new drafts and two updated drafts. These profiles will be available to the public on or about October 17, 2009. Electronic access to these documents will be available at the ATSDR Web site: http:// www.atsdr.cdc.gov/toxpro2.html. Set 23 Toxicological Profiles The following toxicological profiles are now being developed: SUMMARY: This notice announces the development of Set 23 Toxicological Profiles. Set 23 Toxicological Profiles Toxicological profile 1. 2. 3. 4. CAS No. Acrylamide* ...................................................................................................................................... Carbon Monoxide* ........................................................................................................................... 1,3-Butadiene .................................................................................................................................. Phosphate Ester Flame Retardants* ............................................................................................... 5. Vanadium ......................................................................................................................................... 79–06–1 630–08–0 106–99–0 126–73–8, 126–71–6, 78–51–3, 115–86–6, 13674–84–5, 13674–87–8, 115–96–8 7440–62–2 * Denotes new profile. The Superfund Amendments and Reauthorization Act of 1986 (SARA) (42 U.S.C. 9601 et seq.) amended the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA or Superfund) (42 U.S.C. 9601 et seq.) by establishing certain requirements for ATSDR and the U.S. Environmental Protection Agency (EPA) with regard to hazardous substances that are most commonly found at facilities on the CERCLA National Priorities List (NPL). Among these statutory requirements is a mandate for the Administrator of ATSDR to prepare toxicological profiles for each substance included on the Priority List of Hazardous Substances (http://www.atsdr.cdc.gov/cercla/ 07list.html). This list names 275 hazardous substances that pose the most significant potential threat to human health as determined by ATSDR and EPA. The availability of the revised list of the 275 priority substances was erowe on DSK5CLS3C1PROD with NOTICES SUPPLEMENTARY INFORMATION: VerDate Nov<24>2008 15:01 Jul 22, 2009 Jkt 217001 announced in the Federal Register on March 6, 2008 (73 FR 12178). For prior versions of the list of substances, see Federal Register notices dated April 17, 1987 (52 FR 12866); October 20, 1988 (53 FR 41280); October 26, 1989 (54 FR 43619); October 17, 1990 (55 FR 42067); October 17, 1991 (56 FR 52166); October 28, 1992 (57 FR 48801); February 28, 1994 (59 FR 9486); April 29, 1996 (61 FR 18744; November 17, 1997 (62 FR 61332); October 21, 1999 (64 FR 56792); October 25, 2001 (66 FR 54014); November 7, 2003 (68 FR 63098); and December 7, 2005 (70 FR 70284). The Set 23 Toxicological Profiles for 1,3-Butadiene and Vanadium are updates of previously published profiles for NPL priority substances. In addition, to address emerging public health concerns related to substances not currently on the NPL, ATSDR is also developing Set 23 Toxicological Profiles for Carbon Monoxide, Acrylamide, and Phosphate Ester Flame Retardants. Carbon monoxide is a toxic gas PO 00000 Frm 00046 Fmt 4703 Sfmt 4703 produced from the incomplete combustion of carbon-based fuels. Because it is colorless and odorless, toxicity can occur with no indication that exposure is occurring. Thousands of hospitalizations and hundreds of deaths occur every year as a result of inadvertent exposure to carbon monoxide. Acrylamide is a known animal carcinogen that is widely used in industry to synthesize polyacrylamides. Acrylamide also occurs naturally in a few foods, is formed in many foods as a byproduct of numerous cooking processes, and has been detected recently in human biomonitoring studies. Phosphate ester flame retardants comprise a large group of structurally related chemicals with increasing uses in clothing, fabrics, furniture, and structural components. However, there is an increasing body of information regarding exposures, body burdens, and toxicity related to this group of chemicals. E:\FR\FM\23JYN1.SGM 23JYN1

Agencies

[Federal Register Volume 74, Number 140 (Thursday, July 23, 2009)]
[Notices]
[Pages 36492-36493]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: E9-17529]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

Agency for Toxic Substances and Disease Registry

[ATSDR-253]


Availability of Draft Toxicological Profile for Perfluoroalkyls

AGENCY: Agency for Toxic Substances and Disease Registry (ATSDR), 
Department of Health and Human Services (HHS).

ACTION: Notice of availability.

-----------------------------------------------------------------------

SUMMARY: This notice announces the availability of the draft 
toxicological profile for perfluoroalkyls, prepared by ATSDR, for 
review and comment.

DATES: In order to be considered, comments on this draft toxicological 
profile must be received on or before October 30, 2009. Comments 
received after the public comment period will be considered at the 
discretion of ATSDR on the basis of what is deemed to be in the best 
interest of the general public.

ADDRESSES: Requests for a printed copy of the draft toxicological 
profile should be sent to the attention of Ms. Olga Dawkins, Division 
of Toxicology and Environmental Medicine, Agency for Toxic Substances 
and Disease Registry, Mailstop F-32, 1600 Clifton Road, NE., Atlanta, 
Georgia 30333. Electronic access to the document is also available at 
the ATSDR Web site: http://www.atsdr.cdc.gov/toxpro2.html.
    Requests for printed copies of the draft toxicological profile must 
be in writing and must specifically identify the toxicological profile 
that you wish to receive. ATSDR reserves the right to provide free of 
charge only one copy of each profile requested. In case of extended 
distribution delays, requestors will be notified.
    Comments regarding the draft toxicological profile for 
perfluoroalkyls should be sent to the attention of Ms. Nickolette 
Roney, Division of Toxicology and Environmental Medicine, Agency for 
Toxic Substances and Disease Registry, Mailstop F-62, 1600 Clifton 
Road, NE., Atlanta, Georgia 30333. Electronic comments may be sent to 
TPPublicComments@cdc.gov. All comments sent electronically should 
contain the docket control number ATSDR-253 in the subject line.
    Written comments and other data submitted in response to this 
notice and the draft toxicological profile should bear the docket 
control number ATSDR-253. Send one copy of all comments and three 
copies of all supporting documents to Ms. Roney at the above address by 
the end of the comment period. Because all public comments regarding 
ATSDR toxicological profiles are available for public inspection, no 
confidential information should be submitted in response to this 
notice.

FOR FURTHER INFORMATION CONTACT: Ms. Olga Dawkins, Division of 
Toxicology and Environmental Medicine, Agency for Toxic Substances and 
Disease Registry, Mailstop F-62, 1600 Clifton Road, NE., Atlanta, 
Georgia 30333; telephone number (800) 232-4636 or (770) 488-3315.

SUPPLEMENTARY INFORMATION: This draft toxicological profile for 
perfluoroalkyls was prepared in accordance with guidelines developed by 
the Agency for Toxic Substances and Disease Registry and the 
Environmental Protection Agency (EPA) for the preparation of 
toxicological profiles. The original guidelines were published in the 
Federal Register on April 17, 1987. While perfluoroalkyls are not found 
on the ATSDR Priority List of Hazardous Substances, ATSDR has 
determined that a profile for these substances was necessary because 
data indicate that some perfluoroalkyls are found in the blood of the 
United States general population and in the environment. The agency 
also determined that it was important to characterize the current 
available information regarding the health effects from exposure to 
perfluoroalkyls in order to support and inform public health responses 
and activities by ATSDR and others. This profile will be revised and 
republished as necessary.
    Section 104(i)(3) of the Comprehensive Environmental Response, 
Compensation, and Liability Act [42 U.S.C. 9604(i)(3)] outlines the 
content of the toxicological profiles. Each profile includes an 
examination, a summary, and an interpretation of available 
toxicological information and epidemiologic evaluations. This 
information and these data are to be used to identify the levels of 
significant human exposure to a substance and the associated health 
effects. The profiles must also include a determination of whether 
adequate information on the health effects of each substance is 
available or in the process of development. When adequate information 
is not available, ATSDR, in cooperation with the National Toxicology 
Program (NTP), will initiate a research program to determine these 
health effects.
    Although key studies for this substance were considered during the 
profile development process, this Federal Register notice solicits any 
additional studies, particularly unpublished data and ongoing studies, 
which will be evaluated for possible addition to the profile now or in 
the future.

[[Page 36493]]

    The following draft toxicological profile will be made available to 
the public on or about July 6, 2009.

 
------------------------------------------------------------------------
            Document                Toxicological profile      CAS No.
------------------------------------------------------------------------
1...............................  PERFLUOROALKYLS.........   000375-22-4
                                                             000335-67-1
                                                             001763-23-1
------------------------------------------------------------------------

    All profiles issued as ``Draft for Public Comment'' represent 
ATSDR's best efforts to provide important toxicological information on 
priority substances. We are seeking public comments and additional 
information that may be used to supplement this profile. ATSDR remains 
committed to providing a public comment period for these documents as 
the best means to serve public health and our clients.

Ken Rose,
Director, Office of Policy, Planning, and Evaluation, National Center 
for Environmental Health/Agency for Toxic Substances and Disease 
Registry.
[FR Doc. E9-17529 Filed 7-22-09; 8:45 am]
BILLING CODE 4163-70-P