Notice of Development of Set 23 Toxicological Profiles, 36493-36494 [E9-17527]

Download as PDF 36493 Federal Register / Vol. 74, No. 140 / Thursday, July 23, 2009 / Notices The following draft toxicological profile will be made available to the public on or about July 6, 2009. Document Toxicological profile CAS No. 1 ................................................................. PERFLUOROALKYLS .................................................................................................. 000375–22–4 000335–67–1 001763–23–1 All profiles issued as ‘‘Draft for Public Comment’’ represent ATSDR’s best efforts to provide important toxicological information on priority substances. We are seeking public comments and additional information that may be used to supplement this profile. ATSDR remains committed to providing a public comment period for these documents as the best means to serve public health and our clients. Ken Rose, Director, Office of Policy, Planning, and Evaluation, National Center for Environmental Health/Agency for Toxic Substances and Disease Registry. [FR Doc. E9–17529 Filed 7–22–09; 8:45 am] BILLING CODE 4163–70–P DEPARTMENT OF HEALTH AND HUMAN SERVICES Agency for Toxic Substances and Disease Registry [ATSDR–254] Notice of Development of Set 23 Toxicological Profiles AGENCY: Agency for Toxic Substances and Disease Registry (ATSDR), Department of Health and Human Services (HHS). ACTION: Notice. consists of three new drafts and two updated drafts. These profiles will be available to the public on or about October 17, 2009. Electronic access to these documents will be available at the ATSDR Web site: http:// www.atsdr.cdc.gov/toxpro2.html. Set 23 Toxicological Profiles The following toxicological profiles are now being developed: SUMMARY: This notice announces the development of Set 23 Toxicological Profiles. Set 23 Toxicological Profiles Toxicological profile 1. 2. 3. 4. CAS No. Acrylamide* ...................................................................................................................................... Carbon Monoxide* ........................................................................................................................... 1,3-Butadiene .................................................................................................................................. Phosphate Ester Flame Retardants* ............................................................................................... 5. Vanadium ......................................................................................................................................... 79–06–1 630–08–0 106–99–0 126–73–8, 126–71–6, 78–51–3, 115–86–6, 13674–84–5, 13674–87–8, 115–96–8 7440–62–2 * Denotes new profile. The Superfund Amendments and Reauthorization Act of 1986 (SARA) (42 U.S.C. 9601 et seq.) amended the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA or Superfund) (42 U.S.C. 9601 et seq.) by establishing certain requirements for ATSDR and the U.S. Environmental Protection Agency (EPA) with regard to hazardous substances that are most commonly found at facilities on the CERCLA National Priorities List (NPL). Among these statutory requirements is a mandate for the Administrator of ATSDR to prepare toxicological profiles for each substance included on the Priority List of Hazardous Substances (http://www.atsdr.cdc.gov/cercla/ 07list.html). This list names 275 hazardous substances that pose the most significant potential threat to human health as determined by ATSDR and EPA. The availability of the revised list of the 275 priority substances was erowe on DSK5CLS3C1PROD with NOTICES SUPPLEMENTARY INFORMATION: VerDate Nov<24>2008 15:01 Jul 22, 2009 Jkt 217001 announced in the Federal Register on March 6, 2008 (73 FR 12178). For prior versions of the list of substances, see Federal Register notices dated April 17, 1987 (52 FR 12866); October 20, 1988 (53 FR 41280); October 26, 1989 (54 FR 43619); October 17, 1990 (55 FR 42067); October 17, 1991 (56 FR 52166); October 28, 1992 (57 FR 48801); February 28, 1994 (59 FR 9486); April 29, 1996 (61 FR 18744; November 17, 1997 (62 FR 61332); October 21, 1999 (64 FR 56792); October 25, 2001 (66 FR 54014); November 7, 2003 (68 FR 63098); and December 7, 2005 (70 FR 70284). The Set 23 Toxicological Profiles for 1,3-Butadiene and Vanadium are updates of previously published profiles for NPL priority substances. In addition, to address emerging public health concerns related to substances not currently on the NPL, ATSDR is also developing Set 23 Toxicological Profiles for Carbon Monoxide, Acrylamide, and Phosphate Ester Flame Retardants. Carbon monoxide is a toxic gas PO 00000 Frm 00046 Fmt 4703 Sfmt 4703 produced from the incomplete combustion of carbon-based fuels. Because it is colorless and odorless, toxicity can occur with no indication that exposure is occurring. Thousands of hospitalizations and hundreds of deaths occur every year as a result of inadvertent exposure to carbon monoxide. Acrylamide is a known animal carcinogen that is widely used in industry to synthesize polyacrylamides. Acrylamide also occurs naturally in a few foods, is formed in many foods as a byproduct of numerous cooking processes, and has been detected recently in human biomonitoring studies. Phosphate ester flame retardants comprise a large group of structurally related chemicals with increasing uses in clothing, fabrics, furniture, and structural components. However, there is an increasing body of information regarding exposures, body burdens, and toxicity related to this group of chemicals. E:\FR\FM\23JYN1.SGM 23JYN1 36494 Federal Register / Vol. 74, No. 140 / Thursday, July 23, 2009 / Notices Notice of the availability of drafts of these two updated and three new toxicological profiles for public review and comment will be published in the Federal Register on/or about October 17, 2009, with notice of a 90-day public comment period for each profile, starting from the actual release date. Following the close of the comment period, chemical-specific comments will be addressed, and, where appropriate, changes will be incorporated into each profile. FOR FURTHER INFORMATION CONTACT: Commander Jessilynn B. Taylor, Division of Toxicology and Environmental Medicine, Agency for Toxic Substances and Disease Registry, 1600 Clifton Road, NE., Mail Stop F–32, Atlanta, GA 30333, telephone 770–488– 3313. Ken Rose, Director, Office of Policy, Planning and Evaluation, National Center for Environmental Health/Agency for Toxic Substances and Disease Registry. [FR Doc. E9–17527 Filed 7–22–09; 8:45 am] contract proposals relating to the broad areas within the national center. Matters To Be Discussed: The board will perform a secondary review of previously rated grant applications received by NCPHI based on RFA–HK–09–001; Centers of Excellence in Public Health Informatics (P01) and reviewed by an expert panel convened by NCPHI on July 22—24, 2009. Contact Person for More Information: Dr. Scott McNabb, National Center for Public Health Informatics, CDC, 1600 Clifton Road, NE., (E–78), Atlanta, Georgia 30333, Telephone (404) 498–6427, Fax (404) 498– 6235. The Director, Management Analysis and Services Office, has been delegated the authority to sign Federal Register notices pertaining to announcements of meetings and other committee management activities for both the CDC and the Agency for Toxic Substance and Disease Registry. This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. (Catalogue of Federal Domestic Assistance Program Nos. 93.242, Mental Health Research Grants; 93.281, Scientist Development Award, Scientist Development Award for Clinicians, and Research Scientist Award; 93.282, Mental Health National Research Service Awards for Research Training, National Institutes of Health, HHS) Dated: July 17, 2009. Elaine L. Baker, Management Analysis and Services Office, Centers for Disease Control and Prevention. [FR Doc. E9–17524 Filed 7–22–09; 8:45 am] DEPARTMENT OF HEALTH AND HUMAN SERVICES Dated: July 16, 2009. Jennifer Spaeth, Director, Office of Federal Advisory Committee Policy. [FR Doc. E9–17430 Filed 7–22–09; 8:45 am] BILLING CODE 4140–01–P Centers for Disease Control and Prevention BILLING CODE 4160–18–P Clinical Laboratory Improvement Advisory Committee (CLIAC); Meeting BILLING CODE 4163–70–P DEPARTMENT OF HEALTH AND HUMAN SERVICES DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health In accordance with section 10(a)(2) of the Federal Advisory Committee Act (Pub. L. 92–463), the Centers for Disease Control and Prevention (CDC), announces the following meeting of the aforementioned committee: National Institute of Mental Health; Notice of Closed Meeting Centers for Disease Control and Prevention Board of Scientific Counselors, National Center for Public Health Informatics (BSC, NCPHI) erowe on DSK5CLS3C1PROD with NOTICES In accordance with section 10(a)(2) of the Federal Advisory Committee Act (Pub. L. 92–463), the Centers for Disease Control and Prevention (CDC) announces the following meeting of the aforementioned committee: Time and Date: 1 p.m.–5 p.m., August 7, 2009 (Closed). Place: Teleconference. Status: The meeting will be closed to the public in accordance with provisions set forth in Section 552b(c)(4) and (6), Title 5 U.S.C., and the Determination of the Director, Management Analysis and Services Office, CDC, pursuant to Public Law 92–463. Purpose: The committee shall advise the Secretary, HHS, and the Director, CDC, concerning strategies and goals for the programs and research within the national centers; shall conduct peer-review of scientific programs; and monitor the overall strategic direction and focus of the national centers. The board, after conducting its periodic reviews, shall submit a written description of the results of the review and its recommendations to the Director, CDC. The board shall perform second-level peer review of applications for grants-in-aid for research and research training activities, cooperative agreements, and research VerDate Nov<24>2008 15:01 Jul 22, 2009 Jkt 217001 Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is hereby given of the following meeting. The meeting will be closed to the public in accordance with the provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The grant applications and the discussions could disclose confidential trade secrets or commercial property such as patentable material, and personal information concerning individuals associated with the grant applications, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. Name of Committee: National Institute of Mental Health Special Emphasis Panel, HIV Exploratory Applications. Date: July 28, 2009. Time: 11 a.m. to 3 p.m. Agenda: To review and evaluate grant applications. Place: National Institutes of Health, Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852 (Telephone Conference Call). Contact Person: Enid Light, PhD, Scientific Review Officer, Division of Extramural Activities, National Institute of Mental Health, NIH, Neuroscience Center, 6001 Executive Boulevard, Room 6132, MSC 9608, Bethesda, MD 20852–9608, 301–443–0322, elight@mail.nih.gov. PO 00000 Frm 00047 Fmt 4703 Sfmt 4703 Times and Dates: 8:30 a.m.–5 p.m., September 2, 2009. 8:30 a.m.–3 p.m., September 3, 2009. Place: CDC, 1600 Clifton Road, NE., Tom Harkin Global Communications Center, Building 19, Room 232, Auditorium B, Atlanta, Georgia 30333. New Information—Online Registration Required: In order to expedite the security clearance process at the CDC Roybal Campus located on Clifton Road, all CLIAC attendees are required to register for the meeting online at least 14 days in advance at http:// wwwn.cdc.gov/cliac/default.aspx by clicking the ‘‘Register for a Meeting’’ link and completing all forms according to the instructions given. Please complete all the required fields before submitting your registration and submit no later than August 19, 2009. Status: Open to the public, limited only by the space available. The meeting room accommodates approximately 100 people. Purpose: This Committee is charged with providing scientific and technical advice and guidance to the Secretary of Health and Human Services, the Assistant Secretary for Health, and the Director, CDC, regarding the need for, and the nature of, revisions to the standards under which clinical laboratories are regulated; the impact on medical and laboratory practice of proposed revisions to the standards; and the modification of the standards to accommodate technological advances. Matters To Be Discussed: The agenda will include agency updates from the CDC, the Centers for Medicare & Medicaid Services, E:\FR\FM\23JYN1.SGM 23JYN1

Agencies

[Federal Register Volume 74, Number 140 (Thursday, July 23, 2009)]
[Notices]
[Pages 36493-36494]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: E9-17527]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

Agency for Toxic Substances and Disease Registry

[ATSDR-254]


Notice of Development of Set 23 Toxicological Profiles

AGENCY: Agency for Toxic Substances and Disease Registry (ATSDR), 
Department of Health and Human Services (HHS).

ACTION: Notice.

-----------------------------------------------------------------------

SUMMARY: This notice announces the development of Set 23 Toxicological 
Profiles. Set 23 Toxicological Profiles consists of three new drafts 
and two updated drafts. These profiles will be available to the public 
on or about October 17, 2009. Electronic access to these documents will 
be available at the ATSDR Web site: http://www.atsdr.cdc.gov/toxpro2.html.

Set 23 Toxicological Profiles

    The following toxicological profiles are now being developed:

----------------------------------------------------------------------------------------------------------------
            Toxicological profile                                           CAS No.
----------------------------------------------------------------------------------------------------------------
1. Acrylamide*...............................  79-06-1
2. Carbon Monoxide*..........................  630-08-0
3. 1,3-Butadiene.............................  106-99-0
4. Phosphate Ester Flame Retardants*.........  126-73-8, 126-71-6, 78-51-3, 115-86-6, 13674-84-5, 13674-87-8,
                                                115-96-8
5. Vanadium..................................  7440-62-2
----------------------------------------------------------------------------------------------------------------
* Denotes new profile.


SUPPLEMENTARY INFORMATION: The Superfund Amendments and Reauthorization 
Act of 1986 (SARA) (42 U.S.C. 9601 et seq.) amended the Comprehensive 
Environmental Response, Compensation, and Liability Act of 1980 (CERCLA 
or Superfund) (42 U.S.C. 9601 et seq.) by establishing certain 
requirements for ATSDR and the U.S. Environmental Protection Agency 
(EPA) with regard to hazardous substances that are most commonly found 
at facilities on the CERCLA National Priorities List (NPL). Among these 
statutory requirements is a mandate for the Administrator of ATSDR to 
prepare toxicological profiles for each substance included on the 
Priority List of Hazardous Substances (http://www.atsdr.cdc.gov/cercla/07list.html). This list names 275 hazardous substances that pose the 
most significant potential threat to human health as determined by 
ATSDR and EPA. The availability of the revised list of the 275 priority 
substances was announced in the Federal Register on March 6, 2008 (73 
FR 12178). For prior versions of the list of substances, see Federal 
Register notices dated April 17, 1987 (52 FR 12866); October 20, 1988 
(53 FR 41280); October 26, 1989 (54 FR 43619); October 17, 1990 (55 FR 
42067); October 17, 1991 (56 FR 52166); October 28, 1992 (57 FR 48801); 
February 28, 1994 (59 FR 9486); April 29, 1996 (61 FR 18744; November 
17, 1997 (62 FR 61332); October 21, 1999 (64 FR 56792); October 25, 
2001 (66 FR 54014); November 7, 2003 (68 FR 63098); and December 7, 
2005 (70 FR 70284).
    The Set 23 Toxicological Profiles for 1,3-Butadiene and Vanadium 
are updates of previously published profiles for NPL priority 
substances. In addition, to address emerging public health concerns 
related to substances not currently on the NPL, ATSDR is also 
developing Set 23 Toxicological Profiles for Carbon Monoxide, 
Acrylamide, and Phosphate Ester Flame Retardants. Carbon monoxide is a 
toxic gas produced from the incomplete combustion of carbon-based 
fuels. Because it is colorless and odorless, toxicity can occur with no 
indication that exposure is occurring. Thousands of hospitalizations 
and hundreds of deaths occur every year as a result of inadvertent 
exposure to carbon monoxide. Acrylamide is a known animal carcinogen 
that is widely used in industry to synthesize polyacrylamides. 
Acrylamide also occurs naturally in a few foods, is formed in many 
foods as a byproduct of numerous cooking processes, and has been 
detected recently in human biomonitoring studies. Phosphate ester flame 
retardants comprise a large group of structurally related chemicals 
with increasing uses in clothing, fabrics, furniture, and structural 
components. However, there is an increasing body of information 
regarding exposures, body burdens, and toxicity related to this group 
of chemicals.

[[Page 36494]]

    Notice of the availability of drafts of these two updated and three 
new toxicological profiles for public review and comment will be 
published in the Federal Register on/or about October 17, 2009, with 
notice of a 90-day public comment period for each profile, starting 
from the actual release date. Following the close of the comment 
period, chemical-specific comments will be addressed, and, where 
appropriate, changes will be incorporated into each profile.

FOR FURTHER INFORMATION CONTACT: Commander Jessilynn B. Taylor, 
Division of Toxicology and Environmental Medicine, Agency for Toxic 
Substances and Disease Registry, 1600 Clifton Road, NE., Mail Stop F-
32, Atlanta, GA 30333, telephone 770-488-3313.

Ken Rose,
Director, Office of Policy, Planning and Evaluation, National Center 
for Environmental Health/Agency for Toxic Substances and Disease 
Registry.
[FR Doc. E9-17527 Filed 7-22-09; 8:45 am]
BILLING CODE 4163-70-P