Methoxyfenozide; Pesticide Tolerances for Emergency Exemptions, 22464-22469 [E9-10757]
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22464
Federal Register / Vol. 74, No. 91 / Wednesday, May 13, 2009 / Rules and Regulations
Since tolerances and exemptions that
are established on the basis of a petition
under section 408(d) of FFDCA, such as
the tolerance in this final rule, do not
require the issuance of a proposed rule,
the requirements of the Regulatory
Flexibility Act (RFA) (5 U.S.C. 601 et
seq.) do not apply.
This final rule directly regulates
growers, food processors, food handlers,
and food retailers, not States or tribes,
nor does this action alter the
relationships or distribution of power
and responsibilities established by
Congress in the preemption provisions
of section 408(n)(4) of FFDCA. As such,
the Agency has determined that this
action will not have a substantial direct
effect on States or tribal governments,
on the relationship between the national
government and the States or tribal
governments, or on the distribution of
power and responsibilities among the
various levels of government or between
the Federal Government and Indian
tribes. Thus, the Agency has determined
that Executive Order 13132, entitled
Federalism (64 FR 43255, August 10,
1999) and Executive Order 13175,
entitled Consultation and Coordination
with Indian Tribal Governments (65 FR
67249, November 9, 2000) do not apply
to this final rule. In addition, this final
rule does not impose any enforceable
duty or contain any unfunded mandate
as described under Title II of the
Unfunded Mandates Reform Act of 1995
(UMRA) (Public Law 104–4).
This action does not involve any
technical standards that would require
Agency consideration of voluntary
consensus standards pursuant to section
12(d) of the National Technology
Transfer and Advancement Act of 1995
(NTTAA), Public Law 104–113, section
12(d) (15 U.S.C. 272 note).
X. Congressional Review Act
The Congressional Review Act, 5
U.S.C. 801 et seq., generally provides
that before a rule may take effect, the
agency promulgating the rule must
submit a rule report to each House of
the Congress and to the Comptroller
General of the United States. EPA will
submit a report containing this rule and
other required information to the U.S.
Senate, the U.S. House of
Representatives, and the Comptroller
General of the United States prior to
publication of this final rule in the
Federal Register. This final rule is not
a ‘‘major rule’’ as defined by 5 U.S.C.
804(2).
List of Subjects in 40 CFR Part 180
Environmental protection,
Administrative practice and procedure,
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Agricultural commodities, Pesticides
and pests, Reporting and recordkeeping
requirements.
Dated:May 1, 2009.
Debra Edwards,
Director, Office of Pesticide Programs.
Therefore, 40 CFR chapter I is
amended as follows:
■
PART 180—[AMENDED]
1. The authority citation for part 180
continues to read as follows:
■
Authority: 21 U.S.C. 321(q), 346a and 371.
2. Section 180.1289 is added to
subpart D to read as follows:
■
§ 180.1289 Candida oleophila Strain O;
exemption from the requirement of a
tolerance.
An exemption from the requirement
of a tolerance is established for the
residues of the microbial pesticide,
Candida oleophila Strain O, on apples
and pears when applied/used as a postharvest biofungicide.
[FR Doc. E9–10962 Filed 5–12–09; 8:45 am]
BILLING CODE 6560–50–S
ENVIRONMENTAL PROTECTION
AGENCY
40 CFR Part 180
[EPA–HQ–OPP–2009–0020; FRL–8410–3]
ADDRESSES: EPA has established a
docket for this action under docket
identification (ID) number EPA–HQ–
OPP–2009–0020. All documents in the
docket are listed in the docket index
available in https://www.regulations.gov.
Although listed in the index, some
information is not publicly available,
e.g., Confidential Business Information
(CBI) or other information whose
disclosure is restricted by statute.
Certain other material, such as
copyrighted material, is not placed on
the Internet and will be publicly
available only in hard copy form.
Publicly available docket materials are
available in the electronic docket at
https://www.regulations.gov, or, if only
available in hard copy, at the OPP
Regulatory Public Docket in Rm. S–
4400, One Potomac Yard (South Bldg.),
2777 S. Crystal Dr., Arlington, VA. The
Docket Facility is open from 8:30 a.m.
to 4 p.m., Monday through Friday,
excluding legal holidays. The Docket
Facility telephone number is (703) 305–
5805.
FOR FURTHER INFORMATION CONTACT:
Stacey Groce, Registration Division
(7505P), Office of Pesticide Programs,
Environmental Protection Agency, 1200
Pennsylvania Ave., NW., Washington,
DC 20460–0001; telephone number:
(703) 305–2505; e-mail address:
groce.stacey@epa.gov.
SUPPLEMENTARY INFORMATION:
Methoxyfenozide; Pesticide Tolerances
for Emergency Exemptions
Environmental Protection
Agency (EPA).
ACTION: Final rule.
AGENCY:
SUMMARY: This regulation establishes
time-limited tolerances for residues of
the insecticide methoxyfenozide per se,
in or on sorghum, forage; sorghum,
grain; and sorghum, stover. This action
is in response to a crisis exemption
issued by the Louisiana Department of
Agriculture under section 18 of the
Federal Insecticide, Fungicide and
Rodenticide Act (FIFRA) authorizing
use of the pesticide on grain sorghum.
This regulation establishes a maximum
permissible level for residues of
methoxyfenozide in these feed
commodities. The time-limited
tolerances expire and will be revoked on
December 31, 2012.
DATES: This regulation is effective May
13, 2009. Objections and requests for
hearings must be received on or before
July 13, 2009, and must be filed in
accordance with the instructions
provided in 40 CFR part 178 (see also
Unit I.C. of the SUPPLEMENTARY
INFORMATION).
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I. General Information
A. Does this Action Apply to Me?
You may be potentially affected by
this action if you are an agricultural
producer, food manufacturer, or
pesticide manufacturer. Potentially
affected entities may include, but are
not limited to:
• Crop production (NAICS code 111).
• Animal production (NAICS code
112).
• Food manufacturing (NAICS code
311).
• Pesticide manufacturing (NAICS
code 32532).
This listing is not intended to be
exhaustive, but rather provides a guide
for readers regarding entities likely to be
affected by this action. Other types of
entities not listed in this unit could also
be affected. The North American
Industrial Classification System
(NAICS) codes have been provided to
assist you and others in determining
whether this action might apply to
certain entities. If you have any
questions regarding the applicability of
this action to a particular entity, consult
the person listed under FOR FURTHER
INFORMATION CONTACT.
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Federal Register / Vol. 74, No. 91 / Wednesday, May 13, 2009 / Rules and Regulations
B. How Can I Access Electronic Copies
of this Document?
In addition to accessing electronically
available documents at https://
www.regulations.gov, you may access
this Federal Register document
electronically through the EPA Internet
under the ‘‘Federal Register’’ listings at
https://www.epa.gov/fedrgstr. You may
also access a frequently updated
electronic version of 40 CFR part 180
through the Government Printing
Office’s e-CFR cite at https://
www.gpoaccess.gov/ecfr.
C. Can I File an Objection or Hearing
Request?
Under section 408(g) of the Federal
Food, Drug, and Cosmetic Act (FFDCA),
21 U.S.C. 346a, any person may file an
objection to any aspect of this regulation
and may also request a hearing on those
objections. The EPA procedural
regulations which govern the
submission of objections and requests
for hearings appear in 40 CFR part 178.
You must file your objection or request
a hearing on this regulation in
accordance with the instructions
provided in 40 CFR part 178. To ensure
proper receipt by EPA, you must
identify docket ID number EPA–HQ–
OPP–2009–0020 in the subject line on
the first page of your submission. All
requests must be in writing, and must be
mailed or delivered to the Hearing Clerk
on or before July 13, 2009.
In addition to filing an objection or
hearing request with the Hearing Clerk
as described in 40 CFR part 178, please
submit a copy of the filing that does not
contain any CBI for inclusion in the
public docket that is described in
ADDRESSES. Information not marked
confidential pursuant to 40 CFR part 2
may be disclosed publicly by EPA
without prior notice. Submit your
copies, identified by docket ID number
EPA–HQ–OPP–2009–0020, by one of
the following methods:
• Federal eRulemaking Portal: https://
www.regulations.gov. Follow the on-line
instructions for submitting comments.
• Mail: Office of Pesticide Programs
(OPP) Regulatory Public Docket (7502P),
Environmental Protection Agency, 1200
Pennsylvania Ave., NW., Washington,
DC 20460–0001.
• Delivery: OPP Regulatory Public
Docket (7502P), Environmental
Protection Agency, Rm. S–4400, One
Potomac Yard (South Bldg.), 2777 S.
Crystal Dr., Arlington, VA. Deliveries
are only accepted during the Docket
Facility’s normal hours of operation
(8:30 a.m. to 4 p.m., Monday through
Friday, excluding legal holidays).
Special arrangements should be made
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for deliveries of boxed information. The
Docket Facility telephone number is
(703) 305–5805.
II. Background and Statutory Findings
EPA, on its own initiative, in
accordance with sections 408(e) and
408(l)(6) of FFDCA, 21 U.S.C. 346a(e)
and 346a(1)(6), is establishing timelimited tolerances for residues of the
insecticide methoxyfenozide per se
(benzoic acid, 3-methoxy-2-methyl-,2(3,5-dimethylbenzoyl)-2-(1,1dimethylethyl) hydrazide) in or on
sorghum, forage at 30.0 parts per million
(ppm); sorghum, grain at 0.05 ppm; and
sorghum, stover at 60.0 ppm. These
time-limited tolerances expire and will
be revoked on December 31, 2012. EPA
will publish a subsequent document in
the Federal Register to remove the
revoked tolerances from the CFR.
Section 408(l)(6) of FFDCA requires
EPA to establish a time-limited
tolerance or exemption from the
requirement for a tolerance for pesticide
chemical residues in food that will
result from the use of a pesticide under
an emergency exemption granted by
EPA under section 18 of FIFRA. Such
tolerances can be established without
providing notice or period for public
comment. EPA does not intend for its
actions on section 18 related timelimited tolerances to set binding
precedents for the application of section
408 of FFDCA to other tolerances and
exemptions. Section 408(e) of FFDCA
allows EPA to establish a tolerance or an
exemption from the requirement of a
tolerance on its own initiative, i.e.,
without having received any petition
from an outside party.
Section 408(b)(2)(A)(i) of FFDCA
allows EPA to establish a tolerance (the
legal limit for a pesticide chemical
residue in or on a food) only if EPA
determines that the tolerance is ‘‘safe.’’
Section 408(b)(2)(A)(ii) of FFDCA
defines ‘‘safe’’ to mean that ‘‘there is a
reasonable certainty that no harm will
result from aggregate exposure to the
pesticide chemical residue, including
all anticipated dietary exposures and all
other exposures for which there is
reliable information.’’ This includes
exposure through drinking water and in
residential settings, but does not include
occupational exposure. Section
408(b)(2)(C) of FFDCA requires EPA to
give special consideration to exposure
of infants and children to the pesticide
chemical residue in establishing a
tolerance and to ‘‘ensure that there is a
reasonable certainty that no harm will
result to infants and children from
aggregate exposure to the pesticide
chemical residue. . . .’’
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Section 18 of FIFRA authorizes EPA
to exempt any Federal or State agency
from any provision of FIFRA, if EPA
determines that ‘‘emergency conditions
exist which require such exemption.’’
EPA has established regulations
governing such emergency exemptions
in 40 CFR part 166.
III. Emergency Exemption for
Methoxyfenozide on Various
Commodities: Sorghum, forage;
Sorghum, grain; and Sorghum, stover
and FFDCA Tolerances
The Louisiana Department of
Agriculture requested an emergency
exemption for use of methoxyfenozide
on grain sorghum to control the
southwestern corn borer and sugarcane
borer, and issued a crisis exemption for
this use pursuant to 40 CFR part 166,
subpart C. The Louisiana Department of
Agriculture provided information
indicating that the southwestern corn
borer and sugarcane borer are serious
pests that commonly infest grain
sorghum. Methoxyfenozide has been
authorized under FIFRA section 18 for
use on sorghum, forage, sorghum, grain,
and sorghum, stover to control
southwestern corn borer and sugarcane
borer in Louisiana under the crisis
provision.
As part of its evaluation of the
emergency exemption application, EPA
assessed the potential risks presented by
residues of the insecticide
methoxyfenozide per se in or on
sorghum, forage; sorghum, grain; and
sorghum, stover. In doing so, EPA
considered the safety standard in
section 408(b)(2) of FFDCA, and EPA
decided that the necessary tolerance
under section 408(l)(6) of FFDCA would
be consistent with the safety standard
and with FIFRA section 18. Consistent
with the need to move quickly on the
emergency exemption in order to
address an urgent non-routine situation
and to ensure that the resulting food is
safe and lawful, EPA is issuing this
tolerance without notice and
opportunity for public comment as
provided in section 408(l)(6) of FFDCA.
Although these time-limited tolerances
expire and will be revoked on December
31, 2012, under section 408(l)(5) of
FFDCA, residues of the pesticide not in
excess of the amounts specified in the
tolerance remaining in or on sorghum,
forage; sorghum, grain; and sorghum,
stover after that date will not be
unlawful, provided the pesticide was
applied in a manner that was lawful
under FIFRA, and the residues do not
exceed a level that was authorized by
these time-limited tolerances at the time
of that application. EPA will take action
to revoke these time-limited tolerances
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earlier if any experience with, scientific
data on, or other relevant information
on this pesticide indicate that the
residues are not safe.
Because these time-limited tolerances
are being approved under emergency
conditions, EPA has not made any
decisions about whether
methoxyfenozide meets FIFRA’s
registration requirements for use on
sorghum, forage; sorghum, grain; and
sorghum, stover or whether permanent
tolerances for these uses would be
appropriate. Under these circumstances,
EPA does not believe that these timelimited tolerance decisions serve as a
basis for registration of
methoxyfenozide by a State for special
local needs under FIFRA section 24(c).
Nor do these tolerances serve as the
basis for persons in any State other than
Louisiana to use this pesticide on the
applicable crops under FIFRA section
18 absent the issuance of an emergency
exemption applicable within that State.
For additional information regarding the
emergency exemption for
methoxyfenozide, contact the Agency’s
Registration Division at the address
provided under FOR FURTHER
INFORMATION CONTACT.
IV. Aggregate Risk Assessment and
Determination of Safety
Section 408(b)(2)(A)(i) of FFDCA
allows EPA to establish a tolerance (the
legal limit for a pesticide chemical
residue in or on a food) only if EPA
determines that the tolerance is ‘‘safe.’’
Section 408(b)(2)(A)(ii) of FFDCA
defines ‘‘safe’’ to mean that ‘‘there is a
reasonable certainty that no harm will
result from aggregate exposure to the
pesticide chemical residue, including
all anticipated dietary exposures and all
other exposures for which there is
reliable information.’’ This includes
exposure through drinking water and in
residential settings, but does not include
occupational exposure. Section
408(b)(2)(C) of FFDCA requires EPA to
give special consideration to exposure
of infants and children to the pesticide
chemical residue in establishing a
tolerance and to ‘‘ensure that there is a
reasonable certainty that no harm will
result to infants and children from
aggregate exposure to the pesticide
chemical residue. . . .’’
Consistent with the factors specified
in FFDCA section 408(b)(2)(D), EPA has
reviewed the available scientific data
and other relevant information in
support of this action. EPA has
sufficient data to assess the hazards of
and to make a determination on
aggregate exposure expected as a result
of this emergency exemption request
and the time-limited tolerances for
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residues of the insecticide
methoxyfenozide per se (benzoic acid,
3-methoxy-2-methyl-,2-(3,5dimethylbenzoyl)-2-(1,1-dimethylethyl)
hydrazide) in or on sorghum, forage at
30.0 parts per million (ppm); sorghum,
grain at 0.05 ppm; and sorghum, stover
at 60.0 ppm. EPA’s assessment of
exposures and risks associated with
establishing time-limited tolerances
follows.
A. Toxicological Endpoints
For hazards that have a threshold
below which there is no appreciable
risk, a toxicological point of departure
(POD) is identified as the basis for
derivation of reference values for risk
assessment. The POD may be defined as
the highest dose at which no adverse
effects are observed (the NOAEL) in the
toxicology study identified as
appropriate for use in risk assessment.
However, if a NOAEL cannot be
determined, the lowest dose at which
adverse effects of concern are identified
(the LOAEL) or a Benchmark Dose
(BMD) approach is sometimes used for
risk assessment. Uncertainty/safety
factors (UFs) are used in conjunction
with the POD to take into account
uncertainties inherent in the
extrapolation from laboratory animal
data to humans and in the variations in
sensitivity among members of the
human population as well as other
unknowns. Safety is assessed for acute
and chronic dietary risks by comparing
aggregate food and water exposure to
the pesticide to the acute population
adjusted dose (aPAD) and chronic
population adjusted dose (cPAD). The
aPAD and cPAD are calculated by
dividing the POD by all applicable UFs.
Aggregate short-term, intermediate-term,
and chronic-term risks are evaluated by
comparing food, water, and residential
exposure to the POD to ensure that the
margin of exposure (MOE) called for by
the product of all applicable UFs is not
exceeded. This latter value is referred to
as the Level of Concern (LOC).
For non-threshold risks, the Agency
assumes that any amount of exposure
will lead to some degree of risk. Thus,
the Agency estimates risk in terms of the
probability of an occurrence of the
adverse effect greater than that expected
in a lifetime. For more information on
the general principles EPA uses in risk
characterization and a complete
description of the risk assessment
process, see https://www.epa.gov/
pesticides/factsheets/riskassess.htm.
A summary of the toxicological
endpoints for methoxyfenozide used for
human risk assessment can be found in
the document entitled,
‘‘Methoxyfenozide. Human Health Risk
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Assessment for Proposed Section 18 Use
on Grain Sorghum,’’ dated November
20, 2008, by going to https://
www.regulations.gov. The referenced
document is available in the docket
established by this action, which is
described under ADDRESSES, and is
identified as EPA–HQ–OPP–2009–
0020–0002 in that docket. Locate and
click on the hyperlink for docket ID
number EPA–HQ–OPP–2009–0020.
Double-click on the document to view
the referenced information on page 23 of
34.
B. Exposure Assessment
1. Dietary exposure from food and
feed uses. In evaluating dietary
exposure to methoxyfenozide, EPA
considered exposure under the timelimited tolerances established by this
action as well as exposures pursuant to
existing methoxyfenozide tolerances in
(40 CFR 180.544). EPA assessed dietary
exposures from methoxyfenozide in
food as follows:
i. Acute exposure. No appropriate
toxicological endpoint attributable to a
single exposure was identified in the
available toxicological studies for
methoxyfenozide; therefore, a
quantitative acute dietary exposure
assessment is unnecessary.
ii. Chronic exposure. In conducting
the chronic dietary exposure assessment
EPA used the food consumption data
from the USDA 1994–1996 and 1998
Nationwide Continuing Surveys of food
Intake by Individuals (CSFII). As to
residue levels in food, an unrefined
chronic dietary analysis for
methoxyfenozide was conducted using
tolerance levels and 100% crop-treated
for all existing and proposed uses.
Drinking water was incorporated
directly into the dietary assessment
using the chronic concentration for
surface water generated by the PRZMEXAMS model at 33.1 ppb. The results
of the analysis indicate that chronic risk
from the dietary (food and drinking
water) exposure to methoxyfenozide
will not exceed EPA’s level of concern
for the general U.S. population and all
population subgroups.
iii. Cancer. Methoxyfenozide is not
likely to be carcinogenic to humans;
therefore, a cancer exposure assessment
was not conducted. This classification is
based on the lack of evidence of
carcinogenicity in male and female rats
as well as in male and female mice and
on the lack of genotoxicity in an
acceptable battery of mutagenicity
studies.
iv. Anticipated residue and percent
crop treated (PCT) information. EPA did
not use anticipated residue and/or PCT
information in the dietary assessment
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for methoxyfenozide. Tolerance level
residues and/or 100 PCT were assumed
for all food commodities.
2. Dietary exposure from drinking
water. The Agency used screening level
water exposure models in the dietary
exposure analysis and risk assessment
for methoxyfenozide in drinking water.
These simulation models take into
account data on the physical, chemical,
and fate/transport characteristics of
methoxyfenozide. Further information
regarding EPA drinking water models
used in pesticide exposure assessment
can be found at https://www.epa.gov/
oppefed1/models/water/index.htm.
Based on the Pesticide Root Zone
Model/Exposure Analysis Modeling
System(PRZM/EXAMS) and Screening
Concentration in Ground Water (SCIGROW) models, the estimated drinking
water concentrations (EDWCs) of
methoxyfenozide for acute dietary
exposures are estimated to be 52.2 parts
per billion (ppb) for surface water and
7.43 ppb for ground water. The
estimated drinking water concentrations
(EDWCs) for chronic dietary exposures
for non-cancer assessments are
estimated to be 33.1 ppb for surface
water and 7.43 ppb for ground water.
Modeled estimates of drinking water
concentrations were directly entered
into the dietary exposure model. An
acute dietary endpoint was not
identified; therefore, a quantitative
assessment of risk was not conducted
for methoxyfenozide. For chronic
dietary risk assessment, the water
concentration of 33.1 ppb was used to
assess the contribution from drinking
water.
3. From non-dietary exposure. The
term ‘‘residential exposure’’ is used in
this document to refer to nonoccupational, non-dietary exposure
(e.g., for lawn and garden pest control,
indoor pest control, termiticides, and
flea and tick control on pets).
Methoxyfenozide is not registered for
any specific use patterns that would
result in residential exposure.
4. Cumulative effects from substances
with a common mechanism of toxicity.
Section 408(b)(2)(D)(v) of FFDCA
requires that, when considering whether
to establish, modify, or revoke a
tolerance, the Agency consider
‘‘available information’’ concerning the
cumulative effects of a particular
pesticide’s residues and‘‘ other
substances that have a common
mechanism of toxicity.’’
EPA has not found methoxyfenozide
to share a common mechanism of
toxicity with any other substances, and
methoxyfenozide does not appear to
produce a toxic metabolite produced by
other substances. For the purposes of
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this tolerance action, therefore, EPA has
assumed that methoxyfenozide does not
have a common mechanism of toxicity
with other substances. For information
regarding EPA’s efforts to determine
which chemicals have a common
mechanism of toxicity and to evaluate
the cumulative effects of such
chemicals, see the policy statements
released by EPA’s Office of Pesticide
Programs concerning common
mechanism determinations and
procedures for cumulating effects from
substances found to have a common
mechanism on EPA’s website at https://
www.epa.gov/pesticides/cumulative.
C. Safety Factor for Infants and Children
1. In general. Section 408(b)(2)(C) of
FFDCA provides that EPA shall apply
an additional tenfold (10X) margin of
safety for infants and children in the
case of threshold effects to account for
prenatal and postnatal toxicity and the
completeness of the database on toxicity
and exposure unless EPA determines
based on reliable data that a different
margin of safety will be safe for infants
and children. This additional margin of
safety is commonly referred to as the
FQPA safety factor (SF). In applying this
provision, EPA either retains the default
value of 10X, or uses a different
additional SF when reliable data
available to EPA support the choice of
a different factor.
2. Prenatal and postnatal sensitivity.
There is not a concern for prenatal and/
or postnatal toxicity resulting from
exposure to methoxyfenozide. The
prenatal and postnatal toxicology
database for methoxyfenozide includes
rat and rabbit developmental toxicity
studies and a 2-generation reproductive
study. There was no increased
susceptibility in fetuses as compared to
maternal animals observed following in
utero exposures.
3. Conclusion. EPA has determined
that reliable data show that the safety of
infants and children would be
adequately protected if the FQPA SF
were reduced to 1X. That decision is
based on the following findings:
i. The toxicity database for
methoxyfenozide is complete for
assessment of potential hazard to infants
and children.
ii. There is no indication that
methoxyfenozide is a neurotoxic
chemical and there is no need for a
developmental neurotoxicity study or
additional UFs to account for
neurotoxicity.
iii. There is no evidence that
methoxyfenozide results in increased
susceptibility in in utero rats or rabbits
in the prenatal developmental studies or
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22467
in young rats in the 2-generation
reproduction study.
iv. There are no residual uncertainties
identified in the exposure database. The
exposure assessments will not
underestimate the potential dietary
(food and drinking water) or nondietary
exposures for infants and children from
use of methoxyfenozide. EPA made
conservative (protective) assumptions in
the ground water and surface water
modeling used to assess exposure to
methoxyfenozide in drinking water.
EPA used similarly conservative
assumptions to assess postapplication
exposure of children as well as
incidental oral exposure of toddlers.
These assessments will not
underestimate the exposure and risks
posed by methoxyfenozide.
D. Aggregate Risks and Determination of
Safety
EPA determines whether acute and
chronic pesticide exposures are safe by
comparing aggregate exposure estimates
to the aPAD and cPAD. The aPAD and
cPAD represent the highest safe
exposures, taking into account all
appropriate SFs. EPA calculates the
aPAD and cPAD by dividing the POD by
all applicable UFs. For linear cancer
risks, EPA calculates the probability of
additional cancer cases given the
estimated aggregate exposure. Shortterm, intermediate-term, and chronicterm risks are evaluated by comparing
the estimated aggregate food, water, and
residential exposure to the POD to
ensure that the MOE called for by the
product of all applicable UFs is not
exceeded.
1. Acute risk. An acute aggregate risk
assessment takes into account exposure
estimates from acute dietary
consumption of food and drinking
water. No adverse effect resulting from
a single-oral exposure was identified,
therefore, dietary exposure presents no
acute risks of concern.
2. Chronic risk. Using the exposure
assumptions described in this unit for
chronic exposure, EPA has concluded
that chronic exposure to
methoxyfenozide from food and water
will utilize 56% of the cPAD for
children 1-2 years old, the population
group receiving the greatest exposure.
There are no residential uses for
methoxyfenozide.
3. Short-term risk. Short-term
aggregate exposure takes into account
short-term residential exposure plus
chronic exposure to food and water
(considered to be a background
exposure level).
Methoxyfenozide is not registered for
any use patterns that would result in
residential exposure. Therefore, the
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short-term aggregate risk is the sum of
the risk from exposure to
methoxyfenozide through food and
water. Thus, the chronic aggregate
exposure for the most exposed group is
below EPA’s level of concern.
4. Intermediate-term risk.
Intermediate-term aggregate exposure
takes into account intermediate-term
non-dietary, non-occupational exposure
plus chronic exposure to food and water
(considered to be a background
exposure level).
Methoxyfenozide is not registered for
any use patterns that would result in
intermediate-term residential exposure.
Therefore, the intermediate-term
aggregate risk is the sum of the risk from
exposure to methoxyfenozide through
food and water, which has already been
addressed, and will not be greater than
the chronic aggregate risk.
5. Aggregate cancer risk for U.S.
population. Methoxyfenozide is
classified as a ‘‘not likely’’ human
carcinogen and thus is not expected to
pose a cancer risk to humans. This
classification is based on the lack of
evidence of carcinogenicity in male and
female rats as well as in male and
female mice and on the lack of
genotoxicity in an acceptable battery of
mutagenicity studies.
6. Determination of safety. Based on
these risk assessments, EPA concludes
that there is a reasonable certainty that
no harm will result to the general
population, or to infants and children,
from aggregate exposure to
methoxyfenozide residues.
V. Other Considerations
A. Analytical Enforcement Methodology
Adequate enforcement methodology
(high pressure liquid chromatography
with mass spectrometry (HPLC/MS)) is
available to enforce the tolerance
expression. The method may be
requested from: Chief, Analytical
Chemistry Branch, Environmental
Science Center, 701 Mapes Rd., Ft.
Meade, MD 20755–5350; telephone
number: (410) 305–2905; e-mail address:
residuemethods@epa.gov.
B. International Residue Limits
There are currently no Canadian,
Mexican, or Codex maximum residue
limits (MRLs) for methoxyfenozide on
the commodities for which tolerances
are being established.
VI. Conclusion
Therefore, time-limited tolerances are
established for residues of the
insecticide methoxyfenozide per se
(benzoic acid, 3-methoxy-2-methyl-,2(3,5-dimethylbenzoyl)-2-(1,1-
VerDate Nov<24>2008
17:32 May 12, 2009
Jkt 217001
dimethylethyl) hydrazide) in or on
sorghum, forage at 30.0 ppm; sorghum,
grain at 0.05 ppm; and sorghum, stover
at 60.0 ppm. These tolerances expire
and will be revoked on December 31,
2012.
VII. Statutory and Executive Order
Reviews
This final rule establishes tolerances
under sections 408(e) and 408(l)(6) of
FFDCA in response to a petition
submitted to the Agency. The Office of
Management and Budget (OMB) has
exempted these types of actions from
review under Executive Order 12866,
entitled Regulatory Planning and
Review (58 FR 51735, October 4, 1993).
Because this final rule has been
exempted from review under Executive
Order 12866, this final rule is not
subject to Executive Order 13211,
entitled Actions Concerning Regulations
That Significantly Affect Energy Supply,
Distribution, or Use (66 FR 28355, May
22, 2001) or Executive Order 13045,
entitled Protection of Children from
Environmental Health Risks and Safety
Risks (62 FR 19885, April 23, 1997).
This final rule does not contain any
information collections subject to OMB
approval under the Paperwork
Reduction Act (PRA), 44 U.S.C. 3501 et
seq., nor does it require any special
considerations under Executive Order
12898, entitled Federal Actions to
Address Environmental Justice in
Minority Populations and Low-Income
Populations (59 FR 7629, February 16,
1994).
Since tolerances and exemptions that
are established in accordance with
sections 408(e) and 408(l)(6) of FFDCA,
such as the tolerances in this final rule,
do not require the issuance of a
proposed rule, the requirements of the
Regulatory Flexibility Act (RFA) (5
U.S.C. 601 et seq.) do not apply.
This final rule directly regulates
growers, food processors, food handlers,
and food retailers, not States or tribes,
nor does this action alter the
relationships or distribution of power
and responsibilities established by
Congress in the preemption provisions
of section 408(n)(4) of FFDCA. As such,
the Agency has determined that this
action will not have a substantial direct
effect on States or tribal governments,
on the relationship between the national
government and the States or tribal
governments, or on the distribution of
power and responsibilities among the
various levels of government or between
the Federal Government and Indian
tribes. Thus, the Agency has determined
that Executive Order 13132, entitled
Federalism (64 FR 43255, August 10,
1999) and Executive Order 13175,
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Frm 00048
Fmt 4700
Sfmt 4700
entitled Consultation and Coordination
with Indian Tribal Governments (65 FR
67249, November 9, 2000) do not apply
to this final rule. In addition, this final
rule does not impose any enforceable
duty or contain any unfunded mandate
as described under Title II of the
Unfunded Mandates Reform Act of 1995
(UMRA) (Public Law 104–4).
This action does not involve any
technical standards that would require
Agency consideration of voluntary
consensus standards pursuant to section
12(d) of the National Technology
Transfer and Advancement Act of 1995
(NTTAA), Public Law 104–113, section
12(d) (15 U.S.C. 272 note).
VIII. Congressional Review Act
The Congressional Review Act, 5
U.S.C. 801 et seq., generally provides
that before a rule may take effect, the
agency promulgating the rule must
submit a rule report to each House of
the Congress and to the Comptroller
General of the United States. EPA will
submit a report containing this rule and
other required information to the U.S.
Senate, the U.S. House of
Representatives, and the Comptroller
General of the United States prior to
publication of this final rule in the
Federal Register. This final rule is not
a ‘‘major rule’’ as defined by 5 U.S.C.
804(2).
List of Subjects in 40 CFR Part 180
Environmental protection,
Administrative practice and procedure,
Agricultural commodities, Pesticides
and pests, Reporting and recordkeeping
requirements.
Dated: April 28, 2009.
Daniel J. Rosenblatt,
Acting Director, Registration Division, Office
of Pesticide Programs.
Therefore, 40 CFR chapter I is
amended as follows:
■
PART 180—[AMENDED]
1. The authority citation for part 180
continues to read as follows:
■
Authority: 21 U.S.C. 321(q), 346a and 371.
2. Section 180.544 is amended by
adding paragraph (b) to read as follows:
■
§ 180.544 Methoxyfenozide; tolerances for
residues.
*
*
*
*
*
(b) Section 18 emergency exemptions.
Time-limited tolerances specified in the
following table are established for
residues of the insecticide
methoxyfenozide per se (benzoic acid,
3-methoxy-2-methyl-,2-(3,5dimethylbenzoyl)-2-(1,1-dimethylethyl)
hydrazide), in or on the specified
agricultural commodities, resulting from
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use of the pesticide pursuant to FFIFRA
section 18 emergency exemptions. The
tolerances expire and will be revoked on
the date specified in the table.
Commodity
*
*
30.0
0.05
60.0
*
*
[FR Doc. E9–10757 Filed 5–12–09; 8:45 am]
BILLING CODE 6560–50–S
ENVIRONMENTAL PROTECTION
AGENCY
40 CFR Part 271
[EPA–R06–RCRA–2008–0755; FRL–8901–1]
Texas: Final Authorization of State
Hazardous Waste Management
Program Revision
AGENCY: Environmental Protection
Agency (EPA).
ACTION: Immediate final rule.
SUMMARY: The State of Texas has
applied to the EPA for final
authorization of the changes to its
hazardous waste program under the
Resource Conservation and Recovery
Act (RCRA). EPA has determined that
these changes satisfy all requirements
needed to qualify for final authorization,
and is authorizing the State’s changes
through this immediate final action. The
EPA is publishing this rule to authorize
the changes without a prior proposal
because we believe this action is not
controversial and do not expect
comments that oppose it. Unless we
receive written comments which oppose
this authorization during the comment
period, the decision to authorize Texas’
changes to its hazardous waste program
will take effect. If we receive comments
that oppose this action, we will publish
a document in the Federal Register
withdrawing this rule before it takes
effect, and a separate document in the
proposed rules section of this Federal
Register will serve as a proposal to
authorize the changes.
DATES: This final authorization will
become effective on July 13, 2009 unless
the EPA receives adverse written
comment by June 12, 2009. If the EPA
receives such comment, it will publish
a timely withdrawal of this immediate
final rule in the Federal Register and
inform the public that this authorization
will not take effect.
ADDRESSES: Submit your comments by
one of the following methods:
VerDate Nov<24>2008
Expiration/revocation
date
Parts per million
Sorghum, forage
Sorghum, grain
Sorghum, stover
*
17:32 May 12, 2009
Jkt 217001
22469
1. Federal eRulemaking Portal:
https://www.regulations.gov. Follow the
on-line instructions for submitting
comments.
2. E-mail: patterson.alima@epa.gov.
3. Mail: Alima Patterson, Region 6,
Regional Authorization Coordinator,
State/Tribal Oversight Section (6PD–O),
Multimedia Planning and Permitting
Division, EPA Region 6, 1445 Ross
Avenue, Dallas, Texas 75202–2733.
4. Hand Delivery or Courier: Deliver
your comments to Alima Patterson,
Region 6, Regional Authorization
Coordinator, State/Tribal Oversight
Section (6PD–O), Multimedia Planning
and Permitting Division, EPA Region 6,
1445 Ross Avenue, Dallas, Texas 75202–
2733.
Instructions: Do not submit
information that you consider to be CBI
or otherwise protected through
regulations.gov, or e-mail. The Federal
regulations.gov Web site is an
‘‘anonymous access’’ system, which
means the EPA will not know your
identity or contact information unless
you provide it in the body of your
comment. If you send an e-mail
comment directly to the EPA without
going through regulations.gov, your email address will be automatically
captured and included as part of the
comment that is placed in the public
docket and made available on the
Internet. If you submit an electronic
comment, the EPA recommends that
you include your name and other
contact information in the body of your
comment and with any disk or CD–ROM
you submit. If the EPA cannot read your
comment due to technical difficulties
and cannot contact you for clarification,
the EPA may not be able to consider
your comment. Electronic files should
avoid the use of special characters, any
form of encryption, and be free of any
defects or viruses. You can view and
copy Texas’ application and associated
publicly available materials from 8:30
a.m. to 4 p.m. Monday through Friday
at the following locations: Texas
Commission on Environmental Quality
(TCEQ), 12100 Park S. Circle, Austin TX
78753–3087, (512) 239–6079 and EPA,
Region 6, 1445 Ross Avenue, Dallas,
Texas 75202–2733, phone number (214)
665–8533. Interested persons wanting to
PO 00000
Frm 00049
Fmt 4700
Sfmt 4700
December 31, 2012
December 31, 2012
December 31, 2012
examine these documents should make
an appointment with the office at least
two weeks in advance.
FOR FURTHER INFORMATION CONTACT:
Alima Patterson, Region 6 Regional
Authorization Coordinator, State/Tribal
Oversight Section (6PD–O), Multimedia
Planning and Permitting Division, (214)
665–8533, EPA Region 1445 Ross
Avenue, Dallas, Texas 75202–2733, and
E-mail address
patterson.alima@epa.gov.
SUPPLEMENTARY INFORMATION:
A. Why Are Revisions to State
Programs Necessary?
States which have received final
authorization from the EPA under RCRA
section 3006(b), 42 U.S.C. 6926(b), must
maintain a hazardous waste program
that is equivalent to, consistent with,
and no less stringent than the Federal
program. As the Federal program
changes, States must change their
programs and ask the EPA to authorize
the changes. Changes to State programs
may be necessary when Federal or State
statutory or regulatory authority is
modified or when certain other changes
occur. Most commonly, States must
change their programs because of
changes to the EPA’s regulations in 40
Code of Federal Regulations (CFR) parts
124, 260 through 268, 270, 273, and 279.
B. What Decisions Have We Made in
This Rule?
We conclude that the State of
Texas’application to revise its
authorized program meets all of the
statutory and regulatory requirements
established by RCRA. Therefore, we
grant the State of Texas Final
Authorization to operate its hazardous
waste program with the changes
described in the authorization
application. The State of Texas has
responsibility for permitting treatment,
storage, and disposal facilities within its
borders (except in Indian Country) and
for carrying out the aspects of the RCRA
program described in its revised
program application, subject to the
limitations of the Hazardous and Solid
Waste Amendments of 1984 (HSWA).
New Federal requirements and
prohibitions imposed by Federal
regulations that the EPA promulgates
E:\FR\FM\13MYR1.SGM
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Agencies
[Federal Register Volume 74, Number 91 (Wednesday, May 13, 2009)]
[Rules and Regulations]
[Pages 22464-22469]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: E9-10757]
-----------------------------------------------------------------------
ENVIRONMENTAL PROTECTION AGENCY
40 CFR Part 180
[EPA-HQ-OPP-2009-0020; FRL-8410-3]
Methoxyfenozide; Pesticide Tolerances for Emergency Exemptions
AGENCY: Environmental Protection Agency (EPA).
ACTION: Final rule.
-----------------------------------------------------------------------
SUMMARY: This regulation establishes time-limited tolerances for
residues of the insecticide methoxyfenozide per se, in or on sorghum,
forage; sorghum, grain; and sorghum, stover. This action is in response
to a crisis exemption issued by the Louisiana Department of Agriculture
under section 18 of the Federal Insecticide, Fungicide and Rodenticide
Act (FIFRA) authorizing use of the pesticide on grain sorghum. This
regulation establishes a maximum permissible level for residues of
methoxyfenozide in these feed commodities. The time-limited tolerances
expire and will be revoked on December 31, 2012.
DATES: This regulation is effective May 13, 2009. Objections and
requests for hearings must be received on or before July 13, 2009, and
must be filed in accordance with the instructions provided in 40 CFR
part 178 (see also Unit I.C. of the SUPPLEMENTARY INFORMATION).
ADDRESSES: EPA has established a docket for this action under docket
identification (ID) number EPA-HQ-OPP-2009-0020. All documents in the
docket are listed in the docket index available in https://www.regulations.gov. Although listed in the index, some information is
not publicly available, e.g., Confidential Business Information (CBI)
or other information whose disclosure is restricted by statute. Certain
other material, such as copyrighted material, is not placed on the
Internet and will be publicly available only in hard copy form.
Publicly available docket materials are available in the electronic
docket at https://www.regulations.gov, or, if only available in hard
copy, at the OPP Regulatory Public Docket in Rm. S-4400, One Potomac
Yard (South Bldg.), 2777 S. Crystal Dr., Arlington, VA. The Docket
Facility is open from 8:30 a.m. to 4 p.m., Monday through Friday,
excluding legal holidays. The Docket Facility telephone number is (703)
305-5805.
FOR FURTHER INFORMATION CONTACT: Stacey Groce, Registration Division
(7505P), Office of Pesticide Programs, Environmental Protection Agency,
1200 Pennsylvania Ave., NW., Washington, DC 20460-0001; telephone
number: (703) 305-2505; e-mail address: groce.stacey@epa.gov.
SUPPLEMENTARY INFORMATION:
I. General Information
A. Does this Action Apply to Me?
You may be potentially affected by this action if you are an
agricultural producer, food manufacturer, or pesticide manufacturer.
Potentially affected entities may include, but are not limited to:
Crop production (NAICS code 111).
Animal production (NAICS code 112).
Food manufacturing (NAICS code 311).
Pesticide manufacturing (NAICS code 32532).
This listing is not intended to be exhaustive, but rather provides
a guide for readers regarding entities likely to be affected by this
action. Other types of entities not listed in this unit could also be
affected. The North American Industrial Classification System (NAICS)
codes have been provided to assist you and others in determining
whether this action might apply to certain entities. If you have any
questions regarding the applicability of this action to a particular
entity, consult the person listed under FOR FURTHER INFORMATION
CONTACT.
[[Page 22465]]
B. How Can I Access Electronic Copies of this Document?
In addition to accessing electronically available documents at
https://www.regulations.gov, you may access this Federal Register
document electronically through the EPA Internet under the ``Federal
Register'' listings at https://www.epa.gov/fedrgstr. You may also access
a frequently updated electronic version of 40 CFR part 180 through the
Government Printing Office's e-CFR cite at https://www.gpoaccess.gov/ecfr.
C. Can I File an Objection or Hearing Request?
Under section 408(g) of the Federal Food, Drug, and Cosmetic Act
(FFDCA), 21 U.S.C. 346a, any person may file an objection to any aspect
of this regulation and may also request a hearing on those objections.
The EPA procedural regulations which govern the submission of
objections and requests for hearings appear in 40 CFR part 178. You
must file your objection or request a hearing on this regulation in
accordance with the instructions provided in 40 CFR part 178. To ensure
proper receipt by EPA, you must identify docket ID number EPA-HQ-OPP-
2009-0020 in the subject line on the first page of your submission. All
requests must be in writing, and must be mailed or delivered to the
Hearing Clerk on or before July 13, 2009.
In addition to filing an objection or hearing request with the
Hearing Clerk as described in 40 CFR part 178, please submit a copy of
the filing that does not contain any CBI for inclusion in the public
docket that is described in ADDRESSES. Information not marked
confidential pursuant to 40 CFR part 2 may be disclosed publicly by EPA
without prior notice. Submit your copies, identified by docket ID
number EPA-HQ-OPP-2009-0020, by one of the following methods:
Federal eRulemaking Portal: https://www.regulations.gov.
Follow the on-line instructions for submitting comments.
Mail: Office of Pesticide Programs (OPP) Regulatory Public
Docket (7502P), Environmental Protection Agency, 1200 Pennsylvania
Ave., NW., Washington, DC 20460-0001.
Delivery: OPP Regulatory Public Docket (7502P),
Environmental Protection Agency, Rm. S-4400, One Potomac Yard (South
Bldg.), 2777 S. Crystal Dr., Arlington, VA. Deliveries are only
accepted during the Docket Facility's normal hours of operation (8:30
a.m. to 4 p.m., Monday through Friday, excluding legal holidays).
Special arrangements should be made for deliveries of boxed
information. The Docket Facility telephone number is (703) 305-5805.
II. Background and Statutory Findings
EPA, on its own initiative, in accordance with sections 408(e) and
408(l)(6) of FFDCA, 21 U.S.C. 346a(e) and 346a(1)(6), is establishing
time-limited tolerances for residues of the insecticide methoxyfenozide
per se (benzoic acid, 3-methoxy-2-methyl-,2-(3,5-dimethylbenzoyl)-2-
(1,1-dimethylethyl) hydrazide) in or on sorghum, forage at 30.0 parts
per million (ppm); sorghum, grain at 0.05 ppm; and sorghum, stover at
60.0 ppm. These time-limited tolerances expire and will be revoked on
December 31, 2012. EPA will publish a subsequent document in the
Federal Register to remove the revoked tolerances from the CFR.
Section 408(l)(6) of FFDCA requires EPA to establish a time-limited
tolerance or exemption from the requirement for a tolerance for
pesticide chemical residues in food that will result from the use of a
pesticide under an emergency exemption granted by EPA under section 18
of FIFRA. Such tolerances can be established without providing notice
or period for public comment. EPA does not intend for its actions on
section 18 related time-limited tolerances to set binding precedents
for the application of section 408 of FFDCA to other tolerances and
exemptions. Section 408(e) of FFDCA allows EPA to establish a tolerance
or an exemption from the requirement of a tolerance on its own
initiative, i.e., without having received any petition from an outside
party.
Section 408(b)(2)(A)(i) of FFDCA allows EPA to establish a
tolerance (the legal limit for a pesticide chemical residue in or on a
food) only if EPA determines that the tolerance is ``safe.'' Section
408(b)(2)(A)(ii) of FFDCA defines ``safe'' to mean that ``there is a
reasonable certainty that no harm will result from aggregate exposure
to the pesticide chemical residue, including all anticipated dietary
exposures and all other exposures for which there is reliable
information.'' This includes exposure through drinking water and in
residential settings, but does not include occupational exposure.
Section 408(b)(2)(C) of FFDCA requires EPA to give special
consideration to exposure of infants and children to the pesticide
chemical residue in establishing a tolerance and to ``ensure that there
is a reasonable certainty that no harm will result to infants and
children from aggregate exposure to the pesticide chemical residue. . .
.''
Section 18 of FIFRA authorizes EPA to exempt any Federal or State
agency from any provision of FIFRA, if EPA determines that ``emergency
conditions exist which require such exemption.'' EPA has established
regulations governing such emergency exemptions in 40 CFR part 166.
III. Emergency Exemption for Methoxyfenozide on Various Commodities:
Sorghum, forage; Sorghum, grain; and Sorghum, stover and FFDCA
Tolerances
The Louisiana Department of Agriculture requested an emergency
exemption for use of methoxyfenozide on grain sorghum to control the
southwestern corn borer and sugarcane borer, and issued a crisis
exemption for this use pursuant to 40 CFR part 166, subpart C. The
Louisiana Department of Agriculture provided information indicating
that the southwestern corn borer and sugarcane borer are serious pests
that commonly infest grain sorghum. Methoxyfenozide has been authorized
under FIFRA section 18 for use on sorghum, forage, sorghum, grain, and
sorghum, stover to control southwestern corn borer and sugarcane borer
in Louisiana under the crisis provision.
As part of its evaluation of the emergency exemption application,
EPA assessed the potential risks presented by residues of the
insecticide methoxyfenozide per se in or on sorghum, forage; sorghum,
grain; and sorghum, stover. In doing so, EPA considered the safety
standard in section 408(b)(2) of FFDCA, and EPA decided that the
necessary tolerance under section 408(l)(6) of FFDCA would be
consistent with the safety standard and with FIFRA section 18.
Consistent with the need to move quickly on the emergency exemption in
order to address an urgent non-routine situation and to ensure that the
resulting food is safe and lawful, EPA is issuing this tolerance
without notice and opportunity for public comment as provided in
section 408(l)(6) of FFDCA. Although these time-limited tolerances
expire and will be revoked on December 31, 2012, under section
408(l)(5) of FFDCA, residues of the pesticide not in excess of the
amounts specified in the tolerance remaining in or on sorghum, forage;
sorghum, grain; and sorghum, stover after that date will not be
unlawful, provided the pesticide was applied in a manner that was
lawful under FIFRA, and the residues do not exceed a level that was
authorized by these time-limited tolerances at the time of that
application. EPA will take action to revoke these time-limited
tolerances
[[Page 22466]]
earlier if any experience with, scientific data on, or other relevant
information on this pesticide indicate that the residues are not safe.
Because these time-limited tolerances are being approved under
emergency conditions, EPA has not made any decisions about whether
methoxyfenozide meets FIFRA's registration requirements for use on
sorghum, forage; sorghum, grain; and sorghum, stover or whether
permanent tolerances for these uses would be appropriate. Under these
circumstances, EPA does not believe that these time-limited tolerance
decisions serve as a basis for registration of methoxyfenozide by a
State for special local needs under FIFRA section 24(c). Nor do these
tolerances serve as the basis for persons in any State other than
Louisiana to use this pesticide on the applicable crops under FIFRA
section 18 absent the issuance of an emergency exemption applicable
within that State. For additional information regarding the emergency
exemption for methoxyfenozide, contact the Agency's Registration
Division at the address provided under FOR FURTHER INFORMATION CONTACT.
IV. Aggregate Risk Assessment and Determination of Safety
Section 408(b)(2)(A)(i) of FFDCA allows EPA to establish a
tolerance (the legal limit for a pesticide chemical residue in or on a
food) only if EPA determines that the tolerance is ``safe.'' Section
408(b)(2)(A)(ii) of FFDCA defines ``safe'' to mean that ``there is a
reasonable certainty that no harm will result from aggregate exposure
to the pesticide chemical residue, including all anticipated dietary
exposures and all other exposures for which there is reliable
information.'' This includes exposure through drinking water and in
residential settings, but does not include occupational exposure.
Section 408(b)(2)(C) of FFDCA requires EPA to give special
consideration to exposure of infants and children to the pesticide
chemical residue in establishing a tolerance and to ``ensure that there
is a reasonable certainty that no harm will result to infants and
children from aggregate exposure to the pesticide chemical residue. . .
.''
Consistent with the factors specified in FFDCA section
408(b)(2)(D), EPA has reviewed the available scientific data and other
relevant information in support of this action. EPA has sufficient data
to assess the hazards of and to make a determination on aggregate
exposure expected as a result of this emergency exemption request and
the time-limited tolerances for residues of the insecticide
methoxyfenozide per se (benzoic acid, 3-methoxy-2-methyl-,2-(3,5-
dimethylbenzoyl)-2-(1,1-dimethylethyl) hydrazide) in or on sorghum,
forage at 30.0 parts per million (ppm); sorghum, grain at 0.05 ppm; and
sorghum, stover at 60.0 ppm. EPA's assessment of exposures and risks
associated with establishing time-limited tolerances follows.
A. Toxicological Endpoints
For hazards that have a threshold below which there is no
appreciable risk, a toxicological point of departure (POD) is
identified as the basis for derivation of reference values for risk
assessment. The POD may be defined as the highest dose at which no
adverse effects are observed (the NOAEL) in the toxicology study
identified as appropriate for use in risk assessment. However, if a
NOAEL cannot be determined, the lowest dose at which adverse effects of
concern are identified (the LOAEL) or a Benchmark Dose (BMD) approach
is sometimes used for risk assessment. Uncertainty/safety factors (UFs)
are used in conjunction with the POD to take into account uncertainties
inherent in the extrapolation from laboratory animal data to humans and
in the variations in sensitivity among members of the human population
as well as other unknowns. Safety is assessed for acute and chronic
dietary risks by comparing aggregate food and water exposure to the
pesticide to the acute population adjusted dose (aPAD) and chronic
population adjusted dose (cPAD). The aPAD and cPAD are calculated by
dividing the POD by all applicable UFs. Aggregate short-term,
intermediate-term, and chronic-term risks are evaluated by comparing
food, water, and residential exposure to the POD to ensure that the
margin of exposure (MOE) called for by the product of all applicable
UFs is not exceeded. This latter value is referred to as the Level of
Concern (LOC).
For non-threshold risks, the Agency assumes that any amount of
exposure will lead to some degree of risk. Thus, the Agency estimates
risk in terms of the probability of an occurrence of the adverse effect
greater than that expected in a lifetime. For more information on the
general principles EPA uses in risk characterization and a complete
description of the risk assessment process, see https://www.epa.gov/pesticides/factsheets/riskassess.htm.
A summary of the toxicological endpoints for methoxyfenozide used
for human risk assessment can be found in the document entitled,
``Methoxyfenozide. Human Health Risk Assessment for Proposed Section 18
Use on Grain Sorghum,'' dated November 20, 2008, by going to https://www.regulations.gov. The referenced document is available in the docket
established by this action, which is described under ADDRESSES, and is
identified as EPA-HQ-OPP-2009-0020-0002 in that docket. Locate and
click on the hyperlink for docket ID number EPA-HQ-OPP-2009-0020.
Double-click on the document to view the referenced information on page
23 of 34.
B. Exposure Assessment
1. Dietary exposure from food and feed uses. In evaluating dietary
exposure to methoxyfenozide, EPA considered exposure under the time-
limited tolerances established by this action as well as exposures
pursuant to existing methoxyfenozide tolerances in (40 CFR 180.544).
EPA assessed dietary exposures from methoxyfenozide in food as follows:
i. Acute exposure. No appropriate toxicological endpoint
attributable to a single exposure was identified in the available
toxicological studies for methoxyfenozide; therefore, a quantitative
acute dietary exposure assessment is unnecessary.
ii. Chronic exposure. In conducting the chronic dietary exposure
assessment EPA used the food consumption data from the USDA 1994-1996
and 1998 Nationwide Continuing Surveys of food Intake by Individuals
(CSFII). As to residue levels in food, an unrefined chronic dietary
analysis for methoxyfenozide was conducted using tolerance levels and
100% crop-treated for all existing and proposed uses. Drinking water
was incorporated directly into the dietary assessment using the chronic
concentration for surface water generated by the PRZM-EXAMS model at
33.1 ppb. The results of the analysis indicate that chronic risk from
the dietary (food and drinking water) exposure to methoxyfenozide will
not exceed EPA's level of concern for the general U.S. population and
all population subgroups.
iii. Cancer. Methoxyfenozide is not likely to be carcinogenic to
humans; therefore, a cancer exposure assessment was not conducted. This
classification is based on the lack of evidence of carcinogenicity in
male and female rats as well as in male and female mice and on the lack
of genotoxicity in an acceptable battery of mutagenicity studies.
iv. Anticipated residue and percent crop treated (PCT) information.
EPA did not use anticipated residue and/or PCT information in the
dietary assessment
[[Page 22467]]
for methoxyfenozide. Tolerance level residues and/or 100 PCT were
assumed for all food commodities.
2. Dietary exposure from drinking water. The Agency used screening
level water exposure models in the dietary exposure analysis and risk
assessment for methoxyfenozide in drinking water. These simulation
models take into account data on the physical, chemical, and fate/
transport characteristics of methoxyfenozide. Further information
regarding EPA drinking water models used in pesticide exposure
assessment can be found at https://www.epa.gov/oppefed1/models/water/index.htm.
Based on the Pesticide Root Zone Model/Exposure Analysis Modeling
System(PRZM/EXAMS) and Screening Concentration in Ground Water (SCI-
GROW) models, the estimated drinking water concentrations (EDWCs) of
methoxyfenozide for acute dietary exposures are estimated to be 52.2
parts per billion (ppb) for surface water and 7.43 ppb for ground
water. The estimated drinking water concentrations (EDWCs) for chronic
dietary exposures for non-cancer assessments are estimated to be 33.1
ppb for surface water and 7.43 ppb for ground water.
Modeled estimates of drinking water concentrations were directly
entered into the dietary exposure model. An acute dietary endpoint was
not identified; therefore, a quantitative assessment of risk was not
conducted for methoxyfenozide. For chronic dietary risk assessment, the
water concentration of 33.1 ppb was used to assess the contribution
from drinking water.
3. From non-dietary exposure. The term ``residential exposure'' is
used in this document to refer to non-occupational, non-dietary
exposure (e.g., for lawn and garden pest control, indoor pest control,
termiticides, and flea and tick control on pets).
Methoxyfenozide is not registered for any specific use patterns
that would result in residential exposure.
4. Cumulative effects from substances with a common mechanism of
toxicity. Section 408(b)(2)(D)(v) of FFDCA requires that, when
considering whether to establish, modify, or revoke a tolerance, the
Agency consider ``available information'' concerning the cumulative
effects of a particular pesticide's residues and`` other substances
that have a common mechanism of toxicity.''
EPA has not found methoxyfenozide to share a common mechanism of
toxicity with any other substances, and methoxyfenozide does not appear
to produce a toxic metabolite produced by other substances. For the
purposes of this tolerance action, therefore, EPA has assumed that
methoxyfenozide does not have a common mechanism of toxicity with other
substances. For information regarding EPA's efforts to determine which
chemicals have a common mechanism of toxicity and to evaluate the
cumulative effects of such chemicals, see the policy statements
released by EPA's Office of Pesticide Programs concerning common
mechanism determinations and procedures for cumulating effects from
substances found to have a common mechanism on EPA's website at https://www.epa.gov/pesticides/cumulative.
C. Safety Factor for Infants and Children
1. In general. Section 408(b)(2)(C) of FFDCA provides that EPA
shall apply an additional tenfold (10X) margin of safety for infants
and children in the case of threshold effects to account for prenatal
and postnatal toxicity and the completeness of the database on toxicity
and exposure unless EPA determines based on reliable data that a
different margin of safety will be safe for infants and children. This
additional margin of safety is commonly referred to as the FQPA safety
factor (SF). In applying this provision, EPA either retains the default
value of 10X, or uses a different additional SF when reliable data
available to EPA support the choice of a different factor.
2. Prenatal and postnatal sensitivity. There is not a concern for
prenatal and/ or postnatal toxicity resulting from exposure to
methoxyfenozide. The prenatal and postnatal toxicology database for
methoxyfenozide includes rat and rabbit developmental toxicity studies
and a 2-generation reproductive study. There was no increased
susceptibility in fetuses as compared to maternal animals observed
following in utero exposures.
3. Conclusion. EPA has determined that reliable data show that the
safety of infants and children would be adequately protected if the
FQPA SF were reduced to 1X. That decision is based on the following
findings:
i. The toxicity database for methoxyfenozide is complete for
assessment of potential hazard to infants and children.
ii. There is no indication that methoxyfenozide is a neurotoxic
chemical and there is no need for a developmental neurotoxicity study
or additional UFs to account for neurotoxicity.
iii. There is no evidence that methoxyfenozide results in increased
susceptibility in in utero rats or rabbits in the prenatal
developmental studies or in young rats in the 2-generation reproduction
study.
iv. There are no residual uncertainties identified in the exposure
database. The exposure assessments will not underestimate the potential
dietary (food and drinking water) or nondietary exposures for infants
and children from use of methoxyfenozide. EPA made conservative
(protective) assumptions in the ground water and surface water modeling
used to assess exposure to methoxyfenozide in drinking water. EPA used
similarly conservative assumptions to assess postapplication exposure
of children as well as incidental oral exposure of toddlers. These
assessments will not underestimate the exposure and risks posed by
methoxyfenozide.
D. Aggregate Risks and Determination of Safety
EPA determines whether acute and chronic pesticide exposures are
safe by comparing aggregate exposure estimates to the aPAD and cPAD.
The aPAD and cPAD represent the highest safe exposures, taking into
account all appropriate SFs. EPA calculates the aPAD and cPAD by
dividing the POD by all applicable UFs. For linear cancer risks, EPA
calculates the probability of additional cancer cases given the
estimated aggregate exposure. Short-term, intermediate-term, and
chronic-term risks are evaluated by comparing the estimated aggregate
food, water, and residential exposure to the POD to ensure that the MOE
called for by the product of all applicable UFs is not exceeded.
1. Acute risk. An acute aggregate risk assessment takes into
account exposure estimates from acute dietary consumption of food and
drinking water. No adverse effect resulting from a single-oral exposure
was identified, therefore, dietary exposure presents no acute risks of
concern.
2. Chronic risk. Using the exposure assumptions described in this
unit for chronic exposure, EPA has concluded that chronic exposure to
methoxyfenozide from food and water will utilize 56% of the cPAD for
children 1-2 years old, the population group receiving the greatest
exposure. There are no residential uses for methoxyfenozide.
3. Short-term risk. Short-term aggregate exposure takes into
account short-term residential exposure plus chronic exposure to food
and water (considered to be a background exposure level).
Methoxyfenozide is not registered for any use patterns that would
result in residential exposure. Therefore, the
[[Page 22468]]
short-term aggregate risk is the sum of the risk from exposure to
methoxyfenozide through food and water. Thus, the chronic aggregate
exposure for the most exposed group is below EPA's level of concern.
4. Intermediate-term risk. Intermediate-term aggregate exposure
takes into account intermediate-term non-dietary, non-occupational
exposure plus chronic exposure to food and water (considered to be a
background exposure level).
Methoxyfenozide is not registered for any use patterns that would
result in intermediate-term residential exposure. Therefore, the
intermediate-term aggregate risk is the sum of the risk from exposure
to methoxyfenozide through food and water, which has already been
addressed, and will not be greater than the chronic aggregate risk.
5. Aggregate cancer risk for U.S. population. Methoxyfenozide is
classified as a ``not likely'' human carcinogen and thus is not
expected to pose a cancer risk to humans. This classification is based
on the lack of evidence of carcinogenicity in male and female rats as
well as in male and female mice and on the lack of genotoxicity in an
acceptable battery of mutagenicity studies.
6. Determination of safety. Based on these risk assessments, EPA
concludes that there is a reasonable certainty that no harm will result
to the general population, or to infants and children, from aggregate
exposure to methoxyfenozide residues.
V. Other Considerations
A. Analytical Enforcement Methodology
Adequate enforcement methodology (high pressure liquid
chromatography with mass spectrometry (HPLC/MS)) is available to
enforce the tolerance expression. The method may be requested from:
Chief, Analytical Chemistry Branch, Environmental Science Center, 701
Mapes Rd., Ft. Meade, MD 20755-5350; telephone number: (410) 305-2905;
e-mail address: residuemethods@epa.gov.
B. International Residue Limits
There are currently no Canadian, Mexican, or Codex maximum residue
limits (MRLs) for methoxyfenozide on the commodities for which
tolerances are being established.
VI. Conclusion
Therefore, time-limited tolerances are established for residues of
the insecticide methoxyfenozide per se (benzoic acid, 3-methoxy-2-
methyl-,2-(3,5-dimethylbenzoyl)-2-(1,1-dimethylethyl) hydrazide) in or
on sorghum, forage at 30.0 ppm; sorghum, grain at 0.05 ppm; and
sorghum, stover at 60.0 ppm. These tolerances expire and will be
revoked on December 31, 2012.
VII. Statutory and Executive Order Reviews
This final rule establishes tolerances under sections 408(e) and
408(l)(6) of FFDCA in response to a petition submitted to the Agency.
The Office of Management and Budget (OMB) has exempted these types of
actions from review under Executive Order 12866, entitled Regulatory
Planning and Review (58 FR 51735, October 4, 1993). Because this final
rule has been exempted from review under Executive Order 12866, this
final rule is not subject to Executive Order 13211, entitled Actions
Concerning Regulations That Significantly Affect Energy Supply,
Distribution, or Use (66 FR 28355, May 22, 2001) or Executive Order
13045, entitled Protection of Children from Environmental Health Risks
and Safety Risks (62 FR 19885, April 23, 1997). This final rule does
not contain any information collections subject to OMB approval under
the Paperwork Reduction Act (PRA), 44 U.S.C. 3501 et seq., nor does it
require any special considerations under Executive Order 12898,
entitled Federal Actions to Address Environmental Justice in Minority
Populations and Low-Income Populations (59 FR 7629, February 16, 1994).
Since tolerances and exemptions that are established in accordance
with sections 408(e) and 408(l)(6) of FFDCA, such as the tolerances in
this final rule, do not require the issuance of a proposed rule, the
requirements of the Regulatory Flexibility Act (RFA) (5 U.S.C. 601 et
seq.) do not apply.
This final rule directly regulates growers, food processors, food
handlers, and food retailers, not States or tribes, nor does this
action alter the relationships or distribution of power and
responsibilities established by Congress in the preemption provisions
of section 408(n)(4) of FFDCA. As such, the Agency has determined that
this action will not have a substantial direct effect on States or
tribal governments, on the relationship between the national government
and the States or tribal governments, or on the distribution of power
and responsibilities among the various levels of government or between
the Federal Government and Indian tribes. Thus, the Agency has
determined that Executive Order 13132, entitled Federalism (64 FR
43255, August 10, 1999) and Executive Order 13175, entitled
Consultation and Coordination with Indian Tribal Governments (65 FR
67249, November 9, 2000) do not apply to this final rule. In addition,
this final rule does not impose any enforceable duty or contain any
unfunded mandate as described under Title II of the Unfunded Mandates
Reform Act of 1995 (UMRA) (Public Law 104-4).
This action does not involve any technical standards that would
require Agency consideration of voluntary consensus standards pursuant
to section 12(d) of the National Technology Transfer and Advancement
Act of 1995 (NTTAA), Public Law 104-113, section 12(d) (15 U.S.C. 272
note).
VIII. Congressional Review Act
The Congressional Review Act, 5 U.S.C. 801 et seq., generally
provides that before a rule may take effect, the agency promulgating
the rule must submit a rule report to each House of the Congress and to
the Comptroller General of the United States. EPA will submit a report
containing this rule and other required information to the U.S. Senate,
the U.S. House of Representatives, and the Comptroller General of the
United States prior to publication of this final rule in the Federal
Register. This final rule is not a ``major rule'' as defined by 5
U.S.C. 804(2).
List of Subjects in 40 CFR Part 180
Environmental protection, Administrative practice and procedure,
Agricultural commodities, Pesticides and pests, Reporting and
recordkeeping requirements.
Dated: April 28, 2009.
Daniel J. Rosenblatt,
Acting Director, Registration Division, Office of Pesticide Programs.
0
Therefore, 40 CFR chapter I is amended as follows:
PART 180--[AMENDED]
0
1. The authority citation for part 180 continues to read as follows:
Authority: 21 U.S.C. 321(q), 346a and 371.
0
2. Section 180.544 is amended by adding paragraph (b) to read as
follows:
Sec. 180.544 Methoxyfenozide; tolerances for residues.
* * * * *
(b) Section 18 emergency exemptions. Time-limited tolerances
specified in the following table are established for residues of the
insecticide methoxyfenozide per se (benzoic acid, 3-methoxy-2-methyl-
,2-(3,5-dimethylbenzoyl)-2-(1,1-dimethylethyl) hydrazide), in or on the
specified agricultural commodities, resulting from
[[Page 22469]]
use of the pesticide pursuant to FFIFRA section 18 emergency
exemptions. The tolerances expire and will be revoked on the date
specified in the table.
----------------------------------------------------------------------------------------------------------------
Expiration/revocation
Commodity Parts per million date
----------------------------------------------------------------------------------------------------------------
Sorghum, forage 30.0 December 31, 2012
Sorghum, grain 0.05 December 31, 2012
Sorghum, stover 60.0 December 31, 2012
----------------------------------------------------------------------------------------------------------------
* * * * *
[FR Doc. E9-10757 Filed 5-12-09; 8:45 am]
BILLING CODE 6560-50-S