Request for Research Sites To Measure Composition of Sealed Area Atmosphere in Coal Mines, 17202-17203 [E9-8462]
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Federal Register / Vol. 74, No. 70 / Tuesday, April 14, 2009 / Notices
Dated: April 7, 2009.
Anna Snouffer,
Deputy Director, Office of Federal Advisory
Committee Policy.
[FR Doc. E9–8479 Filed 4–13–09; 8:45 am]
BILLING CODE 4140–01–P
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
Related to Neurological Disorders; 93.854,
Biological Basis Research in the
Neurosciences, National Institutes of Health,
HHS)
Dated: April 7, 2009.
Anna Snouffer,
Deputy Director, Office of Federal Advisory
Committee Policy.
[FR Doc. E9–8481 Filed 4–13–09; 8:45 am]
BILLING CODE 4140–01–P
National Institutes of Health
National Institute of Neurological
Disorders and Stroke; Notice of Closed
Meetings
Pursuant to section 10(d) of the
Federal Advisory Committee Act, as
amended (5 U.S.C. App.), notice is
hereby given of the following meetings.
The meetings will be closed to the
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provisions set forth in sections
552b(c)(4) and 552b(c)(6), Title 5 U.S.C.,
as amended. The grant applications and
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would constitute a clearly unwarranted
invasion of personal privacy.
Name of Committee: National Institute of
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Date: April 23, 2009.
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CA∧2+ Signaling in Spines.
Date: April 24, 2009.
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(Catalogue of Federal Domestic Assistance
Program Nos. 93.853, Clinical Research
VerDate Nov<24>2008
17:36 Apr 13, 2009
Jkt 217001
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
Notice of a Public Consultation
Meeting on Proposed Revisions to the
NIH Guidelines for Research Involving
Recombinant DNA Molecule (NIH
Guidelines)
There will be a public consultation
meeting to solicit stakeholder input
regarding the proposed revisions to the
NIH Guidelines. The meeting will be
held on Tuesday, June 23, 2009 at the
Hyatt Regency Crystal City, 2799
Jefferson Davis Highway, Arlington,
Virginia, 22202, from approximately 8
a.m. to 5 p.m.
Discussions will focus on the
proposed revisions to the NIH
Guidelines which include: (1)
Broadening the scope of the NIH
Guidelines, which currently cover
laboratory and clinical research
involving DNA molecules created via
recombinant techniques (i.e., joining of
DNA molecules), to apply to nucleic
acids that are synthesized chemically or
by other means without the use of
recombinant technology; (2) Revising
the criteria for determining when the
introduction of a drug resistance trait
into a microorganism must be reviewed
by the Recombinant DNA Advisory
Committee and approved by the NIH
Director; and (3) Changing the level of
review required for recombinant or
synthetic experiments involving more
than one-half but less than two-thirds of
the genome of certain viruses in tissue
culture as described in Section III–E–1
of the NIH Guidelines.
The Notice of Consideration of a
Proposed Action under the NIH
Guidelines was published in the
Federal Register on March 4, 2009 (74
FR 9411) and may be located at the
following link: https://oba.od.nih.gov/
rdna/rdna.html.
For further information concerning
this meeting contact Ms. Laurie
Lewallen, Advisory Committee
Coordinator, Office of Biotechnology
Activities, Office of the Director,
National Institutes of Health, 6705
PO 00000
Frm 00060
Fmt 4703
Sfmt 4703
Rockledge Drive, Room 750, Bethesda,
MD 20892–7985, 301–496–9838,
lewallenl@od.nih.gov.
The meeting will be open to the
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attend and need special assistance, such
as sign language interpretation or other
reasonable accommodations, should
notify the Contact Person listed above in
advance of the meeting.
A draft agenda and additional
information for the meeting will be
posted on the OBA Web site: https://
oba.od.nih.gov/rdna/rdna.html.
Background and supplemental
information may also be obtained by
contacting NIH OBA by e-mail
oba@od.nih.gov.
Dated: April 8, 2009.
Jacqueline Corrigan-Curay,
Acting Director, Office of Biotechnology
Activities, National Institutes of Health.
[FR Doc. E9–8478 Filed 4–13–09; 8:45 am]
BILLING CODE 4140–01–P
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
Centers for Disease Control and
Prevention
Request for Research Sites To
Measure Composition of Sealed Area
Atmosphere in Coal Mines
AGENCY: National Institute for
Occupational Safety and Health
(NIOSH) of the Centers for Disease
Control and Prevention (CDC),
Department of Health and Human
Services (HHS).
ACTION: Notice.
SUMMARY: The National Institute for
Occupational Safety and Health
(NIOSH) of the Centers for Disease
Control and Prevention (CDC), is
seeking research sites to measure
composition of sealed area atmosphere
in coal mines.
NIOSH seeks to conduct scientific
studies of the composition of sealed area
atmospheres and the mechanisms of
methane accumulation within sealed
areas. Research questions to be
addressed are: (1) Whether potentially
explosive gas mixtures exist within
sealed areas, (2) how extensive such
mixtures might be, (3) how the gas
composition changes over time, (4)
whether methane layering exists, (5) the
homogeneity of the atmosphere, and (6)
how barometric pressure changes
impact the sealed atmosphere. NIOSH
will document measurements of the
composition of the sealed area
atmosphere over time, analyze the
E:\FR\FM\14APN1.SGM
14APN1
Federal Register / Vol. 74, No. 70 / Tuesday, April 14, 2009 / Notices
findings, and report the findings
generically to all interested parties.
DATES: Letter of interest must be
received within 90 calendar days of
publication in the Federal Register.
ADDRESSES: Mining companies able to
provide NIOSH with mine sites for this
research should submit a letter of
interest to the NIOSH Pittsburgh
Research Laboratory (PRL) Director. The
letter should provide the name of the
mine and a brief description of the
anticipated sealing plans. Any questions
should be addressed by phone or e-mail.
¨
Please send letter of interest to: R. Guner
¨
Gurtunca, PhD, NIOSH Pittsburgh
Research Laboratory (PRL), 626
Cochrans Mill Road, Post Office Box
18070, Pittsburgh, PA 15236, telephone
(412) 386–6601, E-mail
GGurtunca@cdc.gov.
Background: Recent research reports
published by NIOSH and the U.S. Army
Corps of Engineers describe the
potential for explosive methane
mixtures to develop within sealed areas
of underground coal mines. The
composition and behavior of the
atmosphere within sealed areas are not
scientifically well-understood. Areas of
interest include the extent and nature of
explosive mixtures of gases, how the
composition of these mixtures change
over time, whether methane layering
exists, the homogeneity of the
atmosphere, and how barometric
pressure changes impact the atmosphere
behind seals.
Description: To conduct these
measurements, NIOSH will deploy a
tube bundle system (TBS) at the mine
site for a period of 2 to 5 months
(usually not more than 3 months). A
TBS is a mechanical system for
collecting and analyzing atmospheric
samples continuously from anywhere in
a mine. The TBS that NIOSH plans to
use is a system that is currently being
successfully deployed in many
Australian underground coal mines.
NIOSH seeks three to four underground
coal mines throughout the U.S. to
cooperate in this study. Underground
coal mines covering at least one square
mile and producing a medium to high
volume of methane are needed.
Sampling will be conducted one mine at
a time. Either longwall or room-andpillar mines are acceptable. NIOSH
wants to deploy the system in a variety
of geological conditions. A soon-to-beabandoned coal mine is another option
for deployment of the TBS.
Prior to sealing, NIOSH will install
plastic sample tubing throughout the
mine and the future sealed area. This
should require a few days to accomplish
and will require minimal effort from the
VerDate Nov<24>2008
16:39 Apr 13, 2009
Jkt 217001
cooperating mine. NIOSH will need to
be present during the sealing process to
insure that the tubing is properly
installed through the seals. After
sealing, NIOSH will monitor the
composition of the atmosphere
throughout the sealed area during the
initial methane-accumulation phase and
for several months thereafter until
stability of the sealed atmosphere
develops. Collected data will not be
analyzed on a real time basis other than
to insure that the system is properly
working.
NIOSH will require the following
assistance from mining company
personnel:
• Site-specific guidance concerning
the area to be sealed and how to most
efficiently run the sampling tube out of
the mine to the sampling analysis
location.
• Transportation to and from the
sealed area during the installation phase
of the TBS and to occasionally check the
status of the TBS underground.
• A surface location to locate the
sampling trailer.
• For a mine site to be acceptable to
NIOSH for this testing, the cooperating
mine must be installing 120 psi seals
that meet the current design standard.
• After installation, NIOSH will
require little assistance from mining
company personnel until NIOSH is
ready to remove the system from the
mine when some transportation
assistance will be needed.
After the data is analyzed, the
cooperating mine will be provided the
data pertaining to its mine. NIOSH will
present and/or publish data in a manner
that does not identify the cooperating
mines. Cooperating mines will have the
opportunity to review publications and
presentations by NIOSH prior to their
release. While NIOSH will not identify
the mines in its publications, the
identity of cooperating mines may be
subject to release in response to a
request for documents made under the
Freedom of Information Act. This
announcement does not obligate NIOSH
to enter into an agreement with any
respondent.
FOR FURTHER INFORMATION CONTACT: R.
¨
¨
Guner Gurtunca, PhD, NIOSH
Pittsburgh Research Laboratory (PRL),
626 Cochrans Mill Road, Post Office Box
18070, Pittsburgh PA, 15236, telephone
(412) 386–6601, e-mail
GGurtunca@cdc.gov.
PO 00000
Frm 00061
Fmt 4703
Sfmt 4703
17203
Dated: April 6, 2009.
Christine M. Branche,
Acting Director, National Institute for
Occupational Safety and Health, Centers for
Disease Control and Prevention.
[FR Doc. E9–8462 Filed 4–13–09; 8:45 am]
BILLING CODE 4163–19–P
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
The Best Pharmaceuticals for Children
Act (BPCA) Priority List of Needs in
Pediatric Therapeutics
ACTION:
Notice.
SUMMARY: For many decades, the
pediatric medical community, the
public health community, and
government agencies have recognized a
range of questions regarding the use of
therapeutics in children, including the
shortage of clinical studies of drugs in
children resulting in inadequate
labeling for pediatric use. The lack of
appropriate labeling results in off-label
use of prescription drugs in many
children and for many conditions.
Contributing factors to this frequent offlabel use of drugs in pediatrics include
the rarity of some conditions in children
with limited patient availability, the
ethical concerns regarding the conduct
of clinical trials in children, the lack of
accurate information about which drugs
are used by children, and the lack of
long-term data on the medications that
are frequently used.
Several steps have been taken in
response to the growing awareness of
the knowledge gaps that exist in
pediatric therapeutics. The BPCA was
originally enacted in January 2002 and
reauthorized in September 2007, with
the overall purpose of improving the
level of information about
pharmaceuticals used to treat children
(https://www.fda.gov/opacom/laws/
pharmkids/contents.html). The BPCA
outlines a number of goals, including
the identification and prioritization of
therapeutic needs in pediatrics,
especially drugs, biologics, or
indications that require study. The
legislation also calls for the conduct of
pediatric research to learn more about
the efficacy and safety of drugs in
children as well as the training of
experts needed to address the
knowledge gaps in pediatric
pharmacology. To identify drugs in
need of further study, the BPCA
mandates that the National Institutes of
Health (NIH), in consultation with the
U.S. Food and Drug Administration
(FDA) and experts in pediatrics, develop
E:\FR\FM\14APN1.SGM
14APN1
]]>Agencies
[Federal Register Volume 74, Number 70 (Tuesday, April 14, 2009)]
[Notices]
[Pages 17202-17203]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: E9-8462]
-----------------------------------------------------------------------
DEPARTMENT OF HEALTH AND HUMAN SERVICES
Centers for Disease Control and Prevention
Request for Research Sites To Measure Composition of Sealed Area
Atmosphere in Coal Mines
AGENCY: National Institute for Occupational Safety and Health (NIOSH)
of the Centers for Disease Control and Prevention (CDC), Department of
Health and Human Services (HHS).
ACTION: Notice.
-----------------------------------------------------------------------
SUMMARY: The National Institute for Occupational Safety and Health
(NIOSH) of the Centers for Disease Control and Prevention (CDC), is
seeking research sites to measure composition of sealed area atmosphere
in coal mines.
NIOSH seeks to conduct scientific studies of the composition of
sealed area atmospheres and the mechanisms of methane accumulation
within sealed areas. Research questions to be addressed are: (1)
Whether potentially explosive gas mixtures exist within sealed areas,
(2) how extensive such mixtures might be, (3) how the gas composition
changes over time, (4) whether methane layering exists, (5) the
homogeneity of the atmosphere, and (6) how barometric pressure changes
impact the sealed atmosphere. NIOSH will document measurements of the
composition of the sealed area atmosphere over time, analyze the
[[Page 17203]]
findings, and report the findings generically to all interested
parties.
DATES: Letter of interest must be received within 90 calendar days of
publication in the Federal Register.
ADDRESSES: Mining companies able to provide NIOSH with mine sites for
this research should submit a letter of interest to the NIOSH
Pittsburgh Research Laboratory (PRL) Director. The letter should
provide the name of the mine and a brief description of the anticipated
sealing plans. Any questions should be addressed by phone or e-mail.
Please send letter of interest to: R. G[uuml]ner G[uuml]rtunca, PhD,
NIOSH Pittsburgh Research Laboratory (PRL), 626 Cochrans Mill Road,
Post Office Box 18070, Pittsburgh, PA 15236, telephone (412) 386-6601,
E-mail GGurtunca@cdc.gov.
Background: Recent research reports published by NIOSH and the U.S.
Army Corps of Engineers describe the potential for explosive methane
mixtures to develop within sealed areas of underground coal mines. The
composition and behavior of the atmosphere within sealed areas are not
scientifically well-understood. Areas of interest include the extent
and nature of explosive mixtures of gases, how the composition of these
mixtures change over time, whether methane layering exists, the
homogeneity of the atmosphere, and how barometric pressure changes
impact the atmosphere behind seals.
Description: To conduct these measurements, NIOSH will deploy a
tube bundle system (TBS) at the mine site for a period of 2 to 5 months
(usually not more than 3 months). A TBS is a mechanical system for
collecting and analyzing atmospheric samples continuously from anywhere
in a mine. The TBS that NIOSH plans to use is a system that is
currently being successfully deployed in many Australian underground
coal mines. NIOSH seeks three to four underground coal mines throughout
the U.S. to cooperate in this study. Underground coal mines covering at
least one square mile and producing a medium to high volume of methane
are needed. Sampling will be conducted one mine at a time. Either
longwall or room-and-pillar mines are acceptable. NIOSH wants to deploy
the system in a variety of geological conditions. A soon-to-be-
abandoned coal mine is another option for deployment of the TBS.
Prior to sealing, NIOSH will install plastic sample tubing
throughout the mine and the future sealed area. This should require a
few days to accomplish and will require minimal effort from the
cooperating mine. NIOSH will need to be present during the sealing
process to insure that the tubing is properly installed through the
seals. After sealing, NIOSH will monitor the composition of the
atmosphere throughout the sealed area during the initial methane-
accumulation phase and for several months thereafter until stability of
the sealed atmosphere develops. Collected data will not be analyzed on
a real time basis other than to insure that the system is properly
working.
NIOSH will require the following assistance from mining company
personnel:
Site-specific guidance concerning the area to be sealed
and how to most efficiently run the sampling tube out of the mine to
the sampling analysis location.
Transportation to and from the sealed area during the
installation phase of the TBS and to occasionally check the status of
the TBS underground.
A surface location to locate the sampling trailer.
For a mine site to be acceptable to NIOSH for this
testing, the cooperating mine must be installing 120 psi seals that
meet the current design standard.
After installation, NIOSH will require little assistance
from mining company personnel until NIOSH is ready to remove the system
from the mine when some transportation assistance will be needed.
After the data is analyzed, the cooperating mine will be provided
the data pertaining to its mine. NIOSH will present and/or publish data
in a manner that does not identify the cooperating mines. Cooperating
mines will have the opportunity to review publications and
presentations by NIOSH prior to their release. While NIOSH will not
identify the mines in its publications, the identity of cooperating
mines may be subject to release in response to a request for documents
made under the Freedom of Information Act. This announcement does not
obligate NIOSH to enter into an agreement with any respondent.
FOR FURTHER INFORMATION CONTACT: R. G[uuml]ner G[uuml]rtunca, PhD,
NIOSH Pittsburgh Research Laboratory (PRL), 626 Cochrans Mill Road,
Post Office Box 18070, Pittsburgh PA, 15236, telephone (412) 386-6601,
e-mail GGurtunca@cdc.gov.
Dated: April 6, 2009.
Christine M. Branche,
Acting Director, National Institute for Occupational Safety and Health,
Centers for Disease Control and Prevention.
[FR Doc. E9-8462 Filed 4-13-09; 8:45 am]
BILLING CODE 4163-19-P
