Voluntary Private Sector Accreditation and Certification Preparedness Program, 114-115 [E8-31155]
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Federal Register / Vol. 74, No. 1 / Friday, January 2, 2009 / Notices
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Office of Technology Transfer, National
Institutes of Health, 6011 Executive
Boulevard, Suite 325, Rockville,
Maryland 20852–3804; telephone: 301/
496–7057; fax: 301/402–0220. A signed
Confidential Disclosure Agreement will
be required to receive copies of the
patent applications.
Knockout of Aryl Hydrocarbon
Receptor (AhR) and Its Binding Partner
Aryl Hydrocarbon Receptor Nuclear
Translocator (Arnt) Each in Separate
Mouse Models
Description of Technology: The
technology relates to two separate
knockout mouse models of related
transcription factors that bind each
other. The aryl hydrocarbon receptor
(AhR) and the aryl hydrocarbon receptor
nuclear translocator (Arnt) protein are
transcription factors that play an
important role in mediating the effects
of man-made environmental toxins.
They also play a role in mammalian
development and physiological
homeostasis. Members of the PAS
domain/bHLH family of transcription
factors, they are obligate dimerization
partners with each other and other
members of this family, such as
hypoxia-inducible factor 1alpha
(HIF1alpha). These transcription factors
have been shown to be important in a
number of specific tissues including
ovary, vascular endothelium,
keratinocytes, T-cells, and liver.
Available for licensing is a knockout
mouse line in which the AhR receptor
has been knocked-out, and a mouse line
containing a floxed allele of the Arnt
gene. The Arnt mouse line can be used
to disrupt the Arnt gene in different
tissues by breeding the Arnt-floxed mice
with transgenic mice in which the Cre
recombinase is under the control of
tissue-specific promoters. These mice
may be used as a research tool for drug
development where PAS/bHLH
transcription factors are targeted.
Applications:
• Tool for drug studies targeting PAS/
bHLH transcription factors.
• Tool to probe the role of the Arnt
protein in a tissue-specific manner.
Inventors: Frank J. Gonzalez and
Pedro M. Fernandez-Salguero (NCI).
Related Publications:
1. S Tomita, CJ Sinal, SH Yim, and FJ
Gonzalez. Conditional disruption of the
aryl hydrocarbon receptor nuclear
translocator (Arnt) gene leads to loss of
target gene induction by the aryl
hydrocarbon receptor and hypoxiainducible factor 1alpha. Mol
Endocrinol. 2000 Oct;14(10):1674–1681.
2. SH Yim, Y Shah, S Tomita, HD
Morris, O Gavrilova, G Lambert, JM
Ward, and FJ Gonzalez. Disruption of
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the Arnt gene in endothelial cells causes
hepatic vascular defects and partial
embryonic lethality in mice.
Hepatology. 2006 Sep;44(3):550–560.
3. P Fernandez-Salguero et al.
Immune system impairment and hepatic
fibrosis in mice lacking the dioxinbinding Ah receptor. Science 1995 May
5;268(5211):722–726.
Patent Status: HHS Reference Nos. E–
046–2009/0 and E–047–2007/0—
Research Tools. Patent protection is not
being pursued for these technologies.
Licensing Status: This technology is
available as a research tool under a
Biological Materials License.
Licensing Contact: Steve Standley,
Ph.D.; 301–435–4074;
sstand@mail.nih.gov.
Collaborative Research Opportunity:
The National Cancer Institute,
Laboratory of Metabolism, Center for
Cancer Research, is seeking statements
of capability or interest from parties
interested in collaborative research to
further develop, evaluate, or
commercialize this technology. Please
contact John D. Hewes, Ph.D. at 301–
435–3121 or hewesj@mail.nih.gov for
more information.
Recombineering Vector
Description of Technology:
Transgenic mouse models have become
a common experimental tool for
unraveling gene function. Bacterial
artificial chromosome (BAC) mediated
transgenesis has proven to be a highly
reliable way to obtain accurate
transgene expression for in vivo studies
of gene expression and function. A ratelimiting step in characterizing large
numbers of genes by this approach has
been the speed and ease by which BACs
can be modified. NIH investigators have
developed a highly efficient
recombineering vector that can be used
for modifying BACs in bacteria. This
new vector contains tetracycline and
chloramphenical resistance as well as
the ccdB gene that encodes a protein
that interferes with E. coli DNA gyrase.
This vector can be propagated in ccdB
resistant E. coli strains but not in other
strains (DH5a, Top10, DH10B, etc.)
unless the ccdB is replaced by DNA
inserts flanked by attB1 and attB2 sites.
This vector was generated to modify
BAC plasmids by RecA-mediated
recombination.
The vector disclosed here bypasses
the rate-limiting step in recombineering
protocols; the efficient cloning of a
modifying vector. It is well suited for
efficient production of engineered BACs
for use in a variety of in vivo studies.
Applications:
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• The fusion of fluorescent protein or
cre recombinase genes to a gene of
interest.
• Generation of dominant negative
mutations.
• Introduction of gene mutations that
would mimic disease conditions.
• Insertion of lox sites for conditional
deletion of transgenes.
• Generation of knock-out or knock-in
constructs.
Inventors: Rafael C. Casellas and
Susan E. Lim (NIAMS).
Patent Status: HHS Reference No. E–
026–2009/0—Research Material. Patent
protection is not being pursued for this
technology.
Licensing Status: Available for
Biological Material Licensing.
Licensing Contact: Suryanarayana
(Sury) Vepa, Ph.D., J.D.; 301–435–5020;
vepas@mail.nih.gov.
Collaborative Research Opportunity:
The NIAMS/NIH Genomics and
Immunity group is seeking statements of
capability or interest from parties
interested in collaborative research to
further develop, evaluate, or
commercialize the engineering of mouse
transgenic constructs using the new
vector and BAC recombineering. Please
contact Rafael Casellas, Ph.D. at 301–
402–7858 or e-mail to
casellar@mail.nih.gov for more
information.
Dated: December 22, 2008.
Richard U. Rodriguez,
Director, Division of Technology Development
and Transfer, Office of Technology Transfer,
National Institutes of Health.
[FR Doc. E8–31239 Filed 12–31–08; 8:45 am]
BILLING CODE 4140–01–P
DEPARTMENT OF HOMELAND
SECURITY
Federal Emergency Management
Agency
[Docket ID FEMA–2008–0017]
Voluntary Private Sector Accreditation
and Certification Preparedness
Program
AGENCY: Federal Emergency
Management Agency, DHS.
ACTION: Public meeting notice.
SUMMARY: This notice announces the
date, time, location, and discussion
topics for a stakeholder meeting open to
the public to engage in dialogue with
Department of Homeland Security
(DHS) leadership and program managers
regarding the Voluntary Private Sector
Preparedness Accreditation and
Certification Program (PS–Prep).
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02JAN1
115
Federal Register / Vol. 74, No. 1 / Friday, January 2, 2009 / Notices
DATES: Tuesday, January 13, 2009,
9 a.m.–2:30 p.m.
ADDRESSES: The meeting will be held at
the U.S. Chamber of Commerce, 1615 H
Street, NW., Washington, DC 20062.
Instructions: Any stakeholder or
member of the public who wishes to
attend the public meeting or make a
presentation is requested to provide his
or her name and contact details, to
include e-mail address and telephone
number, no later than 5 p.m. Eastern
Standard Time, Friday, January 9, 2009
via e-mail to the PS–Prep Program at
privatesectorpreparedness@hsi.dhs.gov,
or via telephone at (703) 416–8407.
Everyone who plans to attend the
meeting is respectfully requested to be
present and seated by 8:45 a.m. Persons
with disabilities who require special
assistance should indicate this in their
admittance request and are encouraged
to identify anticipated special needs as
early as possible. Although every effort
will be made to accommodate all
members of the public, seating is
limited and will be allocated on a firstcome, first-served basis.
FOR FURTHER INFORMATION CONTACT: Mr.
Donald Grant, Incident Management
Systems Integration Division, National
Preparedness Directorate, National
Integration Center, 500 C Street, SW.,
Washington, DC 20472. Phone: 202–
646–3850 or e-mail: FEMANIMS@dhs.gov.
SUPPLEMENTARY INFORMATION: On
December 24, 2008, the Federal
Emergency Management Agency
(FEMA), Department of Homeland
Security (DHS), published a notice
‘‘Voluntary Private Sector Accreditation
and Certification Preparedness
Program,’’ announcing PS–PREP, a DHS
program established under the authority
of Title IX of the 9/11 Recommendations
Act, Public Law 110–53, 121 Stat. 266,
338 (Aug. 3, 2007) (9/11
Recommendations Act). See 73 FR
79140; also available at https://
www.regulations.gov/search/index.jsp.
As discussed in the notice, DHS is
developing PS–PREP to raise the level of
private sector preparedness through a
number of means, including: (i)
Establishing a system for DHS to adopt
private sector preparedness standards;
(ii) encouraging creation of those
standards; (iii) developing a method for
a private sector entity to obtain a
certification of conformity with a
particular DHS-adopted private sector
standard, and encouraging such
certification; and (iv) making
preparedness standards adopted by DHS
more widely available.
The December 24 notice seeks
recommendations from private sector
stakeholders and the public at large
regarding the private sector standards
that DHS should adopt, both initially
and over time. 73 FR at 79142. The
December 24 notice also states that DHS
intends to hold two public meetings in
Washington, DC to provide a forum for
public comment. 73 FR at 79145.
This notice announces the first of
those meetings. FEMA is hosting a
public meeting to discuss issues of
interest pertaining to the PS–Prep
Program. The purpose of this meeting is
to provide an open forum for additional
comment and dialogue with DHS on the
PS–Prep Program. Individuals desiring
to participate will have the opportunity
to make a brief, formal or informal,
presentation of not more than 10
minutes and then, if desired, engage in
a questions and answers session with
DHS staff responsible for implementing
the PS–Prep Program. The specific
issues to be discussed at this meeting
will follow the information requested in
the December 24 notice: Adoption of
private sector preparedness standards;
comments regarding a maturity model
process improvement approach; small
business participation and concerns;
comments regarding the business case;
and comments regarding the
accreditation process and certification
process.
Public attendance is encouraged. This
will assist with the preparation of
meeting materials and seating
arrangements.
Dennis R. Schrader,
Deputy Administrator, National Preparedness
Directorate, Federal Emergency Management
Agency.
[FR Doc. E8–31155 Filed 12–31–08; 8:45 am]
BILLING CODE 9110–10–P
DEPARTMENT OF HOMELAND
SECURITY
U.S. Customs and Border Protection
Notice of Revocation of Customs
Broker License
AGENCY: U.S. Customs and Border
Protection, U.S. Department of
Homeland Security.
ACTION:
General notice.
SUMMARY: Pursuant to section 641 of the
Tariff Act of 1930, as amended, (19
U.S.C. 1641) and the Customs
Regulations (19 CFR 111.51), the
following Customs broker license is
canceled with prejudice.
Name
License No.
Miguel A. Delgado .................................................................................................................................................................
Dated: December 22, 2008.
Daniel Baldwin,
Assistant Commissioner, Office of
International Trade.
[FR Doc. E8–31230 Filed 12–31–08; 8:45 am]
DEPARTMENT OF THE INTERIOR
Bureau of Land Management
[NV–040–07–5101–ER–F164; N–82076; 8–
08807; TAS: 14X5017]
BILLING CODE 9111–14–P
mstockstill on PROD1PC66 with NOTICES
Notice of Availability of the Ely Energy
Center Draft Environmental Impact
Statement, White Pine County, NV
AGENCY:
Bureau of Land Management,
Interior.
ACTION: Notice of availability.
SUMMARY: In accordance with the
National Environmental Policy Act of
1969 (NEPA) 42 U.S.C. 4321 et seq., the
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Issuing
port
Miami.
Bureau of Land Management (BLM) has
prepared a Draft Environmental Impact
Statement (Draft EIS) for rights-of-way
applications for the Ely Energy Center
(EEC), a coal-fired electricity generating
power plant and associated facilities
north of Ely, Nevada, in White Pine
County.
DATES: Written comments on the EEC
Draft EIS must be received by the BLM
within 90 days following the date the
Environmental Protection Agency
publishes the Notice of Availability in
the Federal Register. Public meetings
will be held in Las Vegas, Ely, Elko and
Reno, Nevada. The date, time, and
E:\FR\FM\02JAN1.SGM
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]]>Agencies
[Federal Register Volume 74, Number 1 (Friday, January 2, 2009)]
[Notices]
[Pages 114-115]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: E8-31155]
=======================================================================
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DEPARTMENT OF HOMELAND SECURITY
Federal Emergency Management Agency
[Docket ID FEMA-2008-0017]
Voluntary Private Sector Accreditation and Certification
Preparedness Program
AGENCY: Federal Emergency Management Agency, DHS.
ACTION: Public meeting notice.
-----------------------------------------------------------------------
SUMMARY: This notice announces the date, time, location, and discussion
topics for a stakeholder meeting open to the public to engage in
dialogue with Department of Homeland Security (DHS) leadership and
program managers regarding the Voluntary Private Sector Preparedness
Accreditation and Certification Program (PS-Prep).
[[Page 115]]
DATES: Tuesday, January 13, 2009, 9 a.m.-2:30 p.m.
ADDRESSES: The meeting will be held at the U.S. Chamber of Commerce,
1615 H Street, NW., Washington, DC 20062.
Instructions: Any stakeholder or member of the public who wishes to
attend the public meeting or make a presentation is requested to
provide his or her name and contact details, to include e-mail address
and telephone number, no later than 5 p.m. Eastern Standard Time,
Friday, January 9, 2009 via e-mail to the PS-Prep Program at
privatesectorpreparedness@hsi.dhs.gov, or via telephone at (703) 416-
8407. Everyone who plans to attend the meeting is respectfully
requested to be present and seated by 8:45 a.m. Persons with
disabilities who require special assistance should indicate this in
their admittance request and are encouraged to identify anticipated
special needs as early as possible. Although every effort will be made
to accommodate all members of the public, seating is limited and will
be allocated on a first-come, first-served basis.
FOR FURTHER INFORMATION CONTACT: Mr. Donald Grant, Incident Management
Systems Integration Division, National Preparedness Directorate,
National Integration Center, 500 C Street, SW., Washington, DC 20472.
Phone: 202-646-3850 or e-mail: FEMA-NIMS@dhs.gov.
SUPPLEMENTARY INFORMATION: On December 24, 2008, the Federal Emergency
Management Agency (FEMA), Department of Homeland Security (DHS),
published a notice ``Voluntary Private Sector Accreditation and
Certification Preparedness Program,'' announcing PS-PREP, a DHS program
established under the authority of Title IX of the 9/11 Recommendations
Act, Public Law 110-53, 121 Stat. 266, 338 (Aug. 3, 2007) (9/11
Recommendations Act). See 73 FR 79140; also available at https://
www.regulations.gov/search/index.jsp. As discussed in the notice, DHS
is developing PS-PREP to raise the level of private sector preparedness
through a number of means, including: (i) Establishing a system for DHS
to adopt private sector preparedness standards; (ii) encouraging
creation of those standards; (iii) developing a method for a private
sector entity to obtain a certification of conformity with a particular
DHS-adopted private sector standard, and encouraging such
certification; and (iv) making preparedness standards adopted by DHS
more widely available.
The December 24 notice seeks recommendations from private sector
stakeholders and the public at large regarding the private sector
standards that DHS should adopt, both initially and over time. 73 FR at
79142. The December 24 notice also states that DHS intends to hold two
public meetings in Washington, DC to provide a forum for public
comment. 73 FR at 79145.
This notice announces the first of those meetings. FEMA is hosting
a public meeting to discuss issues of interest pertaining to the PS-
Prep Program. The purpose of this meeting is to provide an open forum
for additional comment and dialogue with DHS on the PS-Prep Program.
Individuals desiring to participate will have the opportunity to make a
brief, formal or informal, presentation of not more than 10 minutes and
then, if desired, engage in a questions and answers session with DHS
staff responsible for implementing the PS-Prep Program. The specific
issues to be discussed at this meeting will follow the information
requested in the December 24 notice: Adoption of private sector
preparedness standards; comments regarding a maturity model process
improvement approach; small business participation and concerns;
comments regarding the business case; and comments regarding the
accreditation process and certification process.
Public attendance is encouraged. This will assist with the
preparation of meeting materials and seating arrangements.
Dennis R. Schrader,
Deputy Administrator, National Preparedness Directorate, Federal
Emergency Management Agency.
[FR Doc. E8-31155 Filed 12-31-08; 8:45 am]
BILLING CODE 9110-10-P
