National Cancer Institute; Notice of Closed Meetings, 56850-56851 [E8-22921]

Download as PDF ebenthall on PROD1PC60 with NOTICES 56850 Federal Register / Vol. 73, No. 190 / Tuesday, September 30, 2008 / Notices deaths caused by cancer in 2008. A major drawback of the current chemotherapy-based therapeutics is the cytotoxic side-effects associated with them. Thus there is a dire need to develop new therapeutic strategies with fewer side-effects. Immuno-therapy has taken a lead among the new therapeutic approaches. Enhancing the innate immune response of an individual has been a key approach for the treatment against different diseases such as cancer and infectious diseases. This technology involves the generation of novel chemoattractant toxins that deplete the T regulatory cells (Treg) or other immunosuppressive or hyperactivated cells locally. Treg controls activation of immune responses by suppressing the induction of adaptive immune responses, particularly T cell responses. Immunosuppressive cells such as tumor infiltrating macrophages or NKT and other cells down regulate antitumor immune responses. The chemoattractant toxins consist of a toxin moiety fused with a chemokine receptor ligand, chemokines and other chemoattractants that enables specific targeting and delivery to the Treg cells. This technology is advantageous over the more harmful antibodies and chemicals that are currently used for the systemic depletion of Treg cells. The current technology can be used therapeutically in a variety of ways. They can be used together with vaccines to increase efficacy of the vaccine for the treatment of cancer, and can be used to locally deplete Treg cells or other immuno suppressive cells to induce cytolytic cell responses at the tumor site or to eliminate chronic infectious diseases such as HIV and tuberculosis. Applications: • New chemoattractant based toxins targeted towards Treg cells. • New chemoattractant based toxins targeted towards immunosuppressive NKT, and macrophages. • New chemoattractant based toxins targeted towards local depletion of hyperactivated CD4 T cells to treat autoimmune diseases. • Chemoattractant based toxins depleting Treg cells or other immunosuppressive cells causing enhanced vaccine immune responses. • Novel immunotherapy by increasing vaccine efficacy against cancer and infectious diseases. Market: • 565,650 deaths from cancer related diseases estimated in 2008. • The technology platform involving novel chemo-attractant based toxins can be used to improve vaccine immune responses. The cancer vaccine market is VerDate Aug<31>2005 15:35 Sep 29, 2008 Jkt 214001 expected to increase from $135 million in 2007 to more than $8 billion in 2012. • The technology platform has additional market in treating several other clinical problems such as autoimmune diseases. Development Status: The technology is currently in the pre-clinical stage of development. Inventors: Arya Biragyn (NIA), Dolgor Bataar (NIA), et al. Related Publications: 1. Copy of manuscript from this technology can be provided once accepted for publication. 2. M Coscia, A Biragyn. Cancer immunotherapy with chemoattractant peptides. Semin Cancer Biol 2004 Jun;14(3):209–218. 3. R Schiavo et al. Chemokine receptor targeting efficiently directs antigens to MHC class I pathways and elicits antigen-specific CD8+ T-cell responses. Blood 2006 Jun 15;107 (12):4597–4605. Patent Status: U.S. Patent Application filed 28 Mar 2008, claiming priority to 30 Sep 2005 (HHS Reference No. E–027–2005/0–US–06). Licensing Status: Available for nonexclusive or exclusive licensing. Licensing Contact: Jennifer Wong; 301–435–4633; wongje@mail.nih.gov. Collaborative Research Opportunity: The NIA Laboratory of Immunology is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize novel chemoattractant-based toxins. Please contact John D. Hewes, Ph.D. at 301–435–3121 or hewesj@mail.nih.gov for more information. Dated: September 18, 2008. Richard U. Rodriguez, Director, Division of Technology Development and Transfer, Office of Technology Transfer, National Institutes of Health. [FR Doc. E8–22889 Filed 9–29–08; 8:45 am] BILLING CODE 4140–01–P DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Cancer Institute; Notice of Closed Meetings Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. Appendix 2), notice is hereby given of the following meetings. The meetings will be closed to the public in accordance with the provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., PO 00000 Frm 00060 Fmt 4703 Sfmt 4703 as amended. The grant applications and the discussions could disclose confidential trade secrets or commercial property such as patentable material, and personal information concerning individuals associated with the grant applications, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. Name of Committee: National Cancer Institute Special Emphasis Panel; Review of Education and Career Development Award Applications. Date: October 24, 2008. Time: 10 a.m. to 1 p.m. Agenda: To review and evaluate grant applications. Place: Sheraton Sand Key Resort, 1160 Gulf Boulevard, Clearwater, FL 33767. Contact Person: Robert Bird, PhD, Scientific Review Officer, Resources and Training Review Branch, Division of Extramural Activities, National Cancer Institute, 6116 Executive Boulevard, Room 8113, Bethesda, MD 20892–8328, 301–496– 7978, birdr@mail.nih.gov. Name of Committee: National Cancer Institute Special Emphasis Panel; Cancer Prevention Research Small Grant Program (R03). Date: October 30–31, 2008. Time: 8 a.m. to 5 p.m. Agenda: To review and evaluate grant applications. Place: Renaissance M Street Hotel, Marriot, 1143 New Hampshire Avenue NW., Washington, DC 20037. Contact Person: Irina Gordienko, PhD, Scientific Review Officer, Scientific Review and Logistics Branch, Division of Extramural Activities, National Cancer Institute, NIH, 6116 Executive Blvd., Rm. 7073, Bethesda, MD 20892, 301–594–1566, gordienkoiv@mail.nih.gov. Name of Committee: National Cancer Institute Special Emphasis Panel; Community Clinical Oncology Program (CCOP). Date: November 5, 2008. Time: 8 a.m. to 5 p.m. Agenda: To review and evaluate grant applications. Place: Bethesda Marriott, 5151 Pooks Hill Road, Bethesda, MD 20814. Contact Person: Gerald G. Lovinger, PhD, Scientific Review Administrator, Special Review and Logistics Branch, Division of Extramural Activities, National Cancer Institute, 6116 Executive Blvd., Room 8101, Bethesda, MD 20892–8329, 301–496–7987, lovingeg@mail.nih.gov. (Catalogue of Federal Domestic Assistance Program Nos. 93.392, Cancer Construction; 93.393, Cancer Cause and Prevention Research; 93.394, Cancer Detection and Diagnosis Research; 93.395, Cancer Treatment Research; 93.396, Cancer Biology Research; 93.397, Cancer Centers Support; 93.398, Cancer Research Manpower; 93.399, Cancer Control, National Institutes of Health, HHS) E:\FR\FM\30SEN1.SGM 30SEN1 Federal Register / Vol. 73, No. 190 / Tuesday, September 30, 2008 / Notices Dated: September 23, 2008. Jennifer Spaeth, Director, Office of Federal Advisory Committee Policy. [FR Doc. E8–22921 Filed 9–29–08; 8:45 am] BILLING CODE 4140–01–P DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Institute of Diabetes and Digestive and Kidney Diseases; Notice of Meetings ebenthall on PROD1PC60 with NOTICES Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. Appendix 2), notice is hereby given of the following meetings. The meetings will be open to the public as indicated below, with attendance limited to space available. Individuals who plan to attend and need special assistance, such as sign language interpretation or other reasonable accommodations, should notify the Contact Person listed below in advance of the meeting. The meetings will be closed to the public in accordance with the provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The grant applications and the discussions could disclose confidential trade secrets or commercial property such as patentable material, and personal information concerning individuals associated with the grant applications, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. Name of Committee: National Institute of Diabetes and Digestive and Kidney Diseases Initial Review Group, Digestive Diseases and Nutrition C Subcommittee. Date: October 15–16, 2008. Open: October 15, 2008, 8 a.m. to 8:30 a.m. Agenda: To review procedures and discuss policy. Place: Crowne Plaza Washington National Airport, 1480 Jefferson Davis Hwy, Arlington, VA 22202. Closed: October 15, 2008, 8:30 a.m. to 5 p.m. Agenda: To review and evaluate grant applications. Place: Crowne Plaza Washington National Airport, 1480 Jefferson Davis Hwy, Arlington, VA 22202. Closed: October 16, 2008, 8 a.m. to 12 p.m. Agenda: To review and evaluate grant applications. Place: Crowne Plaza Washington National Airport, 1480 Jefferson Davis Hwy, Arlington, VA 22202. Contact Person: Dan E. Matsumoto, PhD, Scientific Review Officer, Review Branch, DEA, NIDDK, National Institutes of Health, Room 749, 6707 Democracy Boulevard, VerDate Aug<31>2005 15:35 Sep 29, 2008 Jkt 214001 Bethesda, MD 20892–5452, (301) 594–8894, matsumotod@extra.niddk.nih.gov. Name of Committee: National Institute of Diabetes and Digestive and Kidney Diseases Initial Review Group, Diabetes, Endocrinology and Metabolic Diseases B Subcommittee. Date: October 21–23, 2008. Open: October 21, 2008, 4 p.m. to 5 p.m. Agenda: To review procedures and discuss policy. Place: Hilton Washington/Rockville, 1750 Rockville Pike, Rockville, MD 20852. Closed: October 22, 2008, 8 a.m. to 5 p.m. Agenda: To review and evaluate grant applications. Place: Hilton Washington/Rockville, 1750 Rockville Pike, Rockville, MD 20852. Closed: October 23, 2008, 8 a.m. to 5p.m. Agenda: To review and evaluate grant applications. Place: Hilton Washington/Rockville, 1750 Rockville Pike, Rockville, MD 20852. Contact Person: John F. Connaughton, PhD, Chief, Chartered Committees Section, Review Branch, DEA, NIDDK, National Institutes of Health, Room 753, 6707 Democracy Boulevard, Bethesda, MD 20892–5452, (301)594–7797, connaughtonj@extra.niddk.nih.gov. Name of Committee: National Institute of Diabetes and Digestive and Kidney Diseases Initial Review Group; Kidney, Urologic and Hematologic Diseases D Subcommittee. Date: October 22–23, 2008. Open: October 22, 2008, 8 a.m. to 8:30 a.m. Agenda: To review procedures and discuss policy. Place: Gaithersburg Marriott Washingtonian Center, 9751 Washingtonian Boulevard, Gaithersburg, MD 20878. Closed: October 22, 2008, 8:30 a.m. to 5 p.m. Agenda: To review and evaluate grant applications. Place: Gaithersburg Marriott Washingtonian Center, 9751 Washingtonian Boulevard, Gaithersburg, MD 20878. Closed: October 23, 2008, 8 a.m. to 5 p.m. Agenda: To review and evaluate grant applications. Place: Gaithersburg Marriott Washingtonian Center, 9751 Washingtonian Boulevard, Gaithersburg, MD 20878. Contact Person: Barbara A Woynarowska, PhD, Scientific Review Administrator, Review Branch, DEA, NIDDK, National Institutes of Health, Room 754, 6707 Democracy Boulevard, Bethesda, MD 20892– 5452, (301) 402–7172, woynarowskab@niddk.nih.gov. (Catalogue of Federal Domestic Assistance Program Nos. 93.847, Diabetes, Endocrinology and Metabolic Research; 93.848, Digestive Diseases and Nutrition Research; 93.849, Kidney Diseases, Urology and Hematology Research, National Institutes of Health, HHS) Dated: September 19, 2008. Jennifer Spaeth, Director, Office of Federal Advisory Committee Policy. [FR Doc. E8–22892 Filed 9–29–08; 8:45 am] BILLING CODE 4140–01–P PO 00000 Frm 00061 Fmt 4703 Sfmt 4703 56851 DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. Appendix 2), notice is hereby given of the following meeting. The meeting will be closed to the public in accordance with the provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The grant applications and the discussions could disclose confidential trade secrets or commercial property such as patentable material, and personal information concerning individuals associated with the grant applications, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. Name of Committee: National Institute of Child Health and Human Development Special Emphasis Panel; Iron / Malaria. Date: October 22, 2008. Time: 8 a.m. to 5 p.m. Agenda: To review and evaluate grant applications. Place: Hyatt Regency Bethesda, One Bethesda Metro Center, 7400 Wisconsin Avenue, Bethesda, MD 20814. Contact Person: Rita Anand, PhD., Scientific Review Administrator, Division of Scientific Review, National Institute of Child Health, and Human Development, NIH, 6100 Executive Blvd. Room 5B01, Bethesda, MD 20892, (301) 496–1487, anandr@mail.nih.gov. (Catalogue of Federal Domestic Assistance Program Nos. 93.864, Population Research; 93.865, Research for Mothers and Children; 93.929, Center for Medical Rehabilitation Research; 93.209, Contraception and Infertility Loan Repayment Program, National Institutes of Health, HHS) Dated: September 19, 2008. Jennifer Spaeth, Director, Office of Federal Advisory Committee Policy. [FR Doc. E8–22894 Filed 9–29–08; 8:45 am] BILLING CODE 4140–01–P DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as E:\FR\FM\30SEN1.SGM 30SEN1

Agencies

[Federal Register Volume 73, Number 190 (Tuesday, September 30, 2008)]
[Notices]
[Pages 56850-56851]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: E8-22921]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


National Cancer Institute; Notice of Closed Meetings

    Pursuant to section 10(d) of the Federal Advisory Committee Act, as 
amended (5 U.S.C. Appendix 2), notice is hereby given of the following 
meetings.
    The meetings will be closed to the public in accordance with the 
provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 
U.S.C., as amended. The grant applications and the discussions could 
disclose confidential trade secrets or commercial property such as 
patentable material, and personal information concerning individuals 
associated with the grant applications, the disclosure of which would 
constitute a clearly unwarranted invasion of personal privacy.

    Name of Committee: National Cancer Institute Special Emphasis 
Panel; Review of Education and Career Development Award 
Applications.
    Date: October 24, 2008.
    Time: 10 a.m. to 1 p.m.
    Agenda: To review and evaluate grant applications.
    Place: Sheraton Sand Key Resort, 1160 Gulf Boulevard, 
Clearwater, FL 33767.
    Contact Person: Robert Bird, PhD, Scientific Review Officer, 
Resources and Training Review Branch, Division of Extramural 
Activities, National Cancer Institute, 6116 Executive Boulevard, 
Room 8113, Bethesda, MD 20892-8328, 301-496-7978, 
birdr@mail.nih.gov.

    Name of Committee: National Cancer Institute Special Emphasis 
Panel; Cancer Prevention Research Small Grant Program (R03).
    Date: October 30-31, 2008.
    Time: 8 a.m. to 5 p.m.
    Agenda: To review and evaluate grant applications.
    Place: Renaissance M Street Hotel, Marriot, 1143 New Hampshire 
Avenue NW., Washington, DC 20037.
    Contact Person: Irina Gordienko, PhD, Scientific Review Officer, 
Scientific Review and Logistics Branch, Division of Extramural 
Activities, National Cancer Institute, NIH, 6116 Executive Blvd., 
Rm. 7073, Bethesda, MD 20892, 301-594-1566, 
gordienkoiv@mail.nih.gov.

    Name of Committee: National Cancer Institute Special Emphasis 
Panel; Community Clinical Oncology Program (CCOP).
    Date: November 5, 2008.
    Time: 8 a.m. to 5 p.m.
    Agenda: To review and evaluate grant applications.
    Place: Bethesda Marriott, 5151 Pooks Hill Road, Bethesda, MD 
20814.
    Contact Person: Gerald G. Lovinger, PhD, Scientific Review 
Administrator, Special Review and Logistics Branch, Division of 
Extramural Activities, National Cancer Institute, 6116 Executive 
Blvd., Room 8101, Bethesda, MD 20892-8329, 301-496-7987, 
lovingeg@mail.nih.gov.

(Catalogue of Federal Domestic Assistance Program Nos. 93.392, 
Cancer Construction; 93.393, Cancer Cause and Prevention Research; 
93.394, Cancer Detection and Diagnosis Research; 93.395, Cancer 
Treatment Research; 93.396, Cancer Biology Research; 93.397, Cancer 
Centers Support; 93.398, Cancer Research Manpower; 93.399, Cancer 
Control, National Institutes of Health, HHS)


[[Page 56851]]


    Dated: September 23, 2008.
Jennifer Spaeth,
Director, Office of Federal Advisory Committee Policy.
[FR Doc. E8-22921 Filed 9-29-08; 8:45 am]
BILLING CODE 4140-01-P
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