Prospective Grant of Exclusive License: Geldanamycin Derivative and Method of Treating Viral Infections, 34770 [E8-13671]

Download as PDF 34770 Federal Register / Vol. 73, No. 118 / Wednesday, June 18, 2008 / Notices ACTION: DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Institute of Diabetes and Digestive and Kidney Diseases; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. Appendix 2), notice is hereby given of the following meeting. The meeting will be closed to the public in accordance with the provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The grant applications and the discussions could disclose confidential trade secrets or commercial property such as patentable material, and personal information concerning individuals associated with the grant applications, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. Name of Committee: National Institute of Diabetes and Digestive and Kidney Diseases Special Emphasis Panel; Modulation of Iron Deposition in SCD and Other Hemoglobinopathies. Date: July 9, 2008. Time: 3 p.m. to 4 p.m. Agenda: To review and evaluate grant applications. Place: National Institutes of Health, Two Democracy Plaza, 6707 Democracy Boulevard, Bethesda, MD 20892, (Telephone Conference Call). Contact Person: Lakshmanan Sankaran, PhD, Scientific Review Officer, Review Branch, DEA, NIDDK, National Institutes of Health, Room 755, 6707 Democracy Boulevard, Bethesda, MD 20892–5452, (301) 594–7799, ls38oz@nih.gov. (Catalogue of Federal Domestic Assistance Program Nos. 93.847, Diabetes, Endocrinology and Metabolic Research; 93.848, Digestive Diseases and Nutrition Research; 93.849, Kidney Diseases, Urology and Hematology Research, National Institutes of Health, HHS) Dated: June 11, 2008. Jennifer Spaeth, Director, Office of Federal Advisory Committee Policy. [FR Doc. E8–13701 Filed 6–17–08; 8:45 am] BILLING CODE 4140–01–P DEPARTMENT OF HEALTH AND HUMAN SERVICES rwilkins on PROD1PC63 with NOTICES National Institutes of Health Prospective Grant of Exclusive License: Geldanamycin Derivative and Method of Treating Viral Infections National Institutes of Health, Public Health Service, HHS. AGENCY: VerDate Aug<31>2005 18:01 Jun 17, 2008 Jkt 214001 Notice. SUMMARY: This is notice, in accordance with 35 U.S.C. 209(c)(1) and 37 CFR Part 404.7(a)(1)(i), that the National Institutes of Health, Department of Health and Human Services, is contemplating the grant of an exclusive patent license to practice the invention embodied in U.S. Patent No. 6,890,917, issued May 10, 2005, entitled ‘‘Geldanamycin Derivative and Method of Treating Cancer Using Same’’ [E– 050–2000/0–US–15] and foreign equivalents, to Avira Therapeutics, LLC, having a place of business in Menlo Park, California. The patent rights in these inventions have been assigned to the United States of America. The prospective exclusive license territory may be worldwide, and the field of use may be limited to the use of the manufacture, use, distribution and sale of 17–DMAG, an analog of geldanamycin, as a therapeutic to inhibit the influenza virus, respiratory syncytial virus (RSV) and dengue virus. This replaces a notice published in 73 FR 31702 on Tuesday, June 3, 2008, which omitted the name of the potential licensee. DATES: Only written comments and/or applications for a license which are received by the NIH Office of Technology Transfer on or before August 18, 2008 will be considered. ADDRESSES: Requests for copies of the patent application, inquiries, comments, and other materials relating to the contemplated exclusive license should be directed to: Adaku Madu, J.D., Technology Licensing Specialist, Office of Technology Transfer, National Institutes of Health, 6011 Executive Boulevard, Suite 325, Rockville, MD 20852–3804; Telephone: (301) 435– 5560; Facsimile: (301) 402–0220; E-mail: madua@mail.nih.gov. SUPPLEMENTARY INFORMATION: This technology relates to novel cytotoxic compounds derived from 17aminoalkylamino-substituted geldanamycin and pharmaceutical compositions thereof. In particular, this invention refers to 17-(dimehtylamino) propylamino-geldanamycin, 17(dimethylamino) ethylaminogeldanamycin, and the hydrochloride salt of 17-(dimethylamino) ethylaminogeldanamycin (DMAG and analogs). These compounds are Hsp90 inhibitors. Hsp90 inhibition downregulates B–Raf, decreases cell proliferation and reduces activation of the MEK/ERK pathways in some cells. Hsp90 plays an essential role in maintaining stability and activity in its client proteins. Hsp90 inhibitors interfere with diverse signaling PO 00000 Frm 00073 Fmt 4703 Sfmt 4703 pathways by destabilizing and attenuating activity of such proteins, and thus exhibit antitumor activity. Specifically, 17–DMAG shows cytotoxicity against a number of human colon and lung cell lines, specific melanoma, renal and breast lines, and potentially against various viral infections. In addition, these compounds appear to have favorable pharmaceutical properties including oral activity and improved watersolubility. The prospective exclusive license will be royalty bearing and will comply with the terms and conditions of 35 U.S.C. 209 and 37 CFR Part 404.7. The prospective exclusive license may be granted unless within sixty (60) days from the date of this published notice, the NIH receives written evidence and argument that establishes that the grant of the license would not be consistent with the requirements of 35 U.S.C. 209 and 37 CFR 404.7. Applications for a license in the field of use filed in response to this notice will be treated as objections to the grant of the contemplated exclusive license. Comments and objections submitted to this notice will not be made available for public inspection and, to the extent permitted by law, will not be released under the Freedom of Information Act, 5 U.S.C. 552. Dated: June 9, 2008. Richard U. Rodriguez, Director, Division of Technology Development and Transfer, Office of Technology Transfer, National Institutes of Health. [FR Doc. E8–13671 Filed 6–17–08; 8:45 am] BILLING CODE 4140–01–P DEPARTMENT OF HOMELAND SECURITY Office of the Secretary DEPARTMENT OF STATE Office of the Secretary Exercise of Authority Under Section 212(d)(3)(B)(i) of the Immigration and Nationality Act Office of the Secretary, DHS; Office of the Secretary, DOS. ACTION: Notice of Determination. AGENCY: This determination is effective June 3, 2008. DATES: Authority: 8 U.S.C. 1182(d)(3)(B)(i). The Secretary of Homeland Security and the Secretary of State, following consultations with the Attorney General, hereby conclude, as a matter of E:\FR\FM\18JNN1.SGM 18JNN1

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[Federal Register Volume 73, Number 118 (Wednesday, June 18, 2008)]
[Notices]
[Page 34770]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: E8-13671]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Prospective Grant of Exclusive License: Geldanamycin Derivative 
and Method of Treating Viral Infections

AGENCY: National Institutes of Health, Public Health Service, HHS.

ACTION: Notice.

-----------------------------------------------------------------------

SUMMARY: This is notice, in accordance with 35 U.S.C. 209(c)(1) and 37 
CFR Part 404.7(a)(1)(i), that the National Institutes of Health, 
Department of Health and Human Services, is contemplating the grant of 
an exclusive patent license to practice the invention embodied in U.S. 
Patent No. 6,890,917, issued May 10, 2005, entitled ``Geldanamycin 
Derivative and Method of Treating Cancer Using Same'' [E-050-2000/0-US-
15] and foreign equivalents, to Avira Therapeutics, LLC, having a place 
of business in Menlo Park, California. The patent rights in these 
inventions have been assigned to the United States of America.
    The prospective exclusive license territory may be worldwide, and 
the field of use may be limited to the use of the manufacture, use, 
distribution and sale of 17-DMAG, an analog of geldanamycin, as a 
therapeutic to inhibit the influenza virus, respiratory syncytial virus 
(RSV) and dengue virus.
    This replaces a notice published in 73 FR 31702 on Tuesday, June 3, 
2008, which omitted the name of the potential licensee.

DATES: Only written comments and/or applications for a license which 
are received by the NIH Office of Technology Transfer on or before 
August 18, 2008 will be considered.

ADDRESSES: Requests for copies of the patent application, inquiries, 
comments, and other materials relating to the contemplated exclusive 
license should be directed to: Adaku Madu, J.D., Technology Licensing 
Specialist, Office of Technology Transfer, National Institutes of 
Health, 6011 Executive Boulevard, Suite 325, Rockville, MD 20852-3804; 
Telephone: (301) 435-5560; Facsimile: (301) 402-0220; E-mail: 
madua@mail.nih.gov.

SUPPLEMENTARY INFORMATION: This technology relates to novel cytotoxic 
compounds derived from 17-aminoalkylamino-substituted geldanamycin and 
pharmaceutical compositions thereof. In particular, this invention 
refers to 17-(dimehtylamino) propylamino-geldanamycin, 17-
(dimethylamino) ethylamino-geldanamycin, and the hydrochloride salt of 
17-(dimethylamino) ethylamino-geldanamycin (DMAG and analogs). These 
compounds are Hsp90 inhibitors. Hsp90 inhibition downregulates B-Raf, 
decreases cell proliferation and reduces activation of the MEK/ERK 
pathways in some cells. Hsp90 plays an essential role in maintaining 
stability and activity in its client proteins. Hsp90 inhibitors 
interfere with diverse signaling pathways by destabilizing and 
attenuating activity of such proteins, and thus exhibit antitumor 
activity. Specifically, 17-DMAG shows cytotoxicity against a number of 
human colon and lung cell lines, specific melanoma, renal and breast 
lines, and potentially against various viral infections. In addition, 
these compounds appear to have favorable pharmaceutical properties 
including oral activity and improved water-solubility.
    The prospective exclusive license will be royalty bearing and will 
comply with the terms and conditions of 35 U.S.C. 209 and 37 CFR Part 
404.7. The prospective exclusive license may be granted unless within 
sixty (60) days from the date of this published notice, the NIH 
receives written evidence and argument that establishes that the grant 
of the license would not be consistent with the requirements of 35 
U.S.C. 209 and 37 CFR 404.7.
    Applications for a license in the field of use filed in response to 
this notice will be treated as objections to the grant of the 
contemplated exclusive license. Comments and objections submitted to 
this notice will not be made available for public inspection and, to 
the extent permitted by law, will not be released under the Freedom of 
Information Act, 5 U.S.C. 552.

    Dated: June 9, 2008.
Richard U. Rodriguez,
Director, Division of Technology Development and Transfer, Office of 
Technology Transfer, National Institutes of Health.
[FR Doc. E8-13671 Filed 6-17-08; 8:45 am]
BILLING CODE 4140-01-P

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