National Institute of Dental & Craniofacial Research; Notice of Closed Meeting, 24078 [E8-9404]
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Federal Register / Vol. 73, No. 85 / Thursday, May 1, 2008 / Notices
pwalker on PROD1PC71 with NOTICES
under the control of a baculovirus
promoter so that the cells express GFP
when they are infected with the virus.
The baculovirus titer can then be
quantitated from the level of GFP
expression in the insect host cell. The
results are obtained within 3 days
compared to the 7–8 day period typical
of the traditional CPE based methods.
The GFP based system is capable of
replacing the traditional methods as it is
faster, more accurate and may be less
expensive than the currently used
systems. This proprietary technology
can become an indispensible tool for the
quantitation of baculovirus titers; a step
that is important in the production of
recombinant proteins and vaccine like
particles (VLPs) for academic and
commercial purposes.
Applications: Baculovirus based
recombinant protein expression.
Advantages: Fast, accurate, and
inexpensive determination of
baculovirus titers for protein expression.
Inventors: Ralph F. Hopkins III and
Dominic Esposito (SAIC/NCI).
Patent Status: U.S. Provisional
Application No. 61/019,562 filed 07 Jan
2008 (HHS Reference No. E–009–2008/
0–US–01).
Licensing Status: Available for
exclusive or non-exclusive licensing.
Licensing Contact: Jasbir (Jesse) S.
Kindra, J.D., M.S.; 301–435–5170;
kindraj@mail.nih.gov.
A Molecular Grading System for Ductal
Carcinoma In Situ (DCIS) of the Breast:
A New Molecular Diagnostic To
Determine Disease Stages of DCIS
Description of Technology: The
technology describes the comprehensive
profiling of Ductal Carcinoma in situ
(DCIS) in breast cancer patients. The
inventors have developed a molecular
grading system for DCIS utilizing both
gene expression profiling and genomic
change profiling. The inventors have
identified molecular profiles that
identify early stage patients at risk of
disease progression requiring more
aggressive therapy. These observations
suggest that a clinical assay could be
developed for the grading of DCIS.
Furthermore, the invention
demonstrates that the profiles correlate
with the molecular grade and with cell
proliferation, suggesting that a clinical
assay using routine methods, based on
the nuclear grade and staining for Ki67
as a measure of proliferation, could also
potentially be developed.
Advantages and Applications:
The technology has the potential of
being developed into an accurate
diagnostic test for DCIS patients
according to their risk of tumor
progression.
VerDate Aug<31>2005
17:13 Apr 30, 2008
Jkt 214001
The diagnostic profiling can assist
physicians in making clinically
informed and personalized therapy
decisions for DCIS patients.
In the studies, tissue samples
collected via laser capture microdissection from in situ breast cancer
patients were used, which validate and
authenticate the relevance of the study.
Development Status: Larger clinical
study is currently being planned.
Inventors: Paul S. Meltzer et al. (NCI).
Patent Status: U.S. Provisional
Application No. 60/936,526 filed 20 Jun
2007 (HHS Reference No. E–192–2007/
0–US–01).
Licensing Status: Available for
exclusive and non-exclusive licensing.
Licensing Contact: Mojdeh Bahar, J.D.;
301–435–2950; baharm@mail.nih.gov.
Collaborative Research Opportunity:
The National Cancer Institute, Genetics
Branch, is seeking statements of
capability or interest from parties
interested in collaborative research to
further develop, evaluate, or
commercialize molecular grading of
DCIS. Please contact John D. Hewes,
Ph.D. at 301–435–3121 or
hewesj@mail.nih.gov for more
information.
April 24, 2008.
David Sadowski,
Deputy Director, Division of Technology
Development and Transfer, Office of
Technology Transfer, National Institutes of
Health.
[FR Doc. E8–9535 Filed 4–30–08; 8:45 am]
BILLING CODE 4140–01–P
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
National Institute of Dental &
Craniofacial Research; Notice of
Closed Meeting
Pursuant to section 10(d) of the
Federal Advisory Committee Act, as
amended (5 U.S.C. Appendix 2), notice
is hereby given of the following
meeting.
The meeting will be closed to the
public in accordance with the
provisions set forth in sections
552b(c)(4) and 552b(c)(6), Title 5 U.S.C.,
as amended. The grant applications and
the discussions could disclose
confidential trade secrets or commercial
property such as patentable material,
and personal information concerning
individuals associated with the grant
applications, the disclosure of which
would constitute a clearly unwarranted
invasion of personal privacy.
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Name of Committee: National Institute of
Dental and Craniofacial Research Special
Emphasis Panel.
Date: June 19, 2008.
Time: 2 p.m. to 4 p.m.
Agenda: To review and evaluate grant
applications.
Place: National Institutes of Health, One
Democracy Plaza, 6701 Democracy
Boulevard, Bethesda, MD 20892 (Telephone
Conference Call).
Contact Person: Sooyoun (Sonia) Kim, MS,
Scientific Review Officer, Scientific Review
Branch, Division of Extramural Activities,
NIDCR/NIH, 6701 Democracy Blvd, Rm 675,
Bethesda, MD 20892–4878, (301) 594–4827,
kims@email.nidr.nih.gov.
(Catalogue of Federal Domestic Assistance
Program Nos. 93.121, Oral Diseases and
Disorders Research, National Institutes of
Health, HHS)
Dated: April 23, 2008.
Jennifer Spaeth,
Director, Office of Federal Advisory
Committee Policy.
[FR Doc. E8–9404 Filed 4–30–08; 8:45 am]
BILLING CODE 4140–01–M
DEPARTMENT OF HOMELAND
SECURITY
Office of the Secretary
Public Workshop: Privacy Compliance
Fundamentals—PTAs, PIAs, and
SORNs
Privacy Office, Department of
Homeland Security (DHS).
ACTION: Notice announcing public
workshop.
AGENCY:
SUMMARY: The Department of Homeland
Security Privacy Office will host a
public workshop, ‘‘Privacy Compliance
Fundamentals—PTAs, PIAs, and
SORNs.’’
The workshop will be held on
May 23, 2008, from 9 a.m. to 4:30 p.m.
ADDRESSES: The workshop will be held
in the auditorium at the DHS Offices at
the GSA Regional Headquarters
Building located at 7th and D Streets,
SW., Washington, DC, 20024.
FOR FURTHER INFORMATION CONTACT:
Tamara Baker, Privacy Office,
Department of Homeland Security,
Washington, DC 20528; by telephone
703–235–0780; by facsimile 703–235–
0442; or by e-mail at
privacyworkshop@dhs.gov.
DATES:
The
Department of Homeland Security
(DHS) Privacy Office is holding a public
workshop that will provide in-depth
training on the privacy compliance
process at DHS, and specifically how to
write privacy impact assessments (PIAs)
SUPPLEMENTARY INFORMATION:
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]]>Agencies
[Federal Register Volume 73, Number 85 (Thursday, May 1, 2008)]
[Notices]
[Page 24078]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: E8-9404]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health
National Institute of Dental & Craniofacial Research; Notice of
Closed Meeting
Pursuant to section 10(d) of the Federal Advisory Committee Act, as
amended (5 U.S.C. Appendix 2), notice is hereby given of the following
meeting.
The meeting will be closed to the public in accordance with the
provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5
U.S.C., as amended. The grant applications and the discussions could
disclose confidential trade secrets or commercial property such as
patentable material, and personal information concerning individuals
associated with the grant applications, the disclosure of which would
constitute a clearly unwarranted invasion of personal privacy.
Name of Committee: National Institute of Dental and Craniofacial
Research Special Emphasis Panel.
Date: June 19, 2008.
Time: 2 p.m. to 4 p.m.
Agenda: To review and evaluate grant applications.
Place: National Institutes of Health, One Democracy Plaza, 6701
Democracy Boulevard, Bethesda, MD 20892 (Telephone Conference Call).
Contact Person: Sooyoun (Sonia) Kim, MS, Scientific Review
Officer, Scientific Review Branch, Division of Extramural
Activities, NIDCR/NIH, 6701 Democracy Blvd, Rm 675, Bethesda, MD
20892-4878, (301) 594-4827, kims@email.nidr.nih.gov.
(Catalogue of Federal Domestic Assistance Program Nos. 93.121, Oral
Diseases and Disorders Research, National Institutes of Health, HHS)
Dated: April 23, 2008.
Jennifer Spaeth,
Director, Office of Federal Advisory Committee Policy.
[FR Doc. E8-9404 Filed 4-30-08; 8:45 am]
BILLING CODE 4140-01-M
