National Institute of Mental Health; Notice of Meeting, 20930 [E8-8226]
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20930
Federal Register / Vol. 73, No. 75 / Thursday, April 17, 2008 / Notices
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Nitrite and Nitrite-Methemoglobin
Therapy To Detoxify Stroma-Free
Hemoglobin Based Blood Substitutes
Description of Technology: Cell-free
hemoglobin based oxygen carriers
(HBOCs) are blood substitutes and
resuscitative agents that can be used to
replace whole blood donations, alleviate
blood shortages and reduce the risks of
infections such as HIV and hepatitis.
Stroma-free HBOCs offer the advantages
of increased stability, consistency of
supply, and reduced immunogenicity
over the use of the alternative cell based
sources. However, the side effects
associated with their use, including
vascular toxicity, pulmonary and
systemic hypertension, myocardial
infarction, inflammation, and platelet
aggregation severely limit their scope of
clinical applications. These adverse
effects are due in part to the ability of
free deoxygenated hemoglobin
(deoxyHb) to scavenge for nitric oxide
(NO) thus rendering it unavailable for
vasodilating blood vessels.
This technology is a method of using
nitrites to reduce the deleterious effects
associated with HBOC use as blood
substitutes. Free nitrites or nitritemethemoglobin when added to stromafree HBOCs are converted to NO and
N2O3 which escapes the scavenging
activity of deoxyHb and thus is free to
vasodilate blood vessels. This maintains
oxygen release and NO delivery
enabling improved clinical outcomes.
Recent studies, using this technology as
a blood substitute, have led to a reversal
of vasoconstriction, hypertension and
hemorrhagic shock in animal models.
This new approach also reduces the
toxicity associated with the use of
HBOCs as a blood substitute and may
allow the widespread use of HBOCs as
an alternative to cell based sources. In
combination with this technology,
HBOC blood substitutes may now be
used to efficiently deliver therapeutic
agents and maintain organ perfusion
during trauma and surgery.
Advantages: Reduced toxicity of cell
free hemoglobin blood substitutes;
Increased blood perfusion in patients;
Decreased dependence on blood
donations.
Development Status: Pre-clinical.
Inventors: Mark T. Gladwin (NHLBI)
et al.
Publication: S Basu, R Grubina, J
Huang, J Conradie, Z Huang, A Jeffers,
A Jiang, X He, I Azarov, R Seibert, A
Mehta, R Patel, SB King, N Hogg, A
Ghosh, MT Gladwin, DB Kim-Shapiro.
Catalytic generation of N2O3 by the
concerted nitrite reductase and
anhydrase activity of hemoglobin. Nat
Chem Biol. 2007 Dec;3(12):785–794.
VerDate Aug<31>2005
18:11 Apr 16, 2008
Jkt 214001
Patent Status: U.S. Provisional
Application No. 60/996,530 filed 31
Aug 2007 (HHS Reference No. E–259–
2007/0–US–01).
Licensing Status: Available for
licensing.
Licensing Contact: Fatima Sayyid,
M.H.P.M.; 301–435–4521;
Fatima.Sayyid@nih.hhs.gov.
Dated: April 8, 2008.
Steven M. Ferguson,
Director, Division of Technology Development
and Transfer, Office of Technology Transfer,
National Institutes of Health.
[FR Doc. E8–8218 Filed 4–16–08; 8:45 am]
BILLING CODE 4140–01–P
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
National Institute of Mental Health;
Notice of Meeting
Notice is hereby given of a meeting of
the Services Subcommittee of the
Interagency Autism Coordinating
Committee (IACC).
The purpose of the Services
Subcommittee is to review the current
state of services and supports for
individuals with Autism Spectrum
Disorder (ASD) and their families in
order to improve these services. The
Subcommittee meeting will be closed to
the public with attendance limited to
IACC members. The Subcommittee will
report on its meeting at the next meeting
of the IACC on May 12, 2008.
Name of Committee: Interagency Autism
Coordinating Committee (IACC).
Type of meeting: Services Subcommittee.
Date: April 30, 2008.
Time: 1 p.m. to 3 p.m.
Agenda: Review the current state of
services and supports for individuals with
ASD and their families.
Place: National Institutes of Health,
Neuroscience Center, 6001 Executive
Boulevard, Bethesda, MD 20892–9669.
(Telephone Conference Call)
Contact Person: Tanya Pryor, National
Institute of Mental Health, NIH,
Neuroscience Center, 6001 Executive
Boulevard, Room 6198, Bethesda, MD 20892–
9669, 301–443–7153, pryort@mail.nih.gov.
Information about the IACC is available on
the Web site: https://www.nimh.nih.gov/
research-funding/scientific-meetings/
recurring-meetings/iacc/index.shtml.
Dated: April 8, 2008.
Jennifer Spaeth,
Director, Office of Federal Advisory
Committee Policy.
[FR Doc. E8–8226 Filed 4–16–08; 8:45 am]
BILLING CODE 4140–01–P
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DEPARTMENT OF HOUSING AND
URBAN DEVELOPMENT
[Docket No. FR–5187–N–20]
Renewal Communities Annual
Progress Reporting
Office of the Chief Information
Officer, HUD.
ACTION: Notice.
AGENCY:
SUMMARY: The proposed information
collection requirement described below
has been submitted to the Office of
Management and Budget (OMB) for
review, as required by the Paperwork
Reduction Act. The Department is
soliciting public comments on the
subject proposal.
Renewal Communities are required to
submit annual reports to HUD on the
progress of their Tax Incentive
Utilization Plan in assisting State and
local governments and communitybased organizations in their outreach to
the business community and residents.
DATES: Comments Due Date: May 19,
2008.
ADDRESSES: Interested persons are
invited to submit comments regarding
this proposal. Comments should refer to
the proposal by name and/or OMB
approval number (2506–0173) and
should be sent to: HUD Desk Officer,
Office of Management and Budget, New
Executive Office Building, Washington,
DC 20503; fax: 202–395–6974.
FOR FURTHER INFORMATION CONTACT:
Lillian Deitzer, Reports Management
Officer, QDAM, Department of Housing
and Urban Development, 451 Seventh
Street, SW., Washington, DC 20410;
e-mail Lillian Deitzer at
Lillian_L_Deitzer@HUD.gov or
telephone (202) 402–8048. This is not a
toll-free number. Copies of available
documents submitted to OMB may be
obtained from Ms. Deitzer.
SUPPLEMENTARY INFORMATION: This
notice informs the public that the
Department of Housing and Urban
Development has submitted to OMB a
request for approval of the information
collection described below. This notice
is soliciting comments from members of
the public and affecting agencies
concerning the proposed collection of
information to: (1) Evaluate whether the
proposed collection of information is
necessary for the proper performance of
the functions of the agency, including
whether the information will have
practical utility; (2) Evaluate the
accuracy of the agency’s estimate of the
burden of the proposed collection of
information; (3) Enhance the quality,
utility, and clarity of the information to
be collected; and (4) Minimize the
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[Federal Register Volume 73, Number 75 (Thursday, April 17, 2008)]
[Notices]
[Page 20930]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: E8-8226]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health
National Institute of Mental Health; Notice of Meeting
Notice is hereby given of a meeting of the Services Subcommittee of
the Interagency Autism Coordinating Committee (IACC).
The purpose of the Services Subcommittee is to review the current
state of services and supports for individuals with Autism Spectrum
Disorder (ASD) and their families in order to improve these services.
The Subcommittee meeting will be closed to the public with attendance
limited to IACC members. The Subcommittee will report on its meeting at
the next meeting of the IACC on May 12, 2008.
Name of Committee: Interagency Autism Coordinating Committee
(IACC).
Type of meeting: Services Subcommittee.
Date: April 30, 2008.
Time: 1 p.m. to 3 p.m.
Agenda: Review the current state of services and supports for
individuals with ASD and their families.
Place: National Institutes of Health, Neuroscience Center, 6001
Executive Boulevard, Bethesda, MD 20892-9669. (Telephone Conference
Call)
Contact Person: Tanya Pryor, National Institute of Mental
Health, NIH, Neuroscience Center, 6001 Executive Boulevard, Room
6198, Bethesda, MD 20892-9669, 301-443-7153, pryort@mail.nih.gov.
Information about the IACC is available on the Web site: https://
www.nimh.nih.gov/research-funding/scientific-meetings/recurring-
meetings/iacc/index.shtml.
Dated: April 8, 2008.
Jennifer Spaeth,
Director, Office of Federal Advisory Committee Policy.
[FR Doc. E8-8226 Filed 4-16-08; 8:45 am]
BILLING CODE 4140-01-P
