Nominations to the FIFRA Scientific Advisory Panel; Request for Comments, 14794-14800 [E8-5556]

Agencies

• ENVIRONMENTAL PROTECTION AGENCY

[Federal Register Volume 73, Number 54 (Wednesday, March 19, 2008)]
[Notices]
[Pages 14794-14800]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: E8-5556]



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ENVIRONMENTAL PROTECTION AGENCY

[EPA-HQ-OPP-2008-0045; FRL-8354-2]


Nominations to the FIFRA Scientific Advisory Panel; Request for 
Comments

AGENCY: Environmental Protection Agency (EPA).

ACTION: Notice.

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SUMMARY: This notice provides the names, addresses, professional 
affiliations, and selected biographical data of persons nominated to 
serve on the Scientific Advisory Panel (SAP) established under section 
25(d) of the Federal Insecticide, Fungicide, and Rodenticide Act 
(FIFRA). The Panel was created on November 28, 1975, and made a 
statutory Panel by amendment to FIFRA, dated October 25, 1988. The 
Agency is, at this time, selecting two new members to serve on the 
panel as a result of membership terms that will expire this year. 
Public comment on the nominations is invited, as these comments will be 
used to assist the Agency in selecting the new chartered Panel members.

DATES: Comments, identified by docket ID number EPA-OPP-2008-0045, must 
be received on or before April 18, 2008.

ADDRESSES: Submit your comments, identified by docket identification 
(ID) number EPA-HQ-OPP-2008-0045, by one of the following methods:
     Federal eRulemaking Portal: https://www.regulations.gov. 
Follow the on-line instructions for submitting comments.
     Mail: Office of Pesticide Programs (OPP) Regulatory Public 
Docket (7502P), Environmental Protection Agency, 1200 Pennsylvania 
Ave., NW., Washington, DC 20460-0001.
     Delivery: OPP Regulatory Public Docket (7502P), 
Environmental Protection Agency, Rm. S-4400, One Potomac Yard (South 
Bldg.), 2777 S. Crystal Drive, Arlington, VA. Deliveries are only 
accepted during the Docket's normal hours of operation from 8:30 a.m. 
to 4 p.m., Monday through Friday, excluding legal holidays. Special 
arrangements should be made for deliveries of boxed information. The 
Docket telephone number is (703) 305-5805.
    Instructions: Direct your comments to docket ID number EPA-HQ-OPP-
2008-0045. EPA's policy is that all comments received will be included 
in the docket without change and may be made available on-line at 
https://www.regulations.gov, including any personal information 
provided, unless the comment includes information claimed to be 
Confidential Business Information (CBI) or other information whose 
disclosure is restricted by statute. Do not submit information that you 
consider to be CBI or otherwise protected through regulations.gov or e-
mail. The Federal regulations.gov website is an ``anonymous access'' 
system, which means EPA will not know your identity or contact 
information unless you provide it in the body of your comment. If you 
send an e-mail comment directly to EPA without going through 
regulations.gov, your e-mail address will be automatically captured and 
included as part of the comment that is placed in the docket and made 
available on the Internet. If you submit an electronic comment, EPA 
recommends that you include your name and other contact information in 
the body of your comment and with any disk or CD-ROM you submit. If EPA 
cannot read your comment due to technical difficulties and cannot 
contact you for clarification, EPA may not be able to consider your 
comment. Electronic files should avoid the use of special characters, 
any form of encryption, and be free of any defects or viruses.
    Docket: All documents in the docket are listed in the docket index. 
Although listed in the index, some information is not publicly 
available, e.g., CBI or other information whose disclosure is 
restricted by statute. Certain other material, such as copyrighted 
material, is not placed on the Internet and will be publicly available 
only in hard copy form. Publicly available docket materials are 
available either in the electronic docket at https://
www.regulations.gov, or, if only available in hard copy, at the OPP 
Regulatory Public Docket in Rm. S-4400, One Potomac Yard (South Bldg.), 
2777 S. Crystal Drive, Arlington, VA. The hours of operation of this 
Docket Facility are from 8:30 a.m. to 4 p.m., Monday through Friday, 
excluding legal holidays. The Docket telephone number is (703) 305-
5805.

FOR FURTHER INFORMATION CONTACT: Joseph E. Bailey, Designated Federal 
Official, FIFRA SAP, Office of Science Coordination and Policy (7201M), 
Environmental Protection Agency, 1200 Pennsylvania Ave., NW., 
Washington, DC 20460; telephone number: (202) 564-2045; fax number: 
(202) 564-8382; e-mail addresses: bailey.joseph@epa.gov.

SUPPLEMENTARY INFORMATION:

I. General Information

A. Does this Action Apply to Me?

    This action is directed to the public in general. This action may, 
however, be of interest to persons who are or may be required to 
conduct testing of chemical substances under the Federal Food, Drug, 
and Cosmetic Act (FFDCA), FIFRA, and the Food Quality Protection Act of 
1996 (FQPA). Since other entities may also be interested, the Agency 
has not attempted to describe all the specific entities that may be 
affected by this action. If you have any questions regarding the 
applicability of this action to a particular entity, consult the DFO 
listed under FOR FURTHER INFORMATION CONTACT.

B. What Should I Consider as I Prepare My Comments for EPA?

    Tips for preparing your comments. When submitting comments, 
remember to:
    i. Identify the document by docket ID number and other identifying 
information (subject heading, Federal Register date, and page number).
    ii. Follow directions. The Agency may ask you to respond to 
specific questions or organize comments by referencing a Code of 
Federal Regulations (CFR) part or section number.
    iii. Explain why you agree or disagree; suggest alternatives and 
substitute language for your requested changes.
    iv. Describe any assumptions and provide any technical information 
and/or data that you used.
    v. If you estimate potential costs or burdens, explain how you 
arrived at your estimate in sufficient detail to allow for it to be 
reproduced.
    vi. Provide specific examples to illustrate your concerns and 
suggest alternatives.
    vii. Explain your views as clearly as possible, avoiding the use of 
profanity or personal threats.
    viii. Make sure to submit your comments by the comment period 
deadline identified.

II. Background

    The FIFRA SAP serves as the primary scientific peer review 
mechanism of the U.S. Environmental Protection Agency (EPA), Office of 
Prevention, Pesticides and Toxic Substances and is structured to 
provide scientific advice, information and recommendations to the EPA 
Administrator on pesticides and pesticide-related issues as to the 
impact of regulatory actions on health and the environment. The FIFRA 
SAP is a Federal advisory committee, established in 1975 under FIFRA, 
that operates in accordance with requirements of the

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Federal Advisory Committee Act. The FIFRA SAP is composed of a 
permanent panel consisting of seven members who are appointed by the 
EPA Administrator from nominees provided by the National Institutes of 
Health (NIH) and the National Science Foundation (NSF). FIFRA, as 
amended by the FQPA of 1996, established a Science Review Board 
consisting of at least 60 scientists who are available to the 
Scientific Advisory Panel on an ad hoc basis to assist in reviews 
conducted by the Panel. As a peer review mechanism, the FIFRA SAP 
provides comments, evaluations and recommendations to improve the 
effectiveness and quality of analyses made by Agency scientists. 
Members of the FIFRA SAP are scientists who have sufficient 
professional qualifications, including training and experience, to 
provide expert advice and recommendation to the Agency.
    The Agency is, at this time, selecting two new members to serve on 
the permanent panel as a result of membership terms that will expire 
this year. The Agency requested nominations of experts to be selected 
from the fields of toxicology, pathology, endocrine disruption and 
environmental exposure analysis. Nominees should be well published and 
current in their fields of expertise. The statute further stipulates 
that we publish the name, address, and professional affiliations in the 
Federal Register.

III. Charter

    A Charter for the FIFRA Scientific Advisory Panel dated October 25, 
2006 was issued in accordance with the requirements of the Federal 
Advisory Committee Act, Public Law 92-463, 86 Stat. 770 (5 U.S.C. App. 
I).

A. Qualifications of Members

    FIFRA SAP members are scientists who have sufficient professional 
qualifications, including training and experience, to be capable of 
providing expert comments as to the impact of pesticides on health and 
the environment. No persons are ineligible to serve on the Panel by 
reason of their membership on any other advisory committee to a Federal 
department or agency or their employment by a Federal department or 
agency (except the EPA). The Deputy Administrator appoints individuals 
to serve on the Panel for staggered terms of 4 years. Panel members are 
subject to the provisions of 40 CFR part 3, subpart F, Standards of 
Conduct for Special Government Employees, which include rules regarding 
conflicts of interest. Each nominee selected by the Deputy 
Administrator, before being formally appointed, is requested to submit 
a confidential statement of employment and financial interests, which 
shall fully disclose, among other financial interests, the nominee's 
sources of research support, if any.
    In accordance with section 25(d)(1) of FIFRA, the Deputy 
Administrator shall require all nominees to the Panel to furnish 
information concerning their professional qualifications, educational 
background, employment history, and scientific publications.

B. Applicability of Existing Regulations

    With respect to the requirements of section 25(d) of FIFRA that the 
Administrator promulgate regulations regarding conflicts of interest, 
the Charter provides that EPA's existing regulations applicable to 
Special Government Employees, which include advisory committee members, 
will apply to the members of the Scientific Advisory Panel. These 
regulations appear in 40 CFR part 3, subpart F. In addition, the 
Charter provides for open meetings with opportunities for public 
participation.

C. Process of Obtaining Nominees

    In accordance with the provisions of section 25(d) of FIFRA, EPA, 
in March 2007, requested that the National Institutes of Health (NIH) 
and the National Science Foundation (NSF) nominate scientists to fill 
two vacancies soon to occur on the Panel. The Agency requested 
nominations of experts in the fields of toxicology, pathology, 
endocrine disruption and environmental exposure analysis. NIH and NSF 
responded by letter, providing the Agency with a total of 24 nominees. 
Thirteen of the 24 nominees are interested and available to actively 
participate in SAP meetings (see Unit IV. of this document). The 
following 11 nominees are not available:
    1. Barnthouse, Lawrence W., Ph.D., LWB Environmental Service, Inc., 
Hamilton, OH;
    2. Daston, George, Ph.D., The Proctor and Gamble Company, 
Cincinnati, OH;
    3. Dement, John, Ph.D., CIH, Duke University Medical Centers, 
Durham, NC;
    4. Faustman, Elaine, Ph.D., DABT, University of Washington, 
Seattle, WA;
    5. MacGregor, James, Ph.D., Toxicology Consulting Services, Arnold, 
MD;
    6. Oberdorster, Eva, Ph.D., Southern Methodist University, Dallas, 
TX;
    7. Piegorsch, Water, Ph.D., University of South Carolina, Columbia, 
SC;
    8. Popp, James, DVM, Ph.D., Stratoxon, Lancaster, PA;
    9. Wilson, Elizabeth, Ph.D., University of North Carolina, Chapel 
Hill, NC;
    10. Yager, James, Ph.D., Johns Hopkins University, Baltimore, MD;
    11. Welsch, Frank, DVM, Ph.D., DABT, Orbitox, Santa Fe, NM.

IV. Nominees

    The following are the names, addresses, professional affiliations, 
and selected biographical data of nominees being considered for 
membership on the FIFRA Scientific Advisory Panel. The Agency expects 
to select two of the nominees to fill vacancies occurring this year.
    1. Nominee: Bruckner, James, Ph.D., Professor of Pharmacology and 
Toxicology, Department of Pharmaceutical and Biomedical Sciences, 
College of Pharmacy, University of Georgia, Athens, GA.
    i. Expertise: Toxicology and Toxicokinetics;
    ii. Education: B.S., Pharmacy, University of Texas at Austin, 
College of Pharmacy; M.S., Toxicology, University of Texas at Austin; 
Ph.D., Toxicology, University of Michigan;
    iii. Professional Experience: James V. Bruckner has a B.S. in 
pharmacy and a M.S. in Toxicology from the University of Texas, as well 
as a Ph.D. in Toxicology from the University of Michigan. He has held 
faculty positions at the University of Kansas, the University of Texas 
Medical School at Houston, and the University of Georgia (UGA). Dr. 
Bruckner served as a member of the University of Texas Health Sciences 
Center internal review (human subjects) board for some 8 years. He is 
currently Professor of Pharmacology and Toxicology at the UGA College 
of Pharmacy. He was director of UGA's Interdisciplinary Graduate 
Program in Toxicology for some 15 years. He is actively engaged in 
graduate education and in research. Dr. Bruckner has served on the 
editorial boards of Toxicology and Applied Pharmacology, Journal of 
Toxicology and Environmental Health, Toxicology, Chemosphere and the 
International Journal of Toxicology.
    Dr. Bruckner's research focus is on the toxicology and 
toxicokinetics of solvents, drug-solvent interactions at environmental 
exposure levels, and toxicokinetic bases for susceptibility of children 
to insecticides and other chemicals. The relevance of experimental 
designs to ``real life'' chemical exposures is of particular interest. 
One current project involves: characterization of presystemic 
elimination as a protective mechanism against ingestion of trace levels 
of trichloroethylene (TCE); and determination of the influence of

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metabolic interactions of alcohol and other drugs on cancer risks of 
trace amounts of TCE. Another project involves development of a 
physiological model to predict the toxicokinetics of pyrethroid 
insecticides in children and adults. Dr. Bruckner has published more 
than 200 journal articles, book chapters and abstracts. He has served 
on a variety of expert panels and committees for the USEPA, NIH, 
National Aeronautics and Space Administration, Air Force, Agency for 
Toxic Substances and Disease Regitry/Center for Disease Control (CDC), 
Food and Drug Administration (FDA) and the National Academy of Sciences 
(NAS). The NAS appointments have included, among others, the Committees 
on Safe Drinking Water, Pesticides in the Diets of Infants and 
Children; Health and Safety Consequences of Child Labor; Use of Third 
Party Toxicity Research with Human Participants; and Toxicology.
    2. Nominee: Donnelly, Kirby, Ph.D., Professor and Head, Department 
of Environmental and Occupational Health, Health Science Center, School 
of Rural Public Health, Texas A and M University, College Station, TX.
    i. Expertise: Toxicology and Exposure Assessment;
    ii. Education: B.S., Microbiology, Texas A and M University; Ph.D., 
Toxicology, Texas A and M University;
    iii. Professional Experience: Dr. K.C. Donnelly received a B.S. in 
Microbiology from Texas A and M University in 1974. After graduation, 
he worked as a technician for 10 years supervising a variety of field 
research projects at the Texas A and M farm in Burleson County. In 1984 
he entered a doctoral program and earned a Ph.D. in Toxicology in 1988. 
Afterwards, he was employed as a Post-Doctoral Research Associate under 
the direction of Dr. Kirk Brown in the Soil & Crop Sciences Department 
at Texas A and M. He accepted a faculty position in 1991 and is 
currently a Professor and Head of the Environmental & Occupational 
Health Department in the School of Rural Public Health at the Texas A 
and M University System Health Science Center. Teaching 
responsibilities include an undergraduate course in Public Health 
Practices and two graduate courses, the first covering Basic 
Environmental Toxicology and a second lab course reviewing methods for 
Chemical Hazard Assessment. Dr. Donnelly also organizes workshops on 
Environmental Health for public health professionals, most recently in 
June, 2007 in Baku, Azerbaijan. He also provides continuing education 
courses for nurses and physicians in ``Children's Environmental 
Health'' and ``Safe Drinking Water.'' Dr. Donnelly currently serves as 
the Director of the Integrated Health Sciences Facility Core for the 
National Institute for Environmental Health and Safety (NIEHS) Center 
for Environmental & Rural Health; and, he is the Associate Director for 
the NIEHS funded Superfund Basic Research Program at Texas A and M. 
Responsibilities for the Environmental Health Center include analytical 
support and sample collection for human population studies; and, 
support for Community Outreach and Education activities. For the 
Superfund Basic Research Program, Dr. Donnelly is the principal 
investigator for Project 2, Genotoxicity of Complex Mixtures and 
supervises cell culture, whole animal and human population studies to 
obtain information regarding population exposures and toxicity of 
complex chemical mixtures. He is currently involved in exposure studies 
in Azerbaijan, Czech Republic, Shanxi, China and numerous locations in 
the United States. Dr. Donnelly has conducted research on childhood 
exposure to pesticides for more than 10 years. Most recently, this has 
included a collaborative study with the Centers for Disease Control and 
EPA to conduct a longitudinal study on pesticide exposure in children 
from 90 households in four rural communities. He is currently in the 
second year of a 3 year Health Resources and Service Administration 
(HRSA) project to investigate the utility of health education as an 
intervention to reduce childhood exposure to pesticides in Texas 
colonias. This project employs promotoras (community health workers) to 
deliver health education to individual families, and monitors 
behavioral changes through a household inventory of pesticide use and 
by monitoring urinary elimination of pesticides in children. Dr. 
Donnelly has more than 30 years experience in basic and applied 
research. More recent activities have incorporated health promotion 
activities into research protocols as a means of preventing disease by 
reducing exposures. Dr. Donnelly is also involved in collaboration with 
the Texas Department of State Health Services, the Webb County Health 
Department, and the Poison Control Center in San Antonio to develop a 
``Physicians Handbook for Pesticide Exposures.''
    3. Nominee: Harwell, Mark, Ph.D., Ecosystems Ecologist and Partner, 
Harwell Gentile & Associates, LC, Hammock, FL.
    i. Expertise: Ecological risk assessment and ecosystem management;
    ii. Education: B.S., Biology, Emory University; M.S., Marine 
Ecology, University of Miami, Institute of Marine Science; Ph.D., 
Systems Ecology, Emory University;
    iii. Professional Experience: Dr. Harwell is an ecosystems 
ecologist with expertise in ecological risk assessments and ecosystem 
management. He (with colleague Dr. Jack Gentile) is currently a Partner 
in Harwell Gentile & Associates, LC, following a 25-year career in 
academia at Cornell University, the University of Miami Rosenstiel 
School, and Florida A and M University. Drs. Harwell and Gentile were 
leaders in the development of the USEPA ecological risk assessment 
framework, and have led several large risk assessments, including 
comparative ecological risk assessments of oil spills in Tampa Bay and 
the Bay of Fundy; an ecological risk assessment of the effects of 
climate change and the South Florida ecosystem restoration on the 
Everglades and Biscayne Bay; an ecotoxicological risk assessment of the 
Coeur d'Alene River watershed; and an assessment of the current 
ecological significance of effects from the Exxon Valdez oil spill on 
Prince William Sound. Dr. Harwell led a series of interdisciplinary 
studies on human interactions with the South Florida environment, 
including field, mesocosm, and modeling studies in Biscayne Bay and the 
Florida Keys National Marine Sanctuary. He coordinated 
interdisciplinary studies in five National Estuarine Research Reserves, 
developing conceptual models of coupled human-environment systems, and 
contributing to ecological assessments using remote sensing and 
hyperspectral imagery. Dr. Harwell served for more than a decade as a 
member of the USEPA Science Advisory Board (SAB), including two terms 
as Chair of the Ecological Processes and Effects Committee. He led the 
ecological risk component of the USEPA Unfinished Business Project, and 
was a member of the USEPA SAB Reducing Risk project. He chaired the 
U.S. Man and the Biosphere Human-Dominated Systems Directorate, and led 
its project on ecological sustainability, ecosystem management, and an 
ecosystem integrity report card framework. He led the Scientific 
Committee on Problems of the Environment (SCOPE) 5-year international 
study to assess the global environmental consequences of nuclear war 
(ENUWAR), with emphasis on ecological responses to climate change. He 
directed the PAN-EARTH Project, a series of national-level case studies 
on the ecological and agricultural effects of climate variability on 
Venezuela, India, Japan, China, and Sub-Saharan Africa; he was a member 
of the U.S. Global

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Change Research Program's National Assessment working group on coastal 
resources effects; and he serves as an expert reviewer for the 
Intergovernmental Panel on Climate Change. He served on the National 
Academy of Sciences panel on ecological risks in the United States and 
Poland, and was a member of the NAS panel on risk communications. Dr. 
Harwell also served as a member of the National Academy of Sciences 
Board on Environmental Studies and Toxicology, and was elected a Fellow 
of the American Association for the Advancement of Science.
    4. Nominee: Haschek-Hock, Wanda, Ph.D., DVM, DACVP, DABT, 
Veterinary Pathologist and Professor of Comparative Pathology, 
Department of Pathobiology, College of Veterinary Medicine, University 
of Illinois, Urbana, IL.
    i. Expertise: Veterinary and Toxicologic Pathology;
    ii. Education: BVSc (DVM equivalent), University of Sidney; Ph.D., 
Veterinary Pathology, Cornell University;
    iii. Professional Experience: Dr. Wanda M. Haschek-Hock, a 
veterinary pathologist and Professor of Comparative Pathology at the 
University of Illinois College of Veterinary Medicine, has over 30 
years of experience in veterinary and toxicologic pathology including 
teaching, research and service. Dr. Haschek-Hock received her BVSc (DVM 
equivalent) from the University of Sydney and her Ph.D. from Cornell 
University. She is a diplomate of the American College of Veterinary 
Pathologists (ACVP) and the American Board of Toxicology (ABT). Her 
research has been in the pathophysiology of chemicals and natural 
toxins found in the environment with the current focus on mycotoxins 
and food safety. She has over 100 scientific peer reviewed publications 
in the fields of pathology and toxicology, and is senior editor of the 
Handbook of Toxicologic Pathology (1991, 2002) and Fundamentals of 
Toxicologic Pathology (1998) published by Academic Press. She developed 
and directs the Graduate Training Program in Toxicologic Pathology and 
the biannual international continuing education course in Industrial 
Toxicology and Pathology. She served as head of the department for 6 
years. In regard to professional service, she has served as President 
of the Society of Toxicology's Comparative and Veterinary Specialty 
Section, on the Board of Directors of the American Board of Toxicology; 
as Associate Editor for Toxicological Sciences and currently for 
Toxicologic Pathology; as Editorial Board member for Fundamental and 
Applied Toxicology, Veterinary Pathology and Toxicologic Pathology. She 
has also served as Councilor of the American College of Veterinary 
Pathologists and as Executive Committee member and Secretary Treasurer 
of the Society of Toxicologic Pathology. She has served on the USFDA 
Veterinary Medicine Advisory Committee for the Center for Veterinary 
Medicine and as an ad hoc member for the EPA's FIFRA Scientific 
Advisory Panel. She was awarded the Society of Toxicologic Pathology's 
Achievement Award in 2007.
    5. Nominee: Kelly, Elizabeth J., Ph.D., Statistician, Statistical 
Sciences Group, Los Alamos National Laboratory, Los Alamos, NM.
    i. Expertise: Environmental Statistics and Risk Analysis;
    ii. Education: B.S., M.A., Mathematics, University of Southern 
California; Ph.D., Biostatistics, University of California at Los 
Angeles;
    iii. Professional Experience: Elizabeth J. Kelly has a Ph.D. in 
Biostatistics from the University of California at Los Angeles and a 
M.A. and a B.S. in Mathematics from the University of Southern 
California. Dr. Kelly has worked in the areas of risk assessment, 
statistics and operations research, using these disciplines to solve 
problems in the fields of environmental risk, defense and medicine. Dr. 
Kelly is a staff member in the Statistical Sciences Group at Los Alamos 
National Laboratory. The mission of the Statistical Sciences Group is 
to bring statistical reasoning and rigor to multi-disciplinary 
scientific investigations through development, application, and 
communication of cutting-edge statistical sciences research. Dr. 
Kelly's research has focused on environmental risk assessments and 
environmental statistics. She led the Risk Assessment Team for the 
Environmental Restoration Program at Los Alamos, developing, 
documenting, and communicating a cost-effective, defensible technical 
approach for data collection, data evaluation, and human health and 
ecological risk assessments in support of environmental decision-
making. Dr. Kelly has served on numerous NSF and EPA grant panels. She 
served on the NSF Advisory Committee for Environmental Research and 
Education (2000-2004) and was a contributor to the NSF report, Complex 
Environmental Systems, Synthesis for Earth, Life, and Society in the 
21st Century. Dr. Kelly also chaired the Committee of Visitors (COV) 
for the NSF Biocomplexity Program, co-authoring the ``COV Report for 
Biocomplexity in the Environment.'' In addition Dr. Kelly served on the 
NSF Advisory Committee for Government Performance and Results Act, 
which evaluates all of the NSF funded programs and reports to congress.
    6. Nominee: Klaassen, Curtis, Ph.D., DABT, Distinguished Professor 
and Chairman of the Department of Pharmacology, Toxicology and 
Therapeutics; University of Kansas, Kansas City, KS.
    i. Expertise: Toxicology;
    ii. Education: B.A., Biology, Wartburg College; M.S., Pharmacology, 
University of Iowa; Ph.D., Pharmacology, University of Iowa;
    iii. Professional Experience: Dr. Klaassen is University 
Distinguished Professor and Chairman of the Department of Pharmacology, 
Toxicology and Therapeutics at the University of Kansas Medical Center 
in Kansas City, Kansas. He received his B.S. from Wartburg College in 
Waverly, Iowa in 1964, and a M.S. and Ph.D. in Pharmacology from the 
University of Iowa in 1966 and 1968, respectively. He has been on the 
faculty at the University of Kansas Medical Center since 1968. Dr. 
Klaassen is certified in toxicology by the American Board of Toxicology 
(1980) and the Academy of Toxicological Sciences (1991).
    Dr. Klaassen's research interests have centered on how we adapt to 
chemicals in the environment. Studies have included the hepatobiliary 
disposition of xenobiotics, the toxicity of cadmium, the hepatotoxicity 
of chemicals, and mechanisms of chemical-induced thyroid tumors. He has 
published over 400 peer-reviewed articles, and more than 75 review 
articles and chapters for books. He received the Achievement Award from 
the Society of Toxicology in 1978 for his research accomplishments. He 
was cited by Eugen Garfield in Current Contents (January 18, 1993) as 
the scientist that had the fourth highest scientific impact in the 
United States in the study of xenobiotics (drugs and other chemicals), 
and in 2002 was named a ``Highly Cited Researcher'' in Pharmacology 
(top 0.5%) by the Institute for Scientific Information.
    Dr. Klaassen has been an associate editor of a number of journals 
including the Journal of Pharmacology and Experimental Therapeutics for 
24 years and Toxicology and Applied Pharmacology for 10 years. He was 
the first Editor-in-Chief of Toxicological Sciences , the new journal 
of the Society of Toxicology. He has served on numerous national and 
international committees including those with the National Institutes 
of Health, the Food and Drug Administration, the National

[[Page 14798]]

Library of Medicine, the Environmental Protection Agency, the National 
Academy of Science, the National Toxicology Program, the National 
Institute of Occupational Safety and the Health, International Life 
Science Institute, United States Air Force, World Health Organization, 
Agency for Toxic Substances and Disease Registry, American Dental 
Association, and International Agency for Research on Cancer.
    Dr. Klaassen has been elected by his peers to many national and 
international offices in toxicology, including President of the Society 
of Toxicology (USA) in 1990-1991, as well as President of the 
International Union of Toxicology (1992-1995). He was also President of 
the Seventh International Congress of Toxicology (1995) and the Fourth 
International Metallothionein Meeting (1997).
    Dr. Klaasen is a leader in toxicology education. He has trained 
over 80 Ph.D. and Postdoctoral students. He is Founder (1980) and 
Course Director of the Mid-America Toxicology Course, an annual 
postgraduate course in toxicology. He is author of the toxicology 
section of Goodman and Gilman's Pharmacological Basis of Therapeutics 
and Editor of Casarett and Doull's Toxicology: The Basic Science of 
Poisons. He has presented over 400 lectures on toxicology around the 
world. He received the ``Education Award'' from the Society of 
Toxicology in 1993.
    7. Nominee: Klaine, Stephen J., Ph.D., Professor, Department of 
Biological Sciences, Clemson University, Clemson, SC.
    i. Expertise: Environmental Toxicology;
    ii. Education: B.S., Biology, University of Cincinnati, M.S., 
Environmental Science, Rice University; Ph.D., Environmental Science, 
Rice University;
    iii. Professional Experience: Stephen J. Klaine is a Professor in 
the Department of Biological Sciences and the Graduate Program of 
Environmental Toxicology at Clemson University. His research interest 
involves quantifying the impact of land use on aquatic ecosystems and 
developing strategies by which economically viable land-use can coexist 
with good environmental quality. He received his doctorate from the 
Department of Environmental Science and Engineering, Rice University in 
1982 and has spent the last 25 years conducting environmental research 
and educating graduate students. He joined the Department of Biology, 
University of Memphis, in 1982 where he developed an undergraduate 
concentration in toxicology, an extramurally-funded research program in 
environmental toxicology, and a graduate program. In 1991, he moved his 
laboratory to Clemson University to help found the graduate program in 
environmental toxicology. Current research in his laboratory focuses on 
characterizing the bioavailability of metals and pesticides in aquatic 
systems; the comparative phytotoxicity of pesticides; the response of 
aquatic organisms to episodic contaminant exposures; the water quality 
consequences of land use; the effects of pharmaceuticals on fish 
behavior; the bioavailability of single-walled carbon nanotubes in 
aquatic systems; and the bioavailability of PCBs in aquatic systems and 
the movement of PCBs through the aquatic and terrestrial food chain.
    Dr. Klaine has published over 100 scientific publications and has 
served as principal investigator or co-principal investigator on over 
$8 million in research funding. He has previously served on the board 
of directors for the Society of Environmental Toxicology and Chemistry 
(SETAC) and is currently an aquatic toxicology editor for the journal 
Environmental Toxicology and Chemistry. He also sits on the board of 
the SETAC foundation and is a member of SETAC World Council finance 
committee. In the last decade, he has served on several USEPA 
Scientific Advisory Panels and workshops involving pesticide and metal 
fate, effects and risk. Most recently, he received the Outstanding 
Researcher award from the Sigma Xi chapter at Clemson University.
    8. Nominee: Krieger, Robert I., Ph.D., Cooperative Extension 
Specialist (Toxicology), Department of Entomology, Personal Chemical 
Exposure Program, University of California at Riverside, Riverside, CA.
    i. Expertise: Toxicology and Exposure Assessment;
    ii. Education: B.S., Chemistry, Pacific Lutheran University; Ph.D., 
Toxicology, Cornell University;
    iii. Professional Experience: Dr. Krieger is a Cooperative 
Extension Toxicologist in the Department of Entomology, University of 
California at Riverside and a member of the Graduate Program in 
Environmental Toxicology. He holds a B.S. cum laude in Chemistry from 
Pacific Lutheran University (1967) and a Ph.D. from Cornell University 
(1970) where he was a student in the Department of Entomology and NIEHS 
Trainee in Environmental Toxicology. Graduate study fields included 
toxicology, physiology and biochemistry. He has held tenured academic 
appointments at the University of California at Davis (1971-1980) and 
in the Washington-Oregon-Idaho Regional Veterinary Medical Education 
Program (1981-1986) where he was Professor of Veterinary and 
Comparative Toxicology. In 1986 he became staff toxicologist and later 
Branch Chief, Worker Health and Safety, California Department of Food 
and Agriculture (now California EPA). Dr. Krieger worked with two major 
Washington D.C. consulting firms (1991-1994) in exposure and risk 
assessment before returning to the University of California as an 
Extension Toxicologist (1994-present) specializing in pesticide 
exposure assessment and worker health and safety. He has taught 
toxicology at both the undergraduate and graduate levels and received 
several teaching awards including the Society of Toxicology's Education 
Award in 1986. His research concerns the fate and effects of pesticides 
in humans, risk assessment, and risk communication. Current studies 
concern methods and techniques for determining the availability of 
chemical residues on surfaces, exposure biomonitoring of urban and 
agricultural populations that are exposed to pesticides and other 
chemicals. At the Universty of California at Riverside, Dr. Krieger 
heads the Personal Chemical Exposure Program that includes research and 
extension activities in urban and agricultural settings. He also headed 
the distinguished editorial team that produced the Handbook of 
Pesticide Toxicology (2001).
    9. Nominee: La Point, Thomas, Ph.D., Director of the Institute of 
Applied Sciences and Professor and Senior Scientist in the Department 
of Biological Sciences, University of North Texas, Denton, TX.
    i. Expertise: Ecosystem Toxicology;
    ii. Education: B.S., Zoology and Physiology, University of Wyoming; 
M.S., Population Biology, University of Houston; Ph.D., Aquatic 
Biology, Idaho State University;
    iii. Professional Experience: Dr. La Point directs the Institute of 
Applied Sciences at the University of North Texas and is a Professor in 
the Department of Biological Sciences. He received his Ph.D. from the 
Department of Biological Sciences at Idaho State University in Aquatic 
Biology. His primary research and teaching interests include 
contaminant effects on freshwater aquatic communities, specifically in 
how metals and organic contaminants affect benthic population dynamics 
and freshwater fisheries. He has published on ecosystem measures, 
contaminant bioaccumulation, and sub-lethal effects on aquatic 
populations. Dr.

[[Page 14799]]

La Point has served on several USEPA Scientific Advisory Panels 
concerned with pesticides and ecological risk and has worked as a 
consultant on Superfund issues at large sites. Dr. La Point also served 
on a National Academy of Science NRC Committee on Superfund Site 
Assessment and Remediation in the Coeur d'Alene River Basin. He is 
serving as Chair of a Water Environment Research Foundation 
subcommittee on whole-effluent testing as an indicator of aquatic 
health. He has served on several NSF, USEPA and United States 
Geological Survey panels to review proposals submitted for funding. He 
is on the editorial board for Chemosphere and Environmental Toxicology 
and Pharmacology and has served as Editor of the Society of 
Environmental Toxicology and Chemistry (SETAC) Special Publication 
Series. Dr. La Point's current research is funded by the USEPA, U.S. 
Army Corps of Engineers, and the City of Denton, TX.
    10. Nominee: Law, Jerry, DVM, Ph.D., ACVP, Associate Professor of 
Pathology and Aquatic Ecotoxicology, Department of Population Health 
and Pathobiology, College of Veterinary Medicine, North Carolina State 
University, Raleigh, NC.
    i. Expertise: Pathology;
    ii. Education: D.V.M. , Veterinary Medicine, Louisiana State 
University, Baton Rouge, LA; Ph.D., Veterinary Pathology, Louisiana 
State University, Baton Rouge, LA;
    iii. Professional Experience: Dr. Law received his D.V.M in 
Veterinary Medicine from Louisiana State University in 1985 and his 
Ph.D. in Veterinary Pathology from Louisiana State University in 1995. 
He is a certified Diplomate of the American College of Veterinary 
Pathologists and serves as an Education Committee Member of the 
Americal College of Veterinary Pathologists, as an Advisory Board 
Member of the Genetics and Environmental Mutagenesis Society and as a 
Council Member of the North Carolina Society of Toxicology. Dr. Law's 
research focuses on mechanisms of carcinogenesis and comparative 
pathology of aquatic animals. The approach is twofold:
    a. Mechanistic investigations using histopathology, molecular 
biology, and analytical techniques such as gas chromatography/mass 
spectrometry and high performance liquid chromatography with 
electrochemical detection to further establish small fish species as 
viable alternative animal models in toxicologic testing. Fish models 
such as the medaka, Oryzias latipes, and the zebrafish, Danio rerio, 
are used in these studies.
    b. Laboratory, mesocosm, and field investigations designed to 
establish reliable biological markers in aquatic organisms as sentinels 
of environmental degradation. These biomarkers incorporate 
histopathology, clinical pathology, and immunologic techniques to 
determine the health of aquatic animals and ecosystems. Expected 
benefits of Dr. Law's research include increased knowledge of basic 
mechanisms of carcinogenesis, more rapid and economical testing of 
potential carcinogens, sensitive monitoring of aquatic pollutants, and 
better assessment of seafood safety.
    11. Nominee: Pope, Carey, Ph.D., Professor, Head and Sitlington 
Chair in Toxicology, Department of Physiological Sciences, College of 
Veterinary Medicine, Oklahoma State University, Stillwater, OK.
    i. Expertise: Toxicology;
    ii. Education: B.S., Biology, Austin State University; M.S., 
Biology, Austin State University; Ph.D., Pharmacology/Toxicology, 
University of Texas Graduate School of Biomedical Sciences;
    iii. Professional Experience: Dr. Carey Pope is Professor, Head and 
Sitlington Chair in Toxicology in the Department of Physiological 
Sciences at the Oklahoma State University Center for Veterinary Health 
Sciences, Stillwater, Oklahoma. He received a Ph.D. degree from the 
University of Texas Graduate School of Biomedical Sciences in Houston, 
Texas in 1985, and completed postdoctoral training in the Neurology 
Department at Baylor College of Medicine (1985) and the U.S. 
Environmental Protection Agency's National Health and Environmental 
Effects Research Laboratory (1986-1989). He previously served on the 
faculty of the College of Pharmacy, University of Louisiana at Monroe 
(1989-1999). Dr. Pope's research primarily involves the evaluation of 
intrinsic and extrinsic factors that modify neurotoxicity from exposure 
to acetylcholinesterase inhibitors. He has previously served as a 
consultant for the U.S. Army's external research programs, was a member 
of the NAS/National Research Council Subcommittee on Toxicologic 
Assessment of Low-Level Exposures to Chemical Warfare Agents and is 
currently a member of the NIEHS Neurotoxicology and Alcohol study 
section. Dr. Pope has been a member of the Food Quality Protection Act 
Science Review Board since 1996.
    12. Nominee: Spitsbergen, Jan, Ph.D., DVM, ACVP, Research Assistant 
Professor, Center for Fish Disease Research, Oregon State University, 
Corvallis, OR.
    i. Expertise: Veterinary Pathology and Toxicology;
    ii. Education: B.S., Fisheries and Wildlife, Michigan State 
University; D.V.M., Michigan State University College of Veterinary 
Medicine; Ph.D., Immunology and Pathology, Cornell University;
    iii. Professional Experience: Dr. Spitsbergen is one of a few 
board-certified veterinary pathologists in the world who has strong 
expertise in fish diseases, fish pathology, and toxicologic pathology. 
She taught finfish histology, histopathology and tumor biology for 7 
years in the Aquavet Program, an educational program based in Woods 
Hole, MA, to train veterinarians, veterinary students, and fish health 
scientists about aquatic animal health, husbandry, and diseases. She 
has conducted field epidemiology and experimental laboratory research 
studies in fish toxicology and pathology for over 25 years. Her 
research includes studies in early life stage toxicity of environmental 
contaminants; effects of toxicants on sex determination, fertility and 
fecundity; effects of halogenated aromatic hydrocarbons on disease 
resistance and immune responses; naturally occurring thiamine 
deficiency as the cause of early life stage mortality in salmonids in 
natural waters; field and laboratory studies of the complex causes of 
epizootics of neoplasia in skin and liver of fish. She has focused her 
research on spontaneous and carcinogen-induced tumors in zebrafish for 
the past 12 years. She has collaborated with scientists from the 
University of Oregon, the University of Wisconsin at Madison, 
Children's Hospital and the Dana Farber Cancer Research Institute at 
Harvard University, the National University of Singapore, and 
biotechnology companies in the United States and Hungary. Recently her 
collaborations involve development of zebrafish models for the study of 
Fanconi anemia, an inherited disease of humans that results in aplastic 
anemia or leukemia by young adulthood. Survivors of the current 
treatment of choice, a bone marrow transplant, are at high risk for 
developing solid tumors such as squamous cell carcinoma of head and 
neck. Fanconi anemia results from genomic instability and increased 
susceptibility to oxidant damage when homozygous mutation occurs in one 
of 12 genes in the Fanconi anemia signaling network. Dr. Spitsbergen 
also studies myelodysplastic syndrome and leukemia which occur 
spontaneously in certain mutant lines of zebrafish. One remarkable 
finding in Dr. Spitsbergen's recent zebrafish tumor research is the

[[Page 14800]]

fact that diet and husbandry systems can profoundly influence tumor 
incidences in tanks of zebrafish. These findings are important because 
zebrafish husbandry practices are much less standardized currently than 
the protocols for most other laboratory animals like mice.
    13. Nominee: Timchalk, Charles, Ph.D., DABT, Staff Scientist, 
Pacific Northwest National Laboratories, Center for Biological 
Monitoring and Modeling, Richland, WA.
    i. Expertise: Toxicology;
    ii. Education: B.S., Biology, State University of New York at 
Oneonta; Ph.D., Toxicology/Pharmacology, The Albany Medical College of 
Union University;
    iii. Professional Experience: Charles Timchalk received a B.S. in 
Biology in 1978 from the State University of New York, and a Ph.D. in 
1986 from the Department of Pharmacology and Toxicology, The Albany 
Medical College. He is currently certified as a Diplomat of the 
American Board of Toxicology. In 1986 he joined the Dow Chemical 
Company as a post-doctoral fellow within the Biotransformation and 
Molecular Toxicology Group of the Toxicology Research Laboratory. At 
Dow he was a research and technical leader within the Pharmacokinetics 
and Metabolism group prior to accepting his current position. In 1997 
he joined the Center for Biological Monitoring and Modeling within 
Battelle Pacific Northwest Laboratory as a Staff Scientist. In this 
position he is continuing to pursue his interest in the application of 
pharmacokinetics for evaluation of human health risk. His research is 
currently focused around three themes:
    a. The development of new technologies and approaches for non-
invasive biological monitoring;
    b. Advancing pharmacokinetic and pharmacodynamic modeling to focus 
on the assessment of risk to potentially sensitive populations, such as 
children, and to evaluate the health risk implications of exposure to 
low dose chemical mixtures; and
    c. The utilization of advanced imaging and 3-dimensional modeling 
approaches to develop new dosimetry and biological response models.
    Dr. Timchalk is currently the principal investigator or co-
investigator on seven Department of Health and Human Services/National 
Institutes of Health (DHHS/NIH) grants and has four recently completed 
projects for DHHS and EPA. He has also provided technical leadership in 
support of several Pacific Northwest National Laboratory (PNNL) 
initiatives including: The Environmental Health and Environmental 
Biomarkers Initiative. He has likewise provided support on technical 
review and advisory committees including: NIH/NIEHS Superfund Basic 
Research Grant Review; NIH/National Cancer Institute Special Emphasis 
Review; Dichloromethane Peer Review Panel; Austrian Science Fund Grant 
Review; International Life Sciences Institute, Health and Environmental 
Science Institute, Agricultural Chemical Safety Assessment Steering 
Committee; CDC/National Institute for Occupational Safety and Heatlh 
Safety and Occupational Health Study Section and the EPA-STAR Grant 
Review Panel. He has served as President of the Society of Toxicology, 
Biological Modeling Specialty Section. Over the course of his career 
Dr. Timchalk has been acknowledged both for his professional 
accomplishments and for his ongoing interest in supporting the 
development of young scientist. His research has been recognized by 
awards from the Environmental Business Journal (Technical Merit award, 
2001), and R & D 100 Nomination (2004). In addition, he received the 
Department of Energy, Office of Science Outstanding Mentor Award 
(2002); and the PNNL, Chester I. Cooper Mentor of the Year Award 
(2003).

List of Subjects

    Environmental protection, Pesticides and pests.


    Dated: March 13, 2008.
Mary Belefski,
Acting Director, Office of Science Coordination and Policy.

[FR Doc. E8-5556 Filed 3-18-08; 8:45 am]
 BILLING CODE 6560-50-S