National Toxicology Program (NTP); Report on Carcinogens (RoC); Request for Public Comments on the RoC Expert Panel's Recommendations on Listing Status for Captafol and Ortho-nitrotoluene in the 12th RoC and the Scientific Justifications for the Recommendations, 12736-12737 [E8-4782]

Download as PDF 12736 Federal Register / Vol. 73, No. 47 / Monday, March 10, 2008 / Notices 1. Approval of the minutes of the February 19, 2008 Board member meeting. 2. Thrift Savings Plan activity report by the Executive Director. a. Monthly Participant Activity Report. b. Monthly Investment Performance Report. c. Legislative Report. Safety and Health (NIOSH), 4676 Columbia Parkway, MS C–46, Cincinnati, OH 45226, Telephone 513– 533–6800 (this is not a toll-free number). Information requests can also be submitted by e-mail to OCAS@CDC.GOV. Dated: March 5, 2008. John Howard, Director, National Institute for Occupational Safety and Health. [FR Doc. E8–4761 Filed 3–7–08; 8:45 am] Dated: March 5, 2008. John Howard, Director, National Institute for Occupational Safety and Health. [FR Doc. E8–4762 Filed 3–7–08; 8:45 am] DEPARTMENT OF HEALTH AND HUMAN SERVICES Parts Closed to the Public BILLING CODE 4163–19–P MATTERS TO BE CONSIDERED: Parts Open to the Public 3. Procurement. 4. Personnel. FOR FURTHER INFORMATION CONTACT: Thomas J. Trabucco, Director, Office of External Affairs, (202) 942–1640. Dated: March 6, 2008. Thomas K. Emswiler, Secretary, Federal Retirement Thrift Investment Board. [FR Doc. 08–1004 Filed 3–6–08; 3:58pm] BILLING CODE 6760–01–P National Institute for Occupational Safety and Health (NIOSH), Department of Health and Human Services (HHS). National Institute for Occupational Safety and Health; Decision To Evaluate a Petition To Designate a Class of Employees at the Savannah River Site, Aiken, SC, To Be Included in the Special Exposure Cohort National Institute for Occupational Safety and Health (NIOSH), Department of Health and Human Services (HHS). ACTION: Notice. pwalker on PROD1PC71 with NOTICES AGENCY: SUMMARY: The Department of Health and Human Services (HHS) gives notice as required by 42 CFR 83.12(e) of a decision to evaluate a petition to designate a class of employees at the Savannah River Site, Aiken, South Carolina, to be included in the Special Exposure Cohort under the Energy Employees Occupational Illness Compensation Program Act of 2000. The initial proposed definition for the class being evaluated, subject to revision as warranted by the evaluation, is as follows: Facility: Savannah River Site. Location: Aiken, South Carolina. Job Titles and/or Job Duties: All workers. Period of Employment: January 1, 1950 through December 31, 2007. FOR FURTHER INFORMATION CONTACT: Larry Elliott, Director, Office of Compensation Analysis and Support, National Institute for Occupational 16:39 Mar 07, 2008 National Institute for Occupational Safety and Health; Decision To Evaluate a Petition To Designate a Class of Employees at the Savannah River Site, Aiken, SC, To Be Included in the Special Exposure Cohort AGENCY: DEPARTMENT OF HEALTH AND HUMAN SERVICES VerDate Aug<31>2005 DEPARTMENT OF HEALTH AND HUMAN SERVICES Jkt 214001 ACTION: Notice. SUMMARY: The Department of Health and Human Services (HHS) gives notice as required by 42 CFR 83.12(e) of a decision to evaluate a petition to designate a class of employees at the Savannah River Site, Aiken, South Carolina, to be included in the Special Exposure Cohort under the Energy Employees Occupational Illness Compensation Program Act of 2000. The initial proposed definition for the class being evaluated, subject to revision as warranted by the evaluation, is as follows: Facility: Savannah River Site. Location: Aiken, South Carolina. Job Titles and/or Job Duties: All laborers, foremen, and construction workers. Period of Employment: March 9, 1951 through October 24, 1986. FOR FURTHER INFORMATION CONTACT: Larry Elliott, Director, Office of Compensation Analysis and Support, National Institute for Occupational Safety and Health (NIOSH), 4676 Columbia Parkway, MS C–46, Cincinnati, OH 45226, Telephone 513– 533–6800 (this is not a toll-free number). Information requests can also be submitted by e-mail to OCAS@CDC.GOV. PO 00000 Frm 00035 Fmt 4703 Sfmt 4703 BILLING CODE 4163–19–P National Toxicology Program (NTP); Report on Carcinogens (RoC); Request for Public Comments on the RoC Expert Panel’s Recommendations on Listing Status for Captafol and Orthonitrotoluene in the 12th RoC and the Scientific Justifications for the Recommendations National Institute of Environmental Health Sciences (NIEHS); National Institutes of Health (NIH). ACTION: Request for public comment. AGENCY: SUMMARY: The RoC Office invites public comment on the recommendations from an expert panel on listing status for captafol and ortho-nitrotoluene in the 12th RoC and the scientific justification for the recommendations. The recommendation and scientific justification for each candidate substance are available electronically in Part B of the Expert Panel Report http://ntp.niehs.nih.gov/go/29682, (see Expert Panel Report Part B) or in printed text from the RoC Office (see FOR FURTHER INFORMATION CONTACT below). The RoC Office convened a ninemember expert panel of scientists from the public and private sectors on October 15–16, 2007. The panel was asked (1) to apply the RoC listing criteria to the relevant scientific evidence and make a recommendation regarding listing status (i.e., known to be a human carcinogen, reasonably anticipated to be a human carcinogen, or not to list) for captafol and for orthonitrotoluene in the 12th RoC and (2) to provide the scientific justification for the recommendation. DATES: The Expert Panel Report (Part B) for captafol and for ortho-nitrotoluene will be available for public comment by March 3, 2008. Written comments should be submitted by April 24, 2008. ADDRESSES: Comments should be sent to Dr. Ruth Lunn, RoC Office [NIEHS, P.O. Box 12233, MD EC–14, Research Triangle Park, NC 27709, FAX: (919) 541–0144, or lunn@niehs.nih.gov. Courier address: Report on Carcinogens, 79 T.W. Alexander Drive, Building 4401, Room 3118, Research Triangle Park, NC 27709]. E:\FR\FM\10MRN1.SGM 10MRN1 Federal Register / Vol. 73, No. 47 / Monday, March 10, 2008 / Notices Dr. Ruth Lunn, RoC Office, 919–316–4637 lunn@niehs.nih.gov. FOR FURTHER INFORMATION CONTACT: SUPPLEMENTARY INFORMATION: pwalker on PROD1PC71 with NOTICES Background Captafol and ortho-nitrotoluene are among the candidate substances under review for possible listing in the 12th RoC (see complete list at http:// ntp.niehs.nih.gov/go/10091). Captafol (CAS RN: 2425–06–1) is a broadspectrum fungicide that was widely used in the United States prior to the mid 1980s on fruits, vegetables, and other plants, as well as on timber products. In 1999, the U.S. Environmental Protection Agency (EPA) revoked all captafol tolerances except those for onions, potatoes, and tomatoes. In 2006, EPA revoked specific tolerances and tolerance exemptions for captafol, and stakeholders withdrew their support for import tolerances. Although many countries have now banned its use, captafol is still registered in some countries (such as Mexico). The potential exists for past, extensive exposure for U.S. workers producing the chemical, as well as for agricultural workers because of past production and use of millions of pounds of captafol. Ortho-nitrotoluene (CAS RN: 88–72– 2) is used to synthesize agricultural and organic chemicals, explosives, azo and sulfur dyes, and dyes for cotton, wool, silk, leather, and paper. Orthonitrotoluene is a high production volume chemical, and its U.S. production was between 10 million and 50 million pounds for every four-year reporting period from 1986 to 2002. Exposure to ortho-nitrotoluene in the United States is primarily a result of occupational exposure during the production and use of this chemical. As part of the RoC review process (available at http://ntp.niehs.nih.gov/go/ 15208), the NTP announced the availability of the draft background documents for captafol and orthonitrotoluene in the Federal Register (72 FR 41755, July 31, 2007), invited public comments on the draft background documents, and announced the captafol and ortho-nitrotoluene expert panel meeting. The RoC Office convened a nine-member expert panel of scientists from the public and private sectors to evaluate these two substances. The expert panel met on October 15–16, 2007, in a public forum at the Sheraton Chapel Hill Hotel in North Carolina. The panel first addressed captafol and then ortho-nitrotoluene in its deliberations. The panel was charged to peer review the draft background VerDate Aug<31>2005 16:39 Mar 07, 2008 Jkt 214001 12737 document for the candidate substance and then to make a recommendation on its listing status in the 12th RoC and to provide a scientific justification for that recommendation. Details about the meeting, including public comments received and the expert panel reports, are available on the RoC Web site (http://ntp.niehs.nih.gov/go/29682). The expert panel report for each candidate substance contains two parts: Part A contains the peer-review comments on the draft background document and Part B is the recommendation on listing status and its scientific justification. The expert panel recommended that (1) captafol be listed in the 12th RoC as reasonably anticipated to be a human carcinogen and (2) ortho-nitrotoluene be listed in the 12th RoC as reasonably anticipated to be a human carcinogen. The panel’s recommendation on listing status and its scientific justification are now being released for public comment. send them to Dr. Lunn (see ADDRESSES above). The deadline for submission of written comments is April 24, 2008. Next Steps The RoC Office is in the process of finalizing the background document for each candidate substance based upon the expert panel’s peer review comments and the public comments received (72 FR 41755). Persons can register free-of-charge with the NTP listserve (http://ntp.niehs.nih.gov/go/ 231) to receive notification when the final background documents are posted on the RoC Web site (http:// ntp.niehs.nih.gov/go/10091). As part of the RoC review process, two government groups will also conduct reviews of captafol and orthonitrotoluene; these meetings are not open to the public. Upon completion of these reviews, the NTP will (1) draft a substance profile, for captafol and for ortho-nitrotoluene which contains its listing recommendation for the 12th RoC and the scientific information supporting that recommendation; (2) solicit public comment on the draft substance profiles; and (3) convene a meeting of the Board of Scientific Counselors to peer review the draft substance profiles. Dated: February 29, 2008. Samuel H. Wilson, Acting Director, National Institute of Environmental Health Sciences and National Toxicology Program. [FR Doc. E8–4782 Filed 3–7–08; 8:45 am] Request for Comments The RoC Office invites written public comments on the expert panel’s recommendations on listing status for captafol and ortho-nitrotoluene and the scientific justifications for the recommendations. All comments received will be posted on the RoC Web site. Persons submitting written comments are asked to include their name and contact information (affiliation, mailing address, telephone and facsimile numbers, e-mail, and sponsoring organization, if any) and PO 00000 Frm 00036 Fmt 4703 Sfmt 4703 Background Information on the RoC The RoC is a Congressionally mandated document that identifies and discusses agents, substances, mixtures, or exposure circumstances (collectively referred to as ‘‘substances’’) that may pose a hazard to human health by virtue of their carcinogenicity. The RoC follows a formal, multi-step process for review and evaluation of selected chemicals. Substances are listed in the report as either known or reasonably anticipated human carcinogens. The NTP prepares the RoC on behalf of the Secretary of Health and Human Services. Information about the RoC and the review process are available on its Web site (http://ntp.niehs.nih.gov/go/ roc) or by contacting Dr. Lunn (see FOR FURTHER INFORMATION CONTACT above). BILLING CODE 4140–01–P DEPARTMENT OF HEALTH AND HUMAN SERVICES Agency for Healthcare Research and Quality Statement of Organization, Functions, and Delegations of Authority The Agency for Healthcare Research and Quality (AHRQ) is amending Part E, Chapter E, of the Statement of Organization, Functions, and Delegations of Authority for the Department of Health and Human Services (61 FR 15955, April 10, 1996, most recently amended at 68 FR 44084, July 25, 2003) to reflect recent organizational changes. AHRQ is consolidating all existing Office of Communications and Knowledge Transfer (OCKT) (see http://www.ahrq.gov/about/ockt/ ocktmiss.htm) subdivisions to streamline information synthesis and dissemination activities. The specific amendments are as follows, under Section E–20, Functions: • Delete the title and statement for Division of Print and Electronic Publishing (EBB) in its entirety; • Delete the title and statement for Division of Public Affairs (ENC) in its entirety; and, E:\FR\FM\10MRN1.SGM 10MRN1

Agencies

[Federal Register Volume 73, Number 47 (Monday, March 10, 2008)]
[Notices]
[Pages 12736-12737]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: E8-4782]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES


National Toxicology Program (NTP); Report on Carcinogens (RoC); 
Request for Public Comments on the RoC Expert Panel's Recommendations 
on Listing Status for Captafol and Ortho-nitrotoluene in the 12th RoC 
and the Scientific Justifications for the Recommendations

AGENCY: National Institute of Environmental Health Sciences (NIEHS); 
National Institutes of Health (NIH).

ACTION: Request for public comment.

-----------------------------------------------------------------------

SUMMARY: The RoC Office invites public comment on the recommendations 
from an expert panel on listing status for captafol and ortho-
nitrotoluene in the 12th RoC and the scientific justification for the 
recommendations. The recommendation and scientific justification for 
each candidate substance are available electronically in Part B of the 
Expert Panel Report http://ntp.niehs.nih.gov/go/29682, (see Expert 
Panel Report Part B) or in printed text from the RoC Office (see FOR 
FURTHER INFORMATION CONTACT below). The RoC Office convened a nine-
member expert panel of scientists from the public and private sectors 
on October 15-16, 2007. The panel was asked (1) to apply the RoC 
listing criteria to the relevant scientific evidence and make a 
recommendation regarding listing status (i.e., known to be a human 
carcinogen, reasonably anticipated to be a human carcinogen, or not to 
list) for captafol and for ortho-nitrotoluene in the 12th RoC and (2) 
to provide the scientific justification for the recommendation.

DATES: The Expert Panel Report (Part B) for captafol and for ortho-
nitrotoluene will be available for public comment by March 3, 2008. 
Written comments should be submitted by April 24, 2008.

ADDRESSES: Comments should be sent to Dr. Ruth Lunn, RoC Office [NIEHS, 
P.O. Box 12233, MD EC-14, Research Triangle Park, NC 27709, FAX: (919) 
541-0144, or lunn@niehs.nih.gov. Courier address: Report on 
Carcinogens, 79 T.W. Alexander Drive, Building 4401, Room 3118, 
Research Triangle Park, NC 27709].

[[Page 12737]]


FOR FURTHER INFORMATION CONTACT: Dr. Ruth Lunn, RoC Office, 919-316-
4637 lunn@niehs.nih.gov.

SUPPLEMENTARY INFORMATION:

Background

    Captafol and ortho-nitrotoluene are among the candidate substances 
under review for possible listing in the 12th RoC (see complete list at 
http://ntp.niehs.nih.gov/go/10091). Captafol (CAS RN: 2425-06-1) is a 
broad-spectrum fungicide that was widely used in the United States 
prior to the mid 1980s on fruits, vegetables, and other plants, as well 
as on timber products. In 1999, the U.S. Environmental Protection 
Agency (EPA) revoked all captafol tolerances except those for onions, 
potatoes, and tomatoes. In 2006, EPA revoked specific tolerances and 
tolerance exemptions for captafol, and stakeholders withdrew their 
support for import tolerances. Although many countries have now banned 
its use, captafol is still registered in some countries (such as 
Mexico). The potential exists for past, extensive exposure for U.S. 
workers producing the chemical, as well as for agricultural workers 
because of past production and use of millions of pounds of captafol.
    Ortho-nitrotoluene (CAS RN: 88-72-2) is used to synthesize 
agricultural and organic chemicals, explosives, azo and sulfur dyes, 
and dyes for cotton, wool, silk, leather, and paper. Ortho-nitrotoluene 
is a high production volume chemical, and its U.S. production was 
between 10 million and 50 million pounds for every four-year reporting 
period from 1986 to 2002. Exposure to ortho-nitrotoluene in the United 
States is primarily a result of occupational exposure during the 
production and use of this chemical.
    As part of the RoC review process (available at http://
ntp.niehs.nih.gov/go/15208), the NTP announced the availability of the 
draft background documents for captafol and ortho-nitrotoluene in the 
Federal Register (72 FR 41755, July 31, 2007), invited public comments 
on the draft background documents, and announced the captafol and 
ortho-nitrotoluene expert panel meeting. The RoC Office convened a 
nine-member expert panel of scientists from the public and private 
sectors to evaluate these two substances. The expert panel met on 
October 15-16, 2007, in a public forum at the Sheraton Chapel Hill 
Hotel in North Carolina. The panel first addressed captafol and then 
ortho-nitrotoluene in its deliberations. The panel was charged to peer 
review the draft background document for the candidate substance and 
then to make a recommendation on its listing status in the 12th RoC and 
to provide a scientific justification for that recommendation. Details 
about the meeting, including public comments received and the expert 
panel reports, are available on the RoC Web site (http://
ntp.niehs.nih.gov/go/29682). The expert panel report for each candidate 
substance contains two parts: Part A contains the peer-review comments 
on the draft background document and Part B is the recommendation on 
listing status and its scientific justification. The expert panel 
recommended that (1) captafol be listed in the 12th RoC as reasonably 
anticipated to be a human carcinogen and (2) ortho-nitrotoluene be 
listed in the 12th RoC as reasonably anticipated to be a human 
carcinogen. The panel's recommendation on listing status and its 
scientific justification are now being released for public comment.

Next Steps

    The RoC Office is in the process of finalizing the background 
document for each candidate substance based upon the expert panel's 
peer review comments and the public comments received (72 FR 41755). 
Persons can register free-of-charge with the NTP listserve (http://
ntp.niehs.nih.gov/go/231) to receive notification when the final 
background documents are posted on the RoC Web site (http://
ntp.niehs.nih.gov/go/10091).
    As part of the RoC review process, two government groups will also 
conduct reviews of captafol and ortho-nitrotoluene; these meetings are 
not open to the public. Upon completion of these reviews, the NTP will 
(1) draft a substance profile, for captafol and for ortho-nitrotoluene 
which contains its listing recommendation for the 12th RoC and the 
scientific information supporting that recommendation; (2) solicit 
public comment on the draft substance profiles; and (3) convene a 
meeting of the Board of Scientific Counselors to peer review the draft 
substance profiles.

Request for Comments

    The RoC Office invites written public comments on the expert 
panel's recommendations on listing status for captafol and ortho-
nitrotoluene and the scientific justifications for the recommendations. 
All comments received will be posted on the RoC Web site. Persons 
submitting written comments are asked to include their name and contact 
information (affiliation, mailing address, telephone and facsimile 
numbers, e-mail, and sponsoring organization, if any) and send them to 
Dr. Lunn (see ADDRESSES above). The deadline for submission of written 
comments is April 24, 2008.

Background Information on the RoC

    The RoC is a Congressionally mandated document that identifies and 
discusses agents, substances, mixtures, or exposure circumstances 
(collectively referred to as ``substances'') that may pose a hazard to 
human health by virtue of their carcinogenicity. The RoC follows a 
formal, multi-step process for review and evaluation of selected 
chemicals. Substances are listed in the report as either known or 
reasonably anticipated human carcinogens. The NTP prepares the RoC on 
behalf of the Secretary of Health and Human Services. Information about 
the RoC and the review process are available on its Web site (http://
ntp.niehs.nih.gov/go/roc) or by contacting Dr. Lunn (see FOR FURTHER 
INFORMATION CONTACT above).

    Dated: February 29, 2008.
Samuel H. Wilson,
Acting Director, National Institute of Environmental Health Sciences 
and National Toxicology Program.
[FR Doc. E8-4782 Filed 3-7-08; 8:45 am]
BILLING CODE 4140-01-P