National Toxicology Program (NTP); Report on Carcinogens (RoC); Request for Public Comments on the RoC Expert Panel's Recommendations on Listing Status for Captafol and Ortho-nitrotoluene in the 12th RoC and the Scientific Justifications for the Recommendations, 12736-12737 [E8-4782]
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Federal Register / Vol. 73, No. 47 / Monday, March 10, 2008 / Notices
1. Approval of the minutes of the
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OCAS@CDC.GOV.
Dated: March 5, 2008.
John Howard,
Director, National Institute for Occupational
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[FR Doc. E8–4761 Filed 3–7–08; 8:45 am]
Dated: March 5, 2008.
John Howard,
Director, National Institute for Occupational
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[FR Doc. E8–4762 Filed 3–7–08; 8:45 am]
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National Institute for
Occupational Safety and Health
(NIOSH), Department of Health and
Human Services (HHS).
National Institute for Occupational
Safety and Health; Decision To
Evaluate a Petition To Designate a
Class of Employees at the Savannah
River Site, Aiken, SC, To Be Included
in the Special Exposure Cohort
National Institute for
Occupational Safety and Health
(NIOSH), Department of Health and
Human Services (HHS).
ACTION: Notice.
pwalker on PROD1PC71 with NOTICES
AGENCY:
SUMMARY: The Department of Health and
Human Services (HHS) gives notice as
required by 42 CFR 83.12(e) of a
decision to evaluate a petition to
designate a class of employees at the
Savannah River Site, Aiken, South
Carolina, to be included in the Special
Exposure Cohort under the Energy
Employees Occupational Illness
Compensation Program Act of 2000. The
initial proposed definition for the class
being evaluated, subject to revision as
warranted by the evaluation, is as
follows:
Facility: Savannah River Site.
Location: Aiken, South Carolina.
Job Titles and/or Job Duties: All
workers.
Period of Employment: January 1,
1950 through December 31, 2007.
FOR FURTHER INFORMATION CONTACT:
Larry Elliott, Director, Office of
Compensation Analysis and Support,
National Institute for Occupational
16:39 Mar 07, 2008
National Institute for Occupational
Safety and Health; Decision To
Evaluate a Petition To Designate a
Class of Employees at the Savannah
River Site, Aiken, SC, To Be Included
in the Special Exposure Cohort
AGENCY:
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
VerDate Aug<31>2005
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
Jkt 214001
ACTION:
Notice.
SUMMARY: The Department of Health and
Human Services (HHS) gives notice as
required by 42 CFR 83.12(e) of a
decision to evaluate a petition to
designate a class of employees at the
Savannah River Site, Aiken, South
Carolina, to be included in the Special
Exposure Cohort under the Energy
Employees Occupational Illness
Compensation Program Act of 2000. The
initial proposed definition for the class
being evaluated, subject to revision as
warranted by the evaluation, is as
follows:
Facility: Savannah River Site.
Location: Aiken, South Carolina.
Job Titles and/or Job Duties: All
laborers, foremen, and construction
workers.
Period of Employment: March 9, 1951
through October 24, 1986.
FOR FURTHER INFORMATION CONTACT:
Larry Elliott, Director, Office of
Compensation Analysis and Support,
National Institute for Occupational
Safety and Health (NIOSH), 4676
Columbia Parkway, MS C–46,
Cincinnati, OH 45226, Telephone 513–
533–6800 (this is not a toll-free
number). Information requests can also
be submitted by e-mail to
OCAS@CDC.GOV.
PO 00000
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BILLING CODE 4163–19–P
National Toxicology Program (NTP);
Report on Carcinogens (RoC); Request
for Public Comments on the RoC
Expert Panel’s Recommendations on
Listing Status for Captafol and Orthonitrotoluene in the 12th RoC and the
Scientific Justifications for the
Recommendations
National Institute of
Environmental Health Sciences
(NIEHS); National Institutes of Health
(NIH).
ACTION: Request for public comment.
AGENCY:
SUMMARY: The RoC Office invites public
comment on the recommendations from
an expert panel on listing status for
captafol and ortho-nitrotoluene in the
12th RoC and the scientific justification
for the recommendations. The
recommendation and scientific
justification for each candidate
substance are available electronically in
Part B of the Expert Panel Report
https://ntp.niehs.nih.gov/go/29682, (see
Expert Panel Report Part B) or in printed
text from the RoC Office (see FOR
FURTHER INFORMATION CONTACT below).
The RoC Office convened a ninemember expert panel of scientists from
the public and private sectors on
October 15–16, 2007. The panel was
asked (1) to apply the RoC listing
criteria to the relevant scientific
evidence and make a recommendation
regarding listing status (i.e., known to be
a human carcinogen, reasonably
anticipated to be a human carcinogen,
or not to list) for captafol and for orthonitrotoluene in the 12th RoC and (2) to
provide the scientific justification for
the recommendation.
DATES: The Expert Panel Report (Part B)
for captafol and for ortho-nitrotoluene
will be available for public comment by
March 3, 2008. Written comments
should be submitted by April 24, 2008.
ADDRESSES: Comments should be sent to
Dr. Ruth Lunn, RoC Office [NIEHS, P.O.
Box 12233, MD EC–14, Research
Triangle Park, NC 27709, FAX: (919)
541–0144, or lunn@niehs.nih.gov.
Courier address: Report on Carcinogens,
79 T.W. Alexander Drive, Building
4401, Room 3118, Research Triangle
Park, NC 27709].
E:\FR\FM\10MRN1.SGM
10MRN1
Federal Register / Vol. 73, No. 47 / Monday, March 10, 2008 / Notices
Dr.
Ruth Lunn, RoC Office, 919–316–4637
lunn@niehs.nih.gov.
FOR FURTHER INFORMATION CONTACT:
SUPPLEMENTARY INFORMATION:
pwalker on PROD1PC71 with NOTICES
Background
Captafol and ortho-nitrotoluene are
among the candidate substances under
review for possible listing in the 12th
RoC (see complete list at https://
ntp.niehs.nih.gov/go/10091). Captafol
(CAS RN: 2425–06–1) is a broadspectrum fungicide that was widely
used in the United States prior to the
mid 1980s on fruits, vegetables, and
other plants, as well as on timber
products. In 1999, the U.S.
Environmental Protection Agency (EPA)
revoked all captafol tolerances except
those for onions, potatoes, and
tomatoes. In 2006, EPA revoked specific
tolerances and tolerance exemptions for
captafol, and stakeholders withdrew
their support for import tolerances.
Although many countries have now
banned its use, captafol is still
registered in some countries (such as
Mexico). The potential exists for past,
extensive exposure for U.S. workers
producing the chemical, as well as for
agricultural workers because of past
production and use of millions of
pounds of captafol.
Ortho-nitrotoluene (CAS RN: 88–72–
2) is used to synthesize agricultural and
organic chemicals, explosives, azo and
sulfur dyes, and dyes for cotton, wool,
silk, leather, and paper. Orthonitrotoluene is a high production
volume chemical, and its U.S.
production was between 10 million and
50 million pounds for every four-year
reporting period from 1986 to 2002.
Exposure to ortho-nitrotoluene in the
United States is primarily a result of
occupational exposure during the
production and use of this chemical.
As part of the RoC review process
(available at https://ntp.niehs.nih.gov/go/
15208), the NTP announced the
availability of the draft background
documents for captafol and orthonitrotoluene in the Federal Register (72
FR 41755, July 31, 2007), invited public
comments on the draft background
documents, and announced the captafol
and ortho-nitrotoluene expert panel
meeting. The RoC Office convened a
nine-member expert panel of scientists
from the public and private sectors to
evaluate these two substances. The
expert panel met on October 15–16,
2007, in a public forum at the Sheraton
Chapel Hill Hotel in North Carolina.
The panel first addressed captafol and
then ortho-nitrotoluene in its
deliberations. The panel was charged to
peer review the draft background
VerDate Aug<31>2005
16:39 Mar 07, 2008
Jkt 214001
12737
document for the candidate substance
and then to make a recommendation on
its listing status in the 12th RoC and to
provide a scientific justification for that
recommendation. Details about the
meeting, including public comments
received and the expert panel reports,
are available on the RoC Web site
(https://ntp.niehs.nih.gov/go/29682). The
expert panel report for each candidate
substance contains two parts: Part A
contains the peer-review comments on
the draft background document and Part
B is the recommendation on listing
status and its scientific justification. The
expert panel recommended that (1)
captafol be listed in the 12th RoC as
reasonably anticipated to be a human
carcinogen and (2) ortho-nitrotoluene be
listed in the 12th RoC as reasonably
anticipated to be a human carcinogen.
The panel’s recommendation on listing
status and its scientific justification are
now being released for public comment.
send them to Dr. Lunn (see ADDRESSES
above). The deadline for submission of
written comments is April 24, 2008.
Next Steps
The RoC Office is in the process of
finalizing the background document for
each candidate substance based upon
the expert panel’s peer review
comments and the public comments
received (72 FR 41755). Persons can
register free-of-charge with the NTP
listserve (https://ntp.niehs.nih.gov/go/
231) to receive notification when the
final background documents are posted
on the RoC Web site (https://
ntp.niehs.nih.gov/go/10091).
As part of the RoC review process,
two government groups will also
conduct reviews of captafol and orthonitrotoluene; these meetings are not
open to the public. Upon completion of
these reviews, the NTP will (1) draft a
substance profile, for captafol and for
ortho-nitrotoluene which contains its
listing recommendation for the 12th
RoC and the scientific information
supporting that recommendation; (2)
solicit public comment on the draft
substance profiles; and (3) convene a
meeting of the Board of Scientific
Counselors to peer review the draft
substance profiles.
Dated: February 29, 2008.
Samuel H. Wilson,
Acting Director, National Institute of
Environmental Health Sciences and National
Toxicology Program.
[FR Doc. E8–4782 Filed 3–7–08; 8:45 am]
Request for Comments
The RoC Office invites written public
comments on the expert panel’s
recommendations on listing status for
captafol and ortho-nitrotoluene and the
scientific justifications for the
recommendations. All comments
received will be posted on the RoC Web
site. Persons submitting written
comments are asked to include their
name and contact information
(affiliation, mailing address, telephone
and facsimile numbers, e-mail, and
sponsoring organization, if any) and
PO 00000
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Fmt 4703
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Background Information on the RoC
The RoC is a Congressionally
mandated document that identifies and
discusses agents, substances, mixtures,
or exposure circumstances (collectively
referred to as ‘‘substances’’) that may
pose a hazard to human health by virtue
of their carcinogenicity. The RoC
follows a formal, multi-step process for
review and evaluation of selected
chemicals. Substances are listed in the
report as either known or reasonably
anticipated human carcinogens. The
NTP prepares the RoC on behalf of the
Secretary of Health and Human
Services. Information about the RoC and
the review process are available on its
Web site (https://ntp.niehs.nih.gov/go/
roc) or by contacting Dr. Lunn (see FOR
FURTHER INFORMATION CONTACT above).
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Agency for Healthcare Research and
Quality
Statement of Organization, Functions,
and Delegations of Authority
The Agency for Healthcare Research
and Quality (AHRQ) is amending Part E,
Chapter E, of the Statement of
Organization, Functions, and
Delegations of Authority for the
Department of Health and Human
Services (61 FR 15955, April 10, 1996,
most recently amended at 68 FR 44084,
July 25, 2003) to reflect recent
organizational changes.
AHRQ is consolidating all existing
Office of Communications and
Knowledge Transfer (OCKT) (see
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ocktmiss.htm) subdivisions to
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E:\FR\FM\10MRN1.SGM
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]]>Agencies
[Federal Register Volume 73, Number 47 (Monday, March 10, 2008)]
[Notices]
[Pages 12736-12737]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: E8-4782]
-----------------------------------------------------------------------
DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Toxicology Program (NTP); Report on Carcinogens (RoC);
Request for Public Comments on the RoC Expert Panel's Recommendations
on Listing Status for Captafol and Ortho-nitrotoluene in the 12th RoC
and the Scientific Justifications for the Recommendations
AGENCY: National Institute of Environmental Health Sciences (NIEHS);
National Institutes of Health (NIH).
ACTION: Request for public comment.
-----------------------------------------------------------------------
SUMMARY: The RoC Office invites public comment on the recommendations
from an expert panel on listing status for captafol and ortho-
nitrotoluene in the 12th RoC and the scientific justification for the
recommendations. The recommendation and scientific justification for
each candidate substance are available electronically in Part B of the
Expert Panel Report https://ntp.niehs.nih.gov/go/29682, (see Expert
Panel Report Part B) or in printed text from the RoC Office (see FOR
FURTHER INFORMATION CONTACT below). The RoC Office convened a nine-
member expert panel of scientists from the public and private sectors
on October 15-16, 2007. The panel was asked (1) to apply the RoC
listing criteria to the relevant scientific evidence and make a
recommendation regarding listing status (i.e., known to be a human
carcinogen, reasonably anticipated to be a human carcinogen, or not to
list) for captafol and for ortho-nitrotoluene in the 12th RoC and (2)
to provide the scientific justification for the recommendation.
DATES: The Expert Panel Report (Part B) for captafol and for ortho-
nitrotoluene will be available for public comment by March 3, 2008.
Written comments should be submitted by April 24, 2008.
ADDRESSES: Comments should be sent to Dr. Ruth Lunn, RoC Office [NIEHS,
P.O. Box 12233, MD EC-14, Research Triangle Park, NC 27709, FAX: (919)
541-0144, or lunn@niehs.nih.gov. Courier address: Report on
Carcinogens, 79 T.W. Alexander Drive, Building 4401, Room 3118,
Research Triangle Park, NC 27709].
[[Page 12737]]
FOR FURTHER INFORMATION CONTACT: Dr. Ruth Lunn, RoC Office, 919-316-
4637 lunn@niehs.nih.gov.
SUPPLEMENTARY INFORMATION:
Background
Captafol and ortho-nitrotoluene are among the candidate substances
under review for possible listing in the 12th RoC (see complete list at
https://ntp.niehs.nih.gov/go/10091). Captafol (CAS RN: 2425-06-1) is a
broad-spectrum fungicide that was widely used in the United States
prior to the mid 1980s on fruits, vegetables, and other plants, as well
as on timber products. In 1999, the U.S. Environmental Protection
Agency (EPA) revoked all captafol tolerances except those for onions,
potatoes, and tomatoes. In 2006, EPA revoked specific tolerances and
tolerance exemptions for captafol, and stakeholders withdrew their
support for import tolerances. Although many countries have now banned
its use, captafol is still registered in some countries (such as
Mexico). The potential exists for past, extensive exposure for U.S.
workers producing the chemical, as well as for agricultural workers
because of past production and use of millions of pounds of captafol.
Ortho-nitrotoluene (CAS RN: 88-72-2) is used to synthesize
agricultural and organic chemicals, explosives, azo and sulfur dyes,
and dyes for cotton, wool, silk, leather, and paper. Ortho-nitrotoluene
is a high production volume chemical, and its U.S. production was
between 10 million and 50 million pounds for every four-year reporting
period from 1986 to 2002. Exposure to ortho-nitrotoluene in the United
States is primarily a result of occupational exposure during the
production and use of this chemical.
As part of the RoC review process (available at https://
ntp.niehs.nih.gov/go/15208), the NTP announced the availability of the
draft background documents for captafol and ortho-nitrotoluene in the
Federal Register (72 FR 41755, July 31, 2007), invited public comments
on the draft background documents, and announced the captafol and
ortho-nitrotoluene expert panel meeting. The RoC Office convened a
nine-member expert panel of scientists from the public and private
sectors to evaluate these two substances. The expert panel met on
October 15-16, 2007, in a public forum at the Sheraton Chapel Hill
Hotel in North Carolina. The panel first addressed captafol and then
ortho-nitrotoluene in its deliberations. The panel was charged to peer
review the draft background document for the candidate substance and
then to make a recommendation on its listing status in the 12th RoC and
to provide a scientific justification for that recommendation. Details
about the meeting, including public comments received and the expert
panel reports, are available on the RoC Web site (https://
ntp.niehs.nih.gov/go/29682). The expert panel report for each candidate
substance contains two parts: Part A contains the peer-review comments
on the draft background document and Part B is the recommendation on
listing status and its scientific justification. The expert panel
recommended that (1) captafol be listed in the 12th RoC as reasonably
anticipated to be a human carcinogen and (2) ortho-nitrotoluene be
listed in the 12th RoC as reasonably anticipated to be a human
carcinogen. The panel's recommendation on listing status and its
scientific justification are now being released for public comment.
Next Steps
The RoC Office is in the process of finalizing the background
document for each candidate substance based upon the expert panel's
peer review comments and the public comments received (72 FR 41755).
Persons can register free-of-charge with the NTP listserve (https://
ntp.niehs.nih.gov/go/231) to receive notification when the final
background documents are posted on the RoC Web site (https://
ntp.niehs.nih.gov/go/10091).
As part of the RoC review process, two government groups will also
conduct reviews of captafol and ortho-nitrotoluene; these meetings are
not open to the public. Upon completion of these reviews, the NTP will
(1) draft a substance profile, for captafol and for ortho-nitrotoluene
which contains its listing recommendation for the 12th RoC and the
scientific information supporting that recommendation; (2) solicit
public comment on the draft substance profiles; and (3) convene a
meeting of the Board of Scientific Counselors to peer review the draft
substance profiles.
Request for Comments
The RoC Office invites written public comments on the expert
panel's recommendations on listing status for captafol and ortho-
nitrotoluene and the scientific justifications for the recommendations.
All comments received will be posted on the RoC Web site. Persons
submitting written comments are asked to include their name and contact
information (affiliation, mailing address, telephone and facsimile
numbers, e-mail, and sponsoring organization, if any) and send them to
Dr. Lunn (see ADDRESSES above). The deadline for submission of written
comments is April 24, 2008.
Background Information on the RoC
The RoC is a Congressionally mandated document that identifies and
discusses agents, substances, mixtures, or exposure circumstances
(collectively referred to as ``substances'') that may pose a hazard to
human health by virtue of their carcinogenicity. The RoC follows a
formal, multi-step process for review and evaluation of selected
chemicals. Substances are listed in the report as either known or
reasonably anticipated human carcinogens. The NTP prepares the RoC on
behalf of the Secretary of Health and Human Services. Information about
the RoC and the review process are available on its Web site (https://
ntp.niehs.nih.gov/go/roc) or by contacting Dr. Lunn (see FOR FURTHER
INFORMATION CONTACT above).
Dated: February 29, 2008.
Samuel H. Wilson,
Acting Director, National Institute of Environmental Health Sciences
and National Toxicology Program.
[FR Doc. E8-4782 Filed 3-7-08; 8:45 am]
BILLING CODE 4140-01-P
