Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. Appendix 2), notice is hereby given of the following meeting., 9819 [08-794]

Download as PDF Federal Register / Vol. 73, No. 36 / Friday, February 22, 2008 / Notices mstockstill on PROD1PC66 with NOTICES Related Publications: 1. A manuscript directly related to this technology will be available as soon as it is accepted for publication. 2. E Calvo. Collagen-platelet aggregation inhibitor from mosquito salivary glands. Biacore T100 seminar series, November 2006, St. Louis, Missouri. 3. S Yoshida and H Watanabe. Robust salivary gland-specific transgene expression in Anopheles stephensi mosquito. Insect Mol Biol. 2006 Aug; 15(4):403–410. 4. D Sun et al. Expression of functional recombinant mosquito salivary apyrase: a potential therapeutic platelet aggregation inhibitor. Platelets. 2006 May; 17(3):178–184. Patent Status: U.S. Provisional Application No. 60/198,629 filed 09 Jul 2007 (HHS Reference No. E–172–2007/ 0–US–01); U.S. Provisional Application No. 60/982,241 filed 24 Oct 2007 (HHS Reference No. E–172–2007/1–US–01) Licensing Status: Available for exclusive or non-exclusive licensing. Licensing Contact: Jennifer Wong; 301/435–4633; wongje@mail.nih.gov Collaborative Research Opportunity: The National Institute of Allergy and Infectious Diseases, Laboratory of Malaria and Vector Research, is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize the platelet aggregation inhibitor Aegyptin. Please contact Dr. Jose Ribeiro, Head, Vector Biology Section, at 301–496–9389 or jribeiro@niaid.nih.gov for more information. Manganese Superoxide Dimutase VAL16ALA Polymorphism Predicts Resistance to Doxorubicin Cancer Therapy Description of Technology: Cancer is the second leading cause of death in the United States and it is estimated that there will be approximately 600,000 deaths caused by cancer in 2006. Major drawbacks of the existing cancer therapies are the interindividual differences in the response and the cytotoxic side-effects that are associated with them. Thus, there is a need to develop new therapeutic approaches to optimize treatment and increase patient survival. This technology describes the identification of a manganese superoxide dismutase (MnSOD) polymorphism as a novel biomarker for the prognosis of doxorubicin therapeutic response in breast cancer patients, wherein a Val16Ala polymorphism of MnSOD is indicative of patient survival. More specifically, VerDate Aug<31>2005 16:38 Feb 21, 2008 Jkt 214001 patients undergoing doxorubicin combination therapy with Val/Val, Val/ Ala, and Ala/Ala genotypes had 95.2%, 79%, and 45.5% survival rates, respectively, in a case study of 70 unselected breast cancer patients. Carriers of the Ala/Ala genotype had a highly significantly poorer breast cancer-specific survival in a multivariate Cox regression analysis than carriers of the Val/Val genotype. This technology can be developed into an assay to screen for breast cancer patients who will be responsive to doxorubicin treatment. Further, as the MnSOD polymorphism is common in the population (15% to 20% of patients have the Ala/Ala genotype), it is a common risk factor for doxorubicin therapy. This technology can potentially be utilized as a screening tool applicable for all cancer types treated with doxorubicin. Applications: A novel genetic marker that can predict breast cancer patient survival with doxorubicin treatment. A screening test based on MnSOD Val16Ala genotype that predicts patient response to doxorubicin cancer therapy, wherein treatment can be subsequently individualized according to patient MnSOD genotype. Development Status: Future studies include determining the mechanism in which the polymorphism modulates doxorubicin toxicity. Inventors: Stefan Ambs and Brenda Boersma (NCI). Patent Status: U.S. Provisional Application No. 60/799,788 filed 11 May 2006 (HHS Reference No. E–137– 2006/0–US–01); PCT Application No. PCT/US2007/068588 filed 09 May 2007 (HHS Reference No. E–137–2006/0– PCT–02). Licensing Status: Available for nonexclusive or exclusive licensing. Licensing Contact: Jennifer Wong; 301/435–4633; wongje@mail.nih.gov. Collaborative Research Opportunity: The Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize MnSOD genotyping assays to assess a patient’s response to doxorubicin combination therapy. Please contact John D. Hewes, PhD, at 301–435–3121 or hewesj@mail.nih.gov for more information. PO 00000 Frm 00063 Fmt 4703 Sfmt 4703 9819 Dated: February 15, 2008. David Sadowski, Deputy Director, Division of Technology Development and Transfer, Office of Technology Transfer, National Institutes of Health. [FR Doc. E8–3274 Filed 2–21–08; 8:45 am] BILLING CODE 4140–01–P DEPARTMENT OF HEALTH AND HUMAN SERVICES National Cancer Institute; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. Appendix 2), notice is hereby given of the following meeting. The meeting will be closed to the public in accordance with the provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The grant applications and the discussions could disclose confidential trade secrets or commercial property such as patentable material, and personal information concerning individuals associated with the grant applications, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. Name of Committee: National Cancer Institute Initial Review Group, Subcommittee A — Cancer Centers. Date: April 22–23, 2008. Time: 8 a.m. to 2:30 p.m. Agenda: To review and evaluate grant applications. Place: Crown Plaza Silver Spring, 8777 Georgia Avenue, Silver Spring, MD 20910. Contact Person: Gail J. Bryant, MD, Scientific Review Officer, Resources and Training Review Branch, Division of Extramural Activities, National Cancer Institute, 6116 Executive Blvd, Room 8107, MSC 8328, Bethesda, MD 20892–8329, (301) 402–0801, gb30t@nih.gov. (Catalogue of Federal Domestic Assistance Program Nos. 93.392, Cancer Construction; 93.393, Cancer Cause and Prevention Research; 93.394, Cancer Detection and Diagnosis Research; 93.395, Cancer Treatment Research; 93.396, Cancer Biology Research; 93.397, Cancer Centers Support; 93.398, Cancer Research Manpower; 93.399, Cancer Control, National Institutes of Health, HHS) Dated: February 14, 2008. Jennifer Spaeth, Director, Office of Federal Advisory Committee Policy. [FR Doc. 08–794 Filed 2–21–08; 8:45 am] BILLING CODE 4140–01–M E:\FR\FM\22FEN1.SGM 22FEN1

Agencies

[Federal Register Volume 73, Number 36 (Friday, February 22, 2008)]
[Notices]
[Page 9819]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: 08-794]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Cancer Institute; Notice of Closed Meeting


Pursuant to section 10(d) of the Federal Advisory Committee Act, 
as amended (5 U.S.C. Appendix 2), notice is hereby given of the 
following meeting.

    The meeting will be closed to the public in accordance with the 
provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 
U.S.C., as amended. The grant applications and the discussions could 
disclose confidential trade secrets or commercial property such as 
patentable material, and personal information concerning individuals 
associated with the grant applications, the disclosure of which would 
constitute a clearly unwarranted invasion of personal privacy.

    Name of Committee: National Cancer Institute Initial Review 
Group, Subcommittee A -- Cancer Centers.
    Date: April 22-23, 2008.
    Time: 8 a.m. to 2:30 p.m.
    Agenda: To review and evaluate grant applications.
    Place: Crown Plaza Silver Spring, 8777 Georgia Avenue, Silver 
Spring, MD 20910.
    Contact Person: Gail J. Bryant, MD, Scientific Review Officer, 
Resources and Training Review Branch, Division of Extramural 
Activities, National Cancer Institute, 6116 Executive Blvd, Room 
8107, MSC 8328, Bethesda, MD 20892-8329, (301) 402-0801, 
gb30t@nih.gov.

(Catalogue of Federal Domestic Assistance Program Nos. 93.392, 
Cancer Construction; 93.393, Cancer Cause and Prevention Research; 
93.394, Cancer Detection and Diagnosis Research; 93.395, Cancer 
Treatment Research; 93.396, Cancer Biology Research; 93.397, Cancer 
Centers Support; 93.398, Cancer Research Manpower; 93.399, Cancer 
Control, National Institutes of Health, HHS)

     Dated: February 14, 2008.
 Jennifer Spaeth,
Director, Office of Federal Advisory Committee Policy.
[FR Doc. 08-794 Filed 2-21-08; 8:45 am]
BILLING CODE 4140-01-M

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