Draft Toxicological Review of Acrylamide: In Support of Summary Information on the Integrated Risk Information System (IRIS), 73813-73814 [E7-25282]
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Federal Register / Vol. 72, No. 248 / Friday, December 28, 2007 / Notices
C. How and to Whom Do I Submit
Comments?
ENVIRONMENTAL PROTECTION
AGENCY
To submit comments, or access the
public docket, please follow the detailed
instructions as provided in ADDRESSES
and Unit I.B of the SUPPLEMENTARY
INFORMATION of the October 31, 2007
Federal Register document. If you have
questions, consult the person listed
under FOR FURTHER INFORMATION
CONTACT.
[FRL–8511–8; Docket ID No. EPA–HQ–ORD–
2007–1141]
II. What Action is EPA Taking?
This document extends the public
comment period established in the
Federal Register of October 31, 2007, 72
FR 61638 (FRL–8152–6). In that
document, EPA announced the
availability of and sought comment on
the draft Pesticide Registration Notice
(PR Notice) entitled ‘‘Label Statements
Regarding Third-Party Endorsements &
Cause Marketing Claims.’’ In response to
requests from multiple entities, EPA is
hereby extending the comment period,
which was set to end on December 31,
2007, to March 27, 2008.
III. What is the Agency’s Authority for
Taking this Action?
This action is taken as provided in
Section 21(c) of the Federal, Insecticide,
Fungicide, and Rodencticide Act, which
reads:
In addition to any other authority relating
to public hearings and solicitation of views,
in connection with the suspension or
cancellation of a pesticide product
registration or any other actions authorized
under this subchapter, the Administrator
may, at the Administrator’s discretion, solicit
the views of all interested persons, either
orally or in writing, and seek such advice
from scientists, farmers, farm organizations,
and other qualified persons as the
Administrator deems proper.
List of Subjects
Environmental protection, Pesticides
and pests, Administrative practice and
procedure, Agricultural commodities.
Dated: December 19, 2007.
Debra Edwards,
Director, Office of Pesticide Programs.
[FR Doc. E7–25089 Filed 12–28–07; 8:45 am]
mstockstill on PROD1PC66 with NOTICES
BILLING CODE 6560–50–S
VerDate Aug<31>2005
22:27 Dec 27, 2007
Jkt 214001
Draft Toxicological Review of
Acrylamide: In Support of Summary
Information on the Integrated Risk
Information System (IRIS)
Environmental Protection
Agency (EPA).
ACTION: Notice of Public Comment
Period.
AGENCY:
SUMMARY: The EPA is announcing a
public comment period to review the
final draft document titled,
‘‘Toxicological Review of Acrylamide:
In Support of Summary Information on
the Integrated Risk Information System
(IRIS)’’ (EPA/635/R–07/009), related to
the human health assessment for
acrylamide. The document was
prepared by the National Center for
Environmental Assessment (NCEA)
within EPA’s Office of Research and
Development.
EPA is releasing this draft document
solely for the purpose of predissemination peer review under
applicable information quality
guidelines. This document has not been
formally disseminated by EPA. It does
not represent and should not be
construed to represent any Agency
policy or determination. EPA will
consider any public comments
submitted in accordance with this
notice when revising the document.
DATES: The 60-day public comment
period begins on December 28, 2007 and
ends February 26, 2008. Technical
comments should be in writing and
must be received by EPA by February
26, 2008.
ADDRESSES: The draft ‘‘Draft
Toxicological Review of Acrylamide: In
Support of Summary Information on the
Integrated Risk Information System
(IRIS)’’ (EPA/635/R–07/009) is available
primarily via the Internet on NCEA’s
home page under the Recent Additions
menu at www.epa.gov/ncea. A limited
number of paper copies are available by
contacting the IRIS Hotline at (202) 566–
1676, (202) 566–1749 (facsimile), or
hotline.iris@epa.gov. If you are
requesting a paper copy, please provide
your name, mailing address, the
document title, and the EPA number of
the requested publication.
Technical comments may be
submitted electronically via
www.regulations.gov, by mail, by
facsimile, or by hand delivery/courier.
Please follow the detailed instructions
provided in the SUPPLEMENTARY
INFORMATION section of this notice.
PO 00000
Frm 00057
Fmt 4703
Sfmt 4703
73813
For
information on the public comment
period, contact the Office of
Environmental Information Docket;
telephone: 202–566–1752; facsimile:
202–566–1753; or e-mail:
ORD.Docket@epa.gov.
For general information about the IRIS
assessment process, terms, and existing
values go to NCEA’s home page via the
Internet and click on ‘‘IRIS’’ in the
Quick Finder section at www.epa.gov/
ncea (or go to https://www.epa.gov/
iriswebp/iris/ ). For
information on the status and estimated
completion dates of the Toxicological
Review of Acrylamide go to the IRIS
home page and click on ‘‘IRIS Track’’ in
the left hand column (or go to: https://
cfpub.epa.gov/iristrac/index.cfm).
If you have questions or need
information regarding communications
and outreach, contact Linda Tuxen,
National Center for Environmental
Assessment; telephone: 703–347–8609;
facsimile: 703–347–8699; e-mail:
tuxen.linda@epa.gov.
For technical and scientific questions
concerning the draft Toxicological
Review of Acrylamide, contact the
Chemical Manager, Robert DeWoskin,
National Center for Environmental
Assessment; telephone: 919–541–1089;
facsimile: 919–541–0248; e-mail:
dewoskin.rob@epa.gov.
FOR FURTHER INFORMATION CONTACT:
SUPPLEMENTARY INFORMATION:
I. Information About the Document
Acrylamide is a monomer used
primarily in the production of
polyacrylamide polymers.
Polyacrylamides are used as a flocculent
in water purification, oil recovery, and
soil stabilization; and in the
manufacturing of a wide range of
products as a coating, matrix, additive,
or stabilizer. Human exposure to
acrylamide occurs primarily in the
workplace from dermal contact and
inhalation of dust and vapor during
processing or use. The public may be
exposed to acrylamide through
emissions from production facilities,
use in consumer products,
contaminated drinking water, and
cigarette smoke. In early 2002, Swedish
scientists reported high concentrations
of acrylamide in certain fried, baked,
and deep-fried foods. Subsequent
research demonstrated that acrylamide
forms ‘‘de novo’’ (i.e., newly formed, not
present as an environmental
contaminant) during high temperature
cooking of carbohydrate-rich foods that
contain asparagine and in a few other
food processes. Considerable research is
on-going to assess the level of and the
potential risk from exposure to
E:\FR\FM\28DEN1.SGM
28DEN1
73814
Federal Register / Vol. 72, No. 248 / Friday, December 28, 2007 / Notices
mstockstill on PROD1PC66 with NOTICES
acrylamide in food (additional
information is available on the U.S.
FDA’s Internet site for acrylamide:
https://www.cfsan.fda.gov/lrd/
pestadd.html#acrylamide).
This public review draft of
‘‘Toxicological Review of Acrylamide’’
is an update and reassessment of the
human health effects that may result
from exposure to acrylamide. The
acrylamide oral and inhalation reference
values and carcinogenicity classification
have been revised based upon new data
and changes in guidance that have
occurred since the previous assessment
in 1988.
IRIS is a database of human health
effects that may result from exposure to
various chemical substances found in
the environment. The database
(available on the Internet at https://
www.epa.gov/iris) contains qualitative
and quantitative health effects
information for more than 540 chemical
substances that may be used to support
the first two steps (hazard identification
and dose response evaluation) of the
risk assessment process. When
supported by available data, the
database provides oral reference doses
(RfDs) and inhalation reference
concentrations (RfCs) for health effects,
and oral slope factors and inhalation
unit risks for carcinogenic effects.
Combined with specific exposure
information, government and private
entities use IRIS to help characterize
public health risks of chemical
substances in a site-specific situation
and thereby support risk management
decisions designed to protect public
health.
II. How to Submit Technical Comments
to the Docket at www.regulations.gov
Submit your comments, identified by
Docket ID No. EPA–HQ–ORD–2007–
1141 by one of the following methods:
• www.regulations.gov: Follow the
on-line instructions for submitting
comments.
• E-mail: ORD.Docket@epa.gov.
• Fax: 202–566–1753.
• Mail: Office of Environmental
Information (OEI) Docket (Mail Code:
2822T).
U.S. Environmental Protection
Agency, 1200 Pennsylvania Ave., NW.,
Washington, DC 20460. The phone
number is 202–566–1752.
• Hand Delivery: The OEI Docket is
located in the EPA Headquarters Docket
Center, EPA West Building, Room 3334,
1301 Constitution Ave., NW.,
Washington, DC. The EPA Docket
Center Public Reading Room is open
from 8:30 a.m. to 4:30 p.m., Monday
through Friday, excluding legal
holidays. The telephone number for the
VerDate Aug<31>2005
22:27 Dec 27, 2007
Jkt 214001
Public Reading Room is 202–566–1744.
Such deliveries are only accepted
during the docket’s normal hours of
operation, and special arrangements
should be made for deliveries of boxed
information.
If you provide comments in writing,
please submit one unbound original
with pages numbered consecutively,
and three copies of the comments. For
attachments, provide an index, number
pages consecutively with the comments,
and submit an unbound original and
three copies.
Instructions: Direct your comments to
Docket ID No. EPA–HQ–ORD–2007–
1141. EPA’s policy is that all comments
received will be included in the public
docket without change and may be
made available online at
www.regulations.gov, including any
personal information provided, unless
the comment includes information
claimed to be Confidential Business
Information (CBI) or other information
whose disclosure is restricted by statute.
Do not submit information that you
consider to be CBI or otherwise
protected through www.regulations.gov
or e-mail. The www.regulations.gov Web
site is an ‘‘anonymous access’’ system,
which means EPA will not know your
identity or contact information unless
you provide it in the body of your
comment. If you send an e-mail
comment directly to EPA without going
through www.regulations.gov, your email address will be automatically
captured and included as part of the
comment that is placed in the public
docket and made available on the
Internet. If you submit an electronic
comment, EPA recommends that you
include your name and other contact
information in the body of your
comment and with any disk or CD-ROM
you submit. If EPA cannot read your
comment due to technical difficulties
and cannot contact you for clarification,
EPA may not be able to consider your
comment. Electronic files should avoid
the use of special characters, any form
of encryption, and be free of any defects
or viruses. For additional information
about EPA’s public docket visit the EPA
Docket Center homepage at
www.epa.gov/epahome/dockets.htm.
Docket: All documents in the docket
are listed in the www.regulations.gov
index. Although listed in the index,
some information is not publicly
available, e.g., CBI or other information
whose disclosure is restricted by statute.
Certain other material, such as
copyrighted material, will be publicly
available only in hard copy. Publicly
available docket materials can be
accessed either electronically in
www.regulations.gov or in hard copy
PO 00000
Frm 00058
Fmt 4703
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from the OEI Docket in the EPA
Headquarters Docket Center.
Dated: December 18, 2007.
Rebecca M. Clark,
Acting Director, National Center for
Environmental Assessment.
[FR Doc. E7–25282 Filed 12–27–07; 8:45 am]
BILLING CODE 6560–50–P
EXPORT-IMPORT BANK OF THE
UNITED STATES
Notice of Open Special Meeting of the
Sub-Saharan Africa Advisory
Committee (SAAC) of the ExportImport Bank of the United States
(Export-Import Bank)
SUMMARY: The Sub-Saharan Africa
Advisory Committee was established by
(Pub. L.) 105–121, November 26, 1997,
to advise the Board of Directors on the
development and implementation of
policies and programs designed to
support the expansion of the Bank’s
financial commitments in Sub-Saharan
Africa under the loan, guarantee and
insurance programs of the Bank.
Further, the committee shall make
recommendations on how the Bank can
facilitate greater support by U.S.
commercial banks for trade with SubSaharan Africa.
January 16, at 9:30 a.m.
to 12 p.m. The meeting will be held at
the Export-Import Bank in Room 1143,
811 Vermont Avenue, NW.,
Washington, DC 20571.
Agenda: Introduction of SAAC
members, ethics training, report to
congress, 2007 SAAC recommendations
update, bank operating issues and
processes, business development update
and ‘‘Attracting the interest of new U.S.
companies to the African market’’.
Public Participation: The meeting will
be open to public participation, and the
last 10 minutes will be set aside for oral
questions or comments. Members of the
public may also file written statement(s)
before or after the meeting. If any person
wishes auxiliary aids (such as a sign
language interpreter) or other special
accommodations please contact, prior to
January 16, 2008, Barbara Ransom,
Room 1241, 811 Vermont Avenue, NW.,
Washington, DC 20571, Voice: (202)
565–3525 or TDD (202) 565–3377.
TIME AND PLACE:
For
further information, contact Barbara
Ransom, Room 1241, 811 Vermont
FOR FURTHER INFORMATION CONTACT:
E:\FR\FM\28DEN1.SGM
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Agencies
[Federal Register Volume 72, Number 248 (Friday, December 28, 2007)]
[Notices]
[Pages 73813-73814]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: E7-25282]
-----------------------------------------------------------------------
ENVIRONMENTAL PROTECTION AGENCY
[FRL-8511-8; Docket ID No. EPA-HQ-ORD-2007-1141]
Draft Toxicological Review of Acrylamide: In Support of Summary
Information on the Integrated Risk Information System (IRIS)
AGENCY: Environmental Protection Agency (EPA).
ACTION: Notice of Public Comment Period.
-----------------------------------------------------------------------
SUMMARY: The EPA is announcing a public comment period to review the
final draft document titled, ``Toxicological Review of Acrylamide: In
Support of Summary Information on the Integrated Risk Information
System (IRIS)'' (EPA/635/R-07/009), related to the human health
assessment for acrylamide. The document was prepared by the National
Center for Environmental Assessment (NCEA) within EPA's Office of
Research and Development.
EPA is releasing this draft document solely for the purpose of pre-
dissemination peer review under applicable information quality
guidelines. This document has not been formally disseminated by EPA. It
does not represent and should not be construed to represent any Agency
policy or determination. EPA will consider any public comments
submitted in accordance with this notice when revising the document.
DATES: The 60-day public comment period begins on December 28, 2007 and
ends February 26, 2008. Technical comments should be in writing and
must be received by EPA by February 26, 2008.
ADDRESSES: The draft ``Draft Toxicological Review of Acrylamide: In
Support of Summary Information on the Integrated Risk Information
System (IRIS)'' (EPA/635/R-07/009) is available primarily via the
Internet on NCEA's home page under the Recent Additions menu at
www.epa.gov/ncea. A limited number of paper copies are available by
contacting the IRIS Hotline at (202) 566-1676, (202) 566-1749
(facsimile), or hotline.iris@epa.gov. If you are requesting a paper
copy, please provide your name, mailing address, the document title,
and the EPA number of the requested publication.
Technical comments may be submitted electronically via
www.regulations.gov, by mail, by facsimile, or by hand delivery/
courier. Please follow the detailed instructions provided in the
SUPPLEMENTARY INFORMATION section of this notice.
FOR FURTHER INFORMATION CONTACT: For information on the public comment
period, contact the Office of Environmental Information Docket;
telephone: 202-566-1752; facsimile: 202-566-1753; or e-mail:
ORD.Docket@epa.gov.
For general information about the IRIS assessment process, terms,
and existing values go to NCEA's home page via the Internet and click
on ``IRIS'' in the Quick Finder section at www.epa.gov/ncea (or go to
https://www.epa.gov/iriswebp/iris/ ). For information on the
status and estimated completion dates of the Toxicological Review of
Acrylamide go to the IRIS home page and click on ``IRIS Track'' in the
left hand column (or go to: https://cfpub.epa.gov/iristrac/index.cfm).
If you have questions or need information regarding communications
and outreach, contact Linda Tuxen, National Center for Environmental
Assessment; telephone: 703-347-8609; facsimile: 703-347-8699; e-mail:
tuxen.linda@epa.gov.
For technical and scientific questions concerning the draft
Toxicological Review of Acrylamide, contact the Chemical Manager,
Robert DeWoskin, National Center for Environmental Assessment;
telephone: 919-541-1089; facsimile: 919-541-0248; e-mail:
dewoskin.rob@epa.gov.
SUPPLEMENTARY INFORMATION:
I. Information About the Document
Acrylamide is a monomer used primarily in the production of
polyacrylamide polymers. Polyacrylamides are used as a flocculent in
water purification, oil recovery, and soil stabilization; and in the
manufacturing of a wide range of products as a coating, matrix,
additive, or stabilizer. Human exposure to acrylamide occurs primarily
in the workplace from dermal contact and inhalation of dust and vapor
during processing or use. The public may be exposed to acrylamide
through emissions from production facilities, use in consumer products,
contaminated drinking water, and cigarette smoke. In early 2002,
Swedish scientists reported high concentrations of acrylamide in
certain fried, baked, and deep-fried foods. Subsequent research
demonstrated that acrylamide forms ``de novo'' (i.e., newly formed, not
present as an environmental contaminant) during high temperature
cooking of carbohydrate-rich foods that contain asparagine and in a few
other food processes. Considerable research is on-going to assess the
level of and the potential risk from exposure to
[[Page 73814]]
acrylamide in food (additional information is available on the U.S.
FDA's Internet site for acrylamide: https://www.cfsan.fda.gov/lrd/
pestadd.html#acrylamide).
This public review draft of ``Toxicological Review of Acrylamide''
is an update and reassessment of the human health effects that may
result from exposure to acrylamide. The acrylamide oral and inhalation
reference values and carcinogenicity classification have been revised
based upon new data and changes in guidance that have occurred since
the previous assessment in 1988.
IRIS is a database of human health effects that may result from
exposure to various chemical substances found in the environment. The
database (available on the Internet at https://www.epa.gov/iris)
contains qualitative and quantitative health effects information for
more than 540 chemical substances that may be used to support the first
two steps (hazard identification and dose response evaluation) of the
risk assessment process. When supported by available data, the database
provides oral reference doses (RfDs) and inhalation reference
concentrations (RfCs) for health effects, and oral slope factors and
inhalation unit risks for carcinogenic effects. Combined with specific
exposure information, government and private entities use IRIS to help
characterize public health risks of chemical substances in a site-
specific situation and thereby support risk management decisions
designed to protect public health.
II. How to Submit Technical Comments to the Docket at
www.regulations.gov
Submit your comments, identified by Docket ID No. EPA-HQ-ORD-2007-
1141 by one of the following methods:
www.regulations.gov: Follow the on-line instructions for
submitting comments.
E-mail: ORD.Docket@epa.gov.
Fax: 202-566-1753.
Mail: Office of Environmental Information (OEI) Docket
(Mail Code: 2822T).
U.S. Environmental Protection Agency, 1200 Pennsylvania Ave., NW.,
Washington, DC 20460. The phone number is 202-566-1752.
Hand Delivery: The OEI Docket is located in the EPA
Headquarters Docket Center, EPA West Building, Room 3334, 1301
Constitution Ave., NW., Washington, DC. The EPA Docket Center Public
Reading Room is open from 8:30 a.m. to 4:30 p.m., Monday through
Friday, excluding legal holidays. The telephone number for the Public
Reading Room is 202-566-1744. Such deliveries are only accepted during
the docket's normal hours of operation, and special arrangements should
be made for deliveries of boxed information.
If you provide comments in writing, please submit one unbound
original with pages numbered consecutively, and three copies of the
comments. For attachments, provide an index, number pages consecutively
with the comments, and submit an unbound original and three copies.
Instructions: Direct your comments to Docket ID No. EPA-HQ-ORD-
2007-1141. EPA's policy is that all comments received will be included
in the public docket without change and may be made available online at
www.regulations.gov, including any personal information provided,
unless the comment includes information claimed to be Confidential
Business Information (CBI) or other information whose disclosure is
restricted by statute. Do not submit information that you consider to
be CBI or otherwise protected through www.regulations.gov or e-mail.
The www.regulations.gov Web site is an ``anonymous access'' system,
which means EPA will not know your identity or contact information
unless you provide it in the body of your comment. If you send an e-
mail comment directly to EPA without going through www.regulations.gov,
your e-mail address will be automatically captured and included as part
of the comment that is placed in the public docket and made available
on the Internet. If you submit an electronic comment, EPA recommends
that you include your name and other contact information in the body of
your comment and with any disk or CD-ROM you submit. If EPA cannot read
your comment due to technical difficulties and cannot contact you for
clarification, EPA may not be able to consider your comment. Electronic
files should avoid the use of special characters, any form of
encryption, and be free of any defects or viruses. For additional
information about EPA's public docket visit the EPA Docket Center
homepage at www.epa.gov/epahome/dockets.htm.
Docket: All documents in the docket are listed in the
www.regulations.gov index. Although listed in the index, some
information is not publicly available, e.g., CBI or other information
whose disclosure is restricted by statute. Certain other material, such
as copyrighted material, will be publicly available only in hard copy.
Publicly available docket materials can be accessed either
electronically in www.regulations.gov or in hard copy from the OEI
Docket in the EPA Headquarters Docket Center.
Dated: December 18, 2007.
Rebecca M. Clark,
Acting Director, National Center for Environmental Assessment.
[FR Doc. E7-25282 Filed 12-27-07; 8:45 am]
BILLING CODE 6560-50-P