Draft Toxicological Review of Acrylamide: In Support of Summary Information on the Integrated Risk Information System (IRIS), 73813-73814 [E7-25282]

Download as PDF Federal Register / Vol. 72, No. 248 / Friday, December 28, 2007 / Notices C. How and to Whom Do I Submit Comments? ENVIRONMENTAL PROTECTION AGENCY To submit comments, or access the public docket, please follow the detailed instructions as provided in ADDRESSES and Unit I.B of the SUPPLEMENTARY INFORMATION of the October 31, 2007 Federal Register document. If you have questions, consult the person listed under FOR FURTHER INFORMATION CONTACT. [FRL–8511–8; Docket ID No. EPA–HQ–ORD– 2007–1141] II. What Action is EPA Taking? This document extends the public comment period established in the Federal Register of October 31, 2007, 72 FR 61638 (FRL–8152–6). In that document, EPA announced the availability of and sought comment on the draft Pesticide Registration Notice (PR Notice) entitled ‘‘Label Statements Regarding Third-Party Endorsements & Cause Marketing Claims.’’ In response to requests from multiple entities, EPA is hereby extending the comment period, which was set to end on December 31, 2007, to March 27, 2008. III. What is the Agency’s Authority for Taking this Action? This action is taken as provided in Section 21(c) of the Federal, Insecticide, Fungicide, and Rodencticide Act, which reads: In addition to any other authority relating to public hearings and solicitation of views, in connection with the suspension or cancellation of a pesticide product registration or any other actions authorized under this subchapter, the Administrator may, at the Administrator’s discretion, solicit the views of all interested persons, either orally or in writing, and seek such advice from scientists, farmers, farm organizations, and other qualified persons as the Administrator deems proper. List of Subjects Environmental protection, Pesticides and pests, Administrative practice and procedure, Agricultural commodities. Dated: December 19, 2007. Debra Edwards, Director, Office of Pesticide Programs. [FR Doc. E7–25089 Filed 12–28–07; 8:45 am] mstockstill on PROD1PC66 with NOTICES BILLING CODE 6560–50–S VerDate Aug<31>2005 22:27 Dec 27, 2007 Jkt 214001 Draft Toxicological Review of Acrylamide: In Support of Summary Information on the Integrated Risk Information System (IRIS) Environmental Protection Agency (EPA). ACTION: Notice of Public Comment Period. AGENCY: SUMMARY: The EPA is announcing a public comment period to review the final draft document titled, ‘‘Toxicological Review of Acrylamide: In Support of Summary Information on the Integrated Risk Information System (IRIS)’’ (EPA/635/R–07/009), related to the human health assessment for acrylamide. The document was prepared by the National Center for Environmental Assessment (NCEA) within EPA’s Office of Research and Development. EPA is releasing this draft document solely for the purpose of predissemination peer review under applicable information quality guidelines. This document has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency policy or determination. EPA will consider any public comments submitted in accordance with this notice when revising the document. DATES: The 60-day public comment period begins on December 28, 2007 and ends February 26, 2008. Technical comments should be in writing and must be received by EPA by February 26, 2008. ADDRESSES: The draft ‘‘Draft Toxicological Review of Acrylamide: In Support of Summary Information on the Integrated Risk Information System (IRIS)’’ (EPA/635/R–07/009) is available primarily via the Internet on NCEA’s home page under the Recent Additions menu at www.epa.gov/ncea. A limited number of paper copies are available by contacting the IRIS Hotline at (202) 566– 1676, (202) 566–1749 (facsimile), or hotline.iris@epa.gov. If you are requesting a paper copy, please provide your name, mailing address, the document title, and the EPA number of the requested publication. Technical comments may be submitted electronically via www.regulations.gov, by mail, by facsimile, or by hand delivery/courier. Please follow the detailed instructions provided in the SUPPLEMENTARY INFORMATION section of this notice. PO 00000 Frm 00057 Fmt 4703 Sfmt 4703 73813 For information on the public comment period, contact the Office of Environmental Information Docket; telephone: 202–566–1752; facsimile: 202–566–1753; or e-mail: ORD.Docket@epa.gov. For general information about the IRIS assessment process, terms, and existing values go to NCEA’s home page via the Internet and click on ‘‘IRIS’’ in the Quick Finder section at www.epa.gov/ ncea (or go to http://www.epa.gov/ iriswebp/iris/index.html ). For information on the status and estimated completion dates of the Toxicological Review of Acrylamide go to the IRIS home page and click on ‘‘IRIS Track’’ in the left hand column (or go to: http:// cfpub.epa.gov/iristrac/index.cfm). If you have questions or need information regarding communications and outreach, contact Linda Tuxen, National Center for Environmental Assessment; telephone: 703–347–8609; facsimile: 703–347–8699; e-mail: tuxen.linda@epa.gov. For technical and scientific questions concerning the draft Toxicological Review of Acrylamide, contact the Chemical Manager, Robert DeWoskin, National Center for Environmental Assessment; telephone: 919–541–1089; facsimile: 919–541–0248; e-mail: dewoskin.rob@epa.gov. FOR FURTHER INFORMATION CONTACT: SUPPLEMENTARY INFORMATION: I. Information About the Document Acrylamide is a monomer used primarily in the production of polyacrylamide polymers. Polyacrylamides are used as a flocculent in water purification, oil recovery, and soil stabilization; and in the manufacturing of a wide range of products as a coating, matrix, additive, or stabilizer. Human exposure to acrylamide occurs primarily in the workplace from dermal contact and inhalation of dust and vapor during processing or use. The public may be exposed to acrylamide through emissions from production facilities, use in consumer products, contaminated drinking water, and cigarette smoke. In early 2002, Swedish scientists reported high concentrations of acrylamide in certain fried, baked, and deep-fried foods. Subsequent research demonstrated that acrylamide forms ‘‘de novo’’ (i.e., newly formed, not present as an environmental contaminant) during high temperature cooking of carbohydrate-rich foods that contain asparagine and in a few other food processes. Considerable research is on-going to assess the level of and the potential risk from exposure to E:\FR\FM\28DEN1.SGM 28DEN1 73814 Federal Register / Vol. 72, No. 248 / Friday, December 28, 2007 / Notices mstockstill on PROD1PC66 with NOTICES acrylamide in food (additional information is available on the U.S. FDA’s Internet site for acrylamide: http://www.cfsan.fda.gov/lrd/ pestadd.html#acrylamide). This public review draft of ‘‘Toxicological Review of Acrylamide’’ is an update and reassessment of the human health effects that may result from exposure to acrylamide. The acrylamide oral and inhalation reference values and carcinogenicity classification have been revised based upon new data and changes in guidance that have occurred since the previous assessment in 1988. IRIS is a database of human health effects that may result from exposure to various chemical substances found in the environment. The database (available on the Internet at http:// www.epa.gov/iris) contains qualitative and quantitative health effects information for more than 540 chemical substances that may be used to support the first two steps (hazard identification and dose response evaluation) of the risk assessment process. When supported by available data, the database provides oral reference doses (RfDs) and inhalation reference concentrations (RfCs) for health effects, and oral slope factors and inhalation unit risks for carcinogenic effects. Combined with specific exposure information, government and private entities use IRIS to help characterize public health risks of chemical substances in a site-specific situation and thereby support risk management decisions designed to protect public health. II. How to Submit Technical Comments to the Docket at www.regulations.gov Submit your comments, identified by Docket ID No. EPA–HQ–ORD–2007– 1141 by one of the following methods: • www.regulations.gov: Follow the on-line instructions for submitting comments. • E-mail: ORD.Docket@epa.gov. • Fax: 202–566–1753. • Mail: Office of Environmental Information (OEI) Docket (Mail Code: 2822T). U.S. Environmental Protection Agency, 1200 Pennsylvania Ave., NW., Washington, DC 20460. The phone number is 202–566–1752. • Hand Delivery: The OEI Docket is located in the EPA Headquarters Docket Center, EPA West Building, Room 3334, 1301 Constitution Ave., NW., Washington, DC. The EPA Docket Center Public Reading Room is open from 8:30 a.m. to 4:30 p.m., Monday through Friday, excluding legal holidays. The telephone number for the VerDate Aug<31>2005 22:27 Dec 27, 2007 Jkt 214001 Public Reading Room is 202–566–1744. Such deliveries are only accepted during the docket’s normal hours of operation, and special arrangements should be made for deliveries of boxed information. If you provide comments in writing, please submit one unbound original with pages numbered consecutively, and three copies of the comments. For attachments, provide an index, number pages consecutively with the comments, and submit an unbound original and three copies. Instructions: Direct your comments to Docket ID No. EPA–HQ–ORD–2007– 1141. EPA’s policy is that all comments received will be included in the public docket without change and may be made available online at www.regulations.gov, including any personal information provided, unless the comment includes information claimed to be Confidential Business Information (CBI) or other information whose disclosure is restricted by statute. Do not submit information that you consider to be CBI or otherwise protected through www.regulations.gov or e-mail. The www.regulations.gov Web site is an ‘‘anonymous access’’ system, which means EPA will not know your identity or contact information unless you provide it in the body of your comment. If you send an e-mail comment directly to EPA without going through www.regulations.gov, your email address will be automatically captured and included as part of the comment that is placed in the public docket and made available on the Internet. If you submit an electronic comment, EPA recommends that you include your name and other contact information in the body of your comment and with any disk or CD-ROM you submit. If EPA cannot read your comment due to technical difficulties and cannot contact you for clarification, EPA may not be able to consider your comment. Electronic files should avoid the use of special characters, any form of encryption, and be free of any defects or viruses. For additional information about EPA’s public docket visit the EPA Docket Center homepage at www.epa.gov/epahome/dockets.htm. Docket: All documents in the docket are listed in the www.regulations.gov index. Although listed in the index, some information is not publicly available, e.g., CBI or other information whose disclosure is restricted by statute. Certain other material, such as copyrighted material, will be publicly available only in hard copy. Publicly available docket materials can be accessed either electronically in www.regulations.gov or in hard copy PO 00000 Frm 00058 Fmt 4703 Sfmt 4703 from the OEI Docket in the EPA Headquarters Docket Center. Dated: December 18, 2007. Rebecca M. Clark, Acting Director, National Center for Environmental Assessment. [FR Doc. E7–25282 Filed 12–27–07; 8:45 am] BILLING CODE 6560–50–P EXPORT-IMPORT BANK OF THE UNITED STATES Notice of Open Special Meeting of the Sub-Saharan Africa Advisory Committee (SAAC) of the ExportImport Bank of the United States (Export-Import Bank) SUMMARY: The Sub-Saharan Africa Advisory Committee was established by (Pub. L.) 105–121, November 26, 1997, to advise the Board of Directors on the development and implementation of policies and programs designed to support the expansion of the Bank’s financial commitments in Sub-Saharan Africa under the loan, guarantee and insurance programs of the Bank. Further, the committee shall make recommendations on how the Bank can facilitate greater support by U.S. commercial banks for trade with SubSaharan Africa. January 16, at 9:30 a.m. to 12 p.m. The meeting will be held at the Export-Import Bank in Room 1143, 811 Vermont Avenue, NW., Washington, DC 20571. Agenda: Introduction of SAAC members, ethics training, report to congress, 2007 SAAC recommendations update, bank operating issues and processes, business development update and ‘‘Attracting the interest of new U.S. companies to the African market’’. Public Participation: The meeting will be open to public participation, and the last 10 minutes will be set aside for oral questions or comments. Members of the public may also file written statement(s) before or after the meeting. If any person wishes auxiliary aids (such as a sign language interpreter) or other special accommodations please contact, prior to January 16, 2008, Barbara Ransom, Room 1241, 811 Vermont Avenue, NW., Washington, DC 20571, Voice: (202) 565–3525 or TDD (202) 565–3377. TIME AND PLACE: For further information, contact Barbara Ransom, Room 1241, 811 Vermont FOR FURTHER INFORMATION CONTACT: E:\FR\FM\28DEN1.SGM 28DEN1

Agencies

[Federal Register Volume 72, Number 248 (Friday, December 28, 2007)]
[Notices]
[Pages 73813-73814]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: E7-25282]


-----------------------------------------------------------------------

ENVIRONMENTAL PROTECTION AGENCY

[FRL-8511-8; Docket ID No. EPA-HQ-ORD-2007-1141]


Draft Toxicological Review of Acrylamide: In Support of Summary 
Information on the Integrated Risk Information System (IRIS)

AGENCY: Environmental Protection Agency (EPA).

ACTION: Notice of Public Comment Period.

-----------------------------------------------------------------------

SUMMARY: The EPA is announcing a public comment period to review the 
final draft document titled, ``Toxicological Review of Acrylamide: In 
Support of Summary Information on the Integrated Risk Information 
System (IRIS)'' (EPA/635/R-07/009), related to the human health 
assessment for acrylamide. The document was prepared by the National 
Center for Environmental Assessment (NCEA) within EPA's Office of 
Research and Development.
    EPA is releasing this draft document solely for the purpose of pre-
dissemination peer review under applicable information quality 
guidelines. This document has not been formally disseminated by EPA. It 
does not represent and should not be construed to represent any Agency 
policy or determination. EPA will consider any public comments 
submitted in accordance with this notice when revising the document.

DATES: The 60-day public comment period begins on December 28, 2007 and 
ends February 26, 2008. Technical comments should be in writing and 
must be received by EPA by February 26, 2008.

ADDRESSES: The draft ``Draft Toxicological Review of Acrylamide: In 
Support of Summary Information on the Integrated Risk Information 
System (IRIS)'' (EPA/635/R-07/009) is available primarily via the 
Internet on NCEA's home page under the Recent Additions menu at 
www.epa.gov/ncea. A limited number of paper copies are available by 
contacting the IRIS Hotline at (202) 566-1676, (202) 566-1749 
(facsimile), or hotline.iris@epa.gov. If you are requesting a paper 
copy, please provide your name, mailing address, the document title, 
and the EPA number of the requested publication.
    Technical comments may be submitted electronically via 
www.regulations.gov, by mail, by facsimile, or by hand delivery/
courier. Please follow the detailed instructions provided in the 
SUPPLEMENTARY INFORMATION section of this notice.

FOR FURTHER INFORMATION CONTACT: For information on the public comment 
period, contact the Office of Environmental Information Docket; 
telephone: 202-566-1752; facsimile: 202-566-1753; or e-mail: 
ORD.Docket@epa.gov.
    For general information about the IRIS assessment process, terms, 
and existing values go to NCEA's home page via the Internet and click 
on ``IRIS'' in the Quick Finder section at www.epa.gov/ncea (or go to 
http://www.epa.gov/iriswebp/iris/index.html ). For information on the 
status and estimated completion dates of the Toxicological Review of 
Acrylamide go to the IRIS home page and click on ``IRIS Track'' in the 
left hand column (or go to: http://cfpub.epa.gov/iristrac/index.cfm).
    If you have questions or need information regarding communications 
and outreach, contact Linda Tuxen, National Center for Environmental 
Assessment; telephone: 703-347-8609; facsimile: 703-347-8699; e-mail: 
tuxen.linda@epa.gov.
    For technical and scientific questions concerning the draft 
Toxicological Review of Acrylamide, contact the Chemical Manager, 
Robert DeWoskin, National Center for Environmental Assessment; 
telephone: 919-541-1089; facsimile: 919-541-0248; e-mail: 
dewoskin.rob@epa.gov.

SUPPLEMENTARY INFORMATION: 

I. Information About the Document

    Acrylamide is a monomer used primarily in the production of 
polyacrylamide polymers. Polyacrylamides are used as a flocculent in 
water purification, oil recovery, and soil stabilization; and in the 
manufacturing of a wide range of products as a coating, matrix, 
additive, or stabilizer. Human exposure to acrylamide occurs primarily 
in the workplace from dermal contact and inhalation of dust and vapor 
during processing or use. The public may be exposed to acrylamide 
through emissions from production facilities, use in consumer products, 
contaminated drinking water, and cigarette smoke. In early 2002, 
Swedish scientists reported high concentrations of acrylamide in 
certain fried, baked, and deep-fried foods. Subsequent research 
demonstrated that acrylamide forms ``de novo'' (i.e., newly formed, not 
present as an environmental contaminant) during high temperature 
cooking of carbohydrate-rich foods that contain asparagine and in a few 
other food processes. Considerable research is on-going to assess the 
level of and the potential risk from exposure to

[[Page 73814]]

acrylamide in food (additional information is available on the U.S. 
FDA's Internet site for acrylamide: http://www.cfsan.fda.gov/lrd/
pestadd.html#acrylamide).
    This public review draft of ``Toxicological Review of Acrylamide'' 
is an update and reassessment of the human health effects that may 
result from exposure to acrylamide. The acrylamide oral and inhalation 
reference values and carcinogenicity classification have been revised 
based upon new data and changes in guidance that have occurred since 
the previous assessment in 1988.
    IRIS is a database of human health effects that may result from 
exposure to various chemical substances found in the environment. The 
database (available on the Internet at http://www.epa.gov/iris) 
contains qualitative and quantitative health effects information for 
more than 540 chemical substances that may be used to support the first 
two steps (hazard identification and dose response evaluation) of the 
risk assessment process. When supported by available data, the database 
provides oral reference doses (RfDs) and inhalation reference 
concentrations (RfCs) for health effects, and oral slope factors and 
inhalation unit risks for carcinogenic effects. Combined with specific 
exposure information, government and private entities use IRIS to help 
characterize public health risks of chemical substances in a site-
specific situation and thereby support risk management decisions 
designed to protect public health.

II. How to Submit Technical Comments to the Docket at 
www.regulations.gov

    Submit your comments, identified by Docket ID No. EPA-HQ-ORD-2007-
1141 by one of the following methods:
     www.regulations.gov: Follow the on-line instructions for 
submitting comments.
     E-mail: ORD.Docket@epa.gov.
     Fax: 202-566-1753.
     Mail: Office of Environmental Information (OEI) Docket 
(Mail Code: 2822T).
    U.S. Environmental Protection Agency, 1200 Pennsylvania Ave., NW., 
Washington, DC 20460. The phone number is 202-566-1752.
     Hand Delivery: The OEI Docket is located in the EPA 
Headquarters Docket Center, EPA West Building, Room 3334, 1301 
Constitution Ave., NW., Washington, DC. The EPA Docket Center Public 
Reading Room is open from 8:30 a.m. to 4:30 p.m., Monday through 
Friday, excluding legal holidays. The telephone number for the Public 
Reading Room is 202-566-1744. Such deliveries are only accepted during 
the docket's normal hours of operation, and special arrangements should 
be made for deliveries of boxed information.
    If you provide comments in writing, please submit one unbound 
original with pages numbered consecutively, and three copies of the 
comments. For attachments, provide an index, number pages consecutively 
with the comments, and submit an unbound original and three copies.
    Instructions: Direct your comments to Docket ID No. EPA-HQ-ORD-
2007-1141. EPA's policy is that all comments received will be included 
in the public docket without change and may be made available online at 
www.regulations.gov, including any personal information provided, 
unless the comment includes information claimed to be Confidential 
Business Information (CBI) or other information whose disclosure is 
restricted by statute. Do not submit information that you consider to 
be CBI or otherwise protected through www.regulations.gov or e-mail. 
The www.regulations.gov Web site is an ``anonymous access'' system, 
which means EPA will not know your identity or contact information 
unless you provide it in the body of your comment. If you send an e-
mail comment directly to EPA without going through www.regulations.gov, 
your e-mail address will be automatically captured and included as part 
of the comment that is placed in the public docket and made available 
on the Internet. If you submit an electronic comment, EPA recommends 
that you include your name and other contact information in the body of 
your comment and with any disk or CD-ROM you submit. If EPA cannot read 
your comment due to technical difficulties and cannot contact you for 
clarification, EPA may not be able to consider your comment. Electronic 
files should avoid the use of special characters, any form of 
encryption, and be free of any defects or viruses. For additional 
information about EPA's public docket visit the EPA Docket Center 
homepage at www.epa.gov/epahome/dockets.htm.
    Docket: All documents in the docket are listed in the 
www.regulations.gov index. Although listed in the index, some 
information is not publicly available, e.g., CBI or other information 
whose disclosure is restricted by statute. Certain other material, such 
as copyrighted material, will be publicly available only in hard copy. 
Publicly available docket materials can be accessed either 
electronically in www.regulations.gov or in hard copy from the OEI 
Docket in the EPA Headquarters Docket Center.

    Dated: December 18, 2007.
Rebecca M. Clark,
Acting Director, National Center for Environmental Assessment.
[FR Doc. E7-25282 Filed 12-27-07; 8:45 am]
BILLING CODE 6560-50-P