Proposed Collection; Comment Request; Process Evaluation of the Global Health Research Initiative Program for New Foreign Investigators (GRIP), 67737-67738 [E7-23235]
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67737
Federal Register / Vol. 72, No. 230 / Friday, November 30, 2007 / Notices
developmental form to assess audience
comprehension, reactions, and
perceptions. The information obtained
from audience research and pretesting
results in more effective messages,
materials, and programmatic strategies.
By maximizing the effectiveness of these
messages and strategies for reaching
targeted audiences, the frequency with
which publications, products, and
programs need to be modified is
reduced. Frequency of Response: On
occasion. Affected Public: Individuals.
Type of Respondents: Adults at risk for
HIV/AIDS, particularly those who are
Black/African-American, Hispanic/
Estimated
number of
respondents
Type of respondents
Latino, or men who have sex with men;
healthcare providers; representatives of
organizations disseminating HIV-related
messages or materials. The annual
reporting burden is shown in the table
below. There are no Capital Costs to
report. There are no Operating or
Maintenance Costs to report.
Estimated
number of
responses per
respondent
Average
burden hours
per response
3,374
50
75
1
1
1
.3422
.75
.50
Total ......................................................................................................
rwilkins on PROD1PC63 with NOTICES
At-risk Adults ................................................................................................
Healthcare providers ....................................................................................
Organization Gatekeepers ...........................................................................
3,499
........................
..........................
Request for Comments: Written
comments and/or suggestions from the
public and affected agencies should
address one or more of the following
points: (1) Evaluate whether the
proposed collection of information is
necessary for the proper performance of
the function of the agency, including
whether the information will have
practical utility; (2) Evaluate the
accuracy of the agency’s estimate of the
burden of the proposed collection of
information, including the validity of
the methodology and assumptions used;
(3) Enhance the quality, utility, and
clarity of the information to be
collected; and (4) Minimize the burden
of the collection of information on those
who are to respond, including the use
of appropriate automated, electronic,
mechanical, or other technological
collection techniques or other forms of
information technology.
Direct Comments to OMB: Written
comments and/or suggestions regarding
the item(s) contained in this notice,
especially regarding the estimated
public burden and associated response
time, should be directed to the: Office
of Management and Budget, Office of
Regulatory Affairs, New Executive
Office Building, Room 10235,
Washington, DC 20503, Attention: Desk
Officer for NIH. To request more
information on the proposed project or
to obtain a copy of the data collection
plans and instruments, contact
Katharine Kripke, Assistant Director,
Vaccine Research Program, Division of
AIDS, NIAID, NIH, 6700B Rockledge
Dr., Bethesda, MD 20892–7628, or call
non-toll-free number 301–402–0846, or
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E-mail your request, including your
address to kripkek@niaid.nih.gov.
Comments Due Date: Comments
regarding this information collection are
best assured of having their full effect if
received within 30 days of the date of
this publication.
Dated: November 7, 2007.
John J. McGowan,
Deputy Director for Science Management
NIAID.
[FR Doc. E7–23183 Filed 11–29–07; 8:45 am]
BILLING CODE 4140–01–P
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
Proposed Collection; Comment
Request; Process Evaluation of the
Global Health Research Initiative
Program for New Foreign Investigators
(GRIP)
SUMMARY: In compliance with the
requirement of section 3506(2)(A) of
the Paperwork Reduction Act of 1995,
for opportunity for public comment on
proposed data collection projects, the
Fogarty International Center (FIC), the
National Institutes of Health (NIH), will
publish periodic summaries of proposed
projects to be submitted to the Office of
Management and Budget (OMB) for
review and approval.
Proposed Collection: Title: Process
evaluation of the Global Health
Research Initiative Program for New
Foreign Investigators (GRIP). Type of
Information Collection Request: NEW.
Need and Use of Information Collection:
This study will assess the outputs of the
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Estimated
total annual
burden hours
requested
1,155
37.5
37.5
1,230
Global Health Research Initiative
Program for New Foreign Investigators
(GRIP) to date, assess the programs
alignment with new strategic goals of
the FIC, and identify potential
directions for program enhancement.
The primary objectives of the study are
to determine if GRIP awards (1) promote
productive re-entry of NIH-trained
foreign investigators into their home
countries, (2) increase the research
capacity of the international scientists
and institution, and (3) stimulate
research on a wide variety of high
priority health-related issues. The
findings will provide valuable
information concerning: (1) Specific
research advances attributable to GRIP
support; (2) specific capacity and career
enhancing advances that are attributable
to GRIP; (3) policy implications for GRIP
at the program level based on survey
responses, such as successes and
challenges of the program’s
implementation, the GRIP support
mechanism, etc. Frequency of Response:
Once. Affected Public: None. Type of
Respondents: Foreign researchers. The
annual reporting burden is as follows:
Estimated Number of Respondents: 101;
Estimated Number of Responses per
Respondent: 1; Average Burden Hours
Per Response: 0.50; and Estimated Total
Annual Burden Hours Requested: 50.5.
The annualized cost to respondents is
estimated at: $656.50. There are no
Capital Costs to report. There are no
Operating or Maintenance Costs to
report. Table 1 and Table 2 respectively
present data concerning the burden
hours and cost burdens for this data
collection.
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67738
Federal Register / Vol. 72, No. 230 / Friday, November 30, 2007 / Notices
TABLE 1.—ANNUALIZED ESTIMATE OF HOUR BURDEN
Number of
respondents
Type of respondents
Frequency of
response
Average time
for response
(hr)
Total hour
burden *
GRIP Awardees ...............................................................................................
101
1
0.50
50.5
Total ..........................................................................................................
101
1
0.50
50.5
* Total Burden = N Respondents × Response Frequency × minutes to complete/60.
TABLE 2.—ANNUALIZED COST TO RESPONDENTS
Number of
respondents
Type of respondents
Frequency of
response
Approximate
hourly wage
rate/hr
Total
respondent
cost *
GRIP Awardees ...............................................................................................
101
1
$13
656.50
Total ..........................................................................................................
101
1
13
656.50
* Total Respondent Cost = N Respondents × Response Frequency × minutes to complete/60 × hourly rate.
Request for Comments: Written
comments and/or suggestions from the
public and affected agencies are invited
on one or more of the following points:
(1) Evaluate whether the proposed
collection of information is necessary
for the proper performance of the
function of the agency, including
whether the information will have
practical utility; (2) Evaluate the
accuracy of the agency’s estimate of the
burden of the proposed collection of
information, including the validity of
the methodology and assumptions used;
(3) Enhance the quality, utility, and
clarity of the information to be
collected; and (4) Minimize the burden
of the collection of information on those
who are to respond, including the use
of appropriate automated, electronic,
mechanical, or other technological
collection techniques or other forms of
information technology.
To
request more information on the
proposed project or to obtain a copy of
the data collection plans and
instruments, contact Dr. Linda Kupfer,
Fogarty International Center, National
Institutes of Health, 16 Center Drive,
Bethesda, MD 20892, or call non-tollfree number 301–496–3288, or e-mail
your request, including your address to:
kupferl@mail.nih.gov.
Comments Due Date: Comments
regarding this information collection are
best assured of having their full effect if
received within 60 days of the date of
this publication.
rwilkins on PROD1PC63 with NOTICES
FOR FURTHER INFORMATION CONTACT:
Dated: November 20, 2007.
Timothy Tosten,
Executive Officer, FIC, National Institutes of
Health.
[FR Doc. E7–23235 Filed 11–29–07; 8:45 am]
BILLING CODE 4140–01–P
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DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
Government-Owned Inventions;
Availability for Licensing
National Institutes of Health,
Public Health Service, HHS.
ACTION: Notice.
AGENCY:
SUMMARY: The inventions listed below
are owned by an agency of the U.S.
Government and are available for
licensing in the U.S. in accordance with
35 U.S.C. 207 to achieve expeditious
commercialization of results of
federally-funded research and
development. Foreign patent
applications are filed on selected
inventions to extend market coverage
for companies and may also be available
for licensing.
ADDRESSES: Licensing information and
copies of the U.S. patent applications
listed below may be obtained by writing
to the indicated licensing contact at the
Office of Technology Transfer, National
Institutes of Health, 6011 Executive
Boulevard, Suite 325, Rockville,
Maryland 20852–3804; telephone: 301/
496–7057; fax: 301/402–0220. A signed
Confidential Disclosure Agreement will
be required to receive copies of the
patent applications.
A Family of Small Molecules for
Selective Inhibition of Wip1
Phosphatase
Description of Technology: The Wip1
phosphatase acts on proteins containing
a particular phosphorylated amino acid
sequence. Studies have shown that
Wip1 is overexpressed in a number of
human cancers, including breast cancer,
neuroblastoma and ovarian cancer.
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Wip1 activity has also been shown to
have a suppressive effect on the tumor
suppressor p53. This suggested that
inhibition of Wip1 could be of
therapeutic value in the treatment of
cancer.
NIH inventors have developed small
molecules that simulate the structure of
the amino acid sequence that Wip1
recognizes. The structure of the small
molecules allows for specific targeting
to Wip1. These small molecules have
the ability to significantly inhibit Wip1
phosphatase activity at the micromolar
level. As a result, these small molecules
can be used in the design of
therapeutics for cancers that
overexpress Wip1.
Applications: Treatment of cancer,
including but not limited to breast
cancer, ovarian cancer and
neuroblastoma.
Can be used either alone or in
combination with other known anticancer therapeutics.
Advantages: Structure of the inhibitor
allows targeting of Wip1 without
inhibition of related phosphatases and
their biological processes, possibly
leading to fewer undesired effects
during treatment.
Small molecules are stable and have
the ability to effectively penetrate cells.
Can be applied to many different
types of cancer.
Benefits: The current lack of Wip1
inhibitors means that development of
the small molecules could lead to the
occupation of a significant position in
the cancer therapeutic market.
The successful inhibition of a new
target in cancer therapy could provide
far-reaching social benefit in the
treatment of multiple cancers.
Inventors: Ettore Appella et al. (NCI).
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]]>Agencies
[Federal Register Volume 72, Number 230 (Friday, November 30, 2007)]
[Notices]
[Pages 67737-67738]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: E7-23235]
-----------------------------------------------------------------------
DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health
Proposed Collection; Comment Request; Process Evaluation of the
Global Health Research Initiative Program for New Foreign Investigators
(GRIP)
SUMMARY: In compliance with the requirement of section
3506(copyright)(2)(A) of the Paperwork Reduction Act of 1995, for
opportunity for public comment on proposed data collection projects,
the Fogarty International Center (FIC), the National Institutes of
Health (NIH), will publish periodic summaries of proposed projects to
be submitted to the Office of Management and Budget (OMB) for review
and approval.
Proposed Collection: Title: Process evaluation of the Global Health
Research Initiative Program for New Foreign Investigators (GRIP). Type
of Information Collection Request: NEW. Need and Use of Information
Collection: This study will assess the outputs of the Global Health
Research Initiative Program for New Foreign Investigators (GRIP) to
date, assess the programs alignment with new strategic goals of the
FIC, and identify potential directions for program enhancement. The
primary objectives of the study are to determine if GRIP awards (1)
promote productive re-entry of NIH-trained foreign investigators into
their home countries, (2) increase the research capacity of the
international scientists and institution, and (3) stimulate research on
a wide variety of high priority health-related issues. The findings
will provide valuable information concerning: (1) Specific research
advances attributable to GRIP support; (2) specific capacity and career
enhancing advances that are attributable to GRIP; (3) policy
implications for GRIP at the program level based on survey responses,
such as successes and challenges of the program's implementation, the
GRIP support mechanism, etc. Frequency of Response: Once. Affected
Public: None. Type of Respondents: Foreign researchers. The annual
reporting burden is as follows: Estimated Number of Respondents: 101;
Estimated Number of Responses per Respondent: 1; Average Burden Hours
Per Response: 0.50; and Estimated Total Annual Burden Hours Requested:
50.5. The annualized cost to respondents is estimated at: $656.50.
There are no Capital Costs to report. There are no Operating or
Maintenance Costs to report. Table 1 and Table 2 respectively present
data concerning the burden hours and cost burdens for this data
collection.
[[Page 67738]]
Table 1.--Annualized Estimate of Hour Burden
----------------------------------------------------------------------------------------------------------------
Average time
Type of respondents Number of Frequency of for response Total hour
respondents response (hr) burden *
----------------------------------------------------------------------------------------------------------------
GRIP Awardees................................... 101 1 0.50 50.5
---------------------------------------------------------------
Total....................................... 101 1 0.50 50.5
----------------------------------------------------------------------------------------------------------------
* Total Burden = N Respondents x Response Frequency x minutes to complete/60.
Table 2.--Annualized Cost to Respondents
----------------------------------------------------------------------------------------------------------------
Approximate Total
Type of respondents Number of Frequency of hourly wage respondent
respondents response rate/hr cost *
----------------------------------------------------------------------------------------------------------------
GRIP Awardees................................... 101 1 $13 656.50
---------------------------------------------------------------
Total....................................... 101 1 13 656.50
----------------------------------------------------------------------------------------------------------------
* Total Respondent Cost = N Respondents x Response Frequency x minutes to complete/60 x hourly rate.
Request for Comments: Written comments and/or suggestions from the
public and affected agencies are invited on one or more of the
following points: (1) Evaluate whether the proposed collection of
information is necessary for the proper performance of the function of
the agency, including whether the information will have practical
utility; (2) Evaluate the accuracy of the agency's estimate of the
burden of the proposed collection of information, including the
validity of the methodology and assumptions used; (3) Enhance the
quality, utility, and clarity of the information to be collected; and
(4) Minimize the burden of the collection of information on those who
are to respond, including the use of appropriate automated, electronic,
mechanical, or other technological collection techniques or other forms
of information technology.
FOR FURTHER INFORMATION CONTACT: To request more information on the
proposed project or to obtain a copy of the data collection plans and
instruments, contact Dr. Linda Kupfer, Fogarty International Center,
National Institutes of Health, 16 Center Drive, Bethesda, MD 20892, or
call non-toll-free number 301-496-3288, or e-mail your request,
including your address to: kupferl@mail.nih.gov.
Comments Due Date: Comments regarding this information collection
are best assured of having their full effect if received within 60 days
of the date of this publication.
Dated: November 20, 2007.
Timothy Tosten,
Executive Officer, FIC, National Institutes of Health.
[FR Doc. E7-23235 Filed 11-29-07; 8:45 am]
BILLING CODE 4140-01-P
