National Institute of Environmental Health Sciences; Notice of Closed Meeting, 65756-65757 [07-5779]

Download as PDF 65756 Federal Register / Vol. 72, No. 225 / Friday, November 23, 2007 / Notices inhibitors. These NNRTIs are highly specific for HIV–1 RT and do not inhibit normal cellular polymerases, resulting in lower cytotoxicity and fewer side effects that the nucleoside analogues, such as AZT. This novel class of compounds could significantly improve the treatment of HIV by increasing compliance with therapy. Inventors: Christopher A. Michejda, Marshall Morningstar, Thomas Roth (NCI). Patent Status: U.S. Patent No. 6,369,235 issued 09 Apr 2002 (HHS Reference No. E–076–1997/1–US–01); U.S. Patent No. 6,894,068 issued 17 May 2005 (HHS Reference No. E–076–1997/ 1–US–02). Licensing Contact: Sally Hu, PhD., MBA; 301/435–5606; hus@mail.nih.gov. Dated: November 9, 2007. Steven M. Ferguson, Director, Division of Technology Development and Transfer, Office of Technology Transfer, National Institutes of Health. [FR Doc. E7–22821 Filed 11–21–07; 8:45 am] BILLING CODE 4140–01–P DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Public Teleconference Regarding Licensing and Collaborative Research Opportunities for: ‘‘Brother of the Regulator of Imprinted Sites’’ (BORIS): A Novel Protein That Can Be Used for Diagnosis and as a Therapeutic Target for the Treatment of Several Cancers; Dr. Victor Lobanenkov et al. (NIAID) National Institutes of Health, Public Health Service, HHS. ACTION: Notice. AGENCY: mstockstill on PROD1PC66 with NOTICES Technology Summary The technology describes the discovery of a novel gene encoding the DNA-binding factor, ‘‘Brother of the Regulator of Imprinted Sites’’, BORIS, related to the unique, evolutionarily conserved, CTCF factor involved in regulation of genomic imprinting and cancer. Furthermore, it describes several splice variants of BORIS that translate into different proteins and antibodies of BORIS that can be used for diagnosis and treatment of cancer. Technology Description A very recent finding is that protein CTCF (expressed in all somatic tissues) binds, in a methylation-dependent manner, to the imprinting control regions thus allowing somatic cells to distinguish functionally maternal from paternal alleles. The new factor, BORIS, VerDate Aug<31>2005 16:16 Nov 21, 2007 Jkt 214001 shares with CTCF the same spectrum of DNA sequence specificity and it is normally expressed only in germ cells of human gonads (when patterns of gene imprinting are re-established), but not in CTCF-expressing somatic cells. Additionally, since cell-growth controlling CTCF has properties of a tumor suppressor gene, abnormal activation of BORIS upon cancerous transformation of somatic cells results in competition with the normal function of CTCF, thereby promoting tumor growth. The inventors found that antibodies against BORIS are present and can be detected in human blood serum taken from patients with cancer but not from healthy donors. Additionally, 14 new alternative splice forms of the BORIS polypeptide have been identified which show specificity to specific cancers, suggesting that circulating antibodies for specific BORIS splice variants in cancer patients can be associated with specific types or stages of malignant tumors. Therefore, BORIS can be used in both diagnostic and therapeutic arenas: First, mutations in BORIS genomic locus or detection of encoded by the BORIS locus mRNAs or polypeptides expressed in any tissue besides normal gonads may be indicative of a pre-cancerous or cancerous state thus serving a diagnostic and/or prognostic purpose; and, second, targeting of abnormally activated BORIS should serve as a novel therapeutic approach to treat cancer. BORIS Technology Can Have Three Major Applications 1. BORIS can be used as a therapeutic target for anti-cancer treatments. 2. BORIS expression can serve as a diagnostic marker for specific cancers other than testis. 3. Detection of antibodies against BORIS in blood serum samples can also be used as an indicator of pre-cancerous or cancerous condition existing. Competitive Advantage of Our Technology Cancer/testis (CT) genes, predominantly expressed in the testis (germ cells) and generally not in other normal tissues, are aberrantly expressed in human cancers. This highly restricted expression provides a unique opportunity to use these CT genes for diagnostics, immunotherapeutic, or other targeted therapies. BORIS is a newly described CT gene shown to be expressed in several cancers including lung, brain, uterine and endometrial among others and thus can be used as a novel diagnostic and therapeutic target. PO 00000 Frm 00059 Fmt 4703 Sfmt 4703 Patent Estate This technology consists of the following patents and patent applications: 1. U.S. Patent Application No. 10/ 505,377 filed October 20, 2004 and all foreign counterparts [E–227–2001/0– US–03]; 2. U.S. Patent Application No. 11/ 575,732 filed March 21, 2007 and all foreign counterparts [E–241–2004/0– US–04]; and 3. PCT Application No. PCT/US2007/ 7728 filed August 30, 2007 [E–117– 2006/0–PCT–02] Next Step: Teleconference There will be a teleconference where the principal investigator will explain this technology. Licensing and collaborative research opportunities will also be discussed. If you are interested in participating in this teleconference please call or e-mail Mojdeh Bahar; (301) 435–2950; baharm@mail.nih.gov. OTT will then e-mail you the date, time and number for the teleconference. Dated: November 9, 2007. Steven M. Ferguson, Director, Division of Technology Development and Transfer, Office of Technology Transfer, National Institutes of Health. [FR Doc. E7–22820 Filed 11–21–07; 8:45 am] BILLING CODE 4140–01–P DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Institute of Environmental Health Sciences; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. Appendix 2), notice is hereby given of the following meeting. The meeting will be closed to the public in accordance with the provisions set forth in sections 552b(c)(4) and 552b(c)(6). Title 5 U.S.C., as amended. The grant applications and the discussions could disclose confidential trade secrets or commercial property such as patentable material, and personal information concerning individuals associated with the grant applications, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. Name of Committee: National Institute of Environmental Health Sciences Special Emphasis Panel, Genetic Environmental Training. Date: November 27, 2007. Time: 8:30 a.m. to 5 p.m. E:\FR\FM\23NON1.SGM 23NON1 Federal Register / Vol. 72, No. 225 / Friday, November 23, 2007 / Notices Agenda: To review and evaluate grant applications. Place: Sheraton Imperial Hotel RTP, Sheraton Imperial Hotel, 4700 Emperor Blvd, Durham, NC 27703. Contact Person: Leroy Worth, Scientific Review Administrator, Scientific Review Branch, Division of Extramural Research and Training, Nat. Institute of Environmental Health Sciences, P.O. Box 12233, MD EC–30/ Room 3171, Research Triangle Park, NC 27709, 919/541–0670, worth@niehs.nih.gov. This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. (Catalogue of Federal Domestic Assistance Program Nos. 93.115, Biometry and Risk Estimation—Health Risks from Environmental Exposures; 93.142, NIEHS Hazardous Waste Worker Health and Safety Training; 93.143, NIEHS Superfund Hazardous Substances—Basic Research and Education; 93.894, Resources and Manpower Development in the Environmental Health Sciences; 93.113, Biological Response to Environmental Health Hazards; 93.114, Applied Toxicological Research and Testing, National Institutes of Health, HHS) Dated: November 14, 2007. Jennifer Spaeth, Director, Office of Federal Advisory Committee Policy. [FR Doc. 07–5779 Filed 11–21–07; 8:45 am] BILLING CODE 4140–01–M DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review; Notice of Closed Meeting mstockstill on PROD1PC66 with NOTICES Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. Appendix 2), notice is hereby given of the following meeting. The meeting will be closed to the public in accordance with the provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The grant applications and the discussions could disclose confidential trade secrets of commercial property such as patentable material, and personal information concerning individuals associated with the grant applications, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. Name of Committee: Center for Scientific Review Special Emphasis Panel, Endocrinology and Metabolism. Date: December 5, 2007. Time: 10 a.m. to 12 p.m. Agenda: To review and evaluate grant applications. Place: National Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892, (Telephone Conference Call). VerDate Aug<31>2005 16:16 Nov 21, 2007 Jkt 214001 Contact Person: Ann A. Jerkins, PhD, Scientific Review Administrator, Center for Scientific Review, National Institutes of Health, 6701 Rockledge Drive, Room 6154, MSC 7892, Bethesda, MD 20892, 301–435– 4514, jerkinsa@csr.nih.gov. (Catalogue of Federal Domestic Assistance Program Nos. 93.306, Comparative Medicine; 93.333, Clinical Research, 93.306, 93.333, 93.337, 93.393–93.396, 93.837–93.844, 93.846–93.878, 93.892, 93.893 National Institutes of Health, HHS) Dated: November 14, 2007. Jennifer Spaeth, Director, Office of Federal Advisory Committee Policy. [FR Doc. 07–5778 Filed 11–21–07; 8:45 am] BILLING CODE 4140–01–M DEPARTMENT OF HOMELAND SECURITY National Protection and Programs Directorate, Office of Infrastructure Protection, Submission for Review Chemical Security Assessment Tool (CSAT) Information Collection 1670– 0007 National Protection and Programs Directorate, DHS. ACTION: 60-Day Notice and request for comments: Revision of an existing information collection request 1670– 0007, DHS Forms 9010, 9002, 9007, 9012, and 9015. AGENCY: SUMMARY: The Department of Homeland Security, Office of the Under Secretary for National Protection and Programs Directorate, Office of Infrastructure Protection, Chemical Security Compliance Division (CSCD) has submitted the following information collection request (ICR) to the Office of Management and Budget (OMB) for review and clearance in accordance with the Paperwork Reduction Act of 1995. Comments are encouraged and will be accepted until January 22, 2008. This process is conducted in accordance with 5 CFR 1320.1. ADDRESSES: Comments and questions about this Information Collection Request should be forwarded to the Office of Infrastructure Protection, Attn: Matthew Bettridge, Department of Homeland Security, NPPD/OIP/CSCD Mail Stop 8100, DHS, Washington, DC 20528. FOR FURTHER INFORMATION CONTACT: Office of Infrastructure Protection, Attn: Matthew Bettridge, Department of Homeland Security, NPPD/OIP/CSCD Mail Stop 8100, DHS, Washington, DC 20528. DATES: PO 00000 Frm 00060 Fmt 4703 Sfmt 4703 65757 Section 550 of the Department of Homeland Security Appropriations Act of 2007, Pub. L. 109–295 (Section 550), directed the Department of Homeland Security to promulgate and enforce regulations to enhance the security of the nation’s high risk chemical facilities. On April 9, 2007, the Department issued an Interim Final Rule, implementing this statutory mandate. (72 FR 17688). Section 550 requires a risk-based approach to security. To facilitate this approach, the Department is employing a risk assessment methodology known as the Chemical Security Assessment Tool (CSAT). The CSAT is a series of public web-based computer applications: Help Desk, User Registration, Top-Screen, Security Vulnerability Assessment, Site Security Plan, and Chemical-terrorism Vulnerability Information (CVI) Authorization. All information collected supports the Department’s effort to reduce the risk of a successful terrorist attack against chemical facilities. These CSAT collections either directly or indirectly support the identification of high risk facilities, the determination of the risk tiers of the facilities, the review and approval of assessments and plans for security measures at the facilities, and/or the protection of Chemicalterrorism Vulnerability Information that would, if disclosed, substantially assist terrorists in planning and targeting the facilities. The Office of Management and Budget is particularly interested in comments which: 1. Evaluate whether the proposed collection of information is necessary for the proper performance of the functions of the agency, including whether the information will have practical utility; 2. Evaluate the accuracy of the agency’s estimate of the burden of the proposed collection of information, including the validity of the methodology and assumptions used; 3. Enhance the quality, utility, and clarity of the information to be collected; and 4. Minimize the burden of the collection of information on those who are to respond, including through the use of appropriate automated, electronic, mechanical, or other technological collection techniques or other forms of information technology, e.g., permitting electronic submissions of responses. SUPPLEMENTARY INFORMATION: Analysis Agency: Department of Homeland Security, Office of the Under Secretary for National Protection and Programs Directorate, Office of Infrastructure E:\FR\FM\23NON1.SGM 23NON1

Agencies

[Federal Register Volume 72, Number 225 (Friday, November 23, 2007)]
[Notices]
[Pages 65756-65757]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: 07-5779]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


National Institute of Environmental Health Sciences; Notice of 
Closed Meeting

    Pursuant to section 10(d) of the Federal Advisory Committee Act, as 
amended (5 U.S.C. Appendix 2), notice is hereby given of the following 
meeting.
    The meeting will be closed to the public in accordance with the 
provisions set forth in sections 552b(c)(4) and 552b(c)(6). Title 5 
U.S.C., as amended. The grant applications and the discussions could 
disclose confidential trade secrets or commercial property such as 
patentable material, and personal information concerning individuals 
associated with the grant applications, the disclosure of which would 
constitute a clearly unwarranted invasion of personal privacy.

    Name of Committee: National Institute of Environmental Health 
Sciences Special Emphasis Panel, Genetic Environmental Training.
    Date: November 27, 2007.
    Time: 8:30 a.m. to 5 p.m.

[[Page 65757]]

    Agenda: To review and evaluate grant applications.
    Place: Sheraton Imperial Hotel RTP, Sheraton Imperial Hotel, 
4700 Emperor Blvd, Durham, NC 27703.
    Contact Person: Leroy Worth, Scientific Review Administrator, 
Scientific Review Branch, Division of Extramural Research and 
Training, Nat. Institute of Environmental Health Sciences, P.O. Box 
12233, MD EC-30/Room 3171, Research Triangle Park, NC 27709, 919/
541-0670, worth@niehs.nih.gov.
    This notice is being published less than 15 days prior to the 
meeting due to the timing limitations imposed by the review and 
funding cycle.

(Catalogue of Federal Domestic Assistance Program Nos. 93.115, 
Biometry and Risk Estimation--Health Risks from Environmental 
Exposures; 93.142, NIEHS Hazardous Waste Worker Health and Safety 
Training; 93.143, NIEHS Superfund Hazardous Substances--Basic 
Research and Education; 93.894, Resources and Manpower Development 
in the Environmental Health Sciences; 93.113, Biological Response to 
Environmental Health Hazards; 93.114, Applied Toxicological Research 
and Testing, National Institutes of Health, HHS)

    Dated: November 14, 2007.
Jennifer Spaeth,
Director, Office of Federal Advisory Committee Policy.
[FR Doc. 07-5779 Filed 11-21-07; 8:45 am]
BILLING CODE 4140-01-M

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