Proposed Collection; Comment Request; NICHD Research Partner Satisfaction Surveys, 60380-60381 [E7-20910]
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Federal Register / Vol. 72, No. 205 / Wednesday, October 24, 2007 / Notices
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individuals with HIV/AIDS identified
and eligible under Title XXVI of the
Number of
respondents
Application
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respondent
PHS Act in the service area within 30
days.
The estimated annual burden is as
follows:
Total
responses
Hours per
response
Total
burden hours
Waiver Request ...............................................
20
1
20
6.5
130
Total ..........................................................
20
............................
20
............................
130
Send comments to Susan G. Queen,
Ph.D., HRSA Reports Clearance Officer,
Room 10–33, Parklawn Building, 5600
Fishers Lane, Rockville, MD 20857.
Written comments should be received
within 60 days of this notice.
Dated: October 18, 2007.
Alexandra Huttinger,
Acting Director, Division of Policy Review
and Coordination.
[FR Doc. E7–20945 Filed 10–23–07; 8:45 am]
BILLING CODE 4165–15–P
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
Proposed Collection; Comment
Request; NICHD Research Partner
Satisfaction Surveys
yshivers on PROD1PC62 with NOTICES
SUMMARY: Under the provisions of
Section 3507(a)(1)(D) of the Paperwork
Reduction Act of 1995, the National
Institute of Child Health and Human
Development (NICHD), the National
Institutes of Health (NIH), has submitted
to the Office of Management and Budget
(OMB) a request to review and approve
the information collection listed below.
The proposed information collection
was previously published in the Federal
Register on July 25, 2007, in Volume 72,
No. 142, pages 40887–40888, and
allowed 60 days for public comment. No
public comments were received. The
purpose of this notice is to allow an
additional 30 days for public comment.
The NIH may not conduct or sponsor,
and the respondent is not required to
respond to, an information collection
that has been extended, revised, or
implemented after October 1, 1995,
unless it displays a currently valid OMB
control number.
Proposed Collection: Title: NICHD
Research Partner Satisfaction Surveys.
Type of Information Collection Request:
Extension without change. Need and
Use of Information Collection: Executive
Order 12862 directs agencies that
provide significant services directly to
the public to survey customers to
determine the kind and quality of
services they want and their level of
satisfaction with existing services. With
this submission, the NICHD seeks to
obtain OMB’s generic approval to
conduct customer satisfaction surveys
surrounding its research programs and
activities.
The NICHD was founded in 1963. Its
mission is to ensure, through research,
the birth of healthy infants and the
opportunity for each to reach full
potential in adulthood, unimpaired by
physical or mental disabilities. The
NICHD conducts and supports research
on the many factors that protect and
enhance the process of human growth
and development. The developmental
focus of the NICHD means that its
research portfolio is unusually broad.
NICHD programs include research on
infant mortality, birth defects, learning
disorders, developmental disabilities,
vaccine development, and demographic
and behavioral sciences, among others.
In addition to supporting basic research,
clinical trials, and epidemiological
studies that explore health processes,
the NICHD forms partnerships with
organizations or institutions to ensure
effective use of scientific findings and
research products.
The NICHD utilizes strategic
assessments to support Institute
planning and policy development, and
to help determine programmatic and
scientific objectives and priorities.
Research partner surveys will augment
NICHD’s ongoing efforts to assess
research-related activities. The two
principal objectives are: (1) To measure
the personal satisfaction of research
Estimated
number of
respondents
Type of
respondents
Web-based .....................................................................................................
Telephone ......................................................................................................
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15:33 Oct 23, 2007
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Sfmt 4703
partners with NICHD programs or
initiatives, including both
responsiveness to scientific aims and
convenience of operations to support
research and its effective use; and (2) to
learn from research partners the ways in
which the NICHD can improve the
overall planning and management of it
programs and initiatives. Findings will
be used to improve NICHD’s research
programs and initiatives in the
following ways: (1) To assess the
effectiveness and efficiency of
operations; (2) to identify opportunities
for improving program performance; (3)
to develop plans to incorporate
innovations in program management; (4)
to measure partner satisfaction and
document program outcomes for
governmental accountability reporting;
and (5) to identify the need for creating
new programs or initiatives or
restructuring existing ones to respond to
emerging scientific opportunities.
Frequency of Response: Annual [As
needed on an ongoing and concurrent
basis]. Affected Public: Members of the
public, researchers, practitioners, and
other health professionals. Type of
Respondents: Members of the public;
eligible grant applicants and actual
applicants (both successful and
unsuccessful); clinicians and other
health professionals; and actual or
potential clinical trials participants. The
annual reporting burden is as follows:
Estimated Number of Respondents:
28,000; Estimated Number of Responses
per Respondent: 1; Average Burden
Hours per Response: Varies with survey
type, see below; and Estimated Total
Annual Burden Hours Requested: 5,883.
The annualized cost to respondents is
estimated at: $109,541.46. There are no
Capital Costs to report. There are no
Operating or Maintenance Costs to
report.
Estimated
number of responses per
respondent
Average burden
hours per
response
Estimated total
annual burden
hours
requested
1
1
0.167
0.50
4,008.00
1,000.00
24,000
2,000
E:\FR\FM\24OCN1.SGM
24OCN1
60381
Federal Register / Vol. 72, No. 205 / Wednesday, October 24, 2007 / Notices
Estimated
number of
respondents
Type of
respondents
Paper .............................................................................................................
In-person ........................................................................................................
1,500
500
Total ........................................................................................................
Average burden
hours per
response
28,000
Request for Comments: Written
comments and/or suggestions from the
public and affected agencies are invited
on one or more of the following points:
(1) Whether the proposed collection of
information is necessary for the proper
performance of the function of the
agency, including whether the
information will have practical utility;
(2) The accuracy of the agency’s
estimate of the burden of the proposed
collection of information, including the
validity of the methodology and
assumptions used; (3) Ways to enhance
the quality, utility, and clarity of the
information to be collected; and (4)
Ways to minimize the burden of the
collection of information on those who
are to respond, including the use of
appropriate automated, electronic,
mechanical, or other technological
collection techniques or other forms of
information technology.
FOR FURTHER INFORMATION: To request
more information on the proposed
project, contact Paul L. Johnson, NIH
NICHD Office of Science Policy,
Analysis and Communication (OSPAC),
9000 Rockville Pike, Bldg. 31, Rm. 2A–
18, Bethesda, Maryland 20892–2425, or
call non-toll-free at 301–402–3213. You
may also e-mail your request to
pjohnson@mail.nih.gov.
Comments Due Date: Comments
regarding this information collection are
best assured of having their full effect if
received within 30 days of the date of
this publication.
Dated: October 17, 2007.
Paul L. Johnson,
Project Clearance Liaison, NICHD National
Institutes of Health.
[FR Doc. E7–20910 Filed 10–23–07; 8:45 am]
BILLING CODE 4140–01–P
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
yshivers on PROD1PC62 with NOTICES
Estimated
number of responses per
respondent
Government-Owned Inventions;
Availability for Licensing
National Institutes of Health,
Public Health Service, HHS.
ACTION: Notice.
AGENCY:
VerDate Aug<31>2005
15:33 Oct 23, 2007
Jkt 214001
SUMMARY: The inventions listed below
are owned by an agency of the U.S.
Government and are available for
licensing in the U.S. in accordance with
35 U.S.C. 207 to achieve expeditious
commercialization of results of
federally-funded research and
development. Foreign patent
applications are filed on selected
inventions to extend market coverage
for companies and may also be available
for licensing.
ADDRESSES: Licensing information and
copies of the U.S. patent applications
listed below may be obtained by writing
to the indicated licensing contact at the
Office of Technology Transfer, National
Institutes of Health, 6011 Executive
Boulevard, Suite 325, Rockville,
Maryland 20852–3804; telephone: 301/
496–7057; fax: 301/402–0220. A signed
Confidential Disclosure Agreement will
be required to receive copies of the
patent applications.
Novel Micro-RNA Sequence
Transforms Non-Functional TLymphocytes to Highly Functional: Key
to Improved Immunotherapy for the
Treatment of Cancers
Description of Technology: This
technology is directed to the therapeutic
use of microRNA-181a in the adoptive
immunotherapy of cancer.
The adoptive transfer of anti-tumor T
cells after a lymphodepleting regimen
can result in the regression of metastatic
cancer both in mouse and human, but
the production of highly-reactive,
tumor-specific T cells still represents a
barrier to broad implementation of T
cell-based immunotherapies. This
technology enables the use of microRNA
(miR)-181a, a recently identified
intrinsic modulator of T-cell receptor
(TCR) signaling, to improve anti-tumor
T cell responsiveness. Micro-RNAs are
short RNA molecules that regulate the
activity of genes and appear to control
biological processes.
We found that genetic engineering of
T lymphocytes with miR-181a
dramatically augmented the function of
poorly responsive human tumorinfiltrating lymphocytes and TCRengineered peripheral blood
lymphocytes, resulting in potent antitumor reactivity. Furthermore, in a
PO 00000
Frm 00072
Fmt 4703
Sfmt 4703
1
1
0.25
1.00
Estimated total
annual burden
hours
requested
375.00
500.00
5,883.00
mouse model, miR-181a increased the
function of self/tumor-specific CD8+ T
cells enabling effective tumor
destruction in the absence of
vaccination or exogenous cytokines that
were otherwise essential requirements.
This technology is the first reported use
of a miRNA gene as tool in the treatment
of disease.
Applications: The microRNA
sequence (‘‘miR-181a’’) can be used to
enhance the tumor recognizing capacity
of T-lymphocytes against several
tumors.
This technology can be used for
selective treatment of several cancers
more effectively.
Advantages: Proof-of concept preclinical data are available and clinical
trials are currently being planned.
This technology is based on adoptive
immunotherapy, which is now an
accepted and effective form of cancer
treatment.
Benefits: The microRNA identified
has the potential to broaden and
enhance the scope of adoptive
immunotherapy.
Development Status: Pre-clinical work
has been completed and clinical studies
are forthcoming.
Inventors: Dr. Nicholas P. Restifo et al.
(NCI).
Relevant Publication: Q Li et al. miR181a is an intrinsic modulator of T cell
sensitivity and selection. Cell. 2007 Apr
6;129(1):147–161.
Patent Status: U.S. Provisional
Application filed 25 May 2007 (HHS
Reference No. E–224–2007/0–US–01).
Licensing Status: This technology is
available for licensing under an
exclusive or non-exclusive patent
license.
Licensing Contact: Michelle A.
Booden, PhD; 301/451–7337;
boodenm@mail.nih.gov.
Collaborative Research Opportunity:
The Surgery Branch of the National
Cancer Institute is seeking statements of
capability or interest from parties
interested in collaborative research to
further develop, evaluate, or
commercialize the therapeutic use of
microRNA-181a in the adoptive
immunotherapy of cancer. Please
contact John D. Hewes, PhD at 301–435–
3121 or hewesj@mail.nih.gov for more
information.
E:\FR\FM\24OCN1.SGM
24OCN1
Agencies
[Federal Register Volume 72, Number 205 (Wednesday, October 24, 2007)]
[Notices]
[Pages 60380-60381]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: E7-20910]
-----------------------------------------------------------------------
DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health
Proposed Collection; Comment Request; NICHD Research Partner
Satisfaction Surveys
SUMMARY: Under the provisions of Section 3507(a)(1)(D) of the Paperwork
Reduction Act of 1995, the National Institute of Child Health and Human
Development (NICHD), the National Institutes of Health (NIH), has
submitted to the Office of Management and Budget (OMB) a request to
review and approve the information collection listed below. The
proposed information collection was previously published in the Federal
Register on July 25, 2007, in Volume 72, No. 142, pages 40887-40888,
and allowed 60 days for public comment. No public comments were
received. The purpose of this notice is to allow an additional 30 days
for public comment. The NIH may not conduct or sponsor, and the
respondent is not required to respond to, an information collection
that has been extended, revised, or implemented after October 1, 1995,
unless it displays a currently valid OMB control number.
Proposed Collection: Title: NICHD Research Partner Satisfaction
Surveys. Type of Information Collection Request: Extension without
change. Need and Use of Information Collection: Executive Order 12862
directs agencies that provide significant services directly to the
public to survey customers to determine the kind and quality of
services they want and their level of satisfaction with existing
services. With this submission, the NICHD seeks to obtain OMB's generic
approval to conduct customer satisfaction surveys surrounding its
research programs and activities.
The NICHD was founded in 1963. Its mission is to ensure, through
research, the birth of healthy infants and the opportunity for each to
reach full potential in adulthood, unimpaired by physical or mental
disabilities. The NICHD conducts and supports research on the many
factors that protect and enhance the process of human growth and
development. The developmental focus of the NICHD means that its
research portfolio is unusually broad. NICHD programs include research
on infant mortality, birth defects, learning disorders, developmental
disabilities, vaccine development, and demographic and behavioral
sciences, among others. In addition to supporting basic research,
clinical trials, and epidemiological studies that explore health
processes, the NICHD forms partnerships with organizations or
institutions to ensure effective use of scientific findings and
research products.
The NICHD utilizes strategic assessments to support Institute
planning and policy development, and to help determine programmatic and
scientific objectives and priorities. Research partner surveys will
augment NICHD's ongoing efforts to assess research-related activities.
The two principal objectives are: (1) To measure the personal
satisfaction of research partners with NICHD programs or initiatives,
including both responsiveness to scientific aims and convenience of
operations to support research and its effective use; and (2) to learn
from research partners the ways in which the NICHD can improve the
overall planning and management of it programs and initiatives.
Findings will be used to improve NICHD's research programs and
initiatives in the following ways: (1) To assess the effectiveness and
efficiency of operations; (2) to identify opportunities for improving
program performance; (3) to develop plans to incorporate innovations in
program management; (4) to measure partner satisfaction and document
program outcomes for governmental accountability reporting; and (5) to
identify the need for creating new programs or initiatives or
restructuring existing ones to respond to emerging scientific
opportunities.
Frequency of Response: Annual [As needed on an ongoing and
concurrent basis]. Affected Public: Members of the public, researchers,
practitioners, and other health professionals. Type of Respondents:
Members of the public; eligible grant applicants and actual applicants
(both successful and unsuccessful); clinicians and other health
professionals; and actual or potential clinical trials participants.
The annual reporting burden is as follows: Estimated Number of
Respondents: 28,000; Estimated Number of Responses per Respondent: 1;
Average Burden Hours per Response: Varies with survey type, see below;
and Estimated Total Annual Burden Hours Requested: 5,883. The
annualized cost to respondents is estimated at: $109,541.46. There are
no Capital Costs to report. There are no Operating or Maintenance Costs
to report.
----------------------------------------------------------------------------------------------------------------
Estimated number of Estimated total
Type of respondents Estimated number of responses per Average burden hours annual burden
respondents respondent per response hours requested
----------------------------------------------------------------------------------------------------------------
Web-based 24,000 1 0.167 4,008.00
Telephone 2,000 1 0.50 1,000.00
[[Page 60381]]
Paper 1,500 1 0.25 375.00
In-person 500 1 1.00 500.00
-----------------------------------------------------------------------------------------
Total............. 28,000 ...................... ...................... 5,883.00
----------------------------------------------------------------------------------------------------------------
Request for Comments: Written comments and/or suggestions from the
public and affected agencies are invited on one or more of the
following points: (1) Whether the proposed collection of information is
necessary for the proper performance of the function of the agency,
including whether the information will have practical utility; (2) The
accuracy of the agency's estimate of the burden of the proposed
collection of information, including the validity of the methodology
and assumptions used; (3) Ways to enhance the quality, utility, and
clarity of the information to be collected; and (4) Ways to minimize
the burden of the collection of information on those who are to
respond, including the use of appropriate automated, electronic,
mechanical, or other technological collection techniques or other forms
of information technology.
FOR FURTHER INFORMATION: To request more information on the proposed
project, contact Paul L. Johnson, NIH NICHD Office of Science Policy,
Analysis and Communication (OSPAC), 9000 Rockville Pike, Bldg. 31, Rm.
2A-18, Bethesda, Maryland 20892-2425, or call non-toll-free at 301-402-
3213. You may also e-mail your request to pjohnson@mail.nih.gov.
Comments Due Date: Comments regarding this information collection
are best assured of having their full effect if received within 30 days
of the date of this publication.
Dated: October 17, 2007.
Paul L. Johnson,
Project Clearance Liaison, NICHD National Institutes of Health.
[FR Doc. E7-20910 Filed 10-23-07; 8:45 am]
BILLING CODE 4140-01-P