Proposed Collection; Comment Request; NICHD Research Partner Satisfaction Surveys, 60380-60381 [E7-20910]

Download as PDF 60380 Federal Register / Vol. 72, No. 205 / Wednesday, October 24, 2007 / Notices Grantees must provide evidence that all of the core medical services listed in the statute, regardless of whether such services are funded by the Ryan White HIV/AIDS Program, are available to all individuals with HIV/AIDS identified and eligible under Title XXVI of the Number of respondents Application Responses per respondent PHS Act in the service area within 30 days. The estimated annual burden is as follows: Total responses Hours per response Total burden hours Waiver Request ............................................... 20 1 20 6.5 130 Total .......................................................... 20 ............................ 20 ............................ 130 Send comments to Susan G. Queen, Ph.D., HRSA Reports Clearance Officer, Room 10–33, Parklawn Building, 5600 Fishers Lane, Rockville, MD 20857. Written comments should be received within 60 days of this notice. Dated: October 18, 2007. Alexandra Huttinger, Acting Director, Division of Policy Review and Coordination. [FR Doc. E7–20945 Filed 10–23–07; 8:45 am] BILLING CODE 4165–15–P DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Proposed Collection; Comment Request; NICHD Research Partner Satisfaction Surveys yshivers on PROD1PC62 with NOTICES SUMMARY: Under the provisions of Section 3507(a)(1)(D) of the Paperwork Reduction Act of 1995, the National Institute of Child Health and Human Development (NICHD), the National Institutes of Health (NIH), has submitted to the Office of Management and Budget (OMB) a request to review and approve the information collection listed below. The proposed information collection was previously published in the Federal Register on July 25, 2007, in Volume 72, No. 142, pages 40887–40888, and allowed 60 days for public comment. No public comments were received. The purpose of this notice is to allow an additional 30 days for public comment. The NIH may not conduct or sponsor, and the respondent is not required to respond to, an information collection that has been extended, revised, or implemented after October 1, 1995, unless it displays a currently valid OMB control number. Proposed Collection: Title: NICHD Research Partner Satisfaction Surveys. Type of Information Collection Request: Extension without change. Need and Use of Information Collection: Executive Order 12862 directs agencies that provide significant services directly to the public to survey customers to determine the kind and quality of services they want and their level of satisfaction with existing services. With this submission, the NICHD seeks to obtain OMB’s generic approval to conduct customer satisfaction surveys surrounding its research programs and activities. The NICHD was founded in 1963. Its mission is to ensure, through research, the birth of healthy infants and the opportunity for each to reach full potential in adulthood, unimpaired by physical or mental disabilities. The NICHD conducts and supports research on the many factors that protect and enhance the process of human growth and development. The developmental focus of the NICHD means that its research portfolio is unusually broad. NICHD programs include research on infant mortality, birth defects, learning disorders, developmental disabilities, vaccine development, and demographic and behavioral sciences, among others. In addition to supporting basic research, clinical trials, and epidemiological studies that explore health processes, the NICHD forms partnerships with organizations or institutions to ensure effective use of scientific findings and research products. The NICHD utilizes strategic assessments to support Institute planning and policy development, and to help determine programmatic and scientific objectives and priorities. Research partner surveys will augment NICHD’s ongoing efforts to assess research-related activities. The two principal objectives are: (1) To measure the personal satisfaction of research Estimated number of respondents Type of respondents Web-based ..................................................................................................... Telephone ...................................................................................................... VerDate Aug<31>2005 15:33 Oct 23, 2007 Jkt 214001 PO 00000 Frm 00071 Fmt 4703 Sfmt 4703 partners with NICHD programs or initiatives, including both responsiveness to scientific aims and convenience of operations to support research and its effective use; and (2) to learn from research partners the ways in which the NICHD can improve the overall planning and management of it programs and initiatives. Findings will be used to improve NICHD’s research programs and initiatives in the following ways: (1) To assess the effectiveness and efficiency of operations; (2) to identify opportunities for improving program performance; (3) to develop plans to incorporate innovations in program management; (4) to measure partner satisfaction and document program outcomes for governmental accountability reporting; and (5) to identify the need for creating new programs or initiatives or restructuring existing ones to respond to emerging scientific opportunities. Frequency of Response: Annual [As needed on an ongoing and concurrent basis]. Affected Public: Members of the public, researchers, practitioners, and other health professionals. Type of Respondents: Members of the public; eligible grant applicants and actual applicants (both successful and unsuccessful); clinicians and other health professionals; and actual or potential clinical trials participants. The annual reporting burden is as follows: Estimated Number of Respondents: 28,000; Estimated Number of Responses per Respondent: 1; Average Burden Hours per Response: Varies with survey type, see below; and Estimated Total Annual Burden Hours Requested: 5,883. The annualized cost to respondents is estimated at: $109,541.46. There are no Capital Costs to report. There are no Operating or Maintenance Costs to report. Estimated number of responses per respondent Average burden hours per response Estimated total annual burden hours requested 1 1 0.167 0.50 4,008.00 1,000.00 24,000 2,000 E:\FR\FM\24OCN1.SGM 24OCN1 60381 Federal Register / Vol. 72, No. 205 / Wednesday, October 24, 2007 / Notices Estimated number of respondents Type of respondents Paper ............................................................................................................. In-person ........................................................................................................ 1,500 500 Total ........................................................................................................ Average burden hours per response 28,000 Request for Comments: Written comments and/or suggestions from the public and affected agencies are invited on one or more of the following points: (1) Whether the proposed collection of information is necessary for the proper performance of the function of the agency, including whether the information will have practical utility; (2) The accuracy of the agency’s estimate of the burden of the proposed collection of information, including the validity of the methodology and assumptions used; (3) Ways to enhance the quality, utility, and clarity of the information to be collected; and (4) Ways to minimize the burden of the collection of information on those who are to respond, including the use of appropriate automated, electronic, mechanical, or other technological collection techniques or other forms of information technology. FOR FURTHER INFORMATION: To request more information on the proposed project, contact Paul L. Johnson, NIH NICHD Office of Science Policy, Analysis and Communication (OSPAC), 9000 Rockville Pike, Bldg. 31, Rm. 2A– 18, Bethesda, Maryland 20892–2425, or call non-toll-free at 301–402–3213. You may also e-mail your request to pjohnson@mail.nih.gov. Comments Due Date: Comments regarding this information collection are best assured of having their full effect if received within 30 days of the date of this publication. Dated: October 17, 2007. Paul L. Johnson, Project Clearance Liaison, NICHD National Institutes of Health. [FR Doc. E7–20910 Filed 10–23–07; 8:45 am] BILLING CODE 4140–01–P DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health yshivers on PROD1PC62 with NOTICES Estimated number of responses per respondent Government-Owned Inventions; Availability for Licensing National Institutes of Health, Public Health Service, HHS. ACTION: Notice. AGENCY: VerDate Aug<31>2005 15:33 Oct 23, 2007 Jkt 214001 SUMMARY: The inventions listed below are owned by an agency of the U.S. Government and are available for licensing in the U.S. in accordance with 35 U.S.C. 207 to achieve expeditious commercialization of results of federally-funded research and development. Foreign patent applications are filed on selected inventions to extend market coverage for companies and may also be available for licensing. ADDRESSES: Licensing information and copies of the U.S. patent applications listed below may be obtained by writing to the indicated licensing contact at the Office of Technology Transfer, National Institutes of Health, 6011 Executive Boulevard, Suite 325, Rockville, Maryland 20852–3804; telephone: 301/ 496–7057; fax: 301/402–0220. A signed Confidential Disclosure Agreement will be required to receive copies of the patent applications. Novel Micro-RNA Sequence Transforms Non-Functional TLymphocytes to Highly Functional: Key to Improved Immunotherapy for the Treatment of Cancers Description of Technology: This technology is directed to the therapeutic use of microRNA-181a in the adoptive immunotherapy of cancer. The adoptive transfer of anti-tumor T cells after a lymphodepleting regimen can result in the regression of metastatic cancer both in mouse and human, but the production of highly-reactive, tumor-specific T cells still represents a barrier to broad implementation of T cell-based immunotherapies. This technology enables the use of microRNA (miR)-181a, a recently identified intrinsic modulator of T-cell receptor (TCR) signaling, to improve anti-tumor T cell responsiveness. Micro-RNAs are short RNA molecules that regulate the activity of genes and appear to control biological processes. We found that genetic engineering of T lymphocytes with miR-181a dramatically augmented the function of poorly responsive human tumorinfiltrating lymphocytes and TCRengineered peripheral blood lymphocytes, resulting in potent antitumor reactivity. Furthermore, in a PO 00000 Frm 00072 Fmt 4703 Sfmt 4703 1 1 0.25 1.00 Estimated total annual burden hours requested 375.00 500.00 5,883.00 mouse model, miR-181a increased the function of self/tumor-specific CD8+ T cells enabling effective tumor destruction in the absence of vaccination or exogenous cytokines that were otherwise essential requirements. This technology is the first reported use of a miRNA gene as tool in the treatment of disease. Applications: The microRNA sequence (‘‘miR-181a’’) can be used to enhance the tumor recognizing capacity of T-lymphocytes against several tumors. This technology can be used for selective treatment of several cancers more effectively. Advantages: Proof-of concept preclinical data are available and clinical trials are currently being planned. This technology is based on adoptive immunotherapy, which is now an accepted and effective form of cancer treatment. Benefits: The microRNA identified has the potential to broaden and enhance the scope of adoptive immunotherapy. Development Status: Pre-clinical work has been completed and clinical studies are forthcoming. Inventors: Dr. Nicholas P. Restifo et al. (NCI). Relevant Publication: Q Li et al. miR181a is an intrinsic modulator of T cell sensitivity and selection. Cell. 2007 Apr 6;129(1):147–161. Patent Status: U.S. Provisional Application filed 25 May 2007 (HHS Reference No. E–224–2007/0–US–01). Licensing Status: This technology is available for licensing under an exclusive or non-exclusive patent license. Licensing Contact: Michelle A. Booden, PhD; 301/451–7337; boodenm@mail.nih.gov. Collaborative Research Opportunity: The Surgery Branch of the National Cancer Institute is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize the therapeutic use of microRNA-181a in the adoptive immunotherapy of cancer. Please contact John D. Hewes, PhD at 301–435– 3121 or hewesj@mail.nih.gov for more information. E:\FR\FM\24OCN1.SGM 24OCN1

Agencies

[Federal Register Volume 72, Number 205 (Wednesday, October 24, 2007)]
[Notices]
[Pages 60380-60381]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: E7-20910]


-----------------------------------------------------------------------

DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Proposed Collection; Comment Request; NICHD Research Partner 
Satisfaction Surveys

SUMMARY: Under the provisions of Section 3507(a)(1)(D) of the Paperwork 
Reduction Act of 1995, the National Institute of Child Health and Human 
Development (NICHD), the National Institutes of Health (NIH), has 
submitted to the Office of Management and Budget (OMB) a request to 
review and approve the information collection listed below. The 
proposed information collection was previously published in the Federal 
Register on July 25, 2007, in Volume 72, No. 142, pages 40887-40888, 
and allowed 60 days for public comment. No public comments were 
received. The purpose of this notice is to allow an additional 30 days 
for public comment. The NIH may not conduct or sponsor, and the 
respondent is not required to respond to, an information collection 
that has been extended, revised, or implemented after October 1, 1995, 
unless it displays a currently valid OMB control number.
    Proposed Collection: Title: NICHD Research Partner Satisfaction 
Surveys. Type of Information Collection Request: Extension without 
change. Need and Use of Information Collection: Executive Order 12862 
directs agencies that provide significant services directly to the 
public to survey customers to determine the kind and quality of 
services they want and their level of satisfaction with existing 
services. With this submission, the NICHD seeks to obtain OMB's generic 
approval to conduct customer satisfaction surveys surrounding its 
research programs and activities.
    The NICHD was founded in 1963. Its mission is to ensure, through 
research, the birth of healthy infants and the opportunity for each to 
reach full potential in adulthood, unimpaired by physical or mental 
disabilities. The NICHD conducts and supports research on the many 
factors that protect and enhance the process of human growth and 
development. The developmental focus of the NICHD means that its 
research portfolio is unusually broad. NICHD programs include research 
on infant mortality, birth defects, learning disorders, developmental 
disabilities, vaccine development, and demographic and behavioral 
sciences, among others. In addition to supporting basic research, 
clinical trials, and epidemiological studies that explore health 
processes, the NICHD forms partnerships with organizations or 
institutions to ensure effective use of scientific findings and 
research products.
    The NICHD utilizes strategic assessments to support Institute 
planning and policy development, and to help determine programmatic and 
scientific objectives and priorities. Research partner surveys will 
augment NICHD's ongoing efforts to assess research-related activities. 
The two principal objectives are: (1) To measure the personal 
satisfaction of research partners with NICHD programs or initiatives, 
including both responsiveness to scientific aims and convenience of 
operations to support research and its effective use; and (2) to learn 
from research partners the ways in which the NICHD can improve the 
overall planning and management of it programs and initiatives. 
Findings will be used to improve NICHD's research programs and 
initiatives in the following ways: (1) To assess the effectiveness and 
efficiency of operations; (2) to identify opportunities for improving 
program performance; (3) to develop plans to incorporate innovations in 
program management; (4) to measure partner satisfaction and document 
program outcomes for governmental accountability reporting; and (5) to 
identify the need for creating new programs or initiatives or 
restructuring existing ones to respond to emerging scientific 
opportunities.
    Frequency of Response: Annual [As needed on an ongoing and 
concurrent basis]. Affected Public: Members of the public, researchers, 
practitioners, and other health professionals. Type of Respondents: 
Members of the public; eligible grant applicants and actual applicants 
(both successful and unsuccessful); clinicians and other health 
professionals; and actual or potential clinical trials participants. 
The annual reporting burden is as follows: Estimated Number of 
Respondents: 28,000; Estimated Number of Responses per Respondent: 1; 
Average Burden Hours per Response: Varies with survey type, see below; 
and Estimated Total Annual Burden Hours Requested: 5,883. The 
annualized cost to respondents is estimated at: $109,541.46. There are 
no Capital Costs to report. There are no Operating or Maintenance Costs 
to report.

 
----------------------------------------------------------------------------------------------------------------
                                                  Estimated number of                            Estimated total
  Type of respondents     Estimated number of        responses per       Average burden hours     annual burden
                              respondents             respondent             per response       hours  requested
----------------------------------------------------------------------------------------------------------------
         Web-based                  24,000                   1                       0.167      4,008.00
         Telephone                   2,000                   1                        0.50      1,000.00

[[Page 60381]]

 
             Paper                   1,500                   1                        0.25        375.00
         In-person                     500                   1                        1.00        500.00
                       -----------------------------------------------------------------------------------------
    Total.............              28,000      ......................  ......................  5,883.00
----------------------------------------------------------------------------------------------------------------

    Request for Comments: Written comments and/or suggestions from the 
public and affected agencies are invited on one or more of the 
following points: (1) Whether the proposed collection of information is 
necessary for the proper performance of the function of the agency, 
including whether the information will have practical utility; (2) The 
accuracy of the agency's estimate of the burden of the proposed 
collection of information, including the validity of the methodology 
and assumptions used; (3) Ways to enhance the quality, utility, and 
clarity of the information to be collected; and (4) Ways to minimize 
the burden of the collection of information on those who are to 
respond, including the use of appropriate automated, electronic, 
mechanical, or other technological collection techniques or other forms 
of information technology.

FOR FURTHER INFORMATION: To request more information on the proposed 
project, contact Paul L. Johnson, NIH NICHD Office of Science Policy, 
Analysis and Communication (OSPAC), 9000 Rockville Pike, Bldg. 31, Rm. 
2A-18, Bethesda, Maryland 20892-2425, or call non-toll-free at 301-402-
3213. You may also e-mail your request to pjohnson@mail.nih.gov.
    Comments Due Date: Comments regarding this information collection 
are best assured of having their full effect if received within 30 days 
of the date of this publication.

    Dated: October 17, 2007.
Paul L. Johnson,
Project Clearance Liaison, NICHD National Institutes of Health.
[FR Doc. E7-20910 Filed 10-23-07; 8:45 am]
BILLING CODE 4140-01-P
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