Prospective Grant of Exclusive License: Adult Human Dental Pulp Stem Cells, Postnatal Stem Cells, and Multipotent Postnatal Stem Cells From Human Periodontal Ligament, 58863-58864 [E7-20520]

Download as PDF Federal Register / Vol. 72, No. 200 / Wednesday, October 17, 2007 / Notices relevance for patients in whom this cell population has been significantly reduced by HIV/AIDS or other conditions resulting in immunodeficiency. The proliferation of isolated CD4+ T cells can be induced through direct contact with TSLP or a nucleic acid encoding TSLP. The patent application also describes methods of inducing or enhancing an immune response through administration of CD4+ T cells that have been isolated and induced to proliferate using TSLP or a nucleic acid encoding TSLP. TSLPR knockout mice are also described in the patent application and available for licensing through a biological materials license agreement. Applications: Immunotherapy. Development Status: Animal (mouse) data available. Inventor: Warren J. Leonard et al. (NHLBI). Patent Status: U.S. Provisional Application No. 60/555,898 filed 23 Mar 2004 (HHS Reference No. E–104–2004/ 0–US–01); U.S. Utility Application No. 11/762,357 filed 13 June 2007 (HHS Reference No. E–104–2004/1–US–02). Licensing Status: Available for licensing. Licensing Contact: Susan Ano, Ph.D.; 301/435–5515; anos@mail.nih.gov. sroberts on PROD1PC70 with NOTICES Retrovirus-Like Particles as Vaccines and Immunogens Description of Technology: This technology describes retrovirus-like particles and their production from retroviral constructs in which the gene encoding of all but seven amino acids of the nucleocapsid (NC) protein was deleted. NC is critical for both genomic RNA packaging into the virion and viral integration into the host cell. Therefore, this deletion functionally eliminates two essential steps in retrovirus replication, thereby resulting in noninfectious retrovirus-like particles that maintain their full complement of antigenic proteins. Furthermore, efficient formation of these particles requires inhibition of the protease enzymatic activity, either by mutation to the protease gene in the construct or by protease inhibitor thereby ensuring the production of non-infectious retroviruslike particles by altering two independent targets. These particles can be used in vaccines or immunogenic compositions. Specific examples using HIV–1 constructs are given. Applications: Retroviral vaccine; Immunogenic compositions. Development Status: In vitro data available. Inventor: David E. Ott (NCI). Publications: VerDate Aug<31>2005 19:05 Oct 16, 2007 Jkt 214001 1. DE Ott et al. Elimination of protease activity restores efficient virion production to a human immunodeficiency virus type 1 nucleocapsid deletion mutant. J Virol. 2003 May;77(10):5547–5556. 2. DE Ott et al. Redundant roles for nucleocapsid and matrix RNA-binding sequences in human immunodeficiency virus type 1 assembly. J Virol. 2005 Nov;79(22), 13839–13847. Patent Status: U.S. Patent Application No. 11/413,614 filed 27 Apr 2006 (HHS Reference No. E–236–2003/0–US–02). Licensing Status: Available for nonexclusive or exclusive licensing. Licensing Contact: Susan Ano, Ph.D.; 301/435–5515; anos@mail.nih.gov. Collaborative Research Opportunity: The NCI, CCR, AIDS Vaccine Program is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize whole retrovirus-like particle vaccines. Please contact John D. Hewes, Ph.D. at 301–435–3121 or hewesj@mail.nih.gov for more information. Potent HIV–1 Entry Inhibitors and Immunogens Description of Technology: This technology relates to HIV antigenic constructs with flexible, heterologous linkers joining gp120 and gp41. The HIV–1 envelope Glycoprotein (Env) undergoes conformational changes while driving entry. The inventors developed these constructs to mimic some of the intermediate Env conformations. Tethered molecules of the invention were stable and potently inhibited cell fusion. Both gp120 and gp41 contain epitopes that may be necessary for the immune system to mount a robust and effective immune response to HIV. By connecting the two components, the current invention stabilizes the exposure of conserved epitopes, thereby increasing the chances that antibodies will form that react with these sites. Applications: HIV vaccine. Development Status: In vitro data available. Inventors: Dimiter S. Dimitrov et al. (NCI). Patent Status: U.S. Utility Application No. 10/506,651 filed 02 Sept 2004 (HHS Reference No. E–039–2002/0–US–02). Licensing Status: Available for exclusive or non-exclusive licensing. Licensing Contact: Susan Ano, Ph.D.; 301/435–5515; anos@mail.nih.gov. Collaborative Research Opportunity: The National Cancer Institute’s Nanobiology Program is seeking statements of capability or interest from parties interested in collaborative PO 00000 Frm 00060 Fmt 4703 Sfmt 4703 58863 research to further develop or evaluate immune response constructs. Please contact John D. Hewes, Ph.D. at 301– 435–3121 or hewesj@mail.nih.gov for more information. Dated: October 10, 2007. Steven M. Ferguson, Director, Division of Technology Development and Transfer, Office of Technology Transfer, National Institutes of Health. [FR Doc. E7–20518 Filed 10–16–07; 8:45 am] BILLING CODE 4140–01–P DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Prospective Grant of Exclusive License: Adult Human Dental Pulp Stem Cells, Postnatal Stem Cells, and Multipotent Postnatal Stem Cells From Human Periodontal Ligament National Institutes of Health, Public Health Service, HHS. AGENCY: ACTION: Notice. SUMMARY: This is notice, in accordance with 35 U.S.C. 209(c)(1) and 37 CFR 404.7(a)(1)(i), that the National Institutes of Health (NIH), Department of Health and Human Services (HHS), is contemplating the grant of an exclusive license worldwide to practice the invention embodied in United States issued Patent Number 7,052,907 titled: ‘‘Adult Human Dental Pulp Stem Cells in vitro and in vivo’’ referenced at HHS as E–233–2000/0–US–03 and corresponding foreign patent applications, United States Patent Application Number 10/553,633 titled: ‘‘Postnatal Stem Cells and Uses Thereof’’ referenced at HHS as E–018– 2003/0–US–02 and corresponding foreign patent applications, United States Patent Application Number 11/ 433,627 titled: ‘‘Multipotent Postnatal Stem Cells from Human Periodontal Ligament’’ referenced at DHHS as E– 033–2004/0–US–03 and corresponding patent applications, to Angioblast Systems, Inc. having a place of business in the state of New York. The field of use may be limited to the following: FDA or similar foreign body approved therapeutic for (1) regeneration/repair of the periodontal ligament lost from chronic periodontitis, (2) regeneration/ repair of dentin/pulp complex lost during deep carious lesions and (3) regeneration/repair of neural networks. The United States of America is the assignee of the patent rights in this invention. The territory may be worldwide. E:\FR\FM\17OCN1.SGM 17OCN1 58864 Federal Register / Vol. 72, No. 200 / Wednesday, October 17, 2007 / Notices Only written comments and/or application for a license, which are received by the NIH Office of Technology Transfer on or before December 17, 2007 will be considered. ADDRESSES: Requests for a copy of the patent applications, inquiries, comments and other materials relating to the contemplated license should be directed to: Fatima Sayyid, Office of Technology Transfer, National Institutes of Health, 6011 Executive Boulevard, Suite 325, Rockville, MD 20852–3804; Telephone: (301) 435–4521; Facsimile: (301) 402–0220; e-mail: Fatima.Sayyid@nih.hhs.gov. SUPPLEMENTARY INFORMATION: The prospective exclusive license will be royalty-bearing and will comply with the terms and conditions of 35 U.S.C. 209 and 37 CFR 404.7. The prospective exclusive license may be granted unless, within 60 days from the date of this published Notice, NIH receives written evidence and argument that establishes that the grant of the license would not be consistent with the requirements of 35 U.S.C. 209 and 37 CFR 404.7. Properly filed competing applications for a license filed in response to this notice will be treated as objections to the contemplated license. Comments and objections submitted in response to this notice will not be made available for public inspection, and, to the extent permitted by law, will not be released under the Freedom of Information Act, 5 U.S.C. 552. DATES: Dated: October 11, 2007. Steven M. Ferguson, Director, Division of Technology Development and Transfer, Office of Technology Transfer, National Institutes of Health. [FR Doc. E7–20520 Filed 10–16–07; 8:45 am] BILLING CODE 4140–01–P DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Prospective Grant of Exclusive License: Treatment of Proliferative Disorders Using an Unexpected mTOR Kinase Inhibitor National Institutes of Health, Public Health Service, HHS. ACTION: Notice. sroberts on PROD1PC70 with NOTICES AGENCY: SUMMARY: This is notice, in accordance with 35 U.S.C. 209(c)(1) and 37 CFR 404.7(a)(1)(i), that the National Institutes of Health (NIH), Department of Health and Human Services (HHS), is contemplating the grant of an exclusive license to practice the invention embodied in PCT patent application VerDate Aug<31>2005 19:05 Oct 16, 2007 Jkt 214001 PCT/US2004/041265 filed December 9, 2004, entitled: ‘‘Methods for Suppressing an Immune Response or Treating a Proliferative Disorder’’ [HHS Reference Number: E–259–2003/0–PCT– 02], to Emiliem, Inc., a Delaware Corporation, having a place of business in Emeryville, California. The field of use may be limited to the use of 2-(4piperazinyl) substituted 4H-1benzopyran-4-one compounds, including 2-(4-piperazinyl)-8-phenyl4H-1-benzopyran-4-one (LY303511), for the treatment of cancer and/or other proliferative disorders not currently licensed, excluding the treatment and prevention of stenosis and restenosis. The United States of America is an assignee of the patent rights in these inventions. DATES: Only written comments and/or application for a license, which are received by the NIH Office of Technology Transfer on or before December 17, 2007 will be considered. ADDRESSES: Requests for a copy of the patent application, inquiries, comments and other materials relating to the contemplated license should be directed to: Susan Carson, D. Phil., Office of Technology Transfer, National Institutes of Health, 6011 Executive Boulevard, Suite 325, Rockville, MD 20852–3804; Email: carsonsu@od.nih.gov; Telephone: (301) 435–5020; Facsimile: (301) 402– 0220. SUPPLEMENTARY INFORMATION: The search for specific kinase inhibitors is an active area of drug development as there is a continued need for effective anti-proliferative therapeutics with acceptable toxicities. The core invention is a novel method of use of one of the 4H-1-benzopyran-4-one derivatives (LY303511) which has been shown to target mTOR and casein kinase 2 (CK2) without affecting PI3K activity (JPET, May 26, 2005, doi: 10.1124/ jpet.105.083550). Proof of concept data is available in an in vivo human zenograft PC–3 prostate tumor model, without observed toxicity. In vitro data suggest that (2-(4-piperazinyl)-8-phenyl4H-1-benzopyran-4-one and derivatives may be effective in treating inflammatory, autoimmune and other proliferative disorders including restenosis, inflammatory bowel disease and a variety of cancers. Method of use claims are directed to derivatives of 2(4-piperazinyl)-substituted 4H-1benzopyran-4-one compounds as antiproliferative, immunosuppressive, antiinflammatory, anti-restenosis and antineoplastic agents. The prospective exclusive license will be royalty bearing and will comply with the terms and conditions of 35 U.S.C. PO 00000 Frm 00061 Fmt 4703 Sfmt 4703 209 and 37 CFR 404.7. The prospective exclusive license may be granted unless, within 60 days from the date of this published Notice, NIH receives written evidence and argument that establishes that the grant of the license would not be consistent with the requirements of 35 U.S.C. 209 and 37 CFR 404.7. Properly filed competing applications for a license filed in response to this notice will be treated as objections to the contemplated license. Comments and objections submitted in response to this notice will not be made available for public inspection, and, to the extent permitted by law, will not be released under the Freedom of Information Act, 5 U.S.C. 552. Dated: October 10, 2007. Steven M. Ferguson, Director, Division of Technology Development and Transfer, Office of Technology Transfer, National Institutes of Health. [FR Doc. E7–20516 Filed 10–16–07; 8:45 am] BILLING CODE 4140–01–P DEPARTMENT OF HOMELAND SECURITY Coast Guard [Docket No. COTP Corpus Christi 07–085] South Texas Area Maritime Security (STAMS) Committee; Vacancy Coast Guard, DHS. Solicitation for membership. AGENCY: ACTION: SUMMARY: This notice requests individuals interested in serving on the South Texas Area Maritime Security (STAMS) Committee to submit their application for a potential opening on the committee to the Corpus Christi Captain of the Port/Federal Maritime Security Coordinator. DATES: Applications should reach the Corpus Christi Captain of the Port/ Federal Maritime Security Coordinator on or before October 30, 2007. ADDRESSES: Requests for membership should be submitted to the Captain of the Port/Federal Maritime Security Coordinator at the following address: Commander, USCG Sector Corpus Christi, 8930 Ocean Drive, Hangar 41, Corpus Christi, Texas 78419. FOR FURTHER INFORMATION CONTACT: Mr. John Zarbock at 361–888–3162 (X501). SUPPLEMENTARY INFORMATION: Authority Section 102 of the Maritime Transportation Security Act (MTSA) of 2002 (Pub. L. 107–295) added section 70112 to Title 46 of the U.S. Code, and authorized the Secretary of the E:\FR\FM\17OCN1.SGM 17OCN1

Agencies

[Federal Register Volume 72, Number 200 (Wednesday, October 17, 2007)]
[Notices]
[Pages 58863-58864]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: E7-20520]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Prospective Grant of Exclusive License: Adult Human Dental Pulp 
Stem Cells, Postnatal Stem Cells, and Multipotent Postnatal Stem Cells 
From Human Periodontal Ligament

AGENCY: National Institutes of Health, Public Health Service, HHS.

ACTION: Notice.

-----------------------------------------------------------------------

SUMMARY: This is notice, in accordance with 35 U.S.C. 209(c)(1) and 37 
CFR 404.7(a)(1)(i), that the National Institutes of Health (NIH), 
Department of Health and Human Services (HHS), is contemplating the 
grant of an exclusive license worldwide to practice the invention 
embodied in United States issued Patent Number 7,052,907 titled: 
``Adult Human Dental Pulp Stem Cells in vitro and in vivo'' referenced 
at HHS as E-233-2000/0-US-03 and corresponding foreign patent 
applications, United States Patent Application Number 10/553,633 
titled: ``Postnatal Stem Cells and Uses Thereof'' referenced at HHS as 
E-018-2003/0-US-02 and corresponding foreign patent applications, 
United States Patent Application Number 11/433,627 titled: 
``Multipotent Postnatal Stem Cells from Human Periodontal Ligament'' 
referenced at DHHS as E-033-2004/0-US-03 and corresponding patent 
applications, to Angioblast Systems, Inc. having a place of business in 
the state of New York. The field of use may be limited to the 
following: FDA or similar foreign body approved therapeutic for (1) 
regeneration/repair of the periodontal ligament lost from chronic 
periodontitis, (2) regeneration/repair of dentin/pulp complex lost 
during deep carious lesions and (3) regeneration/repair of neural 
networks. The United States of America is the assignee of the patent 
rights in this invention. The territory may be worldwide.

[[Page 58864]]


DATES: Only written comments and/or application for a license, which 
are received by the NIH Office of Technology Transfer on or before 
December 17, 2007 will be considered.

ADDRESSES: Requests for a copy of the patent applications, inquiries, 
comments and other materials relating to the contemplated license 
should be directed to: Fatima Sayyid, Office of Technology Transfer, 
National Institutes of Health, 6011 Executive Boulevard, Suite 325, 
Rockville, MD 20852-3804; Telephone: (301) 435-4521; Facsimile: (301) 
402-0220; e-mail: Fatima.Sayyid@nih.hhs.gov.

SUPPLEMENTARY INFORMATION: The prospective exclusive license will be 
royalty-bearing and will comply with the terms and conditions of 35 
U.S.C. 209 and 37 CFR 404.7. The prospective exclusive license may be 
granted unless, within 60 days from the date of this published Notice, 
NIH receives written evidence and argument that establishes that the 
grant of the license would not be consistent with the requirements of 
35 U.S.C. 209 and 37 CFR 404.7.
    Properly filed competing applications for a license filed in 
response to this notice will be treated as objections to the 
contemplated license. Comments and objections submitted in response to 
this notice will not be made available for public inspection, and, to 
the extent permitted by law, will not be released under the Freedom of 
Information Act, 5 U.S.C. 552.

    Dated: October 11, 2007.
Steven M. Ferguson,
Director, Division of Technology Development and Transfer, Office of 
Technology Transfer, National Institutes of Health.
 [FR Doc. E7-20520 Filed 10-16-07; 8:45 am]
BILLING CODE 4140-01-P
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