Indian Gaming, 36717 [E7-12904]

Download as PDF Federal Register / Vol. 72, No. 128 / Thursday, July 5, 2007 / Notices patent license to practice the inventions embodied in U.S. Patent Application 60/870,050, entitled ‘‘Human Cancer Therapy Using Anthrax Lethal Toxin Activated by Tumor Associated Proteases’’ [HHS Reference E–070–2007/ 0–US–01], including background patent rights to U.S. Patent Application 10/ 088,952, entitled ‘‘Mutated Anthrax Toxin Protective Antigen Proteins that Specifically Target Cells Containing High Amounts of Cell-Surface Metalloproteinases or Plasminogen Activator Receptors’’ [HHS Reference E– 293–1999/0–US–03] and foreign counterparts thereto, and U.S. Patents 5,591,631 and 5,677,274, entitled ‘‘Anthrax Toxin Fusion Proteins and Uses Thereof’’ [HHS References E–064– 1993/0–US–01 and E–064–1993/1–US– 01, respectively] and foreign counterparts thereto, to FP BioPharma, LLC, which has offices in Fort Mill, South Carolina. The patent rights in these inventions have been assigned to and/or exclusively licensed to the Government of the United States of America. The prospective exclusive license territory may be worldwide, and the field of use may be limited to: A method for the treatment of cancer involving protease activated cancer toxins, wherein the cancer toxins comprise Anthrax lethal toxin (LeTx) modified at the furinrecognized cleavage site to contain a matrix metalloproteinase cleavage site, as defined by the Licensed Patent Rights, and wherein the cancers include, but are not limited to, melanoma, colon, thyroid, prostate, pancreatic and ovarian cancer. This exclusive licensed field of use shall explicitly exclude vaccines and immunotherapeutics for the prevention or treatment of human diseases. Only written comments and/or applications for a license which are received by the NIH Office of Technology Transfer on or before September 4, 2007 will be considered. ADDRESSES: Requests for copies of the patent application, inquiries, comments, and other materials relating to the contemplated exclusive license should be directed to: David A. Lambertson, PhD, Technology Licensing Specialist, Office of Technology Transfer, National Institutes of Health, 6011 Executive Boulevard, Suite 325, Rockville, MD 20852–3804; Telephone: (301) 435– 4632; Facsimile: (301) 402–0220; E-mail: lambertsond@od.nih.gov. SUPPLEMENTARY INFORMATION: Anthrax lethal toxin (LeTx) has been shown to have significant toxicity to cancer cells, particularly those associated with melanoma. However, LeTx also shows significant toxicity towards normal cells, preventing widespread use of the molecule as a cancer therapy. NIH sroberts on PROD1PC70 with NOTICES DATES: VerDate Aug<31>2005 18:43 Jul 03, 2007 Jkt 211001 inventors have now engineered LeTx to have increased specificity for cancer cells, with little to no effect on normal cells, enhancing the effectiveness of LeTx for cancer treatment. Modifying the LeTx to be activated by a matrix metalloprotease (MMP) increases the specificity of LeTx for cancer cells because those cells are more likely to activate the toxin, resulting in more efficient therapy. Mouse data shows that the modified LeTx (called PrAg–L1/LF) is less cytotoxic to ‘‘normal’’ cells in vivo when compared to wild-type LeTx, while maintaining high toxicity towards implanted human tumors. Modification of the LeTx to contain various protease recognition and cleavage sites can potentially extend application of the technology beyond melanomas to the treatment of lung and colon carcinomas, and various other cancers. The prospective exclusive license will be royalty bearing and will comply with the terms and conditions of 35 U.S.C. 209 and 37 CFR 404.7. The prospective exclusive license may be granted unless within sixty (60) days from the date of this published notice, the NIH receives written evidence and argument that establishes that the grant of the license would not be consistent with the requirements of 35 U.S.C. 209 and 37 CFR 404.7. Applications for a license in the field of use filed in response to this notice will be treated as objections to the grant of the contemplated exclusive license. Comments and objections submitted to this notice will not be made available for public inspection and, to the extent permitted by law, will not be released under the Freedom of Information Act, 5 U.S.C. 552. Dated: June 26, 2007. Steven M. Ferguson, Director, Division of Technology Development and Transfer, Office of Technology Transfer, National Institutes of Health. [FR Doc. E7–12899 Filed 7–3–07; 8:45 am] BILLING CODE 4140–01–P DEPARTMENT OF THE INTERIOR Bureau of Indian Affairs Bureau of Indian Affairs, Interior. ACTION: Notice of approved amended Tribal-State compacts. AGENCY: SUMMARY: This notice publishes approval of the Tribal-State Class III Gaming Compact between the State of New Mexico and the Pueblo of Isleta, PO 00000 Frm 00071 Fmt 4703 Pueblo of Nambe, Pueblo of Picuris, Pueblo of San Felipe, Pueblo of Sandia, Pueblo of Santa Ana, Pueblo of Tesuque, Pueblo of Taos, Pueblo of Santa Clara and Ohkay Owingeh. DATES: Effective Date: July 5, 2007. FOR FURTHER INFORMATION CONTACT: George T. Skibine, Director, Office of Indian Gaming, Office of the Deputy Assistant Secretary—Policy and Economic Development, Washington, DC 20240, (202) 219–4066. SUPPLEMENTARY INFORMATION: Under Section 11 of the Indian Gaming Regulatory Act of 1988 (IGRA), Public Law 100–497, 25 U.S.C. 2710, the Secretary of the Interior shall publish in the Federal Register notice of the approved Tribal-State Compacts and Amendments for the purpose of engaging in Class III gaming activities on Indian lands. This Amendment includes a provision that would eliminate any payments to the state should the state permit any licensed horse racetrack to increase number of machines, increase hours of operation, allow operation of gaming machines outside licensed premises or operate table games. This Amendment extends the term of the Compact until June 30, 2037. Dated: June 18, 2007. George T. Skibine, Principal Deputy Assistant Secretary—Indian Affairs. [FR Doc. E7–12904 Filed 7–3–07; 8:45 am] BILLING CODE 4310–4N–P INTERNATIONAL TRADE COMMISSION Agency Form Submitted for OMB Review United States International Trade Commission. ACTION: In accordance with the provisions of the Paperwork Reduction Act of 1995 (44 U.S.C. Chapter 35), the Commission has submitted a request for emergency processing for review and clearance of questionnaires to the Office of Management and Budget (OMB). AGENCY: July 5, 2007. Purpose of Information Collection: The form is for use by the Commission in connection with investigation No. TR–5003–1, Textiles and Apparel: Effect of Special Rules on Trade Markets and Industries, instituted under section 5003 of Tax Relief and Health Care Act of 2006 (TRHCA) (Public Law No. 109– 432). The Commission must submit its report to Congress by June 20, 2008. EFFECTIVE DATE: Indian Gaming Sfmt 4703 36717 E:\FR\FM\05JYN1.SGM 05JYN1

Agencies

[Federal Register Volume 72, Number 128 (Thursday, July 5, 2007)]
[Notices]
[Page 36717]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: E7-12904]


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DEPARTMENT OF THE INTERIOR

Bureau of Indian Affairs


Indian Gaming

AGENCY: Bureau of Indian Affairs, Interior.

ACTION: Notice of approved amended Tribal-State compacts.

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SUMMARY: This notice publishes approval of the Tribal-State Class III 
Gaming Compact between the State of New Mexico and the Pueblo of 
Isleta, Pueblo of Nambe, Pueblo of Picuris, Pueblo of San Felipe, 
Pueblo of Sandia, Pueblo of Santa Ana, Pueblo of Tesuque, Pueblo of 
Taos, Pueblo of Santa Clara and Ohkay Owingeh.

DATES: Effective Date: July 5, 2007.

FOR FURTHER INFORMATION CONTACT: George T. Skibine, Director, Office of 
Indian Gaming, Office of the Deputy Assistant Secretary--Policy and 
Economic Development, Washington, DC 20240, (202) 219-4066.

SUPPLEMENTARY INFORMATION: Under Section 11 of the Indian Gaming 
Regulatory Act of 1988 (IGRA), Public Law 100-497, 25 U.S.C. 2710, the 
Secretary of the Interior shall publish in the Federal Register notice 
of the approved Tribal-State Compacts and Amendments for the purpose of 
engaging in Class III gaming activities on Indian lands. This Amendment 
includes a provision that would eliminate any payments to the state 
should the state permit any licensed horse racetrack to increase number 
of machines, increase hours of operation, allow operation of gaming 
machines outside licensed premises or operate table games. This 
Amendment extends the term of the Compact until June 30, 2037.

    Dated: June 18, 2007.
George T. Skibine,
Principal Deputy Assistant Secretary--Indian Affairs.
[FR Doc. E7-12904 Filed 7-3-07; 8:45 am]
BILLING CODE 4310-4N-P

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