Findings of Research Misconduct, 34016 [E7-11908]

Download as PDF 34016 Federal Register / Vol. 72, No. 118 / Wednesday, June 20, 2007 / Notices DEPARTMENT OF HEALTH AND HUMAN SERVICES Office of the Secretary Findings of Research Misconduct Office of the Secretary, HHS. Notice. AGENCY: ACTION: SUMMARY: Notice is hereby given that the Office of Research Integrity (ORI) and the Assistant Secretary for Health have taken final action in the following case: Carlos A. Murillo, M.D., University of Texas Medical Branch at Galveston: Based on the report of an inquiry conducted by the University of Texas Medical Branch at Galveston (UTMB) and additional analysis and information obtained by the Office of Research Integrity during its oversight review, the U.S. Public Health Service (PHS) found that Carlos A. Murillo, M.D., former Surgical Resident, Department of Surgery, UTMB, engaged in research misconduct in research supported by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH), grants R01 DK48498 and T32 DK07639. Specifically, Dr. Murillo falsified research on the amelioration by antisense RNA (siRNA) of dextraninduced colonic toxicity in mice. He altered the concentrations of dextran solution fed to mice to induce colonic inflammation, by intentionally including little or no dextran in the drinking water of siRNA treated mice, so that the animals that received siRNA would have few or no colonic lesions. Dr. Murillo has entered into a Voluntary Exclusion Agreement (Agreement) in which he has voluntarily agreed, for a period of three (3) years, beginning on May 30, 2007: (1) That any institution that submits an application for PHS support for a research project on which Dr. Murillo’s participation is proposed or that uses him in any capacity on PHS support research, or that submits a report of PHS-funded research in which he is involved, must concurrently submit a plan for supervision of his duties to the funding agency for approval; the supervisory plan must be designed to ensure the scientific integrity of Dr. Murillo’s research contribution; Dr. Murillo agrees to ensure that a copy of the supervisory plan is also submitted to ORI by the institution and agrees that he will not participate in any PHSsupported research until such a supervision plan is submitted to ORI; (2) to exclude himself from serving in any advisory capacity to PHS, including but not limited to service on any PHS advisory committee, board, and/or peer review committee, or as a consultant; and (3) to request retraction of the abstract entitled ‘‘Inhibition of Phosphoinositol 3-kinase Using Anti-p85 siRNA Attenuates Dextran-Sulfate-Induced Inflammatory Bowel Disease’’ (Gastroenterology 126:A49, 2004), by signing the letter of retraction prepared by ORI attached as Attachment 2 and made part of the Agreement. FOR FURTHER INFORMATION CONTACT: Director, Division of Investigative Oversight, Office of Research Integrity, 1101 Wootton Parkway, Suite 750, Rockville, MD 20852, (240) 453–8800. John Dahlberg, Acting Director,Office of Research Integrity. [FR Doc. E7–11908 Filed 6–19–07; 8:45 am] BILLING CODE 4150–31–P DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention [30Day-07–06BF] Agency Forms Undergoing Paperwork Reduction Act Review The Centers for Disease Control and Prevention (CDC) publishes a list of information collection requests under review by the Office of Management and Budget (OMB) in compliance with the Paperwork Reduction Act (44 U.S.C. Chapter 35). To request a copy of these requests, call the CDC Reports Clearance Officer at (404) 639–5960 or send an email to omb@cdc.gov. Send written comments to CDC Desk Officer, Office of Management and Budget, Washington, DC or by fax to (202) 395–6974. Written Proposed Project Assessment and Evaluation of the Role of Care Coordination (Case Management) in Improving Access and Care within the Spina Bifida Clinic System—New—National Center for Birth Defects and Developmental Disabilities (NCBDDD), Centers for Disease Control and Prevention (CDC). Background and Brief Description CDC is requesting a one-year approval from the Office of Management and Budget to collect information about the effectiveness of care coordination for patients with spina bifida. Studies have shown that care coordination is beneficial for individuals with complex health conditions such as cystic fibrosis and sickle cell anemia, however, the extent to which care coordination is effective for assisting individuals with spina bifida is unknown. Spina bifida is one of the most common birth defects, affecting approximately 3 per 10,000 live births in the United States annually. The proposed activity is part of the National Spina Bifida Program mandated in Section 317C of the Public Health Service Act (42 U.S.C. 247b–4). Researchers will visit 10 spina bifida clinics nationwide. At each clinic, one focus group will be conducted with approximately eight caregivers of children with spina bifida. Each focus group will last about two hours. In addition, interviews will be conducted with approximately five staff members at each clinic; each interview will take approximately 45 minutes. Focus group and interview respondents will be asked a variety of questions related to care coordination for individuals with spina bifida including how care is coordinated in the clinic, barriers and facilitators to the provision of care coordination, the effectiveness of care coordination, and recommendations for improving care coordination. There will be no costs to the respondents other than their time. The total estimated annualized burden hours are 244. Estimated Annualized Burden Hours: Number of respondents Type of respondents rwilkins on PROD1PC63 with NOTICES comments should be received within 30 days of this notice. Form name Caregivers for Spina Bifida Patients ............... Focus Group Response Form ....................... Focus Group Telephone Script ...................... Focus Group Moderator’s Guide ................... Clinic Recruitment Script ................................ Clinic Staff Telephone Interview Script .......... Spina Bifida Clinic Staff .................................. VerDate Aug<31>2005 18:25 Jun 19, 2007 Jkt 211001 PO 00000 Frm 00050 Fmt 4703 Sfmt 4703 E:\FR\FM\20JNN1.SGM 100 100 80 14 55 20JNN1 Number of reponses per respondent 1 1 1 1 1 Average burden per response (in hours) 5/60 15/60 2 15/60 10/60

Agencies

[Federal Register Volume 72, Number 118 (Wednesday, June 20, 2007)]
[Notices]
[Page 34016]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: E7-11908]



[[Page 34016]]

-----------------------------------------------------------------------

DEPARTMENT OF HEALTH AND HUMAN SERVICES

Office of the Secretary


Findings of Research Misconduct

AGENCY: Office of the Secretary, HHS.

ACTION: Notice.

-----------------------------------------------------------------------

SUMMARY: Notice is hereby given that the Office of Research Integrity 
(ORI) and the Assistant Secretary for Health have taken final action in 
the following case:
    Carlos A. Murillo, M.D., University of Texas Medical Branch at 
Galveston: Based on the report of an inquiry conducted by the 
University of Texas Medical Branch at Galveston (UTMB) and additional 
analysis and information obtained by the Office of Research Integrity 
during its oversight review, the U.S. Public Health Service (PHS) found 
that Carlos A. Murillo, M.D., former Surgical Resident, Department of 
Surgery, UTMB, engaged in research misconduct in research supported by 
National Institute of Diabetes and Digestive and Kidney Diseases 
(NIDDK), National Institutes of Health (NIH), grants R01 DK48498 and 
T32 DK07639.
    Specifically, Dr. Murillo falsified research on the amelioration by 
antisense RNA (siRNA) of dextran-induced colonic toxicity in mice. He 
altered the concentrations of dextran solution fed to mice to induce 
colonic inflammation, by intentionally including little or no dextran 
in the drinking water of siRNA treated mice, so that the animals that 
received siRNA would have few or no colonic lesions.
    Dr. Murillo has entered into a Voluntary Exclusion Agreement 
(Agreement) in which he has voluntarily agreed, for a period of three 
(3) years, beginning on May 30, 2007:
    (1) That any institution that submits an application for PHS 
support for a research project on which Dr. Murillo's participation is 
proposed or that uses him in any capacity on PHS support research, or 
that submits a report of PHS-funded research in which he is involved, 
must concurrently submit a plan for supervision of his duties to the 
funding agency for approval; the supervisory plan must be designed to 
ensure the scientific integrity of Dr. Murillo's research contribution; 
Dr. Murillo agrees to ensure that a copy of the supervisory plan is 
also submitted to ORI by the institution and agrees that he will not 
participate in any PHS-supported research until such a supervision plan 
is submitted to ORI;
    (2) to exclude himself from serving in any advisory capacity to 
PHS, including but not limited to service on any PHS advisory 
committee, board, and/or peer review committee, or as a consultant; and
    (3) to request retraction of the abstract entitled ``Inhibition of 
Phosphoinositol 3-kinase Using Anti-p85 siRNA Attenuates Dextran-
Sulfate-Induced Inflammatory Bowel Disease'' (Gastroenterology 126:A49, 
2004), by signing the letter of retraction prepared by ORI attached as 
Attachment 2 and made part of the Agreement.

FOR FURTHER INFORMATION CONTACT: Director, Division of Investigative 
Oversight, Office of Research Integrity, 1101 Wootton Parkway, Suite 
750, Rockville, MD 20852, (240) 453-8800.

John Dahlberg,
Acting Director,Office of Research Integrity.
 [FR Doc. E7-11908 Filed 6-19-07; 8:45 am]
BILLING CODE 4150-31-P
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.