National Heart, Lung, and Blood Institute; Notice of Closed Meeting, 28512 [07-2488]

Download as PDF 28512 Federal Register / Vol. 72, No. 97 / Monday, May 21, 2007 / Notices pwalker on PROD1PC71 with NOTICES Vaccine Against Escherichia Coli 0157 Infection, Composed of Detoxified LPS Conjugated to Proteins Description of Technology: This invention is a conjugate vaccine to prevent infection by E. coli 0157:H7, particularly in young children under 5 years of age. E. coli 0157:H7 is an emerging human pathogen which causes a spectrum of illnesses with high morbidity and mortality, ranging from diarrhea to hemorrhagic colitis and hemolytic-uremic syndrome (HUS). Infection with E. coli 0157:H7 occurs as a result of consumption of water, vegetables, fruits or meat contaminated by feces from infected animals, such as cattle. The most recent large outbreak in the U.S. was from contaminated bag spinach. The conjugate is composed of the O-specific polysaccharide isolated from E. coli 0157, or other Shiga-toxin producing bacteria, conjugated to carrier proteins, such as non-toxic P. aeruginosa exotoxin A or Shiga toxin 1. A Phase I clinical trial, involving adult humans, showed the vaccine is safe and highly immunogenic. Adults, after one injection containing 25 µg of antigen, responded with high titers of bactericidal antibodies. Similarly in a phase II study, fifty 2-to-5- years old children in U.S. were injected with the conjugate vaccines. There were only mild local adverse reactions. More than 90% of the children responded with greater than 10 fold rise of E. coli O157 antibodies of bactericidal ability. Thus the conjugates of the invention are promising vaccines, especially for children and the elderly, who are most likely to suffer serious consequences from infection. Application: Prevention of E. coli O157 infection. Development Status: Clinical studies have been performed and are described in Konadu et al., J Infect Dis. 1998 Feb; 177(2):383–387 and Ahmed et al., J Infect Dis. 2006 Feb; 193(2):515–526. Inventors: Shousun C. Szu, Edward Konadu, and John B. Robbins (NICHD). Patent Status: U.S. Patent 6,858,211 issued 22 Feb 2005 (HHS Reference No. E–158–1998/0–US–06); U.S. Patent Application No. 10/987,428 filed 12 Nov 2004 (HHS Reference No. E–158– 1998/0–US–07); U.S. Patent Application No. 11/015,436 filed 16 Dec 2004 (HHS Reference No. E–158–1998/0–US–08). Licensing Status: Available for nonexclusive or exclusive licensing. Licensing Contact: Peter A. Soukas, J.D.; 301/435–4646; soukasp@mail.nih.gov. Collaborative Research Opportunity: The National Institute of Child Health and Human Development, Laboratory of VerDate Aug<31>2005 15:57 May 18, 2007 Jkt 211001 Developmental and Molecular Immunity, is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize Vaccine for E. coli O157 for Children and Adults. Please contact John D. Hewes, Ph.D., at 301–435–3121 or hewesj@mail.nih.gov for more information. Dated: May 11, 2007. Steven M. Ferguson, Director, Division of Technology Development and Transfer, Office of Technology Transfer, National Institutes of Health. [FR Doc. E7–9656 Filed 5–18–07; 8:45 am] BILLING CODE 4140–01–P DEPARTMENT OF HEALTH AND HUMAN National Institutes of Health National Cancer Institute; Amended Notice of Meeting Notice is hereby given of a change in the meeting of the National Cancer Advisory Board, June 14, 2007, 2 p.m. to June 15, 2007, 12 p.m., National Institutes of Health, Building 31, 31 Center Drive, Bethesda, MD 20892, which was published in the Federal Register on May 2, 2007, 72 FR 24319. The notice is being amended to change the open session start and end times on June 14, 2007 to 1:15 p.m.— 4:20 p.m. and the end time on June 15, 2007 to 11:45 a.m. The meeting is partially Closed to the public. Dated: May 14, 2007. Jennifer Spaeth, Director, Office of Federal Advisory Committee Policy. [FR Doc. 07–2495 Filed 5–18–07; 8:45 am] BILLING CODE 4140–01–M DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. Appendix 2), notice is hereby given of the following meeting. The meeting will be closed to the public in accordance with the provision set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The grant applications and the discussions could disclose confidential trade secrets or commercial property such as patentable material, and PO 00000 Frm 00051 Fmt 4703 Sfmt 4703 personal information concerning individuals associated with the grant applications, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. Name of Committee: Heart, Lung, and Blood Initial Review Group; Clinical Trials Review Committee. Date: June 25, 2007. Time: 8 a.m. to 5 p.m. Agenda: To review and evaluate grant applications. Place: Intercontinental Harbor Court, 550 Light Street, Baltimore, MD 21202. Contact Person: Patricia A Haggerty, PhD, Section Chief, Clinical Studies and Training Scientific Review Group, Review Branch, Division of Extramural Research Activities, National Heart, Lung, and Blood Institute, NIH, 6701 Rockledge Drive, Room 7194, MSC 7924, Bethesda, MD 20892, 301/435–0288, haggertp@nhlbi.nih.gov. (Catalogue of Federal Domestic Assistance Program Nos. 93.233, National Center for Sleep Disorders Research; 93.837, Heart and Vascular Diseases Research; 93.838, Lung Diseases Research; 93.839, Blood Diseases and Resources Research, National Institutes of Health, HHS) Dated: May 14, 2007. Jennifer Spaeth, Director, Office of Federal Advisory Committee Policy. [FR Doc. 07–2488 Filed 5–18–07; 8:45 am] BILLING CODE 4140–01–M DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Heart, Lung and Blood Institute; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. Appendix 2), notice is hereby give of the following meeting. The meeting will be closed to the public in accordance with the provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The grant applications and the discussions could disclose confidential trade secrets or commercial property such as patentable material, and personal information concerning individuals associated with the grant applications, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. Name of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Mentored Scientist Award (K99). Date: June 28–29, 2007. Time: June 28, 2007, 12 p.m. to 10 p.m. Agenda: To review and evaluate grant applications. Place: Washington Plaza, 10 Thomas Circle NW., Washington, DC 20005. E:\FR\FM\21MYN1.SGM 21MYN1

Agencies

[Federal Register Volume 72, Number 97 (Monday, May 21, 2007)]
[Notices]
[Page 28512]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: 07-2488]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


National Heart, Lung, and Blood Institute; Notice of Closed 
Meeting

    Pursuant to section 10(d) of the Federal Advisory Committee Act, as 
amended (5 U.S.C. Appendix 2), notice is hereby given of the following 
meeting.
    The meeting will be closed to the public in accordance with the 
provision set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 
U.S.C., as amended. The grant applications and the discussions could 
disclose confidential trade secrets or commercial property such as 
patentable material, and personal information concerning individuals 
associated with the grant applications, the disclosure of which would 
constitute a clearly unwarranted invasion of personal privacy.

    Name of Committee: Heart, Lung, and Blood Initial Review Group; 
Clinical Trials Review Committee.
    Date: June 25, 2007.
    Time: 8 a.m. to 5 p.m.
    Agenda: To review and evaluate grant applications.
    Place: Intercontinental Harbor Court, 550 Light Street, 
Baltimore, MD 21202.
    Contact Person: Patricia A Haggerty, PhD, Section Chief, 
Clinical Studies and Training Scientific Review Group, Review 
Branch, Division of Extramural Research Activities, National Heart, 
Lung, and Blood Institute, NIH, 6701 Rockledge Drive, Room 7194, MSC 
7924, Bethesda, MD 20892, 301/435-0288, haggertp@nhlbi.nih.gov.

(Catalogue of Federal Domestic Assistance Program Nos. 93.233, 
National Center for Sleep Disorders Research; 93.837, Heart and 
Vascular Diseases Research; 93.838, Lung Diseases Research; 93.839, 
Blood Diseases and Resources Research, National Institutes of 
Health, HHS)

    Dated: May 14, 2007.
Jennifer Spaeth,
Director, Office of Federal Advisory Committee Policy.
[FR Doc. 07-2488 Filed 5-18-07; 8:45 am]
BILLING CODE 4140-01-M

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