National Toxicology Program (NTP); Report on Carcinogens; Request for Nominations of Scientific Experts for Review of Candidate Substances for the 12th Report on Carcinogens, 26394 [E7-8899]

Agencies

• DEPARTMENT OF HEALTH AND HUMAN SERVICES

[Federal Register Volume 72, Number 89 (Wednesday, May 9, 2007)]
[Notices]
[Page 26394]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: E7-8899]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES


National Toxicology Program (NTP); Report on Carcinogens; Request 
for Nominations of Scientific Experts for Review of Candidate 
Substances for the 12th Report on Carcinogens

AGENCY: National Institute of Environmental Health Sciences (NIEHS), 
National Institutes of Health (NIH).

ACTION: Request for nominations of scientific experts.

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SUMMARY: On April 16, 2007, NTP released the final review process for 
preparation of the 12th Report on Carcinogens (RoC, 72FR18999, 
available at https://ntp.niehs.nih.gov/go/9732). This notice invites the 
public to nominate scientists to serve on expert panels. These 
scientists should have expertise and/or knowledge relevant to 
evaluation of the potential carcinogenic hazard of the candidate 
substances that will undergo review for the 12th RoC.

DATES: Nominations of scientific experts received by June 8, 2007.

ADDRESSES: Nominations should be sent to Dr. C. W. Jameson, Report on 
Carcinogens (NIEHS, P.O Box 12233, MD EC-17, Research Triangle Park, NC 
27709; fax: (919) 541-0144, e-mail: jameson@niehs.nih.gov. Courier 
address: Report on Carcinogens, NIEHS, 79 Alexander Drive, Building 
4401, Room 3118, Research Triangle Park, NC 27709).

FOR FURTHER INFORMATION CONTACT: Dr. C. W. Jameson, telephone: (919) 
541-4096 or jameson@niehs.nih.gov.

SUPPLEMENTARY INFORMATION:

Request for Nominations of Scientific Experts

    The review process for preparation of the 12th RoC is available on 
the NTP RoC Web site (https://ntp.niehs.nih.gov/go/15208). The process 
includes development of a draft background document for each candidate 
substance undergoing review for the 12th RoC. The NTP will convene an 
ad hoc expert panel to peer review the draft background document at a 
public meeting and make a recommendation to the NTP on the candidate 
substance's listing status for the RoC. The NTP invites the public to 
nominate scientists to serve on the expert panels who have expertise 
and/or knowledge relevant to the evaluation of carcinogenicity for the 
candidate substances (listed below). Relevant areas of expertise and/or 
knowledge include, for example, biostatistics, carcinogenesis, 
chemistry, epidemiology, exposure assessment, molecular biology, 
pathology, toxicokinetics, and toxicology. Scientists nominated in 
response to a previous notice (70FR60548), which sought names of 
scientists to write and/or review background documents, will also be 
considered as potential candidates for the expert panels.
    Each nomination should include contact information for the nominee 
[name, affiliation (if any), address, telephone, fax, and e-mail], the 
candidate substance(s) for which they have relevant expertise and/or 
knowledge, and a complete curriculum vitae. Final selection of 
individuals to serve on these panels will be made in accordance with 
the Federal Advisory Committee Act and Department of Health and Human 
Services implementing regulations. Previously, NTP sought input on 
substances nominated for possible review for the 12th RoC (69FR28940, 
69FR62276, and 70FR60548). The 14 candidate substances selected for 
review for the 12th RoC are listed below. Information on these 
candidate substances is available on the NTP Web site for the 12th RoC 
(https://ntp.niehs.nih.gov/go/10091) or by contacting Dr. C. W. Jameson 
(see ``FOR FURTHER INFORMATION CONTACT'' above).
    The candidate substances for the 12th RoC are:

 Aristolochic acid-related exposures:
    (1) Botanical products containing aristolochic acid
    (2) Aristolochic acid
 Captafol
 Cobalt-tungsten carbide powders and hard metals
 Di (2-ethylhexyl) phthalate
 Selected DNA topoisomerase II inhibitors:
    (1) Etoposide
    (2) Etoposide in combination with cisplatin and bleomycin
    (3) Teniposide
 Formaldehyde
 Glass wool fibers (certain)
 Metalworking fluids
 ortho-Nitrotoluene
 Riddelliine
 Styrene

Background Information on the Report on Carcinogens

    The RoC is a congressionally mandated document [Section 301(b)(4) 
of the Public Health Services Act, 42 U.S.C. 241(b)(4)], approved by 
the Secretary of Health and Human Services (HHS), that identifies 
agents, substances, mixtures, or exposure circumstances (collectively 
referred to as ``substances'') that may pose a carcinogenic hazard to 
human health. The Secretary, HHS, delegated responsibility for 
preparing the report to the NTP. Substances are listed in the RoC as 
either known to be human carcinogens or reasonably anticipated to be 
human carcinogens. Publication of the RoC is the end result of an 
extensive scientific review and assessment process with multiple 
opportunities for public comment
    The NTP solicits and encourages the broadest participation from 
interested individuals or parties in nominating agents, substances, 
mixtures, or exposure circumstances for review for future RoCs. 
Nominations should contain a rationale for review. Appropriate 
background information and relevant data [e.g., journal articles, NTP 
Technical Reports, International Agency for Research on Cancer (IARC) 
listings, exposure surveys, release inventories, etc.] that support a 
nomination should be provided or referenced when possible. Contact 
information for the nominator should also be included [name, 
affiliation (if any), address, telephone, fax, and e-mail].

    Dated: April 30, 2007.
Samuel H. Wilson,
Deputy Director, National Institute of Environmental Health Sciences 
and National Toxicology Program.
[FR Doc. E7-8899 Filed 5-8-07; 8:45 am]
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