National Toxicology Program (NTP), NTP Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM); Request for Data on the Use of Topical Anesthetics and Systemic Analgesics for In Vivo Eye Irritation Testing, 26396 [E7-8898]

Download as PDF 26396 Federal Register / Vol. 72, No. 89 / Wednesday, May 9, 2007 / Notices Dated: April 30, 2007. Samuel H. Wilson, Deputy Director, National Institute of Environmental Health Sciences and National Toxicology Program. [FR Doc. E7–8896 Filed 5–8–07; 8:45 am] BILLING CODE 4140–01–P DEPARTMENT OF HEALTH AND HUMAN SERVICES National Toxicology Program (NTP), NTP Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM); Request for Data on the Use of Topical Anesthetics and Systemic Analgesics for In Vivo Eye Irritation Testing National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH). ACTION: Request for data on the use of topical anesthetics and systemic analgesics for in vivo ocular irritation testing. AGENCY: SUMMARY: The Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) and NICEATM request the submission of data and information on the use of topical anesthetics and systemic analgesics for alleviating pain and distress in rabbits during eye irritation testing. They also request the submission of information about other procedures and strategies that may reduce or eliminate pain and distress associated with in vivo eye irritation methods. Data should be received by June 25, 2007. ADDRESSES: Data should be sent by mail, fax, or e-mail to Dr. William S. Stokes, Director, NICEATM, NIEHS, P.O. Box 12233, MD EC–17, Research Triangle Park, NC, 27709, (fax) 919–541–0947, (email) niceatm@niehs.nih.gov. Courier address: NICEATM, 79 T.W. Alexander Drive, Building 4401, Room 3128, Research Triangle Park, NC 27709. FOR FURTHER INFORMATION CONTACT: Dr. William S. Stokes, NICEATM Director, (phone) 919–541–2384 or niceatm@niehs.nih.gov. DATES: SUPPLEMENTARY INFORMATION sroberts on PROD1PC70 with NOTICES Background The U.S. Environmental Protection Agency (EPA) nominated to ICCVAM several activities relevant to reducing, replacing, or refining the use of rabbits in the current in vivo eye irritation test method (Federal Register Vol. 69, No. 57, pages 13859–13861, March 24, VerDate Aug<31>2005 18:12 May 08, 2007 Jkt 211001 2004). One activity is to review ways to alleviate pain and suffering that might arise from current in vivo eye irritation testing. ICCVAM endorsed this activity with a high priority and recommended that NICEATM review the data currently available on the use of topical anesthetics and/or systemic analgesics to reduce animal pain and distress. As part of this review, NICEATM requests the submission of data from completed studies on the use of topical anesthetics and/or systemic analgesics for in vivo ocular irritancy testing. These data will be used to evaluate the validation status of the use of topical anesthetics and/or analgesics to reduce pain and distress for in vivo testing situations. ICCVAM and NICEATM also request the submission of information and data from in vivo methods, procedures, and/or strategies that may reduce or eliminate the pain and suffering associated with current in vivo eye irritation methods. Background Information on ICCVAM and NICEATM ICCVAM is an interagency committee composed of representatives from 15 federal regulatory and research agencies that use or generate toxicological information. ICCVAM conducts technical evaluations of new, revised, and alternative methods with regulatory applicability and promotes the scientific validation and regulatory acceptance of toxicological test methods that more accurately assess the safety and hazards of chemicals and products and that refine, reduce, or replace animal use. The ICCVAM Authorization Act of 2000 (42 U.S.C. 285l–3) established ICCVAM as a permanent interagency committee of the NIEHS under NICEATM. NICEATM administers the ICCVAM and provides scientific and operational support for ICCVAM-related activities. Additional information about NICEATM and ICCVAM can be found at the following Web site: https:// iccvam.niehs.nih.gov. Dated: April 30, 2007. Samuel H. Wilson, Deputy Director, National Institute of Environmental Health Sciences and National Toxicology Program. [FR Doc. E7–8898 Filed 5–8–07; 8:45 am] BILLING CODE 4140–01–P PO 00000 Frm 00064 Fmt 4703 Sfmt 4703 DEPARTMENT OF HEALTH AND HUMAN SERVICES Administration on Aging Purpose of Notice: Availability of Funding Opportunity Announcement Funding Opportunity Title/Program Name: Aging and Disability Resource Center Initiative: Integrating Access to Long-Term Care. Announcement Type: Initial. Funding Opportunity Number: HHS– 2007–AoA–DR–0707. Statutory Authority: The Older Americans Act of 2006, Public Law 109–365. Catalog of Federal Domestic Assistance (CFDA) Number: 93.048, Title IV and Title II, Discretionary Projects. Dates: The deadline date for the submission of applications is June 29, 2007. I. Funding Opportunity Description In FY 2003, the Administration on Aging (AoA) and the Centers for Medicare & Medicaid Services (CMS) formed a historic partnership to launch the Aging and Disability Resource Center (ADRC) demonstration grant initiative. The goal of the ADRC program is to empower individuals to make informed choices and to streamline access to long term support services. AoA and CMS share a vision to have Resource Centers in every community serving as highly visible and trusted places where people of all ages can turn for information on the full range of long term support options and a single point of entry to public long term support programs and benefits. ADRCs are a resource for both public and private-pay individuals. They serve older adults, younger individuals with disabilities, family caregivers, as well as persons planning for future long term support needs. ADRCs are also a resource for health and long term support professionals and others who provide services to older adults and to people with disabilities. Since FY 2003, 43 states have received three year grants from AoA and CMS to design and implement ADRC demonstrations serving the elderly and at least one other target population of adults with disabilities in at least one community. An ADRC Program Announcement published in FY 2003 resulted in the funding of twelve states that year with an additional twelve states funded to develop ADRC programs in FY 2004. Nineteen additional states were funded to develop ADRC programs based on a Program Announcement published in E:\FR\FM\09MYN1.SGM 09MYN1

Agencies

[Federal Register Volume 72, Number 89 (Wednesday, May 9, 2007)]
[Notices]
[Page 26396]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: E7-8898]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES


National Toxicology Program (NTP), NTP Interagency Center for the 
Evaluation of Alternative Toxicological Methods (NICEATM); Request for 
Data on the Use of Topical Anesthetics and Systemic Analgesics for In 
Vivo Eye Irritation Testing

AGENCY: National Institute of Environmental Health Sciences (NIEHS), 
National Institutes of Health (NIH).

ACTION: Request for data on the use of topical anesthetics and systemic 
analgesics for in vivo ocular irritation testing.

-----------------------------------------------------------------------

SUMMARY: The Interagency Coordinating Committee on the Validation of 
Alternative Methods (ICCVAM) and NICEATM request the submission of data 
and information on the use of topical anesthetics and systemic 
analgesics for alleviating pain and distress in rabbits during eye 
irritation testing. They also request the submission of information 
about other procedures and strategies that may reduce or eliminate pain 
and distress associated with in vivo eye irritation methods.

DATES: Data should be received by June 25, 2007.

ADDRESSES: Data should be sent by mail, fax, or e-mail to Dr. William 
S. Stokes, Director, NICEATM, NIEHS, P.O. Box 12233, MD EC-17, Research 
Triangle Park, NC, 27709, (fax) 919-541-0947, (e-mail) 
niceatm@niehs.nih.gov. Courier address: NICEATM, 79 T.W. Alexander 
Drive, Building 4401, Room 3128, Research Triangle Park, NC 27709.

FOR FURTHER INFORMATION CONTACT: Dr. William S. Stokes, NICEATM 
Director, (phone) 919-541-2384 or niceatm@niehs.nih.gov.

SUPPLEMENTARY INFORMATION

Background

    The U.S. Environmental Protection Agency (EPA) nominated to ICCVAM 
several activities relevant to reducing, replacing, or refining the use 
of rabbits in the current in vivo eye irritation test method (Federal 
Register Vol. 69, No. 57, pages 13859-13861, March 24, 2004). One 
activity is to review ways to alleviate pain and suffering that might 
arise from current in vivo eye irritation testing. ICCVAM endorsed this 
activity with a high priority and recommended that NICEATM review the 
data currently available on the use of topical anesthetics and/or 
systemic analgesics to reduce animal pain and distress.
    As part of this review, NICEATM requests the submission of data 
from completed studies on the use of topical anesthetics and/or 
systemic analgesics for in vivo ocular irritancy testing. These data 
will be used to evaluate the validation status of the use of topical 
anesthetics and/or analgesics to reduce pain and distress for in vivo 
testing situations. ICCVAM and NICEATM also request the submission of 
information and data from in vivo methods, procedures, and/or 
strategies that may reduce or eliminate the pain and suffering 
associated with current in vivo eye irritation methods.

Background Information on ICCVAM and NICEATM

    ICCVAM is an interagency committee composed of representatives from 
15 federal regulatory and research agencies that use or generate 
toxicological information. ICCVAM conducts technical evaluations of 
new, revised, and alternative methods with regulatory applicability and 
promotes the scientific validation and regulatory acceptance of 
toxicological test methods that more accurately assess the safety and 
hazards of chemicals and products and that refine, reduce, or replace 
animal use. The ICCVAM Authorization Act of 2000 (42 U.S.C. 285l-3) 
established ICCVAM as a permanent interagency committee of the NIEHS 
under NICEATM. NICEATM administers the ICCVAM and provides scientific 
and operational support for ICCVAM-related activities. Additional 
information about NICEATM and ICCVAM can be found at the following Web 
site: https://iccvam.niehs.nih.gov.

    Dated: April 30, 2007.
Samuel H. Wilson,
Deputy Director, National Institute of Environmental Health Sciences 
and National Toxicology Program.
 [FR Doc. E7-8898 Filed 5-8-07; 8:45 am]
BILLING CODE 4140-01-P
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