National Institute of Diabetes and Digestive and Kidney Diseases; Notice of Closed Meeting, 25322-25323 [07-2184]
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Federal Register / Vol. 72, No. 86 / Friday, May 4, 2007 / Notices
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Peptide Inhibitors of Fibronectin and
Related Collagen-Binding Proteins
Description of Technology:
Fibronectin has been implicated in a
variety of cell contact processes,
including cell attachment and
migration. Fibronectin interacts with
collagen through its gelatin-binding
domain and this interaction is
fundamental to the organization of
extracellular matrices and the behavior
of these cells on substrates. Fibronectin
is essential for the attachment and
migration of many cells, including
various tumor and cancer cells.
The issued patents disclose peptide
compositions having binding affinity for
fibronectin, as well as methods for
binding fibronectin with a fibronectinbinding peptide and methods for
inhibiting fibronectin-mediated cell
adhesion. The peptides disclosed are
derived from the extracellular matrix
protein thrombospondin, which is a
modular adhesive glycoprotein that
binds to the gelatin binding domain of
fibronectin. These peptides are strong
inhibitors of fibronectin-mediated cell
adhesion. As such, they may be
applicable to a variety of indications
including cancer, wound healing, and
connective tissue diseases.
Applications:
1. Potential therapeutic use for
applications such as cancer, wound
healing, and connective tissue disease.
2. Research tools for study of cell
adhesion and migration processes.
Inventors: David D. Roberts et al.
(NCI)
Related Publications:
`
1. JM Sipes, N Guo, E Negre, T Vogel,
HC Krutzsch, DD Roberts. Inhibition of
fibronectin binding and fibronectinmediated cell adhesion to collagen by a
peptide from the second type I repeat of
thrombospondin. J Cell Biol. 1993
Apr;121(2):469–477.
2. S Schultz-Cherry, H Chen, DF
Mosher, TM Misenheimer, HC Krutzsch,
DD Roberts, JE Murphy-Ullrich.
Regulation of TGFbeta activity by
peptides from the type I repeats of
thrombospondin-1. J Biol Chem. 1995
Mar 31;270(13):7304–7310.
3. C Daniel, J Wiede, Y Takabatake, M
Mizui, Y Isaka, E Imai, H Rupprecht, E
Schulze-Lohoff, HC Krutzsch, SMF
Ribeiro, DD Roberts, JE Murphy-Ullrich,
C Hugo. Thrombospondin-1 is a major
activator of TGFbeta in fibrotic renal
disease in the rat in vivo. Kidney Int.
2004 Feb;65(2):459–468.
Patent Status:
1. U.S. Patent No. 5,491,130 issued 13
Feb 1996 (HHS Reference No. E–219–
1992/0–US–01).
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2. U.S. Patent No. 5,849,701 issued 15
Dec 1998 (HHS Reference No. E–219–
1992/0–US–10).
3. Foreign counterparts issued in
Australia, Great Britain, France,
Germany, and Japan.
Related Technologies:
1. Heparin- and Sulfatide-Binding
Peptides From the Type I Repeats of
Human Thrombospondin.
a. U.S. Patent No. 5,357,041 issued 18
Oct 1994 (HHS Reference No. E–198–
1991/0–US–01);
b. U.S. Patent No. 5,770,563 issued 23
Jun 1998 (HHS Reference No. E–198–
1991/2–US–01);
c. U.S. Patent No. 6,051,549 issued 18
Apr 2000 (HHS Reference No. E–198–
1991/2–US–03); and
d. foreign counterparts.
2. Compositions for Stimulating TGF
Activity.
a. U.S. Patent No. 6,384,189 issued 07
May 2003 (HHS Reference No. E–019–
1994/1–US–02)
Licensing Availability: Available for
exclusive or non-exclusive licensing.
Licensing Contact: Tara Kirby, PhD;
301/435–4426; tarak@mail.nih.gov.
Collaborative Research Opportunity:
The National Cancer Institute,
Laboratory of Pathology, is seeking
statements of capability or interest from
parties interested in collaborative
research to further develop, evaluate, or
commercialize these peptides. Please
contact John D. Hewes, Ph.D. at (301)
435–3121 or hewesj@mail.nih.gov for
more information.
Name of Committee: President’s Cancer
Panel.
Date: May 24, 2007.
Time: 12:30 p.m. to 2:30 p.m.
Agenda: The Panel will review the final
draft of 2006/2007 Annual Report to the
President.
Place: National Cancer Institute, National
Institutes of Health, Building 6116, Room
212, 6116 Executive Boulevard, Bethesda,
MD 20892, (Telephone Conference Call).
Contact Person: Abby Sandler, PhD,
Executive Secretary, Chief, Institute Review
Office, Office of the Director, National Cancer
Institute, National Institutes of Health,
Building 6116, Room 212, MSC 8349, 6116
Executive Boulevard, Bethesda, MD 20892–
8349, 301/451–9399, sandlera@mail.nih.gov.
Information is also available on the
Institute’s/Center’s home page:
deainfo.nci.nih.gov/advisory/pcp/pcp.htm,
where an agenda and any additional
information for the meeting will be posted
when available.
(Catalogue of Federal Domestic Assistance
Program Nos. 93.392, Cancer Construction;
93.393, Cancer Cause and Prevention
Research; 93.394, Cancer Detection and
Diagnosis Research; 93.395, Cancer
Treatment Research; 93.396, Cancer Biology
Research; 93.397, Cancer Centers Support;
93.398, Cancer Research Manpower; 93.399,
Cancer Control, National Institutes of Health,
HHS)
Dated: April 27, 2007.
Steven M. Ferguson,
Director, Division of Technology Development
and Transfer, Office of Technology Transfer,
National Institutes of Health.
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
[FR Doc. E7–8500 Filed 5–3–07; 8:45 am]
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DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
National Cancer Institute; Notice of
Closed Meeting
Pursuant to section 10(d) of the
Federal Advisory Committee Act, as
amended (5 U.S.C. Appendix 2), notice
is hereby given of the meeting of the
President’s Cancer Panel.
The meeting will be closed to the
public in accordance with the
provisions set forth in sections
552b(c)(9)(b), Title 5 U.S.C., as
amended, because the premature
disclosure of information and the
discussions would likely to significantly
frustrate implementation of
recommendations.
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Dated: April 26, 2007.
Jennifer Spaeth,
Director, Office of Federal Advisory
Committee Policy.
[FR Doc. 07–2190 Filed 5–3–07; 8:45 am]
BILLING CODE 4140–01–M
National Institutes of Health
National Institute of Diabetes and
Digestive and Kidney Diseases; Notice
of Closed Meeting
Pursuant to section 10(d) of the
Federal Advisory Committee Act, as
amended (5 U.S.C. Appendix 2), notice
is hereby given of the following
meeting.
The meeting will be closed to the
public in accordance with the
provisions set forth in sections
552b(c)(4) and 552b(c)(6), Title 5 U.S.C.,
as amended. The grant applications and
the discussions could disclose
confidential trade secrets or commercial
property such as patentable material,
and personal information concerning
individuals associated with the grant
applications, the disclosure of which
would constitute a clearly unwarranted
invasion of personal privacy.
Name of Committee: National Institute of
Diabetes and Digestive and Kidney Diseases
Special Emphasis Panel, NIDDK Diabetes
Centers Applications.
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Federal Register / Vol. 72, No. 86 / Friday, May 4, 2007 / Notices
Date: July 22–24, 2007.
Time: 3 p.m. to 5 p.m.
Agenda: To review and evaluate grant
applications.
Place: Gaithersburg Marriott Washington
Center, 9751 Washingtonian Boulevard,
Gaithersburg, MD 20878.
Contact Person: Atul Sahai, PhD, Scientific
Review Administrator, Review Branch, DEA,
NIDDK, National Institutes of Health, Room
908, 6707 Democracy Boulevard, Bethesda,
MD 20892, (301) 594–2242,
sahaia@niddk.nih.gov.
(Catalogue of Federal Domestic Assistance
Program Nos. 93.847, Diabetes,
Endocrinology and Metabolic Research;
93.848, Digestive Diseases and Nutrition
Research; 93.849, Kidney Diseases, Urology
and Hematology Research, National Institutes
of Health, HHS).
MD 20892–5452, (301) 594–7682,
pateldg@niddk.nih.gov.
This notice is being published less than 15
days prior to the meeting due to the timing
limitations imposed by the review and
funding cycle.
(Catalogue of Federal Domestic Assistance
Program Nos. 93.847, Diabetes,
Endocrinology and Metabolic Research;
93.848, Digestive Diseases and Nutrition
Research; 93.849, Kidney Diseases, Urology
and Hematology Research, National Institutes
of Health, HHS)
Dated: April 27, 2007.
Jennifer Spaeth,
Director, Office of Federal Advisory
Committee Policy.
[FR Doc. 07–2185 Filed 5–3–07; 8:45 am]
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
[FR Doc. 07–2184 Filed 5–3–07; 8:45 am]
BILLING CODE 4140–01–M
National Institutes of Health
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institute on Deafness and
Other Communication Disorders;
Notice of Closed Meeting
National Institutes of Health
National Institute of Diabetes and
Digestive and Kidney Diseases; Notice
of Closed Meeting
cprice-sewell on DSK89S0YB1PROD with NOTICES
Pursuant to section 10(d) of the
Federal Advisory Committee Act, as
amended (5 U.S.C. Appendix 2), notice
is hereby given of the following
meeting.
The meeting will be closed to the
public in accordance with the
provisions set forth in sections
552b(c)(4) and 552b(c)(6), Title 5 U.S.C.,
as amended. The grant applications and
the discussions could disclose
confidential trade secrets or commercial
property such as patentable material,
and personal information concerning
individuals associated with the grant
applications, the disclosure of which
would constitute a clearly unwarranted
invasion of personal privacy.
Name of Committee: National Institute of
Diabetes and Digestive and Kidney Diseases
Special Emphasis Panel, R–13 Conference
Applications.
Date: May 14, 2007.
Time: 2 p.m. to 4 p.m.
Agenda: To review and evaluate grant
applications.
Place: National Institutes of Health, Two
Democracy Plaza, 6707 Democracy
Boulevard, Bethesda, MD 20892, (Telephone
Conference Call).
Contact Person: D.G. Patel, PhD, Scientific
Review Administrator, Review Branch, DEA,
NIDDK, National Institutes of Health, Room
914, 6707 Democracy Boulevard, Bethesda,
14:51 Apr 20, 2010
Jkt 220001
Disorders, National Institutes of Health,
HHS).
Dated: April 26, 2007.
Jennifer Spaeth,
Director, Office of Federal Advisory
Committee Policy.
[FR Doc. 07–2187 Filed 5–3–07; 8:45 am]
BILLING CODE 4140–01–M
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
National Institute on Alcohol Abuse
and Alcoholism; Notice of Closed
Meeting
BILLING CODE 4140–01–M
Dated: April 27, 2007.
Jennifer Spaeth,
Director, Office of Federal Advisory
Committee Policy.
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25323
Pursuant to section 10(d) of the
Federal Advisory Committee Act, as
amended (5 U.S.C. Appendix 2), notice
is hereby given of the following
meeting.
The meeting will be closed to the
public in accordance with the
provisions set forth in sections
552b(c)(4) and 552b(c)(6), Title 5 U.S.C.,
as amended. The grant applications and
the discussions could disclose
confidential trade secrets or commercial
property such as patentable material,
and personal information concerning
individuals associated with the grant
applications, the disclosure of which
would constitute a clearly unwarranted
invasion of personal privacy.
Name of Committee: Communication
Disorders Review Committee, CDRC.
Date: June 21–22, 2007.
Time: June 21, 2007, 8 a.m. to 5 p.m.
Agenda: To review and evaluate grant
applications.
Place: Wyndham Hotel, 101 W. Fayette
Street, Baltimore, MD 21201.
Time: June 22, 2007, 8 a.m. to 5 p.m.
Agenda: To review and evaluate grant
applications.
Place: Wyndham Hotel, 101 W. Fayette
Street, Baltimore, MD 21201.
Contact Person: Sheo Singh, PhD,
Scientific Review Administrator, Scientific
Review Branch, Division of Extramural
Activities, Executive Plaza South, Room
400C, 6120 Executive Blvd., Bethesda, MD
20892, 301–496–8683.
(Catalogue of Federal Domestic Assistance
Program Nos. 93.173, Biological Research
Related to Deafness and Communicative
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Pursuant to section 10(d) of the
Federal Advisory Committee Act, as
amended (5 U.S.C. Appendix 2), notice
is hereby given of the following
meeting.
The meeting will be closed to the
public in accordance with the
provisions set forth in sections
552b(c)(4) and 552b(c)(6), Title 5 U.S.C.,
as amended. The grant applications and
the discussions could disclose
confidential trade secrets or commercial
property such as patentable material,
and personal information concerning
individuals associated with the grant
applications, the disclosure of which
would constitute a clearly unwarranted
invasion of personal privacy.
Name of Committee: National Institute of
Alcohol Abuse and Alcoholism Initial
Review Group, Clinical and Treatment
Subcommittee.
Date: June 5–6, 2007.
Time: 8:30 a.m. and 5 p.m.
Agenda: To review and evaluate grant
applications.
Place: Crown Plaza—Silver Spring, 8777
Georgia Avenue, Silver Spring, MD 20910.
Contact Person: Katrina L Foster, PhD,
Scientific Review Administrator, National
Inst on Alcohol Abuse & Alcoholism,
National Institutes of Health, 5635 Fishers
Lane, Rm. 3042, Rockville, MD 20852, 301–
443–4032, katrina@mail.nih.gov.
(Catalogue of Federal Domestic Assistance
Program Nos. 93.271, Alcohol Research
Career Development Awards for Scientists
and Clinicians; 93.272, Alcohol National
Research Service Awards for Research
Training; 93.273, Alcohol Research Programs;
93.891, Alcohol Research Center Grants,
National Institutes of Health, HHS)
Dated: April 26, 2007.
Jennifer Spaeth,
Director, Office of Federal Advisory
Committee Policy.
[FR Doc. 07–2191 Filed 5–3–07; 8:45 am]
BILLING CODE 4140–01–M
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Agencies
[Federal Register Volume 72, Number 86 (Friday, May 4, 2007)]
[Notices]
[Pages 25322-25323]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: 07-2184]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health
National Institute of Diabetes and Digestive and Kidney Diseases;
Notice of Closed Meeting
Pursuant to section 10(d) of the Federal Advisory Committee Act, as
amended (5 U.S.C. Appendix 2), notice is hereby given of the following
meeting.
The meeting will be closed to the public in accordance with the
provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5
U.S.C., as amended. The grant applications and the discussions could
disclose confidential trade secrets or commercial property such as
patentable material, and personal information concerning individuals
associated with the grant applications, the disclosure of which would
constitute a clearly unwarranted invasion of personal privacy.
Name of Committee: National Institute of Diabetes and Digestive
and Kidney Diseases Special Emphasis Panel, NIDDK Diabetes Centers
Applications.
[[Page 25323]]
Date: July 22-24, 2007.
Time: 3 p.m. to 5 p.m.
Agenda: To review and evaluate grant applications.
Place: Gaithersburg Marriott Washington Center, 9751
Washingtonian Boulevard, Gaithersburg, MD 20878.
Contact Person: Atul Sahai, PhD, Scientific Review
Administrator, Review Branch, DEA, NIDDK, National Institutes of
Health, Room 908, 6707 Democracy Boulevard, Bethesda, MD 20892,
(301) 594-2242, sahaia@niddk.nih.gov.
(Catalogue of Federal Domestic Assistance Program Nos. 93.847,
Diabetes, Endocrinology and Metabolic Research; 93.848, Digestive
Diseases and Nutrition Research; 93.849, Kidney Diseases, Urology
and Hematology Research, National Institutes of Health, HHS).
Dated: April 27, 2007.
Jennifer Spaeth,
Director, Office of Federal Advisory Committee Policy.
[FR Doc. 07-2184 Filed 5-3-07; 8:45 am]
BILLING CODE 4140-01-M