Office of the Director, National Institutes of Health; Notice of Meeting, 10229-10230 [07-1041]

Download as PDF sroberts on PROD1PC70 with NOTICES Federal Register / Vol. 72, No. 44 / Wednesday, March 7, 2007 / Notices antibody and its respective epitope has been characterized at the atomic-level. Applications: 1. Immunogens that elicit immune responses to HIV–1. 2. Efficient development of vaccines against HIV–1. 3. Screening tool to isolate antibodies with activities similar to identified template antibody. Inventors: Peter D. Kwong et al. (NIAID) Publications: 1. G Ofek, W Schief, J Guenaga, et al. Epitope-transplant scaffolds: Automated design, structural analysis, and antigenic characteristics. Manuscript in preparation (2007). 2. T Zhou, L Xu, B Dey, AJ Hessell, DV Ryk, SH Xiang, X Yang, MY Zhang, MB Zwick, J Arthos, DR Burton, DS Dimitrov, J Sodroski, R Wyatt, GJ Nabel, PD Kwong. Structural definition of a conserved neutralization epitope on HIV–1 gp120. Nature. 2007 Feb 15;445(7129):732–737. 3. DC Douek, PD Kwong, GJ Nabel. The rational design of an AIDS vaccine. Cell. 2006 Feb 24;124(4):677–681. 4. G Ofek, M Tang, A Sambor, H Katinger, JR Mascola, R Wyatt, PD Kwong. Structure and mechanistic analysis of the anti-HIV–1 antibody 2F5 in complex with its gp41 epitope. J Virol. 2004 Oct;78(19):10724–10737. Patent Status: 1. PCT Application No. PCT/US2005/ 016633 filed 13 May 2005, which published as WO 2005/111079 on 24 Nov 2005 (HHS Reference No. E–218– 2004/0–PCT–02), and National Stage filed in the U.S. on 26 Nov 2006 (HHS Reference No. E–218–2004/0–US–03), entitled ‘‘HIV Vaccine Immunogens and Immunization Strategies to Elicit Broadly-Neutralizing Anti-HIV–1 Antibodies Against the Membrane Proximal of HIV gp41’’. 2. PCT Application No. PCT/US2006/ 034681 filed 06 Sep 2006 (HHS Reference No. E–324–2005/3–PCT–01), entitled ‘‘Conformationally Stabilized HIV Envelope Immunogens and Triggering HIV-1 Envelope to Reveal Cryptic V3-Loop Epitopes’’ 3. PCT Application No. PCT/US2006/ 034882 filed 06 Sep 2006 (HHS Reference No. E–280–2006/1–PCT–01), entitled ‘‘HIV gp120 Crystal Structure and Its Use to Identify Immunogens’’ 4. U.S. Provisional Application No. 60/840,119 filed 25 Aug 2006 (HHS Reference No. E–302–2006/0–US–01), entitled ‘‘Epitope-Transplant Scaffolds and Their Use’’ Licensing Availability: Available for non-exclusive or exclusive licensing. Licensing Contact: Susan Ano, Ph.D.; 301/435–5515; anos@mail.nih.gov VerDate Aug<31>2005 18:25 Mar 06, 2007 Jkt 211001 CCR5-Specific Human Monoclonal Antibodies Description of Technology: The subject invention provides the composition claims related to anti-CCR5 monoclonal antibodies, their fusion protein, conjugates, derivatives, or fragments, DNA sequences encoding such antibodies, host cells containing such DNA sequences, as well as the methods to produce them recombinantly and their pharmacological composition. It has been demonstrated that the HIV co-receptor CCR5 plays an important role in virus entry. The subject antibodies exhibited neutralization activity against HIV–1 infection by binding to cell associated CCR5 in vitro. Moreover, subject antibodies have potentially lower immunogenicity and toxicity, because they are fully human antibodies. Therefore, subject anti-CCR5 antibodies have a potential as a therapeutic and/or prophylactic in combination with other HIV–1 neutralizing antibodies and antiretroviral drugs. Applications: HIV treatment and prevention. Development Status: In vitro data is available at this time. Inventors: Dimiter S. Dimitrov and Mei-Yun Zhang (NCI). Related Publications: 1. C Pastori et al. Long-lasting CCR5 internalization by antibodies in a subset of long-term nonprogressors: A possible protective effect against disease progression. Blood. 2006 Jun 15;107(12):4825–4833. 2. MY Zhang, B Vu, CC Huang, I Sidirov, V Choudhly, PD Kwong, DS Dimitrov. Identification of human monoclonal antibodies specific for CCR5 from an antibody library derived from HIV-infected long-term nonprogressors. Retrovirology. 2006 Dec 21;3 Suppl 1:S61. 3. DS Dimitrov. Virus entry: molecular mechanisms and biomedical applications. Nat Rev Microbiol. 2004 Feb;2(2):109–122. Patent Status: U.S. Provisional Application No. 60/859,401 filed 15 Nov 2006 (HHS Reference No. E–297– 2006/0–US–01) Licensing Availability: Available for exclusive and non-exclusive licensing. Licensing Contact: Sally Hu, Ph.D.; 301/435–5606; HuS@mail.nih.gov. Collaborative Research Opportunity: The NCI CCR Nanobiology Program is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize monoclonal antibodies. Please contact PO 00000 Frm 00118 Fmt 4703 Sfmt 4703 10229 John D. Hewes, Ph.D. at 301–435–3121 or hewesj@mail.nih.gov for more information. Dated: February 28, 2007. Steven M. Ferguson, Director, Division of Technology Development and Transfer, Office of Technology Transfer National Institutes of Health. [FR Doc. E7–3959 Filed 3–6–07; 8:45 am] BILLING CODE 4140–01–P DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Office of the Director, National Institutes of Health; Notice of Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. Appendix 2), notice is hereby given of a meeting of the Advisory Committee on Research on Women’s Health. The meeting will be open to the public, with attendance limited to space available. Individuals who plan to attend and need special assistance, such as sign language interpretation or other reasonable accommodations, should notify the Contact Person listed below in advance of the meeting. Name of Committee: Advisory Committee on Research on Women’s Health. Date: March 29–30, 2007. Time: March 29, 2007, 9 a.m. to 5 p.m. Agenda: Provide advice to the Office of Research on Women’s Health (ORWH) on appropriate research activities with respect to women’s health and related studies to be undertaken by the National Research Institutes; to provide recommendations regarding ORWH activities; to meet the mandates of the office; and for discussion of scientific issues. Place: National Institutes of Health, Building 31, 31 Center Drive, 6C/10, Bethesda, MD 20892. Time: March 30, 2007, 9 a.m. to 1 p.m. Agenda: Same as above. Place: National Institutes of Health, Building 31, 31 Center Drive, 6C/10, Bethesda, MD 20892. Contact Person: Joyce Rudick, Director, Programs & Management, Office of Research on Women’s Health, Office of the Director, National Institutes of Health, Building 1, Room 201, Bethesda, MD 20892, 301/402– 1770. Information is also available on the Institute’s/Center’s home page: https:// www4.od.nih.gov/orwh/, where an agenda and any additional information for the meeting will be posted when available. (Catalogue of Federal Domestic Assistance Program Nos. 93.14, Intramural Research Training Award; 93.22, Clinical Research Loan Repayment Program for Individuals from Disadvantaged Backgrounds; 93.232, Loan Repayment Program for Research E:\FR\FM\07MRN1.SGM 07MRN1 10230 Federal Register / Vol. 72, No. 44 / Wednesday, March 7, 2007 / Notices Generally; 93.39, Academic Research Enhancement Award; 93.936, NIH Acquired Immunodeficiancy Syndrome Research Loan Repayment Program; 93.187, Undergraduate Scholarship Program for Individuals from Disadvantaged Backgrounds, National Institutes of Health, HHS) Dated: February 28, 2007. Anna Snouffer, Acting Director, Office of Federal Advisory Committee Policy. [FR Doc. 07–1041 Filed 3–6–07; 8:45 am] BILLING CODE 4140–01–M DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Cancer Institute; Notice of Meeting sroberts on PROD1PC70 with NOTICES Pursuant to section 10(a) of the Federal Advisory Committee Act, as amended (5 U.S.C. Appendix 2), notice is hereby given of a meeting of the National Cancer Institute Director’s Consumer Liaison Group. The meeting will be open to the public, with attendance limited to space available. Individuals who plan to attend and need special assistance, such as sign language itnerpretation or other reasonable accommodations, should notify the Contact Person listed below in advance of the meeting. Name of Committee: National Cancer Institute Director’s Consumer Liaison Group. Date: March 29–30, 2007. Time: March 29, 2007, 8:45 a.m. to 5:30 p.m. Agenda: 1. Approval of Minutes; 2. Report from Dr. John E. Niederhuber, NCI Director; 3. Reports on NCI Budget; Legislative Activity; NCI Scientific Initiatives by NCI Staff; Reports of DCLG Working Group and member activity; 4. Report on NCI Listens and Learns Evaluations; 5. Public Comment. Place: National Institutes of Health, Building 31, 31 Center Drive, Conf. Rm. 6, Bethesda, MD 20892. Time: March 30, 2007, 2:00 p.m. to 3:30 p.m. Agenda: Action Items and Conclusion. Place: National Institutes of Health, Building 31, 31 Center Drive, Conf. Rm 6, Bethesda, MD 20892. Contact Person: Barbara Guest, Executive Secretary, Office of Liaison Activities, National Cancer Institute, National Institutes of Health, 6116 Executive Blvd., Room 2202, Bethesda, MD 20892–8324, 301–496–0307, guestb@mail.nih.gov. Any interested person may file written comments with the committee by forwarding the statement to the Contact Person listed on this notice. The statement should include the name, address, telephone number and when applicable, the business or professional affiliation of the interested person. In the interest of security, NIH has institute stringent procedures for entrance onto the VerDate Aug<31>2005 18:25 Mar 06, 2007 Jkt 211001 NIH campus. All visitor vehicles, including taxicabs, hotel, and airport shuttles will be inspected before being allowed on campus. Visitors will be asked to show one form of identification (for example, a governmentissued photo ID, driver’s license, or passport) and to state the purpose of their visit. Information is also available on the Institute’s/Center’s home page: deainfo.nci.nih.gov/advisory/dclg/dclg.htm, where an agenda and any additional information for the meeting will be posted when available. (Catalogue of Federal Domestic Assistance Program Nos. 93.392, Cancer Construction; 93.393, Cancer Cause and Prevention Research; 93.394, Cancer Detection and Diagnosis Research; 93.395, Cancer Treatment Research; 93.396, Cancer Biology Research; 93.397, Cancer Centers Support; 93.398, Cancer Research Manpower; 93.399, Cancer Control, National Institutes of Health, HHS) Dated: February 28, 2007. Anna Snouffer, Acting Director, Office of Federal Advisory Committee Policy. [FR Doc. 07–1035 Filed 3–6–07; 8:45 am] BILLING CODE 4140–01–M DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Cancer Institute; Amended Notice of Meeting Notice is hereby given of a change in the meeting of the National Cancer Institute Special Emphasis Panel, February 15, 2007, 12 p.m. to February 15, 2007, 6 p.m., National Institutes of Health, 6116 Executive Boulevard, Bethesda, MD 20892 which was published in the Federal Register on January 30, 2007, 72FR4276. The meeting notice is changed to reflect the date change from February 15, 2007 to March 7, 2007. The meeting is closed to the public. is hereby given of the following meeting. The meeting will be closed to the public in accordance with the provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The grant applications and the discussions could disclose confidential trade secrets or commercial property such as patentable material, and personal information concerning individuals associated with the grant applications, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. Name of Committee: National Center for Complementary and Alternative Medicine Special Emphasis Panel, Mechanisms of Immune Modulation. Date: March 22–23, 2007. Time: 4 p.m. to 5 p.m. Agenda: To review and evaluate grant applications. Place: Bethesda Marriott, 5151 Pooks Hills Road, Bethesda, MD 20814. Contact Person: Martina Schmidt, PhD, Scientific Review Administrator, Office of Scientific Review, National Center for Complementary and Alternative Medicine, NIH, 6707 Democracy Blvd., Suite 401, Bethesda, MD 20892, 301–594–3456, schmidma@mail.nih.gov. Dated: February 28, 2007. Anna Snouffer, Acting Director, Office of Federal Advisory Committee Policy. [FR Doc. 07–1039 Filed 3–6–07; 8:45 am] BILLING CODE 4140–01–M DEPARTMENT OF HEATLH AND HUMAN SERVICES National Institutes of Health National Center on Minority Health and Health Disparities; Notice of Closed Meeting National Center for Complementary and Alternative Medicine; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. Appendix 2), notice is hereby given of the following meeting. The meeting will be closed to the public in accordance with the provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The grant applications and the discussions could disclose confidential trade secrets or commercial property such as patentable material, and personal information concerning individuals associated with the grant applications, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. Appendix 2), notice Name of Committee: National Center on Minority Health and Health Disparities Special Emphasis Panel, Loan Repayment Dated: February 28, 2007. Anna Snouffer, Acting Director, Office of Federal Advisory Committee Policy. [FR Doc. 07–1036 Filed 3–6–07; 8:45 am] BILLING CODE 4140–01–M DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health PO 00000 Frm 00119 Fmt 4703 Sfmt 4703 E:\FR\FM\07MRN1.SGM 07MRN1

Agencies

[Federal Register Volume 72, Number 44 (Wednesday, March 7, 2007)]
[Notices]
[Pages 10229-10230]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: 07-1041]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Office of the Director, National Institutes of Health; Notice of 
Meeting

    Pursuant to section 10(d) of the Federal Advisory Committee Act, as 
amended (5 U.S.C. Appendix 2), notice is hereby given of a meeting of 
the Advisory Committee on Research on Women's Health.
    The meeting will be open to the public, with attendance limited to 
space available. Individuals who plan to attend and need special 
assistance, such as sign language interpretation or other reasonable 
accommodations, should notify the Contact Person listed below in 
advance of the meeting.

    Name of Committee: Advisory Committee on Research on Women's 
Health.
    Date: March 29-30, 2007.
    Time: March 29, 2007, 9 a.m. to 5 p.m.
    Agenda: Provide advice to the Office of Research on Women's 
Health (ORWH) on appropriate research activities with respect to 
women's health and related studies to be undertaken by the National 
Research Institutes; to provide recommendations regarding ORWH 
activities; to meet the mandates of the office; and for discussion 
of scientific issues.
    Place: National Institutes of Health, Building 31, 31 Center 
Drive, 6C/10, Bethesda, MD 20892.

    Time: March 30, 2007, 9 a.m. to 1 p.m.
    Agenda: Same as above.
    Place: National Institutes of Health, Building 31, 31 Center 
Drive, 6C/10, Bethesda, MD 20892.
    Contact Person: Joyce Rudick, Director, Programs & Management, 
Office of Research on Women's Health, Office of the Director, 
National Institutes of Health, Building 1, Room 201, Bethesda, MD 
20892, 301/402-1770.
    Information is also available on the Institute's/Center's home 
page: https://www4.od.nih.gov/orwh/, where an agenda and any 
additional information for the meeting will be posted when 
available.

(Catalogue of Federal Domestic Assistance Program Nos. 93.14, 
Intramural Research Training Award; 93.22, Clinical Research Loan 
Repayment Program for Individuals from Disadvantaged Backgrounds; 
93.232, Loan Repayment Program for Research

[[Page 10230]]

Generally; 93.39, Academic Research Enhancement Award; 93.936, NIH 
Acquired Immunodeficiancy Syndrome Research Loan Repayment Program; 
93.187, Undergraduate Scholarship Program for Individuals from 
Disadvantaged Backgrounds, National Institutes of Health, HHS)

    Dated: February 28, 2007.
Anna Snouffer,
Acting Director, Office of Federal Advisory Committee Policy.
[FR Doc. 07-1041 Filed 3-6-07; 8:45 am]
BILLING CODE 4140-01-M

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