Government-Owned Inventions; Availability for Licensing, 9540-9541 [E7-3695]

Download as PDF 9540 Federal Register / Vol. 72, No. 41 / Friday, March 2, 2007 / Notices pwalker on PROD1PC71 with NOTICES Tool for the development of MATERbased contraceptives. Market: Approximately 10% of women of reproductive age experience infertility, and approximately 5% per year experience menstrual irregularity. Development Status: Established research test, ready for additional clinical research and commercial development. Inventors: Lawrence M. Nelson and Zhi-Bin Tong (NICHD). Publications: 1. Zhi-Bin Tong et al. A mouse gene encoding an oocyte antigen associated with autoimmune premature ovarian failure. Endocrinology. 1999 Aug;140(8):3720–3726. 2. Zhi-Bin Tong et al. Developmental expression and subcellular localization of mouse MATER, an oocyte-specific protein essential for early development. Endocrinology. 2004 Mar;145(3):1427– 1434. 3. Zhi-Bin Tong et al. A human homologue of mouse Mater, a maternal effect gene essential for early embryonic development. Hum Reprod. 2002 Apr; 17(4):903–911. 4. Zhi-Bin Tong et al. Mater, a maternal effect gene required for early embryonic development in mice. Nat Genet. 2000 Nov;26(3):267–268. Patent Status: 1. PCT Application No. PCT/US01/ 10981 filed 04 Apr 2001, which published as WO02/032955 on 25 Apr 2002 (HHS Reference No. E–239–2000/ 0-PCT–02). 2. U.S. Application No. 10/399,443 filed 16 Apr 2003 (allowed) (HHS Reference No. E–239–2000/0-US–03). 3. U.S. Application No. 11/586,160 filed 24 Oct 2006 (HHS Reference No. E–239–2000/0-US–08). 4. U.S. Application No. 11/586,075 filed 24 Oct 2006 (HHS Reference No. E–239–2000/0-US–09). 5. U.S. Application No. 10/677,943 filed 01 Oct 2003 (allowed) (HHS Reference No. E–239–2000/1-US–02). 6. Foreign counterparts pending in Australia, Canada, Europe, and Japan. Licensing Availability: Available for exclusive or non-exclusive licensing. Licensing Contact: Tara L. Kirby, Ph.D.; 301/435–4426; tarak@mail.nih.gov. Dated: February 26, 2007. Steven M. Ferguson, Director, Division of Technology Development and Transfer, Office of Technology Transfer, National Institutes of Health. [FR Doc. E7–3694 Filed 3–1–07; 8:45 am] BILLING CODE 4140–01–P VerDate Aug<31>2005 18:44 Mar 01, 2007 Jkt 211001 DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Government-Owned Inventions; Availability for Licensing National Institutes of Health, Public Health Service, HHS. ACTION: Notice. AGENCY: SUMMARY: The inventions listed below are owned by an agency of the U.S. Government and are available for licensing in the U.S. in accordance with 35 U.S.C. 207 to achieve expeditious commercialization of results of federally-funded research and development. Foreign patent applications are filed on selected inventions to extend market coverage for companies and may also be available for licensing. ADDRESSES: Licensing information and copies of the U.S. patent applications listed below may be obtained by writing to the indicated licensing contact at the Office of Technology Transfer, National Institutes of Health, 6011 Executive Boulevard, Suite 325, Rockville, Maryland 20852–3804; telephone: 301/ 496–7057; fax: 301/402–0220. A signed Confidential Disclosure Agreement will be required to receive copies of the patent applications. Identification and Isolation of the Receptor for Pigment EpitheliumDerived Factor (PEDF) Description of Technology: This application describes and claims compositions and methods related to PEDF-R, a receptor for pigment epithelium-derived factor (PEDF). PEDF (aka serpin f1 gene product) is a protein, belonging to the serpin superfamily with neurotrophic, gliastatic, neuronotrophic, antiangiogenic, and antitumorigenic properties. However, PEDF lacks the characteristic ability of serpins to inhibit serine protease activity. In particular, the compositions and methods described and claimed in this application are related to the isolation, cloning, expression and characterization of a receptor for PEDF, PEDF-R. The PEDF-R gene (also known as TTS-2.2, iPLA-zeta, ATGL, desnutrin, or PNPLA2) is located on chromosome 11. The sequence of the PEDF-R polypeptide is composed of 504 amino acids, and shares homology with other genes such as for adiponutrin and GS2, contains a patatin-like phospholipase A2 domain and up to four transmembrane regions. PEDF-R exhibits a potent phospholipase A2 activity, binds to PEDF ligands with PO 00000 Frm 00040 Fmt 4703 Sfmt 4703 high affinity, and it localizes to plasma membranes. An extracellular loop region is available for the interactions with extracellular PEDF ligand, which stimulate the phospholipase activity of PEDF-R. The identification of this novel PEDF-R gene in the retina for a phospholipase-linked membrane protein with high affinity for PEDF, suggests a molecular pathway by which ligand/receptor interaction on the cell surface could generate a cellular signal. Applications: 1. Basic research to further elucidate the role of PEDF and its receptor in signal transduction pathways. 2. Development of drug screening assays to identify agonists and antagonists of PEDF activity. 3. Development of new biological molecules to regulate PEDF signaling such as monoclonal antibodies and chimeric IgG-receptor constructs. Development Stage: Information on research being conducted in Dr. Becerra’s laboratory can be found on the Internet at https://www.nei.nih.gov/ intramural/protein_struct_func.asp. The ability of the receptor or receptortargeted molecules and biologics to be used as therapeutics remains the subject of early research and development efforts. Inventors: S. Patricia Becerra (NEI), Luigi Notari (NEI), Jorge Laborda (CDER/FDA), et al. Publications: 1. The patent application has been published as WO 2005/014645 A2 on 17 Feb 2005. 2. L Notari et al. Identification of a lipase-linked cell membrane receptor for pigment epithelium-derived factor. J Biol Chem. 2006 Dec 8; 281(49):38022– 38037. Patent Status: 1. U.S. Patent Application No. 10/ 566,540 filed 16 Oct 2006, entitled ‘‘PEDF-R Receptor and Uses,’’ is pending (HHS Reference No. E–314– 2003/2–US–02). The U.S. Application has not been published. Only U.S. Patent protection has been sought for this technology. There are no foreign counterpart patent applications. 2. PCT/US2004/025560 filed 05 Aug 2004 and published as WO 2005/014645 A2 on 17 Feb 2005, now expired (HHS Reference No. E–314–2003/2–PCT–01). 3. U.S. Provisional Application No. 60/579,177 filed 12 Jun 2004, now abandoned (HHS Reference No. E–314– 2003/1–US–01). 4. U.S. Provisional Application No. 60/493,713 filed 07 Aug 2003, now abandoned (HHS Reference No. E–314– 2003/0–US–01). E:\FR\FM\02MRN1.SGM 02MRN1 Federal Register / Vol. 72, No. 41 / Friday, March 2, 2007 / Notices pwalker on PROD1PC71 with NOTICES Biological Materials Availability: Biological materials related to this technology are not available at this time. Licensing Availability: This application is available for license on a non-exclusive or exclusive basis. Licensing Contact: Susan S. Rucker; 301/435–4478; e-mail: ruckersu@mail.nih.gov. Dated: February 22, 2007. Steven M. Ferguson, Director, Division of Technology Development and Transfer, Office of Technology Transfer, National Institutes of Health. [FR Doc. E7–3695 Filed 3–1–07; 8:45 am] Genes Expressed in Prostate Cancer and Methods of Use Description of Technology: This invention is a novel gene, called New Gene Expressed in Prostate (NGEP). This gene appears to be expressed only in human prostate and prostate cancer. This gene has two known splice variants of significantly different size. The shorter splice variant encodes a cytoplasmic protein, while the longer splice variant encodes a plasma membrane protein, which has been detected on the plasma membrane of human cancer cells. This patent application contains claims to the polypeptide, NGEP, nucleotides encoding NGEP, antibodies that bind NGEP polypeptides, and methods of using these polypeptides, polynucleotides, and antibodies. The presence of the protein on the cell surface and the selective expression in prostate and prostate cancer make this a potential target for prostate cancer diagnostics and therapeutics. Potential therapeutics could be gene-based, vaccines, antibodies, or immunoconjugates. Inventors: Ira Pastan, Tapan Bera, and Byungkook Lee (NCI.) Publications: 1. S Das et al. NGEP, a prostatespecific plasma membrane protein that promotes the association of LNCaP cells. Cancer Res. 2007 Feb 15; 67(4):1594– 1601. 2. TK Bera et al. NGEP, a gene encoding a membrane protein detected only in prostate cancer and normal prostate. Proc Natl Acad Sci USA. 2004 Mar 2; 101(9):3050–3064. Patent Status: 1. U.S. Provisional Application No. 60/461,399 filed 08 Apr 2003 (HHS Reference No. E–148–2003/0–US–01). 2. PCT Application No. PCT/US04/ 10588 filed 05 Apr 2004, which published as WO 2004/092213 on 28 Oct 2004 (HHS Reference No. E–148– 2003/0–PCT–02). 3. U.S. Patent Application No. 10/ 552,515 filed 06 Oct 2005 (HHS Reference No. E–148–2003/0–US–03). Licensing Status: Available for nonexclusive licensing. Licensing Contact: Jesse S. Kindra, J.D.; 301/435–5559; kindraj@mail.nih.gov. DEPARTMENT OF HEALTH AND HUMAN SERVICES VerDate Aug<31>2005 18:44 Mar 01, 2007 Jkt 211001 BILLING CODE 4140–01–P National Institutes of Health Office of the Director, National Institutes of Health; Notice of Meeting Pursuant to section 10(a) of the Federal Advisory Committee Act, as amended (5 U.S.C. Appendix 2), notice is hereby given of a meeting of the Office of AIDS Research Advisory Council. The meeting will be open to the public, with attendance limited to space available. Individuals who plan to attend and need special assistance, such as sign language interpretation or other reasonable accommodations, should notify the Contact Person listed below in advance of the meeting. Name of Committee: Office of AIDS Research Advisory Council. Date: April 19, 2007. Time: 9 a.m. to 5 p.m. Agenda: The meeting will focus on HIVrelated Complications including Malignancies, Cardiovascular Disease, and Metabolic Complications. An update will be provided on the OARAC Working Groups for Treatment and Prevention Guidelines. Place: National Institutes of Health, 5635 Fishers Lane, Rockville, MD 20852. Contact Person: Christina Brackna, Coordinator, Program Planning and Analysis, Office of Aids Research, Office of the Director, NIH, 5635 Fishers Lane MSC 9310, Suite 4000, Rockville, MD 20852, (301) 402– 8655, cm53v@nih.gov. Any member of the public interested in presenting oral comments to the committee may notify the Contact Person listed on this notice at least 10 days in advance of the meeting. Interested individuals and representatives of organizations may submit a letter of intent, a brief description of the organization represented, and a short description of the oral presentation. Only one representative of an organization may be allowed to present oral comments and if accepted by the committee, presentations may be limited to five minutes. Both printed and electronic copies are requested for the record. In addition, any interested person may file written comments with the committee by forwarding their statement to the Contact Person listed on this notice. The statement should include the name, address, telephone number and when applicable, the business or professional affiliation of the interested person. Information is also available on the Institute’s Center’s home page: https:// PO 00000 Frm 00041 Fmt 4703 Sfmt 4703 9541 www.ni.gov/od/oar/index.htm, where an agenda and any additional information for the meeting will be posted when available. (Catalogue of Federal Domestic Assistance Program Nos. 93.14, Intramural Research Training Award; 93.22, Clinical Research Loan Repayment Program for Individuals from Disadvantaged Backgrounds; 93.232, Loan Repayment Program for Research Generally; 93.39, Academic Research Enhancement Award; 93.936, NIH Acquired Immunodeficiency Syndrome Research Loan Repayment Program; 93.187, Undergraduate Scholarship Program for Individuals from Disadvantaged Backgrounds, National Institutes of Health, HHS) Dated: February 23, 2007. Anna Snouffer, Acting Director, Office of Federal Advisory Committee Policy. [FR Doc. 07–961 Filed 3–1–07; 8:45 am] BILLING CODE 4140–01–M DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Notice of Meeting: Secretary’s Advisory Committee on Genetics, Health, and Society Pursuant to Public Law 92–463, notice is hereby given of the twelfth meeting of the Secretary’s Advisory Committee on Genetics, Health, and Society (SACGHS), U.S. Public Health Service. The meeting will be held from 8 a.m. to approximately 5 p.m. on Monday, March 26, 2007 and 8 a.m. to approximately 5 p.m. on Tuesday, March 27, 2007, at the Marriott Inn and Conference Center, University of Maryland—College Park, 3501 University Boulevard East, Adelphi, MD 20783. The meeting will be open to the public with attendance limited to space available. The meeting also will be Web cast. The agenda will focus on the oversight of genetic testing, including the role of the private sector in assuring the quality and validity of genetic tests; the impact of gene patents and licensing practices on patient access to genetic technologies, including a progress report on the Committee’s study; and the status of Federal genetic information nondiscrimination legislation. The Committee will be briefed on the Secretary’s Personalized Health Care Initiative and the work of the American Health Information Community, particularly its Personalized Health Care Working Group. The Committee’s report on the Policy Issues Associated with Undertaking a New Large U.S. Population Cohort Project on Genes, Environment and Disease will be E:\FR\FM\02MRN1.SGM 02MRN1

Agencies

[Federal Register Volume 72, Number 41 (Friday, March 2, 2007)]
[Notices]
[Pages 9540-9541]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: E7-3695]


-----------------------------------------------------------------------

DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Government-Owned Inventions; Availability for Licensing

AGENCY: National Institutes of Health, Public Health Service, HHS.

ACTION: Notice.

-----------------------------------------------------------------------

SUMMARY: The inventions listed below are owned by an agency of the U.S. 
Government and are available for licensing in the U.S. in accordance 
with 35 U.S.C. 207 to achieve expeditious commercialization of results 
of federally-funded research and development. Foreign patent 
applications are filed on selected inventions to extend market coverage 
for companies and may also be available for licensing.

ADDRESSES: Licensing information and copies of the U.S. patent 
applications listed below may be obtained by writing to the indicated 
licensing contact at the Office of Technology Transfer, National 
Institutes of Health, 6011 Executive Boulevard, Suite 325, Rockville, 
Maryland 20852-3804; telephone: 301/496-7057; fax: 301/402-0220. A 
signed Confidential Disclosure Agreement will be required to receive 
copies of the patent applications.

Identification and Isolation of the Receptor for Pigment Epithelium-
Derived Factor (PEDF)

    Description of Technology: This application describes and claims 
compositions and methods related to PEDF-R, a receptor for pigment 
epithelium-derived factor (PEDF). PEDF (aka serpin f1 gene product) is 
a protein, belonging to the serpin superfamily with neurotrophic, 
gliastatic, neuronotrophic, antiangiogenic, and antitumorigenic 
properties. However, PEDF lacks the characteristic ability of serpins 
to inhibit serine protease activity. In particular, the compositions 
and methods described and claimed in this application are related to 
the isolation, cloning, expression and characterization of a receptor 
for PEDF, PEDF-R. The PEDF-R gene (also known as TTS-2.2, iPLA-zeta, 
ATGL, desnutrin, or PNPLA2) is located on chromosome 11. The sequence 
of the PEDF-R polypeptide is composed of 504 amino acids, and shares 
homology with other genes such as for adiponutrin and GS2, contains a 
patatin-like phospholipase A2 domain and up to four transmembrane 
regions. PEDF-R exhibits a potent phospholipase A2 activity, binds to 
PEDF ligands with high affinity, and it localizes to plasma membranes. 
An extracellular loop region is available for the interactions with 
extracellular PEDF ligand, which stimulate the phospholipase activity 
of PEDF-R. The identification of this novel PEDF-R gene in the retina 
for a phospholipase-linked membrane protein with high affinity for 
PEDF, suggests a molecular pathway by which ligand/receptor interaction 
on the cell surface could generate a cellular signal.
    Applications:
    1. Basic research to further elucidate the role of PEDF and its 
receptor in signal transduction pathways.
    2. Development of drug screening assays to identify agonists and 
antagonists of PEDF activity.
    3. Development of new biological molecules to regulate PEDF 
signaling such as monoclonal antibodies and chimeric IgG-receptor 
constructs.
    Development Stage: Information on research being conducted in Dr. 
Becerra's laboratory can be found on the Internet at https://
www.nei.nih.gov/intramural/protein_struct_func.asp. The ability of 
the receptor or receptor-targeted molecules and biologics to be used as 
therapeutics remains the subject of early research and development 
efforts.
    Inventors: S. Patricia Becerra (NEI), Luigi Notari (NEI), Jorge 
Laborda (CDER/FDA), et al.
    Publications:
    1. The patent application has been published as WO 2005/014645 A2 
on 17 Feb 2005.
    2. L Notari et al. Identification of a lipase-linked cell membrane 
receptor for pigment epithelium-derived factor. J Biol Chem. 2006 Dec 
8; 281(49):38022-38037.
    Patent Status:
    1. U.S. Patent Application No. 10/566,540 filed 16 Oct 2006, 
entitled ``PEDF-R Receptor and Uses,'' is pending (HHS Reference No. E-
314-2003/2-US-02). The U.S. Application has not been published. Only 
U.S. Patent protection has been sought for this technology. There are 
no foreign counterpart patent applications.
    2. PCT/US2004/025560 filed 05 Aug 2004 and published as WO 2005/
014645 A2 on 17 Feb 2005, now expired (HHS Reference No. E-314-2003/2-
PCT-01).
    3. U.S. Provisional Application No. 60/579,177 filed 12 Jun 2004, 
now abandoned (HHS Reference No. E-314-2003/1-US-01).
    4. U.S. Provisional Application No. 60/493,713 filed 07 Aug 2003, 
now abandoned (HHS Reference No. E-314-2003/0-US-01).

[[Page 9541]]

    Biological Materials Availability: Biological materials related to 
this technology are not available at this time.
    Licensing Availability: This application is available for license 
on a non-exclusive or exclusive basis.
    Licensing Contact: Susan S. Rucker; 301/435-4478; e-mail: 
ruckersu@mail.nih.gov.

Genes Expressed in Prostate Cancer and Methods of Use

    Description of Technology: This invention is a novel gene, called 
New Gene Expressed in Prostate (NGEP). This gene appears to be 
expressed only in human prostate and prostate cancer. This gene has two 
known splice variants of significantly different size. The shorter 
splice variant encodes a cytoplasmic protein, while the longer splice 
variant encodes a plasma membrane protein, which has been detected on 
the plasma membrane of human cancer cells.
    This patent application contains claims to the polypeptide, NGEP, 
nucleotides encoding NGEP, antibodies that bind NGEP polypeptides, and 
methods of using these polypeptides, polynucleotides, and antibodies.
    The presence of the protein on the cell surface and the selective 
expression in prostate and prostate cancer make this a potential target 
for prostate cancer diagnostics and therapeutics. Potential 
therapeutics could be gene-based, vaccines, antibodies, or 
immunoconjugates.
    Inventors: Ira Pastan, Tapan Bera, and Byungkook Lee (NCI.)
    Publications:
    1. S Das et al. NGEP, a prostate-specific plasma membrane protein 
that promotes the association of LNCaP cells. Cancer Res. 2007 Feb 15; 
67(4):1594-1601.
    2. TK Bera et al. NGEP, a gene encoding a membrane protein detected 
only in prostate cancer and normal prostate. Proc Natl Acad Sci USA. 
2004 Mar 2; 101(9):3050-3064.
    Patent Status:
    1. U.S. Provisional Application No. 60/461,399 filed 08 Apr 2003 
(HHS Reference No. E-148-2003/0-US-01).
    2. PCT Application No. PCT/US04/10588 filed 05 Apr 2004, which 
published as WO 2004/092213 on 28 Oct 2004 (HHS Reference No. E-148-
2003/0-PCT-02).
    3. U.S. Patent Application No. 10/552,515 filed 06 Oct 2005 (HHS 
Reference No. E-148-2003/0-US-03).
    Licensing Status: Available for non-exclusive licensing.
    Licensing Contact: Jesse S. Kindra, J.D.; 301/435-5559; 
kindraj@mail.nih.gov.

    Dated: February 22, 2007.
Steven M. Ferguson,
Director, Division of Technology Development and Transfer, Office of 
Technology Transfer, National Institutes of Health.
[FR Doc. E7-3695 Filed 3-1-07; 8:45 am]
BILLING CODE 4140-01-P

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