Prospective Grant of Exclusive License: The Use of Adenovirus Vectors for the Development of Vaccines Against Human Immunodeficiency Virus and Other Infectious Agents, 7904 [E7-2883]
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Federal Register / Vol. 72, No. 34 / Wednesday, February 21, 2007 / Notices
Scientific Review, National Institutes of
Health, 6701 Rockledge Drive, Room 3028D,
MSC 7770, Bethesda, MD 20892, 301–435–
1251, melnicks@csr.nih.gov.
(Catalogue of Federal Domestic Assistance
Program Nos. 93.306, Comparative Medicine;
93.333, Clinical Research, 93.306, 93.333,
93.337, 93.393–93.396, 93.837–93.844,
93.846–93.878, 93.892, 93.893, National
Institutes of Health, HHS)
Dated: February 8, 2007.
Anna Snouffer,
Acting Director, Office of Federal Advisory
Committee Policy.
[FR Doc. 07–762 Filed 2–20–07; 8:45 am]
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DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
Prospective Grant of Exclusive
License: The Use of Adenovirus
Vectors for the Development of
Vaccines Against Human
Immunodeficiency Virus and Other
Infectious Agents
National Institutes of Health,
Public Health Service, HHS.
ACTION: Notice.
rmajette on PROD1PC67 with NOTICES
AGENCY:
SUMMARY: This is notice, in accordance
with 35 U.S.C. 209(c)(1) and 37 CFR
Part 404.7(a)(1)(i), that the National
Institutes of Health (NIH), Department
of Health and Human Services (HHS), is
contemplating the grant of an exclusive
patent license to practice the inventions
embodied in Patent Cooperation Treaty
Application No. PCT/US02/27592 filed
August 29, 2002 and United States
National Stage Application Serial No.
10/487,974 filed February 27, 2004,
entitled ‘‘New Adenovirus Type 7
Vectors’’ [HHS Reference No. E–236–
2001/0], and United States Patent
Application Serial No. 11/282,319 filed
November 17, 2005, entitled ‘‘Improved
Replication-Competent Adenovirus
Vectors’’ [HHS Reference No. E–203–
2004/0], to PaxVax, Inc., which has
offices in Menlo Park, CA. The patent
rights in these inventions have been
assigned and/or exclusively licensed to
the Government of the United States of
America.
The prospective exclusive license
territory may be the United States of
America, and the field of use may be
limited to the development of vaccines
against human immunodeficiency virus,
human papillomavirus, influenza,
malaria, and tuberculosis.
DATES: Only written comments and/or
applications for a license which are
received by the NIH Office of
VerDate Aug<31>2005
15:09 Feb 20, 2007
Jkt 211001
Technology Transfer on or before April
23, 2007 will be considered.
ADDRESSES: Requests for copies of the
patent application, inquiries, comments,
and other materials relating to the
contemplated exclusive license should
be directed to: Susan Ano, Ph.D.,
Technology Licensing Specialist, Office
of Technology Transfer, National
Institutes of Health, 6011 Executive
Boulevard, Suite 325, Rockville, MD
20852–3804; Telephone: (301) 435–
5515; Facsimile: (301) 402–0220; E-mail:
anos@mail.nih.gov.
SUPPLEMENTARY INFORMATION: The
subject application addresses two (2)
technologies related to specific
techniques for producing adenoviral
vectors and application of such vectors
for gene transfer, vaccine development
and therapeutics. Use of the present
technologies in the prevention and/or
treatment of disease, especially human
immunodeficiency virus (HIV), is the
primary focus of the current subject
inventions.
The first technology (HHS Reference
No. E–236–2001/0) describes a cosmid
adenoviral serotype 7 (Ad7) vector for
use in the prevention and/or treatment
of HIV–1. This invention includes
methods for producing and
administering both replicationcompetent and incompetent Ad7. The
cosmid Ad7 vector includes an Ad7
genome that can be modified to express
specific nucleic acid sequences for
production of a desired protein or
epitope such as an HIV–1 gene product.
This system may be used to generate
proteins or epitopes of infectious agents
for stimulation of desired immunogenic
responses.
The second invention (HHS Reference
No. E–203–2004/0) discloses
improvements upon replicationcompetent Ad vectors, which serve to
produce high level expression of any
gene of interest, i.e., a transgene. This
system incorporates a novel hybrid gene
regulatory unit comprising a CMV
promoter and an adenovirus tripartite
leader sequence for regulation of
transgene expression. Additionally, the
present disclosure provides methods of
producing and administering the
described adenoviral expression vectors,
containing the nucleic acid sequence of
significant HIV–1 proteins as transgenes
for stimulation of an immune response
to HIV–1.
The prospective exclusive license will
be royalty bearing and will comply with
the terms and conditions of 35 U.S.C.
209 and 37 CFR part 404.7. The
prospective exclusive license may be
granted within ninety (90) days from the
date of this published notice, unless the
PO 00000
Frm 00050
Fmt 4703
Sfmt 4703
NIH receives written evidence and
argument that establishes that the grant
of the license would not be consistent
with the requirements of 35 U.S.C. 209
and 37 CFR part 404.7.
Applications for a license in the field
of use filed in response to this notice
will be treated as objections to the grant
of the contemplated exclusive license.
Comments and objections submitted to
this notice will not be made available
for public inspection and, to the extent
permitted by law, will not be released
under the Freedom of Information Act,
5 U.S.C. 552.
Dated: February 12, 2007.
Steven M. Ferguson,
Director, Division of Technology Development
and Transfer, Office of Technology Transfer,
National Institutes of Health.
[FR Doc. E7–2883 Filed 2–20–07; 8:45 am]
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Conference of the Parties to the
Convention on International Trade in
Endangered Species of Wild Fauna
and Flora (CITES); Fourteenth Regular
Meeting; Provisional Agenda;
Announcement of Public Meeting
Fish and Wildlife Service,
Interior.
ACTION: Notice.
AGENCY:
SUMMARY: We, the United States, as a
Party to the Convention on International
Trade in Endangered Species of Wild
Fauna and Flora (CITES), will attend the
fourteenth regular meeting of the
Conference of the Parties to CITES
(CoP14) in The Hague, The Netherlands,
June 3–15, 2007. Currently, the United
States is developing its negotiating
positions on proposed resolutions,
decisions, and amendments to the
CITES Appendices (species proposals),
as well as other agenda items that have
been submitted by other Party countries
and the CITES Secretariat for
consideration at CoP14. With this notice
we announce the provisional agenda for
CoP14, solicit your comments on the
items on the provisional agenda, and
announce a public meeting to discuss
the items on the provisional agenda.
DATES: The public meeting will be held
on April 9, 2007, at 1:30 p.m. In
developing the U.S. negotiating
positions on proposed resolutions,
decisions, and species proposals, and
other agenda items submitted by other
Party countries and the CITES
Secretariat for consideration at CoP14,
we will consider written information
E:\FR\FM\21FEN1.SGM
21FEN1
]]>Agencies
[Federal Register Volume 72, Number 34 (Wednesday, February 21, 2007)]
[Notices]
[Page 7904]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: E7-2883]
-----------------------------------------------------------------------
DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health
Prospective Grant of Exclusive License: The Use of Adenovirus
Vectors for the Development of Vaccines Against Human Immunodeficiency
Virus and Other Infectious Agents
AGENCY: National Institutes of Health, Public Health Service, HHS.
ACTION: Notice.
-----------------------------------------------------------------------
SUMMARY: This is notice, in accordance with 35 U.S.C. 209(c)(1) and 37
CFR Part 404.7(a)(1)(i), that the National Institutes of Health (NIH),
Department of Health and Human Services (HHS), is contemplating the
grant of an exclusive patent license to practice the inventions
embodied in Patent Cooperation Treaty Application No. PCT/US02/27592
filed August 29, 2002 and United States National Stage Application
Serial No. 10/487,974 filed February 27, 2004, entitled ``New
Adenovirus Type 7 Vectors'' [HHS Reference No. E-236-2001/0], and
United States Patent Application Serial No. 11/282,319 filed November
17, 2005, entitled ``Improved Replication-Competent Adenovirus
Vectors'' [HHS Reference No. E-203-2004/0], to PaxVax, Inc., which has
offices in Menlo Park, CA. The patent rights in these inventions have
been assigned and/or exclusively licensed to the Government of the
United States of America.
The prospective exclusive license territory may be the United
States of America, and the field of use may be limited to the
development of vaccines against human immunodeficiency virus, human
papillomavirus, influenza, malaria, and tuberculosis.
DATES: Only written comments and/or applications for a license which
are received by the NIH Office of Technology Transfer on or before
April 23, 2007 will be considered.
ADDRESSES: Requests for copies of the patent application, inquiries,
comments, and other materials relating to the contemplated exclusive
license should be directed to: Susan Ano, Ph.D., Technology Licensing
Specialist, Office of Technology Transfer, National Institutes of
Health, 6011 Executive Boulevard, Suite 325, Rockville, MD 20852-3804;
Telephone: (301) 435-5515; Facsimile: (301) 402-0220; E-mail:
anos@mail.nih.gov.
SUPPLEMENTARY INFORMATION: The subject application addresses two (2)
technologies related to specific techniques for producing adenoviral
vectors and application of such vectors for gene transfer, vaccine
development and therapeutics. Use of the present technologies in the
prevention and/or treatment of disease, especially human
immunodeficiency virus (HIV), is the primary focus of the current
subject inventions.
The first technology (HHS Reference No. E-236-2001/0) describes a
cosmid adenoviral serotype 7 (Ad7) vector for use in the prevention
and/or treatment of HIV-1. This invention includes methods for
producing and administering both replication-competent and incompetent
Ad7. The cosmid Ad7 vector includes an Ad7 genome that can be modified
to express specific nucleic acid sequences for production of a desired
protein or epitope such as an HIV-1 gene product. This system may be
used to generate proteins or epitopes of infectious agents for
stimulation of desired immunogenic responses.
The second invention (HHS Reference No. E-203-2004/0) discloses
improvements upon replication-competent Ad vectors, which serve to
produce high level expression of any gene of interest, i.e., a
transgene. This system incorporates a novel hybrid gene regulatory unit
comprising a CMV promoter and an adenovirus tripartite leader sequence
for regulation of transgene expression. Additionally, the present
disclosure provides methods of producing and administering the
described adenoviral expression vectors, containing the nucleic acid
sequence of significant HIV-1 proteins as transgenes for stimulation of
an immune response to HIV-1.
The prospective exclusive license will be royalty bearing and will
comply with the terms and conditions of 35 U.S.C. 209 and 37 CFR part
404.7. The prospective exclusive license may be granted within ninety
(90) days from the date of this published notice, unless the NIH
receives written evidence and argument that establishes that the grant
of the license would not be consistent with the requirements of 35
U.S.C. 209 and 37 CFR part 404.7.
Applications for a license in the field of use filed in response to
this notice will be treated as objections to the grant of the
contemplated exclusive license. Comments and objections submitted to
this notice will not be made available for public inspection and, to
the extent permitted by law, will not be released under the Freedom of
Information Act, 5 U.S.C. 552.
Dated: February 12, 2007.
Steven M. Ferguson,
Director, Division of Technology Development and Transfer, Office of
Technology Transfer, National Institutes of Health.
[FR Doc. E7-2883 Filed 2-20-07; 8:45 am]
BILLING CODE 4140-01-P
