Government-Owned Inventions; Availability for Licensing, 4275-4276 [E7-1379]

Download as PDF ycherry on PROD1PC64 with NOTICES Federal Register / Vol. 72, No. 19 / Tuesday, January 30, 2007 / Notices of NK cells by self HLA molecules or MHC class I expressing tumors. Claims cover compositions of enriched NK cell populations and method of treating malignancies or prevent recurrence of malignancies and treating any hyperproliferative disorders with these enriched compositions. Claims also cover a method to sensitize malignancies to NK cell TRAILmediated killing by pretreatment with bortezomib. Applications and Modality: New adoptive infusion immunotherapeutic method for treating solid tumors; New cancer treatment method exploiting the function of NK cells; Enriched composition of allogeneic and autologous NK cell population; Enriched NK cell composition has potential to override the natural NK cell inactivation process by HLA or MHC class I expressing tumors; Sensitizing cancers to adoptively infused NK cells by treatment with bortezomib as a method to sensitize to NK cell TRAIL cytotoxicity. Market: In 2006, 600,000 estimated deaths from cancer related diseases; Immunotherapy market is expected to double in the next 5 years; Adoptive immunotherapy is one of the most promising new cancer therapies. Development Status: The technology is currently in the pre-clinical stage of development. Inventors: Richard W. Childs et al. (NHLBI). Related Publications: 1. T Igarashi et al. Enhanced cytotoxicity of allogeneic NK cells with killer immunoglobulinlike receptor ligand incompatibility against melanoma and renal cell carcinoma cells. Blood. 2004 Jul 1;104(1):170–177. 2. A Lundqvist et al. Bortezomib and depsipeptide sensitize tumors to tumor necrosis factor-related apoptosisinducing ligand: a novel method to potentiate natural killer cell tumor cytotoxicity. Cancer Res. 2006 Jul 15;66(14):7317–7325. 3. A Lundqvist et al. Reduction of GVHD and enhanced anti-tumor effects after adoptive infusion of alloreactive Ly49-mismatched NK-cells from MHCmatched donors. Blood. Prepublished online 2006 Dec 19, doi 10.1182/blood2006–05–024315. Patent Status: PCT Application No. PCT/ U.S. 2005/039282 filed 31 Oct 2005, entitled ‘‘Compositions and Methods for Treating Hyperproliferative Disorders,’’ which published as WO 2006/050270 on 11 May 2006 (HHS Reference No. E–183–2004/1–PCT–01). Licensing Status: Available for exclusive and non-exclusive licensing. VerDate Aug<31>2005 15:36 Jan 29, 2007 Jkt 211001 Licensing Contact: Thomas P. Clouse, J.D.; 301/435–4076; clousetp@mail.nih.gov. Collaborative Research Opportunity: The Hematology Branch of the National Heart, Lung, and Blood Institute is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize the use of in vitro expanded adoptively infused NK cells to treat advanced and incurable cancers. Please contact Dr. Richard W. Childs at 301–496–5093 or 301–451–7128 (e-mail: childsr@nih.gov) for more information. Dated: January 19, 2007. Steven M. Ferguson, Director, Division of Technology Development and Transfer, Office of Technology Transfer, National Institutes of Health. [FR Doc. E7–1377 Filed 1–29–07; 8:45 am] BILLING CODE 4140–01–P DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Government-Owned Inventions; Availability for Licensing National Institutes of Health, Public Health Service, HHS. ACTION: Notice. AGENCY: SUMMARY: The inventions listed below are owned by an agency of the U.S. Government and are available for licensing in the U.S. in accordance with 35 U.S.C. 207 to achieve expeditious commercialization of results of federally-funded research and development. Foreign patent applications are filed on selected inventions to extend market coverage for companies and may also be available for licensing. ADDRESSES: Licensing information and copies of the U.S. patent applications listed below may be obtained by writing to the indicated licensing contact at the Office of Technology Transfer, National Institutes of Health, 6011 Executive Boulevard, Suite 325, Rockville, Maryland 20852–3804; telephone: 301/ 496–7057; fax: 301/402–0220. A signed Confidential Disclosure Agreement will be required to receive copies of the patent applications. Diagnostics and Therapeutics for Hydrocephalus Description of Technology: Congenital hydrocephalus is a significant public health problem, affecting approximately one in 500 live births in the United States. Congenital hydrocephalus has an PO 00000 Frm 00045 Fmt 4703 Sfmt 4703 4275 adverse effect on the developing brain and may persist as neurological defects in children and adults. Some of these defects may manifest as mental retardation, cerebral palsy, epilepsy and visual disabilities. Improved diagnostics are needed for assessing the risks of developing this debilitating disease. The inventors have shown that RFX4_v3, a splice variant of the Regulatory Factor X4 (RFX4) transcription factor, is associated with the development of neurological structures. The reduction or absence of RFX4-v3 promotes the development of congenital hydrocephalus. This invention describes RFX4_v3 polypeptides and nucleic acids, as well as methods for detection of RFX4_v3 polymorphisms associated with congenital hydrocephalus. Also described are treatment methods including the RFX4-v3 polypeptide and RFX4-v3 transgenic animals and antibodies. Applications: Prenatal diagnostic assay for identifying children at risk for congenital hydrocephalus; Genotyping assay for congenital hydrocephalus. Market: In the United States, the health care costs for congenital hydrocephalus are estimated at $100 million per year. Development Status: In vitro data are available. Inventors: Perry J. Blackshear, Darryl C. Zeldin, Joan P. Graves, and Deborah J. Stumpo (NIEHS). Publications: 1. Perry J. Blackshear et al. Graded phenotypic response to partial and complete deficiency of a brain-specific transcript variant of the winged helix transcription factor RFX4. Development. 2003 Oct;130(19):4539–4552. 2. Donghui Zhang et al. Identification of potential target genes for RFX4_v3, a transcription factor critical for brain development. J Neurochem. 2006 Aug;98(3):860–875. 3. Donghui Zhang et al. Regulatory factor X4 variant 3 (RFX4_v3): a transcription factor involved in brain development and disease. Submitted for publication, Journal of Neuroscience Research. Patent Status: PCT Application No. PCT/US03/12348 filed 18 Apr 2003, which published as WO 03/088919 on 30 Oct 2003 (HHS Reference No. E–163– 2002/2–PCT–01); U.S. Patent Application No. 10/511,362 filed 15 Oct 2004, which published as U.S. 2005/ 0181369 on 18 Aug 2005 (HHS Reference No. E–163–2002/2–US–02). Licensing Status: Available for exclusive or nonexclusive licensing. Licensing Contact: Tara Kirby, Ph.D.; 301/435–4426; tarak@mail.nih.gov. E:\FR\FM\30JAN1.SGM 30JAN1 4276 Federal Register / Vol. 72, No. 19 / Tuesday, January 30, 2007 / Notices DEPARTMENT OF HEALTH AND HUMAN SERVICES Description of Technology: Cystic fibrosis (CF) is a common genetic disease that affects the entire body, producing thick, sticky mucus that clogs the lungs, pancreas, and other organs. It is the most common fatal genetic disease in the United States, and is caused by a mutation in the cystic fibrosis transmembrane conductance regulator (CFTR). Researchers at NIEHS have developed a cell line, CF/T43, which was produced by infection of airway epithelial cells isolated from CF patients with an SV40T retrovirus. CF/T43 cells maintain the abnormal ion transport characteristics of CF while having proliferation capability beyond that of a primary epithelial cell culture. Key features of the CF/T43 cell line include the formation of functional tight junctions, reduced apical membrane chloride conductance, and activation of apical chloride channels by calcium ionophores but not by cAMP-dependent agonists. This cell line may be used for elucidation of the mechanisms of CF, testing candidate complementary genes for correction of the observed CF abnormalities, and for developing and testing therapeutic CF drugs. Applications: Research tool for developing new therapies to treat cystic fibrosis; Research tool for studying the mechanisms of cystic fibrosis. Inventors: Anton M. Jetten (NIEHS). Publication: AM Jetten, JR Yankaskas, MJ Stutts, NJ Willumsen, and RC Boucher. Persistence of abnormal chloride conductance regulation in SV40 T transformed cystic fibrosis airway epithelia. Science 1989 Jun 23;244(4911):1472–1475. Patent Status: U.S. Patent Application No. 07/368,725 filed 21 June 1989, which issued as U.S. Patent No. 5,420,033 on 30 May 1995 (HHS Reference No. E–201–1989/0–US–01). Licensing Status: Available for exclusive or nonexclusive licensing. Licensing Contact: Tara Kirby, Ph.D.; 301/435–4426; tarak@mail.nih.gov. ycherry on PROD1PC64 with NOTICES Epithelial Cell Line Expressing a Cystic Fibrosis Phenotype National Institutes of Health Dated: January 20, 2007. Steven M. Ferguson, Director, Division of Technology Development and Transfer, Office of Technology Transfer, National Institutes of Health. [FR Doc. E7–1379 Filed 1–29–07; 8:45 am] BILLING CODE 4140–01–P VerDate Aug<31>2005 15:36 Jan 29, 2007 Jkt 211001 National Cancer Institute; Notice of Closed Meetings Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. Appendix 2), notice is hereby given of the following meetings. The meetings will be closed to the public in accordance with the provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5. U.S.C., as amended. The grant applications and/or contact proposals and the discussions could disclose confidential trade secrets or commercial property such as patentable material, and personal information concerning individuals associated with the grant applications and/or contract proposals, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. Name of Committee: National Cancer Institute Special Emphasis Panel, R25 Special Emphasis Panel. Date: February 6, 2007. Time: 5 p.m. to 6 p.m. Agenda: To review and evaluate grant applications. Place: Washington Court Hotel, 525 New Jersey Ave, NW., Washington, DC 20001. Contact Person: David E. Maslow, PhD., Chief, Resources and Training Review Branch, Division of Extramural Activities, National Cancer Institute, National Institutes of Health, 6116 Executive Boulevard—Room 8117, Bethesda, MD 20892–7405, (301) 496– 2330. This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. Name of Committee: National Cancer Institute Special Emphasis Panel, Arrays for Biomarker. Date: February 13, 2007. Time: 12 p.m. to 6 p.m. Agenda: To review and evaluate contract proposals. Place: National Institutes of Health, 6116 Executive Boulevard, Bethesda, MD 20892, (Telephone Conference Call). Contact Person: Lalita D. Palekar, PhD, Scientific Review Administrator, Special Review and Resources Branch, Division of Extramural Activities, National Cancer Institute, National Institutes of Health, 6116 Executive Boulevard, Room 8105, Bethesda, MD 20892–7405, (301) 496–7575. Name of Committee: National Cancer Institute Special Emphasis Panel; Multiplex Affinity Capture Technology. Date: February 15, 2007. Time: 12 p.m. to 6 p.m. Agenda: To review and evaluate contract proposals. PO 00000 Frm 00046 Fmt 4703 Sfmt 4703 Place: National Institutes of Health, 6116 Executive Boulevard, Bethesda, MD 20892, (Telephone Conference Call). Contact Person: Lalita D. Palekar, PhD, Scientific Review Administrator, Special Review and Resources Branch, Division of Extramural Activities, National Cancer Institute, National Institutes of Health, 6116 Executive Boulevard, Room 8105, Bethesda, MD 20892–7405, (301) 496–7575. Name of Committee: National Cancer Institute Special Emphasis Panel; Manpower and Training Grants. Date: February 27–28, 2007. Time: 8 a.m. to 5 p.m. Agenda: To review and evaluate grant applications. Place: Hilton Old Town Alexandria, 1767 King Street, Alexandria, VA 22314. Contact Person: Lynn M Amende, PhD, Scientific Review Administrator, Resources and Training Review Branch, Division of Extramural Activities, National Cancer Institute, 6116 Executive Boulevard Room 8105, Bethesda, MD 20892–8328, 301–451– 4759, amendel@mail.nih.gov. Name of Committee: National Cancer Institute Special Emphasis Panel; Small Grants Program for Cancer Epidemiology and Cancer Prevention Research. Date: March 6–8, 2007. Time: 8 a.m. to 5 p.m. Agenda: To review and evaluate grant applications. Place: Holiday Inn Georgetown, 2101 Wisconsin Avenue, NW., Washington, DC 20007. Contact Person: Irina Gordienko, PhD, Scientific Review Administrator, Special Review and Logistics Branch, Division of Extramural Activities, National Cancer Institute, NIH, 6116 Executive Blvd., Rm. 703, MS 2829, Bethesda, MD 20892, 301– 594–1566, gordienoiv@mail.nih.gov. Name of Committee: National Cancer Institute Special Emphasis Panel, AntiCancer Agents. Date: March 15, 2007. Time: 11 a.m. to 3 p.m. Agenda: To review and evaluate grant applications. Place: National Institutes of Health Events Management, Executive Plaza North Conference Center, 6130 Executive Boulevard, Conference Room D, Rockville, MD 20852, (Telephone Conference Call). Contact Person: Jeannette F Korczak, PhD, Scientific Review Administrator, Resources and Training Review Branch, Division of Extramural Activities, National Cancer Institute, NIH, 6116 Executive Blvd., Room 8115, Bethesda, MD 20892, 301–496–9767, korczakj@mail.nih.gov. (Catalogue of Federal Domestic Assistance Program Nos. 93.392, Cancer Construction; 93.393, Cancer Cause and Prevention Research; 93.394, Cancer Detection and Diagnosis Research; 93.395, Cancer Treatment Research; 93.396, Cancer Biology Research; 93.397, Cancer Centers Support; 93.398, Cancer Research Manpower; 93.399, Cancer Control, National Institutes of Health, HHS) E:\FR\FM\30JAN1.SGM 30JAN1

Agencies

[Federal Register Volume 72, Number 19 (Tuesday, January 30, 2007)]
[Notices]
[Pages 4275-4276]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: E7-1379]


-----------------------------------------------------------------------

DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Government-Owned Inventions; Availability for Licensing

AGENCY: National Institutes of Health, Public Health Service, HHS.

ACTION: Notice.

-----------------------------------------------------------------------

SUMMARY: The inventions listed below are owned by an agency of the U.S. 
Government and are available for licensing in the U.S. in accordance 
with 35 U.S.C. 207 to achieve expeditious commercialization of results 
of federally-funded research and development. Foreign patent 
applications are filed on selected inventions to extend market coverage 
for companies and may also be available for licensing.

ADDRESSES: Licensing information and copies of the U.S. patent 
applications listed below may be obtained by writing to the indicated 
licensing contact at the Office of Technology Transfer, National 
Institutes of Health, 6011 Executive Boulevard, Suite 325, Rockville, 
Maryland 20852-3804; telephone: 301/496-7057; fax: 301/402-0220. A 
signed Confidential Disclosure Agreement will be required to receive 
copies of the patent applications.

Diagnostics and Therapeutics for Hydrocephalus

    Description of Technology: Congenital hydrocephalus is a 
significant public health problem, affecting approximately one in 500 
live births in the United States. Congenital hydrocephalus has an 
adverse effect on the developing brain and may persist as neurological 
defects in children and adults. Some of these defects may manifest as 
mental retardation, cerebral palsy, epilepsy and visual disabilities. 
Improved diagnostics are needed for assessing the risks of developing 
this debilitating disease.
    The inventors have shown that RFX4--v3, a splice variant of the 
Regulatory Factor X4 (RFX4) transcription factor, is associated with 
the development of neurological structures. The reduction or absence of 
RFX4-v3 promotes the development of congenital hydrocephalus. This 
invention describes RFX4--v3 polypeptides and nucleic acids, as well as 
methods for detection of RFX4--v3 polymorphisms associated with 
congenital hydrocephalus. Also described are treatment methods 
including the RFX4-v3 polypeptide and RFX4-v3 transgenic animals and 
antibodies.
    Applications: Prenatal diagnostic assay for identifying children at 
risk for congenital hydrocephalus; Genotyping assay for congenital 
hydrocephalus.
    Market: In the United States, the health care costs for congenital 
hydrocephalus are estimated at $100 million per year.
    Development Status: In vitro data are available.
    Inventors: Perry J. Blackshear, Darryl C. Zeldin, Joan P. Graves, 
and Deborah J. Stumpo (NIEHS).
    Publications:
    1. Perry J. Blackshear et al. Graded phenotypic response to partial 
and complete deficiency of a brain-specific transcript variant of the 
winged helix transcription factor RFX4. Development. 2003 
Oct;130(19):4539-4552.
    2. Donghui Zhang et al. Identification of potential target genes 
for RFX4--v3, a transcription factor critical for brain development. J 
Neurochem. 2006 Aug;98(3):860-875.
    3. Donghui Zhang et al. Regulatory factor X4 variant 3 (RFX4--v3): 
a transcription factor involved in brain development and disease. 
Submitted for publication, Journal of Neuroscience Research.
    Patent Status: PCT Application No. PCT/US03/12348 filed 18 Apr 
2003, which published as WO 03/088919 on 30 Oct 2003 (HHS Reference No. 
E-163-2002/2-PCT-01); U.S. Patent Application No. 10/511,362 filed 15 
Oct 2004, which published as U.S. 2005/0181369 on 18 Aug 2005 (HHS 
Reference No. E-163-2002/2-US-02).
    Licensing Status: Available for exclusive or nonexclusive 
licensing.
    Licensing Contact: Tara Kirby, Ph.D.; 301/435-4426; 
tarak@mail.nih.gov.

[[Page 4276]]

Epithelial Cell Line Expressing a Cystic Fibrosis Phenotype

    Description of Technology: Cystic fibrosis (CF) is a common genetic 
disease that affects the entire body, producing thick, sticky mucus 
that clogs the lungs, pancreas, and other organs. It is the most common 
fatal genetic disease in the United States, and is caused by a mutation 
in the cystic fibrosis transmembrane conductance regulator (CFTR).
    Researchers at NIEHS have developed a cell line, CF/T43, which was 
produced by infection of airway epithelial cells isolated from CF 
patients with an SV40T retrovirus. CF/T43 cells maintain the abnormal 
ion transport characteristics of CF while having proliferation 
capability beyond that of a primary epithelial cell culture. Key 
features of the CF/T43 cell line include the formation of functional 
tight junctions, reduced apical membrane chloride conductance, and 
activation of apical chloride channels by calcium ionophores but not by 
cAMP-dependent agonists. This cell line may be used for elucidation of 
the mechanisms of CF, testing candidate complementary genes for 
correction of the observed CF abnormalities, and for developing and 
testing therapeutic CF drugs.
    Applications: Research tool for developing new therapies to treat 
cystic fibrosis; Research tool for studying the mechanisms of cystic 
fibrosis.
    Inventors: Anton M. Jetten (NIEHS).
    Publication: AM Jetten, JR Yankaskas, MJ Stutts, NJ Willumsen, and 
RC Boucher. Persistence of abnormal chloride conductance regulation in 
SV40 T transformed cystic fibrosis airway epithelia. Science 1989 Jun 
23;244(4911):1472-1475.
    Patent Status: U.S. Patent Application No. 07/368,725 filed 21 June 
1989, which issued as U.S. Patent No. 5,420,033 on 30 May 1995 (HHS 
Reference No. E-201-1989/0-US-01).
    Licensing Status: Available for exclusive or nonexclusive 
licensing.
    Licensing Contact: Tara Kirby, Ph.D.; 301/435-4426; 
tarak@mail.nih.gov.

    Dated: January 20, 2007.
Steven M. Ferguson,
Director, Division of Technology Development and Transfer, Office of 
Technology Transfer, National Institutes of Health.
[FR Doc. E7-1379 Filed 1-29-07; 8:45 am]
BILLING CODE 4140-01-P

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