Government-Owned Inventions; Availability for Licensing, 1549-1550 [E7-350]

Download as PDF Federal Register / Vol. 72, No. 8 / Friday, January 12, 2007 / Notices DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Government-Owned Inventions; Availability for Licensing National Institutes of Health, Public Health Service, HHS. ACTION: Notice. AGENCY: SUMMARY: The inventions listed below are owned by an agency of the U.S. Government and are available for licensing in the U.S. in accordance with 35 U.S.C. 207 to achieve expeditious commercialization of results of federally-funded research and development. Foreign patent applications are filed on selected inventions to extend market coverage for companies and may also be available for licensing. ADDRESSES: Licensing information and copies of the U.S. patent applications listed below may be obtained by writing to the indicated licensing contact at the Office of Technology Transfer, National Institutes of Health, 6011 Executive Boulevard, Suite 325, Rockville, Maryland 20852–3804; telephone: 301/ 496–7057; fax: 301/402–0220. A signed Confidential Disclosure Agreement will be required to receive copies of the patent applications. rmajette on PROD1PC67 with NOTICES In Vivo Assessment of Tissue Microstructure and Microdynamics: Estimation of the Average Propagator From Magnetic Resonance Data Description of Technology: This invention relates to diffusion-weighted magnetic resonance imaging (DW–MRI) and describes a novel method for estimating the 3–D average propagator from DW–MRI data. The average propagator measures the probability that water molecules move from one place to another during a given diffusion time. This quantity provides local information about the tissue microstructure and the microenvironment in which water diffuses without making any a priori assumptions about the underlying diffusion process itself. Several methods, such as 3D q-space magnetic resonance imaging (MRI) and diffusion spectrum imaging have been developed to measure the average propagator, but these techniques currently require acquisition of large numbers of DW images, making them infeasible for routine animal and clinical imaging. The proposed methodology introduces a new data reconstruction concept, which involved using computer tomography (CT) algorithms to estimate the average propagator from the MR data. The VerDate Aug<31>2005 15:41 Jan 11, 2007 Jkt 211001 proposed CT reconstruction requires many fewer DW–MRI data than conventional methods consistent with a clinically feasible period of MR image acquisition. The novel technique can be used to diagnose medical disorders that are associated with alterations in water diffusion, such as stroke and several neurodegenerative diseases and other disorders for which diffusion tensor MRI is currently used. Additional applications include drug development (screening drug candidates), material science (testing the quality of materials that have restricted and hindered compartments, e.g. porous media, gels and films) and food processing (testing structural changes in food). Applications: In vivo Functional MRI of humans and animals; Drug development; Material science; Food processing. Development Status: Early stage; only testing using fixed tissues and numerical phantoms have been performed at this time. Inventors: Peter J. Basser and Valery Pickalov (NICHD). Patent Status: U.S. Patent Application No. 11/407,096 filed 20 Apr 2006 (HHS Reference No. E–164–2006/0–US–01). Licensing Status: Available for nonexclusive or exclusive licensing, as well as for collaborative research, provided that non-disclosure agreements and MTAs have been executed. Licensing Contact: Chekesha S. Clingman, Ph.D.; 301/435–5018; clingmac@mail.nih.gov. Collaborative Research Opportunity: The NICHD Laboratory of Integrative and Medical Biophysics, Section on Tissue Biophysics and Biomimetics, is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize this technology. Please contact Peter J. Basser, Ph.D. at pjbasser@helix.nih.gov for more information. Fast Electron Paramagnetic Resonance Imaging (EPRI) Using CW–EPR Spectrometer With Sinusoidal RapidScan and Digital Signal Processing Description of Technology: Electron Paramagnetic Resonance (EPR) Imaging is an indispensable tool that may be applied to a variety of disciplines for evaluation of chemical species having unpaired electrons such as free radicals and transition metal ions. In Continuous Wave (CW)–EPR the sample is continuously irradiated with weak RF radiation while sweeping the magnetic field relatively slowly. Existing CW– EPR techniques utilize a signal detection method known as phasesensitive detection which results in data PO 00000 Frm 00064 Fmt 4703 Sfmt 4703 1549 acquisition times that are too long for in vivo applications. The present technology represents significant improvements on conventional CW– EPR. The subject technology includes three approaches to collecting image data with increased spatial, temporal and spectral resolution and improved sensitivity. Spectral data acquisition is performed by a direct detection strategy involving mixing a signal to base-band and acquiring data with a fast-digitizer. Projection data is acquired using a sinusoidal magnetic field sweep under gradient magnetic fields. Data collection times are decreased with the utility of rotating gradients. Further, the current technology improves sensitivity by employing Digital Signal Processing, which decreases background analog noise. Increased speed and sensitivity makes CW–EPR a potentially useful and complementary tool to Magnetic Resonance Imaging for in vivo imaging. The presently described improvements to CW–EPR will allow changes of blood perfusion and oxygenation in tumors to be observed in nearly real-time, while improved resolution will permit angiogenesis in and around tumors to be carried out in a non-invasive manner. Additionally, rapid scan imaging provides excellent temporal resolution and will help quantify pharmacokinetics and metabolic degradation kinetics of bioactive free radicals. Applications: (1) Enhanced spatial, temporal, and spectral resolution of Continuous Wave-Electron Paramagnetic Resonance Imaging; (2) Real-time assessment of changes in blood perfusion and oxygenation. Development Status: Preliminary experiments have been conducted and the technology has been tested for feasibility. Inventors: Sankaran Subramanian, Nallathamby Devasahayam, Janusz Koscielniak, James Mitchell, and Murali Krishna (NCI). Publication: S Subramanian, JW Koscielniak, N Devasahayam, RH Pursley, TJ Pohida, TJ Pohida, MC Krishna. A new strategy for fast radiofrequency CW–EPR imaging: Direct detection with rapid scan and rotating gradients. Submitted to Journal of Magnetic Resonance for publication. Patent Status: U.S. Provisional Application No. 60/818,052, filed 30 Jun 2006 (HHS Reference No. E–221–2005/ 0–US–01). Licensing Status: Available for nonexclusive or exclusive licensing and commercial development. E:\FR\FM\12JAN1.SGM 12JAN1 1550 Federal Register / Vol. 72, No. 8 / Friday, January 12, 2007 / Notices Licensing Contact: Chekesha S. Clingman, PhD; 301/435–5018; clingmac@mail.nih.gov. Collaborative Research Opportunity: The Radiation Biology Branch, National Cancer Institute, NIH, Bethesda, MD is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize the above Rapid scan-Rotating gradients strategy for performing routine in vivo Radiofrequency CW–EPR imaging in small animals. Please contact John D. Hewes, PhD at 301–435–3121 or hewesj@mail.nih.gov for more information. Dated: January 5, 2007. Steven M. Ferguson, Director, Division of Technology Development and Transfer, Office of Technology Transfer, National Institutes of Health. [FR Doc. E7–350 Filed 1–11–07; 8:45 am] BILLING CODE 4140–01–P Name of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Shared Resource Grant (R24). Date: January 25, 2007. Time: 3 p.m. to 4:30 p.m. Agenda: To review and evaluate grant applications. Place: National Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892 (Telephone Conference Call). Contact Person: Shelley S. Sehnert, PhD, Scientific Review Administrator, Review Branchy, NIH/NHLBI, 6701 Rockledge Drive, Room 7206, Bethesda, MD 20892–7294, (301) 435–0303, ssehnert@nhlbi.nih.gov. (Catalogue of Federal Domestic Assistance Program Nos. 93.233, National Center for Sleep Disorders Research; 93.837, Heart and Vascular Diseases Research; 93.838, Lung Diseases Research; 93.839, Blood Diseases and Resources Research, National Institutes of Health, HHS) Dated: January 8, 2007. Anna Snouffer, Acting Director, Office of Federal Advisory Committee Policy. [FR Doc. 07–101 Filed 1–11–07; 8:45 am] BILLING CODE 4140–01–M DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health DEPARTMENT OF HEALTH AND HUMAN SERVICES National Heart, Lung, and Blood Institute; Notice of Closed Meetings National Institutes of Health rmajette on PROD1PC67 with NOTICES Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. Appendix 2), notice is hereby given of the following meetings. The meetings will be closed to the public in accordance with provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The grant applications and the discussions could disclose confidential trade secrets or commercial property such as patentable material, and personal information concerning individuals associated with the grant applications, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. Name of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel; Conference Grants (R13). Date: January 24, 2007. Time: 8 a.m. to 9 a.m. Agenda: To review and evaluate grant applications. Place: National Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892 (Telephone Conference). Contact Person: Valerie L. Prenger, PhD, Scientific Review Administrator, Review Branch, Room 7214, Division of Extramural Research Activities, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, MSC 7294, Bethesda, MD 20892–7294, (301) 435–0270, prengerv@nhibi.nih.gov. VerDate Aug<31>2005 15:41 Jan 11, 2007 Jkt 211001 National Institute of Nursing Research; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. Appendix 2), notice is hereby given of the following meeting. The meeting will be closed to the public in accordance with the provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The grant applications and the discussions could disclose confidential trade secrets or commercial property such as patentable material, and personal information concerning individuals associated with the grant applications, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. Name of Committee: National Institute of Nursing Research Initial Review Group. Date: March 5–6, 2007. Time: 8:15 a.m. to 5 p.m. Agenda: To review and evaluate grant applications. Place: Crowne Plaza Hotel, 8777 Georgia Avenue, Silver Spring, MD 20910. Contact Person: Jeffrey M. Chernak, PhD, Scientific Review Administrator, Office of Review, National Institute of Nursing Research, 6701 Democracy Plaza, Suite 710, MSC 4870, Bethesda, MD 20892, (301) 402– 6959, chernak@nih.gov. PO 00000 Frm 00065 Fmt 4703 Sfmt 4703 (Catalogue of Federal Domestic Assistance Program Nos. 93.361, Nursing Research, National Institutes of Health, HHS) Dated: January 8, 2007. Anna Snouffer, Acting Director, Office of Federal Advisory Committee Policy. [FR Doc. 07–98 Filed 1–11–07; 8:45 am] BILLING CODE 4140–01–M DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Institute of Environmental Health Sciences; Notice of Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. Appendix 2) notice is hereby given of a meeting of the National Advisory Environmental Health Sciences Council. The meeting will be open to the public as indicated below, with attendance limited to space available. Individuals who plan to attend and need special assistance, such as sign language interpretation or other reasonable accommodations, should notify the Contact Person listed below in advance of the meeting. The meeting will be closed to the public in accordance with the provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The grant applications and the discussions could disclose confidential trade secrets or commercial property such as patentable material, and personal information concerning individuals associated with the grant applications, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. Name of Committee: National Advisory Environmental Health Sciences Council. Date: February 15, 2007. Open: 8:30 a.m. to 1 p.m. Agenda: Discussion of program policies and issues. Place: Nat. Inst. of Environmental Health Sciences, Building 101, Rodbell Auditorium, 111 T.W. Alexander Drive, Research Triangle Park, NC 27709. Closed: 1 p.m. to 2:30 p.m. Agenda: To review and evaluate grant applications. Place: Nat. Inst. of Environmental Health Sciences, Building 101, Rodbell Auditorium, 111 T.W. Alexander Drive, Research Triangle Park, NC 27709. Open: 2:30 p.m. to 5 p.m. Agenda: Discussion of program policies and issues. Place: Nat. Inst. of Environmental Health Sciences, Building 101, Rodbell Auditorium, 111 T.W. Alexander Drive, Research Triangle Park, NC 27709. E:\FR\FM\12JAN1.SGM 12JAN1

Agencies

[Federal Register Volume 72, Number 8 (Friday, January 12, 2007)]
[Notices]
[Pages 1549-1550]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: E7-350]



[[Page 1549]]

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DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Government-Owned Inventions; Availability for Licensing

AGENCY: National Institutes of Health, Public Health Service, HHS.

ACTION: Notice.

-----------------------------------------------------------------------

SUMMARY: The inventions listed below are owned by an agency of the U.S. 
Government and are available for licensing in the U.S. in accordance 
with 35 U.S.C. 207 to achieve expeditious commercialization of results 
of federally-funded research and development. Foreign patent 
applications are filed on selected inventions to extend market coverage 
for companies and may also be available for licensing.

ADDRESSES: Licensing information and copies of the U.S. patent 
applications listed below may be obtained by writing to the indicated 
licensing contact at the Office of Technology Transfer, National 
Institutes of Health, 6011 Executive Boulevard, Suite 325, Rockville, 
Maryland 20852-3804; telephone: 301/496-7057; fax: 301/402-0220. A 
signed Confidential Disclosure Agreement will be required to receive 
copies of the patent applications.

In Vivo Assessment of Tissue Microstructure and Microdynamics: 
Estimation of the Average Propagator From Magnetic Resonance Data

    Description of Technology: This invention relates to diffusion-
weighted magnetic resonance imaging (DW-MRI) and describes a novel 
method for estimating the 3-D average propagator from DW-MRI data. The 
average propagator measures the probability that water molecules move 
from one place to another during a given diffusion time. This quantity 
provides local information about the tissue microstructure and the 
microenvironment in which water diffuses without making any a priori 
assumptions about the underlying diffusion process itself. Several 
methods, such as 3D q-space magnetic resonance imaging (MRI) and 
diffusion spectrum imaging have been developed to measure the average 
propagator, but these techniques currently require acquisition of large 
numbers of DW images, making them infeasible for routine animal and 
clinical imaging. The proposed methodology introduces a new data 
reconstruction concept, which involved using computer tomography (CT) 
algorithms to estimate the average propagator from the MR data. The 
proposed CT reconstruction requires many fewer DW-MRI data than 
conventional methods consistent with a clinically feasible period of MR 
image acquisition. The novel technique can be used to diagnose medical 
disorders that are associated with alterations in water diffusion, such 
as stroke and several neurodegenerative diseases and other disorders 
for which diffusion tensor MRI is currently used. Additional 
applications include drug development (screening drug candidates), 
material science (testing the quality of materials that have restricted 
and hindered compartments, e.g. porous media, gels and films) and food 
processing (testing structural changes in food).
    Applications: In vivo Functional MRI of humans and animals; Drug 
development; Material science; Food processing.
    Development Status: Early stage; only testing using fixed tissues 
and numerical phantoms have been performed at this time.
    Inventors: Peter J. Basser and Valery Pickalov (NICHD).
    Patent Status: U.S. Patent Application No. 11/407,096 filed 20 Apr 
2006 (HHS Reference No. E-164-2006/0-US-01).
    Licensing Status: Available for non-exclusive or exclusive 
licensing, as well as for collaborative research, provided that non-
disclosure agreements and MTAs have been executed.
    Licensing Contact: Chekesha S. Clingman, Ph.D.; 301/435-5018; 
clingmac@mail.nih.gov.
    Collaborative Research Opportunity: The NICHD Laboratory of 
Integrative and Medical Biophysics, Section on Tissue Biophysics and 
Biomimetics, is seeking statements of capability or interest from 
parties interested in collaborative research to further develop, 
evaluate, or commercialize this technology. Please contact Peter J. 
Basser, Ph.D. at pjbasser@helix.nih.gov for more information.

Fast Electron Paramagnetic Resonance Imaging (EPRI) Using CW-EPR 
Spectrometer With Sinusoidal Rapid-Scan and Digital Signal Processing

    Description of Technology: Electron Paramagnetic Resonance (EPR) 
Imaging is an indispensable tool that may be applied to a variety of 
disciplines for evaluation of chemical species having unpaired 
electrons such as free radicals and transition metal ions. In 
Continuous Wave (CW)-EPR the sample is continuously irradiated with 
weak RF radiation while sweeping the magnetic field relatively slowly. 
Existing CW-EPR techniques utilize a signal detection method known as 
phase-sensitive detection which results in data acquisition times that 
are too long for in vivo applications. The present technology 
represents significant improvements on conventional CW-EPR.
    The subject technology includes three approaches to collecting 
image data with increased spatial, temporal and spectral resolution and 
improved sensitivity. Spectral data acquisition is performed by a 
direct detection strategy involving mixing a signal to base-band and 
acquiring data with a fast-digitizer. Projection data is acquired using 
a sinusoidal magnetic field sweep under gradient magnetic fields. Data 
collection times are decreased with the utility of rotating gradients. 
Further, the current technology improves sensitivity by employing 
Digital Signal Processing, which decreases background analog noise.
    Increased speed and sensitivity makes CW-EPR a potentially useful 
and complementary tool to Magnetic Resonance Imaging for in vivo 
imaging. The presently described improvements to CW-EPR will allow 
changes of blood perfusion and oxygenation in tumors to be observed in 
nearly real-time, while improved resolution will permit angiogenesis in 
and around tumors to be carried out in a non-invasive manner. 
Additionally, rapid scan imaging provides excellent temporal resolution 
and will help quantify pharmaco-kinetics and metabolic degradation 
kinetics of bioactive free radicals.
    Applications: (1) Enhanced spatial, temporal, and spectral 
resolution of Continuous Wave-Electron Paramagnetic Resonance Imaging; 
(2) Real-time assessment of changes in blood perfusion and oxygenation.
    Development Status: Preliminary experiments have been conducted and 
the technology has been tested for feasibility.
    Inventors: Sankaran Subramanian, Nallathamby Devasahayam, Janusz 
Koscielniak, James Mitchell, and Murali Krishna (NCI).
    Publication: S Subramanian, JW Koscielniak, N Devasahayam, RH 
Pursley, TJ Pohida, TJ Pohida, MC Krishna. A new strategy for fast 
radiofrequency CW-EPR imaging: Direct detection with rapid scan and 
rotating gradients. Submitted to Journal of Magnetic Resonance for 
publication.
    Patent Status: U.S. Provisional Application No. 60/818,052, filed 
30 Jun 2006 (HHS Reference No. E-221-2005/0-US-01).
    Licensing Status: Available for non-exclusive or exclusive 
licensing and commercial development.

[[Page 1550]]

    Licensing Contact: Chekesha S. Clingman, PhD; 301/435-5018; 
clingmac@mail.nih.gov.
    Collaborative Research Opportunity: The Radiation Biology Branch, 
National Cancer Institute, NIH, Bethesda, MD is seeking statements of 
capability or interest from parties interested in collaborative 
research to further develop, evaluate, or commercialize the above Rapid 
scan-Rotating gradients strategy for performing routine in vivo 
Radiofrequency CW-EPR imaging in small animals. Please contact John D. 
Hewes, PhD at 301-435-3121 or hewesj@mail.nih.gov for more information.

    Dated: January 5, 2007.
Steven M. Ferguson,
Director, Division of Technology Development and Transfer, Office of 
Technology Transfer, National Institutes of Health.
[FR Doc. E7-350 Filed 1-11-07; 8:45 am]
BILLING CODE 4140-01-P

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