Government-Owned Inventions; Availability for Licensing, 1549-1550 [E7-350]
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Federal Register / Vol. 72, No. 8 / Friday, January 12, 2007 / Notices
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
Government-Owned Inventions;
Availability for Licensing
National Institutes of Health,
Public Health Service, HHS.
ACTION: Notice.
AGENCY:
SUMMARY: The inventions listed below
are owned by an agency of the U.S.
Government and are available for
licensing in the U.S. in accordance with
35 U.S.C. 207 to achieve expeditious
commercialization of results of
federally-funded research and
development. Foreign patent
applications are filed on selected
inventions to extend market coverage
for companies and may also be available
for licensing.
ADDRESSES: Licensing information and
copies of the U.S. patent applications
listed below may be obtained by writing
to the indicated licensing contact at the
Office of Technology Transfer, National
Institutes of Health, 6011 Executive
Boulevard, Suite 325, Rockville,
Maryland 20852–3804; telephone: 301/
496–7057; fax: 301/402–0220. A signed
Confidential Disclosure Agreement will
be required to receive copies of the
patent applications.
rmajette on PROD1PC67 with NOTICES
In Vivo Assessment of Tissue
Microstructure and Microdynamics:
Estimation of the Average Propagator
From Magnetic Resonance Data
Description of Technology: This
invention relates to diffusion-weighted
magnetic resonance imaging (DW–MRI)
and describes a novel method for
estimating the 3–D average propagator
from DW–MRI data. The average
propagator measures the probability that
water molecules move from one place to
another during a given diffusion time.
This quantity provides local information
about the tissue microstructure and the
microenvironment in which water
diffuses without making any a priori
assumptions about the underlying
diffusion process itself. Several
methods, such as 3D q-space magnetic
resonance imaging (MRI) and diffusion
spectrum imaging have been developed
to measure the average propagator, but
these techniques currently require
acquisition of large numbers of DW
images, making them infeasible for
routine animal and clinical imaging.
The proposed methodology introduces a
new data reconstruction concept, which
involved using computer tomography
(CT) algorithms to estimate the average
propagator from the MR data. The
VerDate Aug<31>2005
15:41 Jan 11, 2007
Jkt 211001
proposed CT reconstruction requires
many fewer DW–MRI data than
conventional methods consistent with a
clinically feasible period of MR image
acquisition. The novel technique can be
used to diagnose medical disorders that
are associated with alterations in water
diffusion, such as stroke and several
neurodegenerative diseases and other
disorders for which diffusion tensor
MRI is currently used. Additional
applications include drug development
(screening drug candidates), material
science (testing the quality of materials
that have restricted and hindered
compartments, e.g. porous media, gels
and films) and food processing (testing
structural changes in food).
Applications: In vivo Functional MRI
of humans and animals; Drug
development; Material science; Food
processing.
Development Status: Early stage; only
testing using fixed tissues and
numerical phantoms have been
performed at this time.
Inventors: Peter J. Basser and Valery
Pickalov (NICHD).
Patent Status: U.S. Patent Application
No. 11/407,096 filed 20 Apr 2006 (HHS
Reference No. E–164–2006/0–US–01).
Licensing Status: Available for nonexclusive or exclusive licensing, as well
as for collaborative research, provided
that non-disclosure agreements and
MTAs have been executed.
Licensing Contact: Chekesha S.
Clingman, Ph.D.; 301/435–5018;
clingmac@mail.nih.gov.
Collaborative Research Opportunity:
The NICHD Laboratory of Integrative
and Medical Biophysics, Section on
Tissue Biophysics and Biomimetics, is
seeking statements of capability or
interest from parties interested in
collaborative research to further
develop, evaluate, or commercialize this
technology. Please contact Peter J.
Basser, Ph.D. at pjbasser@helix.nih.gov
for more information.
Fast Electron Paramagnetic Resonance
Imaging (EPRI) Using CW–EPR
Spectrometer With Sinusoidal RapidScan and Digital Signal Processing
Description of Technology: Electron
Paramagnetic Resonance (EPR) Imaging
is an indispensable tool that may be
applied to a variety of disciplines for
evaluation of chemical species having
unpaired electrons such as free radicals
and transition metal ions. In Continuous
Wave (CW)–EPR the sample is
continuously irradiated with weak RF
radiation while sweeping the magnetic
field relatively slowly. Existing CW–
EPR techniques utilize a signal
detection method known as phasesensitive detection which results in data
PO 00000
Frm 00064
Fmt 4703
Sfmt 4703
1549
acquisition times that are too long for in
vivo applications. The present
technology represents significant
improvements on conventional CW–
EPR.
The subject technology includes three
approaches to collecting image data
with increased spatial, temporal and
spectral resolution and improved
sensitivity. Spectral data acquisition is
performed by a direct detection strategy
involving mixing a signal to base-band
and acquiring data with a fast-digitizer.
Projection data is acquired using a
sinusoidal magnetic field sweep under
gradient magnetic fields. Data collection
times are decreased with the utility of
rotating gradients. Further, the current
technology improves sensitivity by
employing Digital Signal Processing,
which decreases background analog
noise.
Increased speed and sensitivity makes
CW–EPR a potentially useful and
complementary tool to Magnetic
Resonance Imaging for in vivo imaging.
The presently described improvements
to CW–EPR will allow changes of blood
perfusion and oxygenation in tumors to
be observed in nearly real-time, while
improved resolution will permit
angiogenesis in and around tumors to be
carried out in a non-invasive manner.
Additionally, rapid scan imaging
provides excellent temporal resolution
and will help quantify pharmacokinetics and metabolic degradation
kinetics of bioactive free radicals.
Applications: (1) Enhanced spatial,
temporal, and spectral resolution of
Continuous Wave-Electron
Paramagnetic Resonance Imaging; (2)
Real-time assessment of changes in
blood perfusion and oxygenation.
Development Status: Preliminary
experiments have been conducted and
the technology has been tested for
feasibility.
Inventors: Sankaran Subramanian,
Nallathamby Devasahayam, Janusz
Koscielniak, James Mitchell, and Murali
Krishna (NCI).
Publication: S Subramanian, JW
Koscielniak, N Devasahayam, RH
Pursley, TJ Pohida, TJ Pohida, MC
Krishna. A new strategy for fast
radiofrequency CW–EPR imaging: Direct
detection with rapid scan and rotating
gradients. Submitted to Journal of
Magnetic Resonance for publication.
Patent Status: U.S. Provisional
Application No. 60/818,052, filed 30 Jun
2006 (HHS Reference No. E–221–2005/
0–US–01).
Licensing Status: Available for nonexclusive or exclusive licensing and
commercial development.
E:\FR\FM\12JAN1.SGM
12JAN1
1550
Federal Register / Vol. 72, No. 8 / Friday, January 12, 2007 / Notices
Licensing Contact: Chekesha S.
Clingman, PhD; 301/435–5018;
clingmac@mail.nih.gov.
Collaborative Research Opportunity:
The Radiation Biology Branch, National
Cancer Institute, NIH, Bethesda, MD is
seeking statements of capability or
interest from parties interested in
collaborative research to further
develop, evaluate, or commercialize the
above Rapid scan-Rotating gradients
strategy for performing routine in vivo
Radiofrequency CW–EPR imaging in
small animals. Please contact John D.
Hewes, PhD at 301–435–3121 or
hewesj@mail.nih.gov for more
information.
Dated: January 5, 2007.
Steven M. Ferguson,
Director, Division of Technology Development
and Transfer, Office of Technology Transfer,
National Institutes of Health.
[FR Doc. E7–350 Filed 1–11–07; 8:45 am]
BILLING CODE 4140–01–P
Name of Committee: National Heart, Lung,
and Blood Institute Special Emphasis Panel;
Shared Resource Grant (R24).
Date: January 25, 2007.
Time: 3 p.m. to 4:30 p.m.
Agenda: To review and evaluate grant
applications.
Place: National Institutes of Health, 6701
Rockledge Drive, Bethesda, MD 20892
(Telephone Conference Call).
Contact Person: Shelley S. Sehnert, PhD,
Scientific Review Administrator, Review
Branchy, NIH/NHLBI, 6701 Rockledge Drive,
Room 7206, Bethesda, MD 20892–7294, (301)
435–0303, ssehnert@nhlbi.nih.gov.
(Catalogue of Federal Domestic Assistance
Program Nos. 93.233, National Center for
Sleep Disorders Research; 93.837, Heart and
Vascular Diseases Research; 93.838, Lung
Diseases Research; 93.839, Blood Diseases
and Resources Research, National Institutes
of Health, HHS)
Dated: January 8, 2007.
Anna Snouffer,
Acting Director, Office of Federal Advisory
Committee Policy.
[FR Doc. 07–101 Filed 1–11–07; 8:45 am]
BILLING CODE 4140–01–M
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Heart, Lung, and Blood
Institute; Notice of Closed Meetings
National Institutes of Health
rmajette on PROD1PC67 with NOTICES
Pursuant to section 10(d) of the
Federal Advisory Committee Act, as
amended (5 U.S.C. Appendix 2), notice
is hereby given of the following
meetings.
The meetings will be closed to the
public in accordance with provisions set
forth in sections 552b(c)(4) and
552b(c)(6), Title 5 U.S.C., as amended.
The grant applications and the
discussions could disclose confidential
trade secrets or commercial property
such as patentable material, and
personal information concerning
individuals associated with the grant
applications, the disclosure of which
would constitute a clearly unwarranted
invasion of personal privacy.
Name of Committee: National Heart, Lung,
and Blood Institute Special Emphasis Panel;
Conference Grants (R13).
Date: January 24, 2007.
Time: 8 a.m. to 9 a.m.
Agenda: To review and evaluate grant
applications.
Place: National Institutes of Health, 6701
Rockledge Drive, Bethesda, MD 20892
(Telephone Conference).
Contact Person: Valerie L. Prenger, PhD,
Scientific Review Administrator, Review
Branch, Room 7214, Division of Extramural
Research Activities, National Heart, Lung,
and Blood Institute, 6701 Rockledge Drive,
MSC 7294, Bethesda, MD 20892–7294, (301)
435–0270, prengerv@nhibi.nih.gov.
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15:41 Jan 11, 2007
Jkt 211001
National Institute of Nursing Research;
Notice of Closed Meeting
Pursuant to section 10(d) of the
Federal Advisory Committee Act, as
amended (5 U.S.C. Appendix 2), notice
is hereby given of the following
meeting.
The meeting will be closed to the
public in accordance with the
provisions set forth in sections
552b(c)(4) and 552b(c)(6), Title 5 U.S.C.,
as amended. The grant applications and
the discussions could disclose
confidential trade secrets or commercial
property such as patentable material,
and personal information concerning
individuals associated with the grant
applications, the disclosure of which
would constitute a clearly unwarranted
invasion of personal privacy.
Name of Committee: National Institute of
Nursing Research Initial Review Group.
Date: March 5–6, 2007.
Time: 8:15 a.m. to 5 p.m.
Agenda: To review and evaluate grant
applications.
Place: Crowne Plaza Hotel, 8777 Georgia
Avenue, Silver Spring, MD 20910.
Contact Person: Jeffrey M. Chernak, PhD,
Scientific Review Administrator, Office of
Review, National Institute of Nursing
Research, 6701 Democracy Plaza, Suite 710,
MSC 4870, Bethesda, MD 20892, (301) 402–
6959, chernak@nih.gov.
PO 00000
Frm 00065
Fmt 4703
Sfmt 4703
(Catalogue of Federal Domestic Assistance
Program Nos. 93.361, Nursing Research,
National Institutes of Health, HHS)
Dated: January 8, 2007.
Anna Snouffer,
Acting Director, Office of Federal Advisory
Committee Policy.
[FR Doc. 07–98 Filed 1–11–07; 8:45 am]
BILLING CODE 4140–01–M
DEPARTMENT OF HEALTH AND
HUMAN SERVICES
National Institutes of Health
National Institute of Environmental
Health Sciences; Notice of Meeting
Pursuant to section 10(d) of the
Federal Advisory Committee Act, as
amended (5 U.S.C. Appendix 2) notice
is hereby given of a meeting of the
National Advisory Environmental
Health Sciences Council.
The meeting will be open to the
public as indicated below, with
attendance limited to space available.
Individuals who plan to attend and
need special assistance, such as sign
language interpretation or other
reasonable accommodations, should
notify the Contact Person listed below
in advance of the meeting.
The meeting will be closed to the
public in accordance with the
provisions set forth in sections
552b(c)(4) and 552b(c)(6), Title 5 U.S.C.,
as amended. The grant applications and
the discussions could disclose
confidential trade secrets or commercial
property such as patentable material,
and personal information concerning
individuals associated with the grant
applications, the disclosure of which
would constitute a clearly unwarranted
invasion of personal privacy.
Name of Committee: National Advisory
Environmental Health Sciences Council.
Date: February 15, 2007.
Open: 8:30 a.m. to 1 p.m.
Agenda: Discussion of program policies
and issues.
Place: Nat. Inst. of Environmental Health
Sciences, Building 101, Rodbell Auditorium,
111 T.W. Alexander Drive, Research Triangle
Park, NC 27709.
Closed: 1 p.m. to 2:30 p.m.
Agenda: To review and evaluate grant
applications.
Place: Nat. Inst. of Environmental Health
Sciences, Building 101, Rodbell Auditorium,
111 T.W. Alexander Drive, Research Triangle
Park, NC 27709.
Open: 2:30 p.m. to 5 p.m.
Agenda: Discussion of program policies
and issues.
Place: Nat. Inst. of Environmental Health
Sciences, Building 101, Rodbell Auditorium,
111 T.W. Alexander Drive, Research Triangle
Park, NC 27709.
E:\FR\FM\12JAN1.SGM
12JAN1
Agencies
[Federal Register Volume 72, Number 8 (Friday, January 12, 2007)]
[Notices]
[Pages 1549-1550]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: E7-350]
[[Page 1549]]
-----------------------------------------------------------------------
DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health
Government-Owned Inventions; Availability for Licensing
AGENCY: National Institutes of Health, Public Health Service, HHS.
ACTION: Notice.
-----------------------------------------------------------------------
SUMMARY: The inventions listed below are owned by an agency of the U.S.
Government and are available for licensing in the U.S. in accordance
with 35 U.S.C. 207 to achieve expeditious commercialization of results
of federally-funded research and development. Foreign patent
applications are filed on selected inventions to extend market coverage
for companies and may also be available for licensing.
ADDRESSES: Licensing information and copies of the U.S. patent
applications listed below may be obtained by writing to the indicated
licensing contact at the Office of Technology Transfer, National
Institutes of Health, 6011 Executive Boulevard, Suite 325, Rockville,
Maryland 20852-3804; telephone: 301/496-7057; fax: 301/402-0220. A
signed Confidential Disclosure Agreement will be required to receive
copies of the patent applications.
In Vivo Assessment of Tissue Microstructure and Microdynamics:
Estimation of the Average Propagator From Magnetic Resonance Data
Description of Technology: This invention relates to diffusion-
weighted magnetic resonance imaging (DW-MRI) and describes a novel
method for estimating the 3-D average propagator from DW-MRI data. The
average propagator measures the probability that water molecules move
from one place to another during a given diffusion time. This quantity
provides local information about the tissue microstructure and the
microenvironment in which water diffuses without making any a priori
assumptions about the underlying diffusion process itself. Several
methods, such as 3D q-space magnetic resonance imaging (MRI) and
diffusion spectrum imaging have been developed to measure the average
propagator, but these techniques currently require acquisition of large
numbers of DW images, making them infeasible for routine animal and
clinical imaging. The proposed methodology introduces a new data
reconstruction concept, which involved using computer tomography (CT)
algorithms to estimate the average propagator from the MR data. The
proposed CT reconstruction requires many fewer DW-MRI data than
conventional methods consistent with a clinically feasible period of MR
image acquisition. The novel technique can be used to diagnose medical
disorders that are associated with alterations in water diffusion, such
as stroke and several neurodegenerative diseases and other disorders
for which diffusion tensor MRI is currently used. Additional
applications include drug development (screening drug candidates),
material science (testing the quality of materials that have restricted
and hindered compartments, e.g. porous media, gels and films) and food
processing (testing structural changes in food).
Applications: In vivo Functional MRI of humans and animals; Drug
development; Material science; Food processing.
Development Status: Early stage; only testing using fixed tissues
and numerical phantoms have been performed at this time.
Inventors: Peter J. Basser and Valery Pickalov (NICHD).
Patent Status: U.S. Patent Application No. 11/407,096 filed 20 Apr
2006 (HHS Reference No. E-164-2006/0-US-01).
Licensing Status: Available for non-exclusive or exclusive
licensing, as well as for collaborative research, provided that non-
disclosure agreements and MTAs have been executed.
Licensing Contact: Chekesha S. Clingman, Ph.D.; 301/435-5018;
clingmac@mail.nih.gov.
Collaborative Research Opportunity: The NICHD Laboratory of
Integrative and Medical Biophysics, Section on Tissue Biophysics and
Biomimetics, is seeking statements of capability or interest from
parties interested in collaborative research to further develop,
evaluate, or commercialize this technology. Please contact Peter J.
Basser, Ph.D. at pjbasser@helix.nih.gov for more information.
Fast Electron Paramagnetic Resonance Imaging (EPRI) Using CW-EPR
Spectrometer With Sinusoidal Rapid-Scan and Digital Signal Processing
Description of Technology: Electron Paramagnetic Resonance (EPR)
Imaging is an indispensable tool that may be applied to a variety of
disciplines for evaluation of chemical species having unpaired
electrons such as free radicals and transition metal ions. In
Continuous Wave (CW)-EPR the sample is continuously irradiated with
weak RF radiation while sweeping the magnetic field relatively slowly.
Existing CW-EPR techniques utilize a signal detection method known as
phase-sensitive detection which results in data acquisition times that
are too long for in vivo applications. The present technology
represents significant improvements on conventional CW-EPR.
The subject technology includes three approaches to collecting
image data with increased spatial, temporal and spectral resolution and
improved sensitivity. Spectral data acquisition is performed by a
direct detection strategy involving mixing a signal to base-band and
acquiring data with a fast-digitizer. Projection data is acquired using
a sinusoidal magnetic field sweep under gradient magnetic fields. Data
collection times are decreased with the utility of rotating gradients.
Further, the current technology improves sensitivity by employing
Digital Signal Processing, which decreases background analog noise.
Increased speed and sensitivity makes CW-EPR a potentially useful
and complementary tool to Magnetic Resonance Imaging for in vivo
imaging. The presently described improvements to CW-EPR will allow
changes of blood perfusion and oxygenation in tumors to be observed in
nearly real-time, while improved resolution will permit angiogenesis in
and around tumors to be carried out in a non-invasive manner.
Additionally, rapid scan imaging provides excellent temporal resolution
and will help quantify pharmaco-kinetics and metabolic degradation
kinetics of bioactive free radicals.
Applications: (1) Enhanced spatial, temporal, and spectral
resolution of Continuous Wave-Electron Paramagnetic Resonance Imaging;
(2) Real-time assessment of changes in blood perfusion and oxygenation.
Development Status: Preliminary experiments have been conducted and
the technology has been tested for feasibility.
Inventors: Sankaran Subramanian, Nallathamby Devasahayam, Janusz
Koscielniak, James Mitchell, and Murali Krishna (NCI).
Publication: S Subramanian, JW Koscielniak, N Devasahayam, RH
Pursley, TJ Pohida, TJ Pohida, MC Krishna. A new strategy for fast
radiofrequency CW-EPR imaging: Direct detection with rapid scan and
rotating gradients. Submitted to Journal of Magnetic Resonance for
publication.
Patent Status: U.S. Provisional Application No. 60/818,052, filed
30 Jun 2006 (HHS Reference No. E-221-2005/0-US-01).
Licensing Status: Available for non-exclusive or exclusive
licensing and commercial development.
[[Page 1550]]
Licensing Contact: Chekesha S. Clingman, PhD; 301/435-5018;
clingmac@mail.nih.gov.
Collaborative Research Opportunity: The Radiation Biology Branch,
National Cancer Institute, NIH, Bethesda, MD is seeking statements of
capability or interest from parties interested in collaborative
research to further develop, evaluate, or commercialize the above Rapid
scan-Rotating gradients strategy for performing routine in vivo
Radiofrequency CW-EPR imaging in small animals. Please contact John D.
Hewes, PhD at 301-435-3121 or hewesj@mail.nih.gov for more information.
Dated: January 5, 2007.
Steven M. Ferguson,
Director, Division of Technology Development and Transfer, Office of
Technology Transfer, National Institutes of Health.
[FR Doc. E7-350 Filed 1-11-07; 8:45 am]
BILLING CODE 4140-01-P