Draft Toxicological Review of 2,2,4-Trimethylpentane: In Support of Summary Information on the Integrated Risk Information System (IRIS), 78434-78436 [E6-22431]
Download as PDF
78434
Federal Register / Vol. 71, No. 250 / Friday, December 29, 2006 / Notices
(703) 308–6415; fax number: (703) 308–
8481; e-mail address:
lantz.tracy@epa.gov.
SUPPLEMENTARY INFORMATION:
I. General Information
A. Does this Action Apply to Me
This action is directed to the public
in general. Although this action may be
of particular interest to those persons
who are required to register pesticides
and those who maintain Heating,
Ventilation, Air Conditioning and
Refrigeration Systems. Since other
entities may also be interested, the
Agency has not attempted to describe all
the specific entities that may be affected
by this action. If you have any questions
regarding the information in this notice,
consult the person listed under FOR
FURTHER INFORMATION CONTACT.
pwalker on PROD1PC69 with NOTICES
B. What Should I Consider as I Prepare
My Comments for EPA?
1. Submitting CBI. Do not submit this
information to EPA through
regulations.gov or e-mail. Clearly mark
the part or all of the information that
you claim to be CBI. For CBI
information in a disk or CD ROM that
you mail to EPA, mark the outside of the
disk or CD ROM as CBI and then
identify electronically within the disk or
CD ROM the specific information that is
claimed as CBI. In addition to one
complete version of the comment that
includes information claimed as CBI, a
copy of the comment that does not
contain the information claimed as CBI
must be submitted for inclusion in the
public docket. Information so marked
will not be disclosed except in
accordance with procedures set forth in
40 CFR part 2.
2. Tips for preparing your comments.
When submitting comments, remember
to:
i. Identify the document by docket ID
number and other identifying
information (subject heading, Federal
Register date and page number).
ii. Follow directions. The Agency may
ask you to respond to specific questions
or organize comments by referencing a
Code of Federal Regulations (CFR) part
or section number.
iii. Explain why you agree or disagree;
suggest alternatives and substitute
language for your requested changes.
iv. Describe any assumptions and
provide any technical information and/
or data that you used.
v. If you estimate potential costs or
burdens, explain how you arrived at
your estimate in sufficient detail to
allow for it to be reproduced.
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18:15 Dec 28, 2006
Jkt 211001
vi. Provide specific examples to
illustrate your concerns and suggest
alternatives.
vii. Explain your views as clearly as
possible, avoiding the use of profanity
or personal threats.
viii. Make sure to submit your
comments by the comment period
deadline identified.
B. How Can I Get Copies of this
Document and Other Related
Information?
1. Docket. EPA has established a
docket for this action under docket
identification (ID) number EPA–HQ–
OPP–2006–0351. Publicly available
docket materials are available either in
the electronic docket at https://
www.regulations.gov, or, if only
available in hard copy, at the Office of
Pesticide Programs (OPP) Regulatory
Public Docket in Rm. S–4400, One
Potomac Yard (South Building), 2777 S.
Crystal Drive Arlington, VA. The hours
of operation of this Docket Facility are
from 8:30 a.m. to 4 p.m., Monday
through Friday, excluding legal
holidays. The Docket telephone number
is (703) 305–5805.
2. Electronic access. You may access
this Federal Register document
electronically through the EPA Internet
under the ‘‘Federal Register’’ listings at
https://www.epa.gov/fedrgstr.
II. What Guidance Does this PR Notice
Provide?
The EPA is concerned that sanitizer,
disinfectant and other antimicrobial
products are being used to treat surfaces
of HVAC&R systems, including but not
limited to use as a part of an air duct
cleaning program. When initially
registered, these products were
approved for use on hard surfaces such
as countertops, but air ducts were not
intended to be included in the broad
hard surface category. EPA is concerned
that data demonstrating efficacy when
used in air ducts have not been
submitted for review by the Agency.
Moreover, use of these products in
HVAC&R systems such as air ducts pose
potential human exposure and health
risks to applicators and building
occupants which have not been assessed
by the Agency.
This draft PR Notice provides
guidance which, once final, the Agency
would provide to registrants concerning
labeling language that EPA believes
would address its current concerns for
sanitizer, disinfectant and other
antimicrobial products whose labels
bear directions for use on, or
incorporation within, hard, non-porous
surfaces, but which have not been
specifically approved for use in
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HVAC&R systems. The PR Notice
describes an Agency approach that
registrants of products subject to this
Notice should add a ‘‘Do Not Use’’
statement to the labeling of such
products. Supporting documents for this
draft PR Notice are contained in the
docket.
EPA originally published this
document for comment in the Federal
Register on September 22, 2006 (71 FR
55471). The public comment period
ended on November 21, 2006. EPA
received a request from The Chlorine
Institute to extend the comment period.
The Chlorine Institute has requested
that the Agency provide additional
information which was utilized in
support of the draft guidance. They have
requested additional time to evaluate
this information. EPA agrees to reopen
the comment period for an additional 60
days.
III. Do PR Notices Contain Binding
Requirements?
The PR Notice discussed in this
notice is intended to provide guidance
to EPA personnel and decision makers
and to pesticide registrants. While the
requirements in the statutes and Agency
regulations are binding on EPA and the
applicants, this PR Notice is not binding
on either EPA or pesticide registrants,
and EPA may depart from the guidance
where circumstances warrant and
without prior notice. Likewise, pesticide
registrants may assert that the guidance
is not appropriate generally or not
applicable to a specific pesticide or
situation.
List of Subjects
Environmental protection,
Administrative practice and procedure,
Labeling, Pesticides and pests.
Dated: December 20, 2006.
James Jones,
Director, Office of Pesticide Programs.
[FR Doc. E6–22304 Filed 12–28–06; 8:45 am]
BILLING CODE 6560–50–S
ENVIRONMENTAL PROTECTION
AGENCY
[FRL–8263–9; Docket ID No. EPA–HQ–ORD–
2006–1009]
Draft Toxicological Review of 2,2,4Trimethylpentane: In Support of
Summary Information on the
Integrated Risk Information System
(IRIS)
Environmental Protection
Agency (EPA).
AGENCY:
E:\FR\FM\29DEN1.SGM
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Federal Register / Vol. 71, No. 250 / Friday, December 29, 2006 / Notices
Notice of public comment
period and external peer review panel
meeting.
pwalker on PROD1PC69 with NOTICES
ACTION:
SUMMARY: The EPA is announcing a
public comment period and an external
peer review panel meeting to review the
draft document titled, ‘‘Toxicological
Review of 2,2,4-Trimethylpentane: In
Support of Summary Information on the
Integrated Risk Information System
(IRIS)’’ (NCEA–S–2202), related to the
human health assessment for 2,2,4trimethylpentane. The document was
prepared by the National Center for
Environmental Assessment (NCEA)
within EPA’s Office of Research and
Development.
EPA is releasing this draft document
solely for the purpose of predissemination peer review under
applicable information quality
guidelines. This document has not been
formally disseminated by EPA. It does
not represent and should not be
construed to represent any Agency
policy or determination. EPA will
consider any public comments
submitted in accordance with this
notice when revising the document.
DATES: The 45-day public comment
period begins on December 29, 2006 and
ends February 12, 2007. Technical
comments should be in writing and
must be received by EPA by February
12, 2007. The peer review panel meeting
will be conducted on February 28, 2007,
by teleconference and will begin at 1
p.m. and end at 4 pm. Members of the
public may call into the teleconference
meeting and are invited to provide oral
statements at the commencement of the
teleconference. (For more information
refer to the instructions for registration
provided in the ADDRESSES section of
this notice.)
ADDRESSES: The external peer review
panel meeting will be held by
teleconference. Under an Interagency
Agreement with EPA and the
Department of Energy, the Oak Ridge
Institute of Science and Education
(ORISE) is organizing, convening, and
conducting the peer review panel
meeting. To obtain the teleconference
call-in number and access code, register
by February 14, 2007, by calling ORISE,
P.O. Box 117, MS 17, Oak Ridge, TN
37831–0117, at (865) 576–2922 or (865)
241–3168 (facsimile). Interested parties
may also register on-line at: https://
www.orau.gov/trimethylpentane. Public
comments submitted to the EPA by
February 12, 2007 will be provided to
the external peer review panel prior to
the teleconference meeting.
The draft, ‘‘Toxicological Review of
2,2,4-Trimethylpentane: In Support of
Summary Information on the Integrated
VerDate Aug<31>2005
18:15 Dec 28, 2006
Jkt 211001
Risk Information System (IRIS)’’ (NCEAS–2202) is available primarily via the
Internet on NCEA’s home page under
the Recent Additions menu at https://
www.epa.gov/ncea. A limited number of
paper copies are available by contacting
the IRIS Hotline at (202) 566–1676,
(202) 566–1749 (facsimile), or
hotline.iris@epa.gov. If you are
requesting a paper copy, please provide
your name, mailing address, the
document title, and the EPA number of
the requested publication. Copies are
not available from ORISE.
Technical comments may be
submitted electronically via
www.regulations.gov, by mail, by
facsimile, or by hand delivery/courier.
Please follow the detailed instructions
provided in the SUPPLEMENTARY
INFORMATION section of this notice.
FOR FURTHER INFORMATION CONTACT:
Questions regarding registration and
logistics should be directed to Margaret
Lyday, ORISE, P.O. Box 117, MS 17,
Oak Ridge, TN 37831–0117, at (865)
576–2922 or (865) 241–3168 (facsimile),
lydaym@orau.gov (email).
If you have questions about the
document, contact John Stanek,
Chemical Manager, National Center for
Environmental Assessment; telephone:
(919) 541–1048; facsimile: (919) 541–
0248; email: stanek.john@epa.gov.
SUPPLEMENTARY INFORMATION:
I. Information About the Document
IRIS is a database that contains
Agency scientific positions on potential
adverse human health effects that may
result from chronic (or lifetime)
exposure to specific chemical
substances found in the environment.
The database (available on the Internet
at https://www.epa.gov/iris) contains
qualitative and quantitative health
effects information for more than 500
chemical substances that may be used to
support the first two steps (hazard
identification and dose-response
evaluation) of the risk assessment
process. When supported by available
data, the database provides oral
reference doses (RfDs) and inhalation
reference concentrations (RfCs) for
chronic health effects, and oral slope
factors and inhalation unit risks for
carcinogenic effects. Combined with
specific exposure information,
government and private entities use IRIS
to help characterize public health risks
of chemical substances in a site-specific
situation and thereby support risk
management decisions designed to
protect public health.
2,2,4-Trimethylpentane, also known
as isooctane or
isobutyltrimethylmethane, is a
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Fmt 4703
Sfmt 4703
78435
hydrocarbon used primarily in deriving
high-octane fuels. It comprises about
10% of unleaded gasoline. 2,2,4Trimethylpentane is released into the
environment through the manufacture,
use, and disposal of products associated
with the gasoline and petroleum
industry. The current assessment posted
on IRIS (1991) does not include an
evaluation of the oral non-cancer or the
cancer literature; for the inhalation RfC,
a message indicates that the health
effects data for 2,2,4-trimethylpentane
were considered inadequate for the
derivation of an inhalation RfC. A
review of the more recent literature
identified mechanistic studies, gavage
studies, and toxicokinetic studies, the
majority of which were designed to
specifically address and characterize the
involvement of alpha2u-globulin
accumulation in the renal toxicity
observed in the male rat. Little or no
evaluation of other endpoints in tissues/
organs other than the kidney was
reported. Therefore, the major issues
discussed in the draft assessment are:
(1) the association of TMP-induced
renal effects in male rats with alpha2uglobulin accumulation, and (2) the lack
of studies with sufficient duration and
dose-response information for any
endpoint from which to derive reference
values.
II. How to Submit Technical Comments
to the Docket at www.regulations.gov
Submit your comments, identified by
Docket ID No. EPA–HQ–ORD–2006–
1009 by one of the following methods:
• https://www.regulations.gov: Follow
the on-line instructions for submitting
comments.
• E-mail: ORD.Docket@epa.gov.
• Fax: (202) 566–1753.
• Mail: Office of Environmental
Information (OEI) Docket (Mail Code:
2822T), U.S. Environmental Protection
Agency, 1200 Pennsylvania Ave., NW.,
Washington, DC 20460. The phone
number is (202) 566–1752.
• Hand Delivery: The OEI Docket is
located in the EPA Headquarters Docket
Center, EPA West Building, Room 3334,
1301 Constitution Ave., NW.,
Washington, DC. The EPA Docket
Center Public Reading Room is open
from 8:30 a.m. to 4:30 p.m., Monday
through Friday, excluding legal
holidays. The telephone number for the
Public Reading Room is
(202) 566–1744. Such deliveries are
only accepted during the docket’s
normal hours of operation, and special
arrangements should be made for
deliveries of boxed information.
If you provide comments in writing,
please submit one unbound original
with pages numbered consecutively,
E:\FR\FM\29DEN1.SGM
29DEN1
78436
Federal Register / Vol. 71, No. 250 / Friday, December 29, 2006 / Notices
pwalker on PROD1PC69 with NOTICES
and three copies of the comments. For
attachments, provide an index, number
pages consecutively with the comments,
and submit an unbound original and
three copies.
Instructions: Direct your comments to
Docket ID No. EPA–HQ–ORD–2006–
1009. EPA’s policy is that all comments
received will be included in the public
docket without change and may be
made available online at https://
www.regulations.gov, including any
personal information provided, unless
the comment includes information
claimed to be Confidential Business
Information (CBI) or other information
whose disclosure is restricted by statute.
Do not submit information that you
consider to be CBI or otherwise
protected through www.regulations.gov
or e-mail. The www.regulations.gov Web
site is an ‘‘anonymous access’’ system,
which means EPA will not know your
identity or contact information unless
you provide it in the body of your
comment. If you send an e-mail
comment directly to EPA without going
through www.regulations.gov, your email address will be automatically
captured and included as part of the
comment that is placed in the public
docket and made available on the
Internet. If you submit an electronic
comment, EPA recommends that you
include your name and other contact
information in the body of your
comment and with any disk or CD–ROM
you submit. If EPA cannot read your
comment due to technical difficulties
and cannot contact you for clarification,
EPA may not be able to consider your
comment. Electronic files should avoid
the use of special characters, any form
of encryption, and be free of any defects
or viruses. For additional information
about EPA’s public docket visit the EPA
Docket Center homepage at https://
www.epa.gov/epahome/dockets.htm.
Docket: All documents in the docket
are listed in the www.regulations.gov
index. Although listed in the index,
some information is not publicly
available, e.g., CBI or other information
whose disclosure is restricted by statute.
Certain other material, such as
copyrighted material, will be publicly
available only in hard copy. Publicly
available docket materials are available
either electronically in
www.regulations.gov or in hard copy at
the OEI Docket in the EPA Headquarters
Docket Center.
Dated: December 20, 2006.
George Alapas,
Deputy Director, National Center for
Environmental Assessment.
[FR Doc. E6–22431 Filed 12–28–06; 8:45 am]
BILLING CODE 6560–50–P
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18:15 Dec 28, 2006
Jkt 211001
ENVIRONMENTAL PROTECTION
AGENCY
[FRL–8264–6]
Fort Ord Superfund Site; Proposed
Notice of Administrative Order on
Consent for Cleanup of Portions of the
Former Fort Ord
Environmental Protection
Agency (EPA).
ACTION: Notice; request for public
comment.
AGENCY:
SUMMARY: Notice is hereby given that a
proposed Administrative Order on
Consent (‘‘Agreement’’) concerning
portions of the Fort Ord Superfund Site
(‘‘Site’’) in Monterey, California has
been negotiated by the United States
Environmental Protection Agency
(‘‘EPA’’), the California Department of
Toxic Substances Control (‘‘DTSC’’) and
the Fort Ord Reuse Authority
(‘‘Respondent’’) subject to the final
review and approval of the EPA, DTSC
and the U.S. Department of Justice. The
proposed Agreement concerns cleanup
of portions of the Site pursuant to the
Comprehensive Environmental
Response, Compensation and Liability
Act, 42 U.S.C. 9604, 9606 and 9622
(‘‘CERCLA’’). Pursuant to a Federal
Facilities Agreement (‘‘FFA’’), the U.S.
Army (‘‘Army’’) is required to perform
the CERCLA response actions for the
Site; however, the FFA will be amended
to suspend the obligations of the Army
to conduct those response actions that
will be undertaken by the Respondent
pursuant to the Agreement. The Army is
preparing a Finding of Suitability for
Early Transfer (‘‘FOSET’’), which will
be submitted to EPA Region 9, and the
State of California for their approval
after a public comment period. Upon
approval of the FOSET, the Army will
transfer portions of the Site to the
Respondent. The Army and the
Respondent will enter into an
Environmental Services Cooperative
Agreement, which will require the
Respondent to perform certain CERCLA
response actions on the transferred
portions of the Site, using grant monies
from the Army. The proposed
Agreement would require the
Respondent to prepare and perform
removal actions, one or more remedial
investigations and feasibility studies
and one or more remedial designs and
remedial actions for certain
contaminants present on the transferred
portions of the Site, under the oversight
of EPA and the State of California. The
proposed Agreement includes EPA and
DTSC covenants not to sue or to take
administrative action against the
Respondent, provided that the
PO 00000
Frm 00042
Fmt 4703
Sfmt 4703
Respondent complies with all the terms
and conditions of the Agreement. The
Agreement also commits the
Respondent to reimburse direct and
indirect future response costs incurred
by EPA and DTSC in connection with
actions conducted under CERCLA at the
transferred portions of the Site.
For thirty (30) calendar days
following the date of publication of this
notice, EPA will receive written
comments relating to the proposed
Agreement. EPA’s response to any
comments received will be available for
public inspection at the U.S.
Environmental Protection Agency, 75
Hawthorne Street, San Francisco, CA
94105.
DATES: Comments must be submitted on
or before January 29, 2007.
ADDRESSES: The proposed Agreement
may be obtained from Judith Winchell,
Docket Clerk, telephone (415) 972–3124.
Comments regarding the proposed
Agreement should be addressed to
Judith Winchell (SFD–7) at United
States EPA Region IX, 75 Hawthorne
Street, San Francisco, California 94105,
and should reference ‘‘Former Fort Ord
Superfund Site,’’ and ‘‘Docket No. R9–
2007–03’’.
FOR FURTHER INFORMATION CONTACT:
Michele Benson, Assistant Regional
Counsel (ORC–3), Office of Regional
Counsel, U.S. EPA Region IX, 75
Hawthorne Street, San Francisco, CA
94105; E-mail: benson.michele@epa.gov;
phone: (415) 972–3918.
Dated: December 20, 2006.
Keith Takata,
Director, Superfund Division, Region IX.
[FR Doc. E6–22430 Filed 12–28–06; 8:45 am]
BILLING CODE 6560–50–P
FEDERAL RESERVE SYSTEM
Agency Information Collection
Activities: Announcement of Board
Approval Under Delegated Authority
and Submission to OMB; Correction
This notice corrects a notice
published on pages 77022–77023 of the
issue for December 22, 2006.
Summary:
Background
Notice is hereby given of the final
approval of proposed information
collection(s) by the Board of Governors
of the Federal Reserve System (Board)
under OMB delegated authority, as per
5 CFR 1320.16 (OMB Regulations on
Controlling Paperwork Burdens on the
Public). Board-approved collections of
information are incorporated into the
official OMB inventory of currently
E:\FR\FM\29DEN1.SGM
29DEN1
Agencies
[Federal Register Volume 71, Number 250 (Friday, December 29, 2006)]
[Notices]
[Pages 78434-78436]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: E6-22431]
-----------------------------------------------------------------------
ENVIRONMENTAL PROTECTION AGENCY
[FRL-8263-9; Docket ID No. EPA-HQ-ORD-2006-1009]
Draft Toxicological Review of 2,2,4-Trimethylpentane: In Support
of Summary Information on the Integrated Risk Information System (IRIS)
AGENCY: Environmental Protection Agency (EPA).
[[Page 78435]]
ACTION: Notice of public comment period and external peer review panel
meeting.
-----------------------------------------------------------------------
SUMMARY: The EPA is announcing a public comment period and an external
peer review panel meeting to review the draft document titled,
``Toxicological Review of 2,2,4-Trimethylpentane: In Support of Summary
Information on the Integrated Risk Information System (IRIS)'' (NCEA-S-
2202), related to the human health assessment for 2,2,4-
trimethylpentane. The document was prepared by the National Center for
Environmental Assessment (NCEA) within EPA's Office of Research and
Development.
EPA is releasing this draft document solely for the purpose of pre-
dissemination peer review under applicable information quality
guidelines. This document has not been formally disseminated by EPA. It
does not represent and should not be construed to represent any Agency
policy or determination. EPA will consider any public comments
submitted in accordance with this notice when revising the document.
DATES: The 45-day public comment period begins on December 29, 2006 and
ends February 12, 2007. Technical comments should be in writing and
must be received by EPA by February 12, 2007. The peer review panel
meeting will be conducted on February 28, 2007, by teleconference and
will begin at 1 p.m. and end at 4 pm. Members of the public may call
into the teleconference meeting and are invited to provide oral
statements at the commencement of the teleconference. (For more
information refer to the instructions for registration provided in the
ADDRESSES section of this notice.)
ADDRESSES: The external peer review panel meeting will be held by
teleconference. Under an Interagency Agreement with EPA and the
Department of Energy, the Oak Ridge Institute of Science and Education
(ORISE) is organizing, convening, and conducting the peer review panel
meeting. To obtain the teleconference call-in number and access code,
register by February 14, 2007, by calling ORISE, P.O. Box 117, MS 17,
Oak Ridge, TN 37831-0117, at (865) 576-2922 or (865) 241-3168
(facsimile). Interested parties may also register on-line at: https://
www.orau.gov/trimethylpentane. Public comments submitted to the EPA by
February 12, 2007 will be provided to the external peer review panel
prior to the teleconference meeting.
The draft, ``Toxicological Review of 2,2,4-Trimethylpentane: In
Support of Summary Information on the Integrated Risk Information
System (IRIS)'' (NCEA-S-2202) is available primarily via the Internet
on NCEA's home page under the Recent Additions menu at https://
www.epa.gov/ncea. A limited number of paper copies are available by
contacting the IRIS Hotline at (202) 566-1676, (202) 566-1749
(facsimile), or hotline.iris@epa.gov. If you are requesting a paper
copy, please provide your name, mailing address, the document title,
and the EPA number of the requested publication. Copies are not
available from ORISE.
Technical comments may be submitted electronically via
www.regulations.gov, by mail, by facsimile, or by hand delivery/
courier. Please follow the detailed instructions provided in the
SUPPLEMENTARY INFORMATION section of this notice.
FOR FURTHER INFORMATION CONTACT: Questions regarding registration and
logistics should be directed to Margaret Lyday, ORISE, P.O. Box 117, MS
17, Oak Ridge, TN 37831-0117, at (865) 576-2922 or (865) 241-3168
(facsimile), lydaym@orau.gov (email).
If you have questions about the document, contact John Stanek,
Chemical Manager, National Center for Environmental Assessment;
telephone: (919) 541-1048; facsimile: (919) 541-0248; email:
stanek.john@epa.gov.
SUPPLEMENTARY INFORMATION:
I. Information About the Document
IRIS is a database that contains Agency scientific positions on
potential adverse human health effects that may result from chronic (or
lifetime) exposure to specific chemical substances found in the
environment. The database (available on the Internet at https://
www.epa.gov/iris) contains qualitative and quantitative health effects
information for more than 500 chemical substances that may be used to
support the first two steps (hazard identification and dose-response
evaluation) of the risk assessment process. When supported by available
data, the database provides oral reference doses (RfDs) and inhalation
reference concentrations (RfCs) for chronic health effects, and oral
slope factors and inhalation unit risks for carcinogenic effects.
Combined with specific exposure information, government and private
entities use IRIS to help characterize public health risks of chemical
substances in a site-specific situation and thereby support risk
management decisions designed to protect public health.
2,2,4-Trimethylpentane, also known as isooctane or
isobutyltrimethylmethane, is a hydrocarbon used primarily in deriving
high-octane fuels. It comprises about 10% of unleaded gasoline. 2,2,4-
Trimethylpentane is released into the environment through the
manufacture, use, and disposal of products associated with the gasoline
and petroleum industry. The current assessment posted on IRIS (1991)
does not include an evaluation of the oral non-cancer or the cancer
literature; for the inhalation RfC, a message indicates that the health
effects data for 2,2,4-trimethylpentane were considered inadequate for
the derivation of an inhalation RfC. A review of the more recent
literature identified mechanistic studies, gavage studies, and
toxicokinetic studies, the majority of which were designed to
specifically address and characterize the involvement of
alpha2u-globulin accumulation in the renal toxicity observed
in the male rat. Little or no evaluation of other endpoints in tissues/
organs other than the kidney was reported. Therefore, the major issues
discussed in the draft assessment are: (1) the association of TMP-
induced renal effects in male rats with alpha2u-globulin
accumulation, and (2) the lack of studies with sufficient duration and
dose-response information for any endpoint from which to derive
reference values.
II. How to Submit Technical Comments to the Docket at
www.regulations.gov
Submit your comments, identified by Docket ID No. EPA-HQ-ORD-2006-
1009 by one of the following methods:
https://www.regulations.gov: Follow the on-line
instructions for submitting comments.
E-mail: ORD.Docket@epa.gov.
Fax: (202) 566-1753.
Mail: Office of Environmental Information (OEI) Docket
(Mail Code: 2822T), U.S. Environmental Protection Agency, 1200
Pennsylvania Ave., NW., Washington, DC 20460. The phone number is (202)
566-1752.
Hand Delivery: The OEI Docket is located in the EPA
Headquarters Docket Center, EPA West Building, Room 3334, 1301
Constitution Ave., NW., Washington, DC. The EPA Docket Center Public
Reading Room is open from 8:30 a.m. to 4:30 p.m., Monday through
Friday, excluding legal holidays. The telephone number for the Public
Reading Room is
(202) 566-1744. Such deliveries are only accepted during the
docket's normal hours of operation, and special arrangements should be
made for deliveries of boxed information.
If you provide comments in writing, please submit one unbound
original with pages numbered consecutively,
[[Page 78436]]
and three copies of the comments. For attachments, provide an index,
number pages consecutively with the comments, and submit an unbound
original and three copies.
Instructions: Direct your comments to Docket ID No. EPA-HQ-ORD-
2006-1009. EPA's policy is that all comments received will be included
in the public docket without change and may be made available online at
https://www.regulations.gov, including any personal information
provided, unless the comment includes information claimed to be
Confidential Business Information (CBI) or other information whose
disclosure is restricted by statute. Do not submit information that you
consider to be CBI or otherwise protected through www.regulations.gov
or e-mail. The www.regulations.gov Web site is an ``anonymous access''
system, which means EPA will not know your identity or contact
information unless you provide it in the body of your comment. If you
send an e-mail comment directly to EPA without going through
www.regulations.gov, your e-mail address will be automatically captured
and included as part of the comment that is placed in the public docket
and made available on the Internet. If you submit an electronic
comment, EPA recommends that you include your name and other contact
information in the body of your comment and with any disk or CD-ROM you
submit. If EPA cannot read your comment due to technical difficulties
and cannot contact you for clarification, EPA may not be able to
consider your comment. Electronic files should avoid the use of special
characters, any form of encryption, and be free of any defects or
viruses. For additional information about EPA's public docket visit the
EPA Docket Center homepage at https://www.epa.gov/epahome/dockets.htm.
Docket: All documents in the docket are listed in the
www.regulations.gov index. Although listed in the index, some
information is not publicly available, e.g., CBI or other information
whose disclosure is restricted by statute. Certain other material, such
as copyrighted material, will be publicly available only in hard copy.
Publicly available docket materials are available either electronically
in www.regulations.gov or in hard copy at the OEI Docket in the EPA
Headquarters Docket Center.
Dated: December 20, 2006.
George Alapas,
Deputy Director, National Center for Environmental Assessment.
[FR Doc. E6-22431 Filed 12-28-06; 8:45 am]
BILLING CODE 6560-50-P