Justia Department Of Health And Human Services National Institute of Environmental Health Sciences; National Toxicology Program; NTP Interagency Center for the Evaluation of Alternative Toxicological Methods; Development of a NICEATM/ICCVAM 5-Year Plan To Research, Develop, Translate, and Validate New and Revised Non-animal and Other Alternative Assays for Integration of Relevant and Reliable Methods Into Federal Agency Testing Programs: Request for Public Comments, 66172-66173 [E6-19094]

National Institute of Environmental Health Sciences; National Toxicology Program; NTP Interagency Center for the Evaluation of Alternative Toxicological Methods; Development of a NICEATM/ICCVAM 5-Year Plan To Research, Develop, Translate, and Validate New and Revised Non-animal and Other Alternative Assays for Integration of Relevant and Reliable Methods Into Federal Agency Testing Programs: Request for Public Comments, 66172-66173 [E6-19094]

Download as PDF 66172 Federal Register / Vol. 71, No. 218 / Monday, November 13, 2006 / Notices percent of the voting shares of Pacific Premier Bank, Costa Mesa, California. Board of Governors of the Federal Reserve System, November 7, 2006. Robert deV. Frierson, Deputy Secretary of the Board. [FR Doc. E6–19092 Filed 11–9–06; 8:45 am] BILLING CODE 6210–01–S DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institute of Environmental Health Sciences; National Toxicology Program; NTP Interagency Center for the Evaluation of Alternative Toxicological Methods; Development of a NICEATM/ICCVAM 5-Year Plan To Research, Develop, Translate, and Validate New and Revised Non-animal and Other Alternative Assays for Integration of Relevant and Reliable Methods Into Federal Agency Testing Programs: Request for Public Comments National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH)m HHS. ACTION: Request for comments. cprice-sewell on PROD1PC66 with NOTICES AGENCY: SUMMARY: The NIEHS and the National Toxicology Program (NTP) Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM) request public comments that can be considered by the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) and agency program offices in development of a NICEATM/ ICCVAM 5-year plan that addresses: (1) Research, development, translation, and validation of new and revised nonanimal and other alternatives assays for integration of relevant and reliable methods into federal agency testing programs and (2) identification of areas of high priority for new and revised non-animal and alternative assays for the replacement, reduction, and refinement (less pain and distress) of animal tests. DATES: Submit comments on or before December 31, 2006. ADDRESSES: Comments should preferably be submitted electronically at the NICEATM/ICCVAM 5-Year Plan Web site: https://iccvam.niehs.nih.gov/ docs/5yearplan.htm. Comments can also be submitted by e-mail to 5yearplan@niehs.nih.gov. Written comments may also be sent by mail or fax to Dr. William S. Stokes, NICEATM Director, NIH/NIEHS, P.O. Box 12233, MD EC–17, Research Triangle Park, NC, VerDate Aug<31>2005 15:22 Nov 09, 2006 Jkt 211001 27709, (phone) 919–541–2384, (fax) 919–541–0947. Courier address: NICEATM, 79 T.W. Alexander Drive, Building 4401, Room 3128, Research Triangle Park, NC 27709. SUPPLEMENTARY INFORMATION: Background Congress established ICCVAM to promote development, validation, and regulatory acceptance of new or revised alternative toxicological test methods that protect human and animal health and the environment while reducing, refining, or replacing animal tests and ensuring human safety and product effectiveness (42 U.S.C. 285l–3). Congress requests of NIEHS that NICEATM and ICCVAM in partnership with relevant federal agencies develop a 5-year plan that addresses (1) research, development, translation, and validation of new and revised nonanimal and other alternative assays for integration into federal agency testing programs and (2) identification of areas of high priority for new and revised non-animal and alternative assays for replacement, reduction, and refinement (less pain and distress) of animal tests. At this time, the NIEHS and NICEATM seek public comments that can be considered by the ICCVAM and agency program offices in development of the plan. The Scientific Advisory Committee on Alternative Toxicological Methods (SACATM) meeting at the NIEHS on November 30 will also provide an additional opportunity for public input (https://ntp.niehs.nih.gov/ go/7441). Request for Comments The NIEHS and NICEATM invite public comments for consideration by ICCVAM and agency program offices in development of the NICEATM/ICCVAM 5-year plan. With regard to refining, reducing, and replacing animal use, ICCVAM has previously identified and ranked the types of regulatory safety tests that it considers should have the highest priority for the development and validation of alternative test methods. 1. Acute eye irritation and corrosion 2. Biologics/vaccines 3. Acute skin toxicity (including irritation/corrosion, sensitization, absorption) 4. Acute systemic toxicity (oral/ dermal/inhalation) 5. Chronic toxicity/carcinogenicity 6. Reproductive/developmental toxicity 7. Endocrine disruptors 8. Neurotoxicity 9. Immunotoxicity The NIEHS and NICEATM seek public input on the following questions. PO 00000 Frm 00017 Fmt 4703 Sfmt 4703 One of the elements that might be considered in answering questions 2–4 is the priority areas listed above. 1. Do you have comments on the priority areas for the development and validation of alternative test methods listed above? 2. Considering available science and technology, what development, translation, and validation activities are most likely to have the greatest impacts within the next five years on refining, reducing, or replacing animal use? 3. What research and development activities hold the greatest promise in the long-term for refining, reducing, or replacing animal use? 4. What are appropriate measures for evaluating progress in enhancing the development and use of alternative test methods? Individuals submitting comments are asked to include appropriate contact information (name, affiliation, mailing address, phone, fax, email and sponsoring organization, if applicable). All comments received by December 31, 2006, will be posted on the ICCVAM– NICEATM Web site (https:// iccvam.niehs.nih.gov/docs/ 5yearplan.htm) and identified by the individual’s name and affiliation and/or sponsoring organization, if applicable. Background Information on ICCVAM and NICEATM ICCVAM is an interagency committee composed of representatives from 15 federal regulatory and research agencies that use, generate, or disseminate toxicological information. ICCVAM conducts technical evaluations of new, revised, and alternative methods with regulatory applicability and promotes scientific validation and regulatory acceptance of toxicological test methods that more accurately assess safety and hazards of chemicals and products and that refine, reduce, and replace animal use. The ICCVAM Authorization Act of 2000 (42 U.S.C. 285l–3, available at https://iccvam.niehs.nih.gov/about/ PL106545.htm) establishes ICCVAM as a permanent interagency committee of the NIEHS under NICEATM. NICEATM administers ICCVAM and provides scientific and operational support for ICCVAM-related activities. NICEATM and ICCVAM work collaboratively to evaluate new and improved test methods applicable to the needs of Federal agencies. SACATM is a federally chartered advisory committee that provides advice to NICEATM, ICCVAM, and NIEHS on ICCVAM and NICEATM activities. Additional information about ICCVAM and NICEATM can be found at the following Website: https://iccvam.niehs.nih.gov. E:\FR\FM\13NON1.SGM 13NON1 Federal Register / Vol. 71, No. 218 / Monday, November 13, 2006 / Notices Information about SACATM is available at https://ntp.niehs.nih.gov/go/167. DEPARTMENT OF HEALTH AND HUMAN SERVICES Dated: November 2, 2006. Samuel H. Wilson, Deputy Director, National Institute of Environmental Health Sciences and National Toxicology Program. [FR Doc. E6–19094 Filed 11–9–06; 8:45 am] Centers for Disease Control and Prevention BILLING CODE 4140–01–P Disease, Disability, and Injury Prevention and Control Special Emphasis Panel: NIOSH Education and Research Center, Program Announcement Number (PAR) 06–485 In accordance with section 10(a)(2) of the Federal Advisory Committee Act (Pub. L. 92–463), the Centers for Disease Control and Prevention (CDC) announces the following meeting: Name: Disease, Disability, and Injury Prevention and Control Special Emphasis 66173 Panel (SEP): NIOSH Education and Research Center, Program Announcement Number (PAR) 06–485. Time and Date: 8 a.m.–5 p.m., March 13, 2007 (Closed). Place: Embassy Suites, 1900 Diagonal Rd. Alexandria, VA 22314, 703.684.5900. Status: The meeting will be closed to the public in accordance with provisions set forth in section 552b(c)(4) and (6), Title 5 U.S.C., and the Determination of the Director, Management Analysis and Services Office, CDC, pursuant to Public Law 92–463. Purpose: The work groups convening at specific sites listed below advise and make recommendations to the Disease, Disability, and Injury Prevention and Control SEP: NIOSH Education and Research Center, PAR 06–485. Specifically, the SEP makes recommendations regarding policies, strategies, and funding. TIMES, DATES, AND PLACES OF THE WORK GROUP MEETINGS 8 a.m.–5 p.m. .... November 13, 2006 (Closed) .................. 8 a.m.–5 p.m. .... November 28, 2006 (Closed) .................. 8 8 8 8 8 December 11, 2006 (Closed) .................. December 14, 2006 (Closed) .................. January 9, 2007 (Closed) ........................ January 16, 2007 (Closed) ...................... February 13, 2007 (Closed) .................... a.m.–5 a.m.–5 a.m.–5 a.m.–5 a.m.–5 p.m. p.m. p.m. p.m. p.m. .... .... .... .... .... Matters to Be Discussed: The SEP meeting will include the review, discussion, and evaluation of research grant applications in response to ‘‘NIOSH Education and Research Center,’’ PAR 06–485. For Further Information Contact: Dr. M. Chris Langub, Designated Federal Officer, 1600 Clifton Road NE, MS E74, Atlanta, GA, 30333, telephone 404.498.2543. The Director, Management Analysis and Services Office, has been delegated the authority to sign Federal Register notices pertaining to announcements of meetings and other committee management activities, for both CDC and the Agency for Toxic Substances and Disease Registry. Dated: November 1, 2006. Alvin Hall, Director, Management Analysis and Services Office, Centers for Disease Control and Prevention. [FR Doc. E6–19100 Filed 11–9–06; 8:45 am] cprice-sewell on PROD1PC66 with NOTICES BILLING CODE 4163–18–P Women’s Faculty Club on the University of California Berkeley campus 510–642– 4175. University of Alabama at Birmingham, Administration Building Penthouse, 701 20th Street South, 14th floor, Conference Room 1, 205–934–0771. Bloomberg School of Public Health, 615 N. Wolfe St, Baltimore, MD 21205. College of Public Health, 13201 Bruce B. Downs Blvd, Tampa, FL 33612. Fitzsimons Campus, Nighthorse Campbell Building, Room 304, Denver, CO. Coffman Memorial Union, 300 Washington Ave. SE., Minneapolis, MN 55455. University Park Marriott, 480 Wakara Way, Salt Lake City, UT 84108 801–584– 3312. DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention National Center for Environmental Health/Agency for Toxic Substances and Disease Registry; Meetings The Health Department Subcommittee of the Board of Scientific Counselors (BSC), Centers for Disease Control and Prevention (CDC), National Center for Environmental Health (NCEH)/Agency for Toxic Substances and Disease Registry (ATSDR): Teleconference Meeting. In accordance with section 10(a)(2) of the Federal Advisory Committee Act (Pub. L. 92–463), The Centers for Disease Control and Prevention, NCEH/ ATSDR announces the following subcommittee teleconference meeting: Name: Health Department Subcommittee (HDS), BSC, NCEH/ATSDR. Time and Date: 12:30 p.m.–2 p.m., November 28, 2006. Place: Century Center, 1825 Century Boulevard, Atlanta, Georgia 30345. To participate please dial 877/315–6535 and enter conference code 383520. Status: Open to the public, teleconference access limited only by availability of telephone ports. VerDate Aug<31>2005 15:22 Nov 09, 2006 Jkt 211001 PO 00000 Frm 00018 Fmt 4703 Sfmt 4703 Purpose: Under the charge of the BSC, NCEH/ATSDR, the Health Department Subcommittee will provide the Board with advice and recommendations on local and state health department issues and concerns that pertain to the mandates and mission of NCEH/ATSDR. Matters To Be Discussed: The meeting agenda will include a review of agenda and approval of minutes; CDC follow-up report on workforce recommendations; membership discussion; bridging NCEH/ATSDR activities including surveillance; public comment; and the next steps for the Health Department Subcommittee. Items are subject to change as priorities dictate. Supplementary Information: This teleconference meeting is scheduled to begin at 12:30 p.m. Eastern Standard Time. The Public Comment period is from 2:00 p.m.– 2:10 p.m. For Further Information Contact: Individuals interested in attending the meeting, please contactShirley D. Little, Committee Management Specialist, NCEH/ ATSDR, 1600 Clifton Road, Mail Stop E–28, Atlanta, GA 30303; telephone 404/498–0003, fax 404/498–0059; E-mail: slittle@cdc.gov. The Director, Management Analysis and Services Office, has been delegated the authority to sign Federal Register notices pertaining to announcements of meetings and other committee management activities for both CDC and the National Center for Environmental Health/Agency for Toxic Substances and Disease Registry. E:\FR\FM\13NON1.SGM 13NON1

Agencies

DEPARTMENT OF HEALTH AND HUMAN SERVICES

[Federal Register Volume 71, Number 218 (Monday, November 13, 2006)]
[Notices]
[Pages 66172-66173]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: E6-19094]


=======================================================================
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DEPARTMENT OF HEALTH AND HUMAN SERVICES


National Institute of Environmental Health Sciences; National 
Toxicology Program; NTP Interagency Center for the Evaluation of 
Alternative Toxicological Methods; Development of a NICEATM/ICCVAM 5-
Year Plan To Research, Develop, Translate, and Validate New and Revised 
Non-animal and Other Alternative Assays for Integration of Relevant and 
Reliable Methods Into Federal Agency Testing Programs: Request for 
Public Comments

AGENCY: National Institute of Environmental Health Sciences (NIEHS), 
National Institutes of Health (NIH)m HHS.

ACTION: Request for comments.

-----------------------------------------------------------------------

SUMMARY: The NIEHS and the National Toxicology Program (NTP) 
Interagency Center for the Evaluation of Alternative Toxicological 
Methods (NICEATM) request public comments that can be considered by the 
Interagency Coordinating Committee on the Validation of Alternative 
Methods (ICCVAM) and agency program offices in development of a 
NICEATM/ICCVAM 5-year plan that addresses: (1) Research, development, 
translation, and validation of new and revised non-animal and other 
alternatives assays for integration of relevant and reliable methods 
into federal agency testing programs and (2) identification of areas of 
high priority for new and revised non-animal and alternative assays for 
the replacement, reduction, and refinement (less pain and distress) of 
animal tests.

DATES: Submit comments on or before December 31, 2006.

ADDRESSES: Comments should preferably be submitted electronically at 
the NICEATM/ICCVAM 5-Year Plan Web site: https://iccvam.niehs.nih.gov/
docs/5yearplan.htm. Comments can also be submitted by e-mail to 
5yearplan@niehs.nih.gov. Written comments may also be sent by mail or 
fax to Dr. William S. Stokes, NICEATM Director, NIH/NIEHS, P.O. Box 
12233, MD EC-17, Research Triangle Park, NC, 27709, (phone) 919-541-
2384, (fax) 919-541-0947. Courier address: NICEATM, 79 T.W. Alexander 
Drive, Building 4401, Room 3128, Research Triangle Park, NC 27709.

SUPPLEMENTARY INFORMATION:

Background

    Congress established ICCVAM to promote development, validation, and 
regulatory acceptance of new or revised alternative toxicological test 
methods that protect human and animal health and the environment while 
reducing, refining, or replacing animal tests and ensuring human safety 
and product effectiveness (42 U.S.C. 285l-3). Congress requests of 
NIEHS that NICEATM and ICCVAM in partnership with relevant federal 
agencies develop a 5-year plan that addresses (1) research, 
development, translation, and validation of new and revised non-animal 
and other alternative assays for integration into federal agency 
testing programs and (2) identification of areas of high priority for 
new and revised non-animal and alternative assays for replacement, 
reduction, and refinement (less pain and distress) of animal tests. At 
this time, the NIEHS and NICEATM seek public comments that can be 
considered by the ICCVAM and agency program offices in development of 
the plan. The Scientific Advisory Committee on Alternative 
Toxicological Methods (SACATM) meeting at the NIEHS on November 30 will 
also provide an additional opportunity for public input (https://
ntp.niehs.nih.gov/go/7441).

Request for Comments

    The NIEHS and NICEATM invite public comments for consideration by 
ICCVAM and agency program offices in development of the NICEATM/ICCVAM 
5-year plan. With regard to refining, reducing, and replacing animal 
use, ICCVAM has previously identified and ranked the types of 
regulatory safety tests that it considers should have the highest 
priority for the development and validation of alternative test 
methods.
    1. Acute eye irritation and corrosion
    2. Biologics/vaccines
    3. Acute skin toxicity (including irritation/corrosion, 
sensitization, absorption)
    4. Acute systemic toxicity (oral/dermal/inhalation)
    5. Chronic toxicity/carcinogenicity
    6. Reproductive/developmental toxicity
    7. Endocrine disruptors
    8. Neurotoxicity
    9. Immunotoxicity
    The NIEHS and NICEATM seek public input on the following questions. 
One of the elements that might be considered in answering questions 2-4 
is the priority areas listed above.
    1. Do you have comments on the priority areas for the development 
and validation of alternative test methods listed above?
    2. Considering available science and technology, what development, 
translation, and validation activities are most likely to have the 
greatest impacts within the next five years on refining, reducing, or 
replacing animal use?
    3. What research and development activities hold the greatest 
promise in the long-term for refining, reducing, or replacing animal 
use?
    4. What are appropriate measures for evaluating progress in 
enhancing the development and use of alternative test methods?
    Individuals submitting comments are asked to include appropriate 
contact information (name, affiliation, mailing address, phone, fax, 
email and sponsoring organization, if applicable). All comments 
received by December 31, 2006, will be posted on the ICCVAM-NICEATM Web 
site (https://iccvam.niehs.nih.gov/docs/5yearplan.htm) and identified by 
the individual's name and affiliation and/or sponsoring organization, 
if applicable.

Background Information on ICCVAM and NICEATM

    ICCVAM is an interagency committee composed of representatives from 
15 federal regulatory and research agencies that use, generate, or 
disseminate toxicological information. ICCVAM conducts technical 
evaluations of new, revised, and alternative methods with regulatory 
applicability and promotes scientific validation and regulatory 
acceptance of toxicological test methods that more accurately assess 
safety and hazards of chemicals and products and that refine, reduce, 
and replace animal use. The ICCVAM Authorization Act of 2000 (42 U.S.C. 
285l-3, available at https://iccvam.niehs.nih.gov/about/PL106545.htm) 
establishes ICCVAM as a permanent interagency committee of the NIEHS 
under NICEATM. NICEATM administers ICCVAM and provides scientific and 
operational support for ICCVAM-related activities. NICEATM and ICCVAM 
work collaboratively to evaluate new and improved test methods 
applicable to the needs of Federal agencies. SACATM is a federally 
chartered advisory committee that provides advice to NICEATM, ICCVAM, 
and NIEHS on ICCVAM and NICEATM activities. Additional information 
about ICCVAM and NICEATM can be found at the following Website: https://
iccvam.niehs.nih.gov.

[[Page 66173]]

Information about SACATM is available at https://ntp.niehs.nih.gov/go/
167.

    Dated: November 2, 2006.
Samuel H. Wilson,
Deputy Director, National Institute of Environmental Health Sciences 
and National Toxicology Program.
 [FR Doc. E6-19094 Filed 11-9-06; 8:45 am]
BILLING CODE 4140-01-P

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