Evaluation of the Carcinogenicity of Ethylene Oxide, 60143-60144 [E6-16921]

Download as PDF Federal Register / Vol. 71, No. 197 / Thursday, October 12, 2006 / Notices Chemical name CAS No. List of Subjects Environmental protection, Acute Exposure Guideline Levels (AEGLs), Hazardous substances. Chlorine pentafluoride 13637–63–3 Chloroacetaldehye 107–20–0 Chloroacetone 78–95–5 Chloroacetonitrile 107–14–2 Chloroacetyl chloride 79–04–9 Cumene 98–82–8 Dichloroacetyl chloride 79–36–7 Dimethyl sulfate 77–78–1 Disulfur dichloride 10025–67–9 Ethyl acrylate 140–88–5 Evaluation of the Carcinogenicity of Ethylene Oxide Ethyl mercaptan 75–08–1 AGENCY: Formaldehyde 50–00–0 Hexane 110–54–3 Hydrogen bromide 10035–10–6 Hydrogen iodide 10034–85–2 Hydrogen selenide 7783–07–5 Isobutyronitrile 78–82–0 Lewisite L-1 541–25–3 Lewisite L-2 40334–69–8 Lewisite L-3 40334–70–1 Malononitrile 109–77–3 Methacrylic acid 79–41–4 Methacrylonitrile 126–98–7 Methyl bromide 74–83–9 Methyl chloride 74–87–3 Methyl methacrylate 80–62–6 Methylene chloride 75–09–2 Oleum 8014–95–7 Piperidine 110–89–4 Propane 74–98–6 Propionaldehyde 123–38–6 Proprionitrile 107–12–0 Styrene 110–42–5 Sulfur trioxide 7446–11–9 Sulfuric acid 7664–93–9 Titanium tetrachloride 7550–45–0 Vinyl chloride 75–01–4 Dated: October 5, 2006. Charles M. Auer, Director, Office of Pollution Prevention and Toxics. [FR Doc. E6–16908 Filed 10–11–06; 8:45 am] rwilkins on PROD1PC63 with NOTICES BILLING CODE 6560–50–S VerDate Aug<31>2005 16:21 Oct 11, 2006 Jkt 211001 ENVIRONMENTAL PROTECTION AGENCY [FRL–8230–7; Docket ID No. EPA–HQ–ORD– 2006–0756] Environmental Protection Agency (EPA). ACTION: Notice of Extension of Public Comment Period. SUMMARY: EPA is announcing an extension of the public comment period for the draft document titled, ‘‘Evaluation of the Carcinogenicity of Ethylene Oxide’’ (EPA/635/R–06/003). The document was prepared by the National Center for Environmental Assessment within EPA’s Office of Research and Development. On September 22, EPA published a Federal Register notice (71 FR 55470) announcing a 30-day comment period that ends October 23, 2007. EPA is extending the public comment period to December 8, 2006, in response to requests. As previously stated in 71 FR 55470, EPA is releasing this draft document solely for the purpose of seeking public comment and for review by the EPA Science Advisory Board (SAB) via a meeting to be held at a later date (time and place to be specified in a separate Federal Register notice). This document has not been formally disseminated by EPA. It does not determination. EPA will consider any public comments submitted in accordance with this notice when revising the document. DATES: The public comment period began September 22, 2006, and ends December 8, 2006. Technical comments should be in writing and must be received by EPA by December 8, 2006. ADDRESSES: The draft ‘‘Evaluation of the Carcinogenicity of Ethylene Oxide’’ is available primarily via the Internet on the National Center for Environmental Assessment’s home page under the Recent Additions and the Data and Publications menus at http:// www.epa.gov/ncea. A limited number of paper copies are available from the PO 00000 Frm 00037 Fmt 4703 Sfmt 4703 60143 Technical Information Staff, NCEA–W; telephone: 202–564–3261; facsimile: 202–565–0050. If you are requesting a paper copy, please provide your name, your mailing address, and the document title, ‘‘Evaluation of the Carcinogenicity of Ethylene Oxide’’. Comments may be submitted electronically via www.regulations.gov, by mail, by facsimile, or by hand delivery/courier. Please follow the detailed instructions provided in the SUPPLEMENTARY INFORMATION section of this notice. FOR FURTHER INFORMATION CONTACT: For information on the public comment period, contact the Office of Environmental Information Docket; telephone: 202–566–1752; facsimile: 202–566–1753; or e-mail: ORD.Docket@epa.gov. For technical information, contact Henry D. Kahn, D.Sc., NCEA; telephone: 202–564–3269; facsimile: 202–565– 0079; or e-mail: kahn.henry@epa.gov. SUPPLEMENTARY INFORMATION: I. Information About the Project/ Document Ethylene oxide (EtO) is a gas at room temperature. It is manufactured from ethylene and used primarily as a chemical intermediate in the manufacture of ethylene glycol. It is also used as a sterilizing agent for medical equipment and as a fumigating agent for spices. The largest sources of human exposure are in occupations involving contact with the gas in production facilities and in hospitals that sterilize medical equipment. EtO can also be inhaled by residents living near production or sterilizing/fumigating facilities. This draft assessment document characterizes the potential for a carcinogenic health hazard from human inhalation exposure to EtO. This is accomplished by a weight-of-evidence evaluation as to how likely EtO is to be a human carcinogen, as well as an evaluation of related dose-response information which leads to the development of lifetime cancer risk estimates per unit of exposure. This assessment, when finalized, will be posted to EPA’s Integrated Risk Information System (IRIS) database. The document was prepared by EPA’s National Center for Environmental Assessment (NCEA). EPA last published a health assessment of the potential carcinogenicity of EtO in 1985. The current assessment reviews the more recently developed database on the carcinogenicity of EtO, pertinent data from the 1985 assessment, and several reviews and assessments issued E:\FR\FM\12OCN1.SGM 12OCN1 60144 Federal Register / Vol. 71, No. 197 / Thursday, October 12, 2006 / Notices by other organizations (IARC, 1994; Health Canada, 2001; CalEPA, 1999; EOIC, 2001). II. How to Submit Technical Comments to the Docket at www.regulations.gov rwilkins on PROD1PC63 with NOTICES Note: The EPA Docket Center suffered damage due to flooding during the last week of June 2006. The Docket Center is continuing to operate. However, during the cleanup, there will be temporary changes to Docket Center telephone numbers, addresses, and hours of operation for people who wish to make hand deliveries or visit the Public Reading Room to view documents. Consult EPA’s Federal Register notice at 71 FR 38147 (July 5, 2006) or the EPA Web site at http:// www.epa.gov/epahome/dockets.htm for current information on docket operations, locations and telephone numbers. The Docket Center’s mailing address for U.S. mail and the procedure for submitting comments to www.regulations.gov are not affected by the flooding and will remain the same. Submit your comments, identified by Docket ID No. EPA–HQ–ORD 2006– 0756 by one of the following methods: • www.regulations.gov: Follow the on-line instructions for submitting comments. • E-mail: ORD.Docket@epa.gov. • Fax: 202–566–1753 • Mail: Office of Environmental Information (OEI) Docket (Mail Code: 2822T), U.S. Environmental Protection Agency, 1200 Pennsylvania Ave., NW., Washington, DC 20460. The phone number is 202–566–1752. • Hand Delivery: The OEI Docket is located in the EPA Headquarters Docket Center, EPA West Building, 1301 Constitution Ave., NW., Washington, DC. The EPA Docket Center Public Reading Room is open from 8:30 a.m. to 4:30 p.m., Monday through Friday, excluding legal holidays. The telephone number for the Public Reading Room is 202–566–1744. Such deliveries are only accepted during the docket’s normal hours of operation, and special arrangements should be made for deliveries of boxed information. If you submit comments by mail or hand delivery, please submit one unbound original with pages numbered consecutively, and three copies of the comments. For attachments, provide an index, number pages consecutively with the comments, and submit an unbound original and three copies. Instructions: Direct your comments to Docket ID No. EPA–HQ–ORD–2006– 0756. Please ensure that your comments are submitted within the specified comment period. Comments received after the closing date will be marked ‘‘late,’’ and may only be considered if time permits. It is EPA’s policy to include all comments it receives in the public docket without change and to VerDate Aug<31>2005 16:21 Oct 11, 2006 Jkt 211001 make the comments available online at www.regulations.gov, including any personal information provided, unless a comment includes information claimed to be Confidential Business Information (CBI) or other information whose disclosure is restricted by statute. Do not submit information that you consider to be CBI or otherwise protected through www.regulations.gov or e-mail. The www.regulations.gov Web site is an ‘‘anonymous access’’ system, which means EPA will not know your identity or contact information unless you provide it in the body of your comment. If you send an e-mail comment directly to EPA without going through www.regulations.gov, your email address will be automatically captured and included as part of the comment that is placed in the public docket and made available on the Internet. If you submit an electronic comment, EPA recommends that you include your name and other contact information in the body of your comment and with any disk or CD–ROM you submit. If EPA cannot read your comment due to technical difficulties and cannot contact you for clarification, EPA may not be able to consider your comment. Electronic files should avoid the use of special characters, any form of encryption, and be free of any defects or viruses. For additional information about EPA’s public docket visit the EPA Docket Center homepage at http:// www.epa.gov/epahome/dockets.htm. Docket: Documents in the docket are listed in the www.regulations.gov index. Although listed in the index, some information is not publicly available, e.g., CBI or other information whose disclosure is restricted by statute. Certain other materials, such as copyrighted material, are publicly available only in hard copy. Publicly available docket materials are available either electronically in www.regulations.gov or in hard copy at the OEI Docket in the EPA Headquarters Docket Center. Dated: October 4, 2006. Peter W. Preuss, Director, National Center for Environmental Assessment. [FR Doc. E6–16921 Filed 10–11–06; 8:45 am] BILLING CODE 6560–50–P PO 00000 Frm 00038 Fmt 4703 Sfmt 4703 ENVIRONMENTAL PROTECTION AGENCY [FRL–8230–3] Compliance Assistance Centers; Request for Suggestions on Candidates for Compliance Assistance Center Development Environmental Protection Agency. ACTION: Solicitation for suggestions. AGENCY: SUMMARY: In partnership with industry, academic institutions, environmental groups, and other agencies, the Environmental Protection Agency (EPA) supports fourteen Compliance Assistance Centers (Centers) to help small- and medium-size businesses and local governments better understand and comply with environmental regulations. These Centers provide easy to understand compliance information targeted to specific sectors, geographic and environmental topics: agriculture; automotive service and repair; automotive recycling, chemical manufacturers; construction; Federal facilities; health care; local governments, metal finishing; paints and coatings; printed wiring board manufacturers; printers; transportation; and the U.S. / Mexico / Canada border environmental issues. Additionally, funding has recently been awarded to initiate the development of a Center for the education sector. All Centers can be accessed at http:// www.assistancecneters.net. EPA would like to expand the Center program to support other sectors, geographical areas or topical issues. To support new Center development, EPA has funded the National Center for Manufacturing Sciences (NCMS) to develop, operate and maintain the Compliance Assistance Center Platform (Platform) from which new Centers will be ‘‘launched.’’ The Platform includes a suite of comprehensive Web-based tools necessary new Centers. States, industry, and compliance assistance providers can work with NCMS to establish Centers that will help the regulated community better understand and more efficiently comply with environmental requirements. The Centers for the metal finishing, printed wiring board manufacturing, paints and coatings, construction sector, automotive recycling sector, health care and U.S. / Mexico / Cananda border environmental issues have been developed in partnership with NCMS and the Platform. Visit http://www.envcap.org to access Platform resources. EPA is exploring new sector, geographical, or topical candidates for E:\FR\FM\12OCN1.SGM 12OCN1

Agencies

[Federal Register Volume 71, Number 197 (Thursday, October 12, 2006)]
[Notices]
[Pages 60143-60144]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: E6-16921]


-----------------------------------------------------------------------

ENVIRONMENTAL PROTECTION AGENCY

[FRL-8230-7; Docket ID No. EPA-HQ-ORD-2006-0756]


Evaluation of the Carcinogenicity of Ethylene Oxide

AGENCY: Environmental Protection Agency (EPA).

ACTION: Notice of Extension of Public Comment Period.

-----------------------------------------------------------------------

SUMMARY: EPA is announcing an extension of the public comment period 
for the draft document titled, ``Evaluation of the Carcinogenicity of 
Ethylene Oxide'' (EPA/635/R-06/003). The document was prepared by the 
National Center for Environmental Assessment within EPA's Office of 
Research and Development. On September 22, EPA published a Federal 
Register notice (71 FR 55470) announcing a 30-day comment period that 
ends October 23, 2007. EPA is extending the public comment period to 
December 8, 2006, in response to requests.
    As previously stated in 71 FR 55470, EPA is releasing this draft 
document solely for the purpose of seeking public comment and for 
review by the EPA Science Advisory Board (SAB) via a meeting to be held 
at a later date (time and place to be specified in a separate Federal 
Register notice). This document has not been formally disseminated by 
EPA. It does not determination. EPA will consider any public comments 
submitted in accordance with this notice when revising the document.

DATES: The public comment period began September 22, 2006, and ends 
December 8, 2006. Technical comments should be in writing and must be 
received by EPA by December 8, 2006.

ADDRESSES: The draft ``Evaluation of the Carcinogenicity of Ethylene 
Oxide'' is available primarily via the Internet on the National Center 
for Environmental Assessment's home page under the Recent Additions and 
the Data and Publications menus at http://www.epa.gov/ncea. A limited 
number of paper copies are available from the Technical Information 
Staff, NCEA-W; telephone: 202-564-3261; facsimile: 202-565-0050. If you 
are requesting a paper copy, please provide your name, your mailing 
address, and the document title, ``Evaluation of the Carcinogenicity of 
Ethylene Oxide''.
    Comments may be submitted electronically via www.regulations.gov, 
by mail, by facsimile, or by hand delivery/courier. Please follow the 
detailed instructions provided in the SUPPLEMENTARY INFORMATION section 
of this notice.

FOR FURTHER INFORMATION CONTACT: For information on the public comment 
period, contact the Office of Environmental Information Docket; 
telephone: 202-566-1752; facsimile: 202-566-1753; or e-mail: 
ORD.Docket@epa.gov.
    For technical information, contact Henry D. Kahn, D.Sc., NCEA; 
telephone: 202-564-3269; facsimile: 202-565-0079; or e-mail: 
kahn.henry@epa.gov.

SUPPLEMENTARY INFORMATION:

I. Information About the Project/Document

    Ethylene oxide (EtO) is a gas at room temperature. It is 
manufactured from ethylene and used primarily as a chemical 
intermediate in the manufacture of ethylene glycol. It is also used as 
a sterilizing agent for medical equipment and as a fumigating agent for 
spices. The largest sources of human exposure are in occupations 
involving contact with the gas in production facilities and in 
hospitals that sterilize medical equipment. EtO can also be inhaled by 
residents living near production or sterilizing/fumigating facilities.
    This draft assessment document characterizes the potential for a 
carcinogenic health hazard from human inhalation exposure to EtO. This 
is accomplished by a weight-of-evidence evaluation as to how likely EtO 
is to be a human carcinogen, as well as an evaluation of related dose-
response information which leads to the development of lifetime cancer 
risk estimates per unit of exposure. This assessment, when finalized, 
will be posted to EPA's Integrated Risk Information System (IRIS) 
database. The document was prepared by EPA's National Center for 
Environmental Assessment (NCEA). EPA last published a health assessment 
of the potential carcinogenicity of EtO in 1985.
    The current assessment reviews the more recently developed database 
on the carcinogenicity of EtO, pertinent data from the 1985 assessment, 
and several reviews and assessments issued

[[Page 60144]]

by other organizations (IARC, 1994; Health Canada, 2001; CalEPA, 1999; 
EOIC, 2001).

II. How to Submit Technical Comments to the Docket at 
www.regulations.gov

    Note: The EPA Docket Center suffered damage due to flooding 
during the last week of June 2006. The Docket Center is continuing 
to operate. However, during the cleanup, there will be temporary 
changes to Docket Center telephone numbers, addresses, and hours of 
operation for people who wish to make hand deliveries or visit the 
Public Reading Room to view documents. Consult EPA's Federal 
Register notice at 71 FR 38147 (July 5, 2006) or the EPA Web site at 
http://www.epa.gov/epahome/dockets.htm for current information on 
docket operations, locations and telephone numbers. The Docket 
Center's mailing address for U.S. mail and the procedure for 
submitting comments to www.regulations.gov are not affected by the 
flooding and will remain the same.

    Submit your comments, identified by Docket ID No. EPA-HQ-ORD 2006-
0756 by one of the following methods:
     www.regulations.gov: Follow the on-line instructions for 
submitting comments.
     E-mail: ORD.Docket@epa.gov.
     Fax: 202-566-1753
     Mail: Office of Environmental Information (OEI) Docket 
(Mail Code: 2822T), U.S. Environmental Protection Agency, 1200 
Pennsylvania Ave., NW., Washington, DC 20460. The phone number is 202-
566-1752.
     Hand Delivery: The OEI Docket is located in the EPA 
Headquarters Docket Center, EPA West Building, 1301 Constitution Ave., 
NW., Washington, DC. The EPA Docket Center Public Reading Room is open 
from 8:30 a.m. to 4:30 p.m., Monday through Friday, excluding legal 
holidays. The telephone number for the Public Reading Room is 202-566-
1744. Such deliveries are only accepted during the docket's normal 
hours of operation, and special arrangements should be made for 
deliveries of boxed information.
    If you submit comments by mail or hand delivery, please submit one 
unbound original with pages numbered consecutively, and three copies of 
the comments. For attachments, provide an index, number pages 
consecutively with the comments, and submit an unbound original and 
three copies.
    Instructions: Direct your comments to Docket ID No. EPA-HQ-ORD-
2006-0756. Please ensure that your comments are submitted within the 
specified comment period. Comments received after the closing date will 
be marked ``late,'' and may only be considered if time permits. It is 
EPA's policy to include all comments it receives in the public docket 
without change and to make the comments available online at 
www.regulations.gov, including any personal information provided, 
unless a comment includes information claimed to be Confidential 
Business Information (CBI) or other information whose disclosure is 
restricted by statute. Do not submit information that you consider to 
be CBI or otherwise protected through www.regulations.gov or e-mail. 
The www.regulations.gov Web site is an ``anonymous access'' system, 
which means EPA will not know your identity or contact information 
unless you provide it in the body of your comment. If you send an e-
mail comment directly to EPA without going through www.regulations.gov, 
your e-mail address will be automatically captured and included as part 
of the comment that is placed in the public docket and made available 
on the Internet. If you submit an electronic comment, EPA recommends 
that you include your name and other contact information in the body of 
your comment and with any disk or CD-ROM you submit. If EPA cannot read 
your comment due to technical difficulties and cannot contact you for 
clarification, EPA may not be able to consider your comment. Electronic 
files should avoid the use of special characters, any form of 
encryption, and be free of any defects or viruses. For additional 
information about EPA's public docket visit the EPA Docket Center 
homepage at http://www.epa.gov/epahome/dockets.htm.
    Docket: Documents in the docket are listed in the 
www.regulations.gov index. Although listed in the index, some 
information is not publicly available, e.g., CBI or other information 
whose disclosure is restricted by statute. Certain other materials, 
such as copyrighted material, are publicly available only in hard copy. 
Publicly available docket materials are available either electronically 
in www.regulations.gov or in hard copy at the OEI Docket in the EPA 
Headquarters Docket Center.

    Dated: October 4, 2006.
Peter W. Preuss,
Director, National Center for Environmental Assessment.
[FR Doc. E6-16921 Filed 10-11-06; 8:45 am]
BILLING CODE 6560-50-P