Draft Toxicological Review of Dichlorobenzenes: In Support of Summary Information on the Integrated Risk Information System (IRIS), 46220-46222 [E6-13205]

Download as PDF 46220 Federal Register / Vol. 71, No. 155 / Friday, August 11, 2006 / Notices Swordfish, and Shark and the Atlantic Billfish Fishery Management Plan, Implementation, Atlantic Coast, Caribbean and Gulf of Mexico. Summary: EPA does not object to the proposed action. Dated: August 8, 2006. Robert W. Hargrove, Director, NEPA Compliance Division, Office of Federal Activities. [FR Doc. E6–13160 Filed 8–10–06; 8:45 am] BILLING CODE 6560–50–P ENVIRONMENTAL PROTECTION AGENCY [ER–FRL–6678–1] hsrobinson on PROD1PC67 with NOTICES1 Environmental Impact Statements; Notice of Availability Responsible Agency: Office of Federal Activities, General Information (202) 564–7167 or https://www.epa.gov/ compliance/nepa/. Weekly receipt of Environmental Impact Statements Filed 07/31/2006 Through 08/04/2006 Pursuant to 40 CFR 1506.9. EIS No. 20060326, Final EIS, BOP, NH, Berlin, Coos County, Proposed Federal Correctional Institution, Construction and Operation, City of Berlin, Coos County, NH, Wait Period Ends: 09/11/2006, Contact: Pamela J. Chandler 202–514–6470. EIS No. 20060327, Final Supplement, AFS, CA, Empire Vegetation Management Project, Additional Information to Clarify Previous Analysis, Vegetation, Fire/Fuels/Air Quality, Wildlife, Watershed, and Botanical Resource/Noxious Weeds, Mount Hough Ranger District, Plumas National Forest, Plumas County, CA, Wait Period Ends: 09/11/2006, Contact: Gary Rotta 530–283–0555. EIS No. 20060328, Draft EIS, NRS, MA, Cape Cod Water Resources Restoration Project, Restore Degraded Salt Marshes, Restore Anadromous Fish Passages, and Improve Water Quality for Shellfishing Area, Cape Cod, Barnstable County, MA, Comment Period Ends: 09/25/2006, Contact: Carl Gustafson 413–253– 4302. EIS No. 20060329, Final EIS, NRS, MO, East Locust Creek Watershed Revised Plan, Installation of Multiple-Purpose Reservoir, Flood Prevention and Watershed Protection, Sullivan and Putnam Counties, MO, Wait Period Ends: 09/11/2006, Contact: Roger A. Hansen 573–876–0901. EIS No. 20060330, Draft EIS, NOA, CA, Channel Islands National Marine Sanctuary (CINES) Project, VerDate Aug<31>2005 15:03 Aug 10, 2006 Jkt 208001 Establishment of No-Take and Limited-Take Marine Zones, Protection of Sanctuary Biodiversity, CA, Comment Period Ends: 10/10/ 2006, Contact: Chris Mobley 805– 966–7107. EIS No. 20060331, Final EIS, FRC, WA, Rocky Reach Hydroelectric Project, (FERC/DEIS–0184D), Application for a New License for the Existing 865.76 Megawatt Facility, Public Utility District No. 1 (PUD), Columbia River, Chelan County, WA, Wait Period Ends: 09/11/2006, Contact: Todd Sedmak 1–866–208–FERC. EIS No. 20060332, Final Supplement, NOA, 00, Amendment 26 to the Gulf of Mexico Reef Fish Fishery Management Plan, Proposed Individual Fishing Quota (IFQ) Program to Reduce Overcapacity in the Commercial Red Snapper Fishery, Wait Period Ends: 09/11/2006, Contact: Roy E. Crabtree 727–824– 5308. EIS No. 20060333, Draft EIS, USA, MD, U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID), Construction and Operation of New USAMRIID Facilities and Decommissioning and Demolition and/or Re-use of Existing USAMRIID Facilities, Fort Detrick, MD, Comment Period Ends: 09/25/2006, Contact: Dave Hand 410–962–8154. EIS No. 20060334, Final Supplement, UAF, 00, Realistic Bomber Training Initiative, Addresses Impacts of Wake Vortices on Surface Structures, Dyess Air Force Base, TX and Barksdale Air Force Base, LA, Wait Period Ends: 09/ 11/2006, Contact: Sheryl Parker 757– 764–9334. Amended Notices EIS No. 20060318, Draft EIS, FHW, NC, Greenville Southwest Bypass Study, Transportation Improvements to NC 11 and U.S. 264 Business, U.S. Army COE Section 404 Permit, Pitt County, NC, Comment Period Ends: 09/18/ 2006, Contact: John F. Sullivan, III 919–856–4346. Revision of FR Notice Published in 08/04/2006: Correction to State from NY to NC. Dated: August 8, 2006. Robert W. Hargrove, Director, NEPA Compliance Division, Office of Federal Activities. [FR Doc. E6–13207 Filed 8–10–06; 8:45 am] BILLING CODE 6560–50–P PO 00000 Frm 00037 Fmt 4703 Sfmt 4703 ENVIRONMENTAL PROTECTION AGENCY [FRL–8208–6; Docket ID No. EPA–HQ–ORD– 2004–0002] Draft Toxicological Review of Dichlorobenzenes: In Support of Summary Information on the Integrated Risk Information System (IRIS) Environmental Protection Agency (EPA). ACTION: Notice of Extension of Public Comment Period and Rescheduled External Peer Review Panel Meeting. AGENCY: SUMMARY: The EPA is extending the public comment period and rescheduling an external peer review panel meeting to review selected sections of the final draft document titled, ‘‘Toxicological Review of Dichlorobenzenes: In Support of Summary Information on the Integrated Risk Information System (IRIS)’’ (EPA/ 635/R–03/015), related to the inhalation reference concentration (RfC) and inhalation cancer assessment for 1,4dichlorobenzene. The document was prepared by the National Center for Environmental Assessment (NCEA) within EPA’s Office of Research and Development. On July 11, 2006, EPA published a Federal Register notice (71 FR 39113) announcing a comment period that ended August 9 and an external peer review panel meeting that was scheduled for August 16. EPA is extending the public comment period to October 10, 2006, in response to requests. The external peer review panel meeting will be held on October 30, 2006. As previously stated in 71 FR 39113, EPA is releasing this draft document solely for the purpose of predissemination peer review under applicable information quality guidelines. This document has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency policy or determination. EPA will consider any public comments submitted in accordance with this notice when revising the document. DATES: The period for submission of comments on the final draft document will end on October 10, 2006. Technical comments should be in writing and must be received by EPA by October 10, 2006. Comments submitted to the EPA by October 10, 2006, will be provided to the external peer review panel prior to the teleconference meeting. The peer review panel meeting will be conducted on October 30, 2006, by teleconference E:\FR\FM\11AUN1.SGM 11AUN1 hsrobinson on PROD1PC67 with NOTICES1 Federal Register / Vol. 71, No. 155 / Friday, August 11, 2006 / Notices and will begin at 1 p.m. and end at 4 p.m. Members of the public may call into the teleconference meeting and are invited to provide oral statements at the commencement of the teleconference. (For more information refer to the instructions for registration provided in the ADDRESSES section of this notice.) ADDRESSES: The external peer review panel meeting will be held by teleconference. Under an Interagency Agreement between EPA and the Department of Energy, the Oak Ridge Institute of Science and Education (ORISE) is organizing, convening, and conducting the peer review panel meeting. To obtain the teleconference call-in number and access code, register by October 10, 2006, by calling ORISE, P.O. Box 117, MS 17, Oak Ridge, TN 37831–0117, at (865) 576–2922 or (865) 241–3168 (facsimile). Interested parties may also register on-line at: https:// www.orau.gov/dichlorobenzene. The draft ‘‘Toxicological Review of Dichlorobenzenes: In Support of Summary Information on the Integrated Risk Information System (IRIS)’’ (EPA/ 635/R–03/015) is available primarily via the Internet on NCEA’s home page under the Recent Additions menu at https://www.epa.gov/ncea. A limited number of paper copies are available by contacting the IRIS Hotline at (202) 566– 1676, (202) 566–1749 (facsimile), or hotline.iris@epa.gov. If you are requesting a paper copy, please provide your name, mailing address, the document title, and the EPA number of the requested publication. Copies are not available from ORISE. Copies of the study by Aiso et al. (2005), referenced in the SUPPLEMENTARY INFORMATION section of this notice are available from the IRIS Hotline in paper or electronic format. If you are requesting a copy, please provide your name, mailing address or e-mail address, and document citation: Aiso et al. (2005) Carcinogenicity and chronic toxicity in mice and rats exposed by inhalation to para-dichlorobenzene for two years. J Vet Med Sci 67(10):1019– 1029. EPA is providing this study in the interest of transparency. EPA does not endorse or support the study or its findings. Technical comments may be submitted electronically via https:// www.regulations.gov, by mail, by facsimile, or by hand delivery/courier. Please follow the detailed instructions provided in the SUPPLEMENTARY INFORMATION section of this notice. FOR FURTHER INFORMATION CONTACT: Questions regarding registration and logistics for the external peer review panel teleconference should be directed VerDate Aug<31>2005 15:03 Aug 10, 2006 Jkt 208001 to Margaret Lyday, ORISE, P.O. Box 117, MS 17, Oak Ridge, TN 37831–0117, at (865) 576–2922 or (865) 241–3168 (facsimile), lydaym@orau.gov (e-mail). If you have questions about the document, contact Audrey Galizia, Chemical Manager, National Center for Environmental Assessment telephone: (732) 906–6887 facsimile: (732) 452– 6429 e-mail: galizia.audrey@epa.gov. SUPPLEMENTARY INFORMATION: I. Information About the Document IRIS is a database that contains Agency scientific positions on potential adverse human health effects that may result from chronic (or lifetime) exposure to specific chemical substances found in the environment. The database (available on the Internet at https://www.epa.gov/iris) contains qualitative and quantitative health effects information for more than 500 chemical substances that may be used to support the first two steps (hazard identification and dose-response evaluation) of the risk assessment process. When supported by available data, the database provides oral reference doses (RfDs) and inhalation reference concentrations (RfCs) for chronic health effects, and oral slope factors and inhalation unit risks for carcinogenic effects. Combined with specific exposure information, government and private entities use IRIS to help characterize public health risks of chemical substances in a site-specific situation and thereby support risk management decisions designed to protect public health. 1,4-Dichlorobenzene is widely used as a space deodorant for toilets and refuse containers, as a moth repellent in moth balls or crystals, and in other pesticide applications. The current IRIS assessment for 1,4-dichlorobenzene was placed on the database in 1994 and contains an inhalation RfC. A reassessment of the potential health effects of dichlorobenzenes has been undertaken. The draft assessment for dichlorobenzenes (including the 1,2-, 1,3-, and 1,4-isomers) was subject to an external peer review and 30-day public comment period in February 2004 (69 FR 4514, January 30, 2004). The scope of the current external peer review and public comment is limited to the analyses based on a chronic inhalation bioassay of 1,4-dichlorobenzene published in the peer-reviewed literature (Aiso et al., 2005. J Vet Med Sci 67(10):1019–29) that was not included in the February 2004 external peer review draft. This study was identified originally as an unpublished study report by the Japan Bioassay Research Center (JBRC, 1995). Data from PO 00000 Frm 00038 Fmt 4703 Sfmt 4703 46221 Aiso et al. (2005) were used subsequently in the quantitative doseresponse assessments for the 1,4dichlorobenzene RfC and inhalation cancer assessment. II. How To Submit Technical Comments to the Docket at www.regulations.gov Note: The EPA Docket Center suffered damage due to flooding during the last week of June 2006. The Docket Center is continuing to operate. However, during the cleanup, there will be temporary changes to Docket Center telephone numbers, addresses, and hours of operation for people who wish to make hand deliveries or visit the Public Reading Room to view documents. Consult EPA’s Federal Register notice at 71 FR 38147 (July 5, 2006) or the EPA Web site at https://www.epa.gov/epahome/dockets.htm for current information on docket operations, locations and telephone numbers. The Docket Center’s mailing address for U.S. mail and the procedure for submitting comments to https://www.regulations.gov are not affected by the flooding and will remain the same. Submit your comments, identified by Docket ID No. EPA-HQ-ORD 2004–0002 by one of the following methods: • https://www.regulations.gov: Follow the online instructions for submitting comments. • E-mail: ORD.Docket@epa.gov. • Mail: Office of Environmental Information (OEI) Docket (Mail Code: 2822T), U.S. Environmental Protection Agency, 1200 Pennsylvania Ave., NW., Washington, DC 20460. The phone number is (202) 566–1752. • Hand Delivery: The OEI Docket is located in the EPA Headquarters Docket Center, EPA West Building, 1301 Constitution Ave., NW., Washington, DC. The EPA Docket Center Public Reading Room is open from 8:30 a.m. to 4:30 p.m., Monday through Friday, excluding legal holidays. The telephone number for the Public Reading Room is (202) 566–1744. Such deliveries are only accepted during the docket’s normal hours of operation, and special arrangements should be made for deliveries of boxed information. If you provide comments in writing, please submit one unbound original with pages numbered consecutively, and three copies of the comments. For attachments, provide an index, number pages consecutively with the comments, and submit an unbound original and three copies. Instructions: Direct your comments to Docket ID No. EPA–HQ–ORD–2004– 0002. EPA’s policy is that all comments received will be included in the public docket without change and may be made available online at https:// www.regulations.gov, including any personal information provided, unless the comment includes information E:\FR\FM\11AUN1.SGM 11AUN1 46222 Federal Register / Vol. 71, No. 155 / Friday, August 11, 2006 / Notices claimed to be Confidential Business Information (CBI) or other information whose disclosure is restricted by statute. Do not submit information that you consider to be CBI or otherwise protected through https:// www.regulations.gov or e-mail. The https://www.regulations.gov Web site is an ‘‘anonymous access’’ system, which means EPA will not know your identity or contact information unless you provide it in the body of your comment. If you send an e-mail comment directly to EPA without going through https:// www.regulations.gov, your e-mail address will be automatically captured and included as part of the comment that is placed in the public docket and made available on the Internet. If you submit an electronic comment, EPA recommends that you include your name and other contact information in the body of your comment and with any disk or CD–ROM you submit. If EPA cannot read your comment due to technical difficulties and cannot contact you for clarification, EPA may not be able to consider your comment. Electronic files should avoid the use of special characters, any form of encryption, and be free of any defects or viruses. For additional information about EPA’s public docket visit the EPA Docket Center homepage at https:// www.epa.gov/epahome/dockets.htm. Docket: All documents in the docket are listed in the https:// www.regulations.gov index. Although listed in the index, some information is not publicly available, e.g., CBI or other information whose disclosure is restricted by statute. Certain other material, such as copyrighted material, will be publicly available only in hard copy. Publicly available docket materials are available either electronically in https:// www.regulations.gov or in hard copy at the OEI Docket in the EPA Headquarters Docket Center. Dated: August 4, 2006. P.W. Preuss, Director, National Center for Environmental Assessment. [FR Doc. E6–13205 Filed 8–10–06; 8:45 am] BILLING CODE 6560–50–P ENVIRONMENTAL PROTECTION AGENCY hsrobinson on PROD1PC67 with NOTICES1 [FRL–8209–3] Meeting of the Mobile Sources Technical Review Subcommittee Environmental Protection Agency (EPA). ACTION: Notice of meeting. AGENCY: VerDate Aug<31>2005 15:03 Aug 10, 2006 Jkt 208001 SUMMARY: Pursuant to the Federal Advisory Committee Act, Public Law 92–463, notice is hereby given that the Mobile Sources Technical Review Subcommittee (MSTRS) will meet on October 4, 2006. This is an open meeting. The meeting will include discussion of current topics and presentations about activities being conducted by EPA’s Office of Transportation and Air Quality. The preliminary agenda for the meeting, as well as the minutes from the previous (March 2006) meeting will be posted on the Subcommittee’s Web site: https:// www.epa.gov/air/caaac/ mobile_sources.html. MSTRS listserver subscribers will receive notification when the agenda is available on the Subcommittee Web site. To subscribe to the MSTRS listserver, go to https:// lists.epa.gov/cgi-bin/ lyris.pl?enter=mstrs. The site contains instructions and prompts for subscribing to the listserver service. DATES: Wednesday, October 4, 2006 from 9 a.m. to 5 p.m. Registration begins at 8:30 a.m. ADDRESSES: The meeting will be held at the Holiday Inn Rosslyn/Key Bridge, 1900 North Fort Myer Drive, Arlington, VA. Phone 703–807–2000. The hotel is located one block from the Rosslyn Metro Station, and is approximately 15 minutes from Washington National Airport by taxi. FOR FURTHER INFORMATION CONTACT: For technical information: John Guy, Designated Federal Officer, Transportation and Regional Programs Division, Mailcode 6406J, U.S. EPA, 1200 Pennsylvania Ave. NW., Washington, DC 20460; Ph: 202–343– 9276; e-mail, guy.john@epa.gov. For logistical and administrative information: Ms. Patty Truesdale, U.S. EPA, Transportation and Regional Programs Division, Mailcode 6406J, U.S. EPA, 1200 Pennsylvania Ave., NW., Washington, DC 20460; 202–343–9401. Background on the work of the Subcommittee is available at: https:// www.epa.gov/air/caaac/ mobile_sources.html. Individuals or organizations wishing to provide comments to the Subcommittee should submit them to Mr. Guy at the address above by September 26, 2006. The Subcommittee expects that public statements presented at its meetings will not be repetitive of previously submitted oral or written statements. During the meeting, the Subcommittee may also hear progress reports from some of its workgroups as well as updates and SUPPLEMENTARY INFORMATION: PO 00000 Frm 00039 Fmt 4703 Sfmt 4703 announcements on activities of general interest to attendees. Dated: August 7, 2006. Christopher Grundler, Acting Director, Office of Transportation and Air Quality. [FR Doc. E6–13156 Filed 8–10–06; 8:45 am] BILLING CODE 6560–50–P ENVIRONMENTAL PROTECTION AGENCY [FRL–8209–1] EPA Science Advisory Board; Notification of Public Meetings of the Integrated Human Exposure and Environmental Health Committees Environmental Protection Agency (EPA). ACTION: Notice. AGENCY: SUMMARY: The Environmental Protection Agency (EPA) Science Advisory Board (SAB) Staff Office announces two public meetings of the Integrated Human Exposure Committee (IHEC) and Environmental Health Committee (EHC) to conduct a consultation on the efforts of the EPA to improve its risk assessment practices and to update its Exposure Guidelines. DATES: September 6–7, 2006; the meeting regarding the EPA Risk Assessment Principles and Practices will be held from 9 a.m. to 5 p.m. (Eastern Time) on Wednesday, September 6, 2006, and the Guidelines for Exposure Assessment will be held from 9 am to 4 pm (Eastern Time) on Thursday September 7, 2006. Location: The meetings will take place at the Science Advisory Board Conference Center, 1025 F St., NW., Washington DC 20004. FOR FURTHER INFORMATION CONTACT: Any member of the public wishing to obtain general information concerning this meeting should contact Dr. Sue Shallal, Designated Federal Officer (DFO), EPA Science Advisory Board (1400F), U.S. Environmental Protection Agency, 1200 Pennsylvania Avenue, NW., Washington, DC 20460; via telephone/ voice mail: (202) 343–9977; fax: (202) 233–0643; or e-mail at: shallal.suhair@epa.gov. General information concerning the EPA Science Advisory Board can be found on the EPA Web Site at: https://www.epa.gov/ sab. Technical Contact: Any questions concerning the Risk Assessment Principles and Practices Staff Paper should be directed to Dr. William Sette, OSA, at phone: (202) 564–0693, or email: sette.william@epa.gov. Any E:\FR\FM\11AUN1.SGM 11AUN1

Agencies

[Federal Register Volume 71, Number 155 (Friday, August 11, 2006)]
[Notices]
[Pages 46220-46222]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: E6-13205]


-----------------------------------------------------------------------

ENVIRONMENTAL PROTECTION AGENCY

[FRL-8208-6; Docket ID No. EPA-HQ-ORD-2004-0002]


Draft Toxicological Review of Dichlorobenzenes: In Support of 
Summary Information on the Integrated Risk Information System (IRIS)

AGENCY: Environmental Protection Agency (EPA).

ACTION: Notice of Extension of Public Comment Period and Rescheduled 
External Peer Review Panel Meeting.

-----------------------------------------------------------------------

SUMMARY: The EPA is extending the public comment period and 
rescheduling an external peer review panel meeting to review selected 
sections of the final draft document titled, ``Toxicological Review of 
Dichlorobenzenes: In Support of Summary Information on the Integrated 
Risk Information System (IRIS)'' (EPA/635/R-03/015), related to the 
inhalation reference concentration (RfC) and inhalation cancer 
assessment for 1,4-dichlorobenzene. The document was prepared by the 
National Center for Environmental Assessment (NCEA) within EPA's Office 
of Research and Development.
    On July 11, 2006, EPA published a Federal Register notice (71 FR 
39113) announcing a comment period that ended August 9 and an external 
peer review panel meeting that was scheduled for August 16. EPA is 
extending the public comment period to October 10, 2006, in response to 
requests. The external peer review panel meeting will be held on 
October 30, 2006.
    As previously stated in 71 FR 39113, EPA is releasing this draft 
document solely for the purpose of pre-dissemination peer review under 
applicable information quality guidelines. This document has not been 
formally disseminated by EPA. It does not represent and should not be 
construed to represent any Agency policy or determination. EPA will 
consider any public comments submitted in accordance with this notice 
when revising the document.

DATES: The period for submission of comments on the final draft 
document will end on October 10, 2006. Technical comments should be in 
writing and must be received by EPA by October 10, 2006. Comments 
submitted to the EPA by October 10, 2006, will be provided to the 
external peer review panel prior to the teleconference meeting. The 
peer review panel meeting will be conducted on October 30, 2006, by 
teleconference

[[Page 46221]]

and will begin at 1 p.m. and end at 4 p.m. Members of the public may 
call into the teleconference meeting and are invited to provide oral 
statements at the commencement of the teleconference. (For more 
information refer to the instructions for registration provided in the 
ADDRESSES section of this notice.)

ADDRESSES: The external peer review panel meeting will be held by 
teleconference. Under an Interagency Agreement between EPA and the 
Department of Energy, the Oak Ridge Institute of Science and Education 
(ORISE) is organizing, convening, and conducting the peer review panel 
meeting. To obtain the teleconference call-in number and access code, 
register by October 10, 2006, by calling ORISE, P.O. Box 117, MS 17, 
Oak Ridge, TN 37831-0117, at (865) 576-2922 or (865) 241-3168 
(facsimile). Interested parties may also register on-line at: https://
www.orau.gov/dichlorobenzene.
    The draft ``Toxicological Review of Dichlorobenzenes: In Support of 
Summary Information on the Integrated Risk Information System (IRIS)'' 
(EPA/635/R-03/015) is available primarily via the Internet on NCEA's 
home page under the Recent Additions menu at https://www.epa.gov/ncea. A 
limited number of paper copies are available by contacting the IRIS 
Hotline at (202) 566-1676, (202) 566-1749 (facsimile), or 
hotline.iris@epa.gov. If you are requesting a paper copy, please 
provide your name, mailing address, the document title, and the EPA 
number of the requested publication. Copies are not available from 
ORISE.
    Copies of the study by Aiso et al. (2005), referenced in the 
SUPPLEMENTARY INFORMATION section of this notice are available from the 
IRIS Hotline in paper or electronic format. If you are requesting a 
copy, please provide your name, mailing address or e-mail address, and 
document citation: Aiso et al. (2005) Carcinogenicity and chronic 
toxicity in mice and rats exposed by inhalation to para-dichlorobenzene 
for two years. J Vet Med Sci 67(10):1019-1029. EPA is providing this 
study in the interest of transparency. EPA does not endorse or support 
the study or its findings.
    Technical comments may be submitted electronically via https://
www.regulations.gov, by mail, by facsimile, or by hand delivery/
courier. Please follow the detailed instructions provided in the 
SUPPLEMENTARY INFORMATION section of this notice.

FOR FURTHER INFORMATION CONTACT: Questions regarding registration and 
logistics for the external peer review panel teleconference should be 
directed to Margaret Lyday, ORISE, P.O. Box 117, MS 17, Oak Ridge, TN 
37831-0117, at (865) 576-2922 or (865) 241-3168 (facsimile), 
lydaym@orau.gov (e-mail).
    If you have questions about the document, contact Audrey Galizia, 
Chemical Manager, National Center for Environmental Assessment 
telephone: (732) 906-6887 facsimile: (732) 452-6429 e-mail: 
galizia.audrey@epa.gov.

SUPPLEMENTARY INFORMATION:

I. Information About the Document

    IRIS is a database that contains Agency scientific positions on 
potential adverse human health effects that may result from chronic (or 
lifetime) exposure to specific chemical substances found in the 
environment. The database (available on the Internet at https://
www.epa.gov/iris) contains qualitative and quantitative health effects 
information for more than 500 chemical substances that may be used to 
support the first two steps (hazard identification and dose-response 
evaluation) of the risk assessment process. When supported by available 
data, the database provides oral reference doses (RfDs) and inhalation 
reference concentrations (RfCs) for chronic health effects, and oral 
slope factors and inhalation unit risks for carcinogenic effects. 
Combined with specific exposure information, government and private 
entities use IRIS to help characterize public health risks of chemical 
substances in a site-specific situation and thereby support risk 
management decisions designed to protect public health.
    1,4-Dichlorobenzene is widely used as a space deodorant for toilets 
and refuse containers, as a moth repellent in moth balls or crystals, 
and in other pesticide applications. The current IRIS assessment for 
1,4-dichlorobenzene was placed on the database in 1994 and contains an 
inhalation RfC. A reassessment of the potential health effects of 
dichlorobenzenes has been undertaken. The draft assessment for 
dichlorobenzenes (including the 1,2-, 1,3-, and 1,4-isomers) was 
subject to an external peer review and 30-day public comment period in 
February 2004 (69 FR 4514, January 30, 2004). The scope of the current 
external peer review and public comment is limited to the analyses 
based on a chronic inhalation bioassay of 1,4-dichlorobenzene published 
in the peer-reviewed literature (Aiso et al., 2005. J Vet Med Sci 
67(10):1019-29) that was not included in the February 2004 external 
peer review draft. This study was identified originally as an 
unpublished study report by the Japan Bioassay Research Center (JBRC, 
1995). Data from Aiso et al. (2005) were used subsequently in the 
quantitative dose-response assessments for the 1,4-dichlorobenzene RfC 
and inhalation cancer assessment.

II. How To Submit Technical Comments to the Docket at 
www.regulations.gov

    Note: The EPA Docket Center suffered damage due to flooding 
during the last week of June 2006. The Docket Center is continuing 
to operate. However, during the cleanup, there will be temporary 
changes to Docket Center telephone numbers, addresses, and hours of 
operation for people who wish to make hand deliveries or visit the 
Public Reading Room to view documents. Consult EPA's Federal 
Register notice at 71 FR 38147 (July 5, 2006) or the EPA Web site at 
https://www.epa.gov/epahome/dockets.htm for current information on 
docket operations, locations and telephone numbers. The Docket 
Center's mailing address for U.S. mail and the procedure for 
submitting comments to https://www.regulations.gov are not affected 
by the flooding and will remain the same.

    Submit your comments, identified by Docket ID No. EPA-HQ-ORD 2004-
0002 by one of the following methods:
     https://www.regulations.gov: Follow the online instructions 
for submitting comments.
     E-mail: ORD.Docket@epa.gov.
     Mail: Office of Environmental Information (OEI) Docket 
(Mail Code: 2822T), U.S. Environmental Protection Agency, 1200 
Pennsylvania Ave., NW., Washington, DC 20460. The phone number is (202) 
566-1752.
     Hand Delivery: The OEI Docket is located in the EPA 
Headquarters Docket Center, EPA West Building, 1301 Constitution Ave., 
NW., Washington, DC. The EPA Docket Center Public Reading Room is open 
from 8:30 a.m. to 4:30 p.m., Monday through Friday, excluding legal 
holidays. The telephone number for the Public Reading Room is (202) 
566-1744. Such deliveries are only accepted during the docket's normal 
hours of operation, and special arrangements should be made for 
deliveries of boxed information.
    If you provide comments in writing, please submit one unbound 
original with pages numbered consecutively, and three copies of the 
comments. For attachments, provide an index, number pages consecutively 
with the comments, and submit an unbound original and three copies.
    Instructions: Direct your comments to Docket ID No. EPA-HQ-ORD-
2004-0002. EPA's policy is that all comments received will be included 
in the public docket without change and may be made available online at 
https://www.regulations.gov, including any personal information 
provided, unless the comment includes information

[[Page 46222]]

claimed to be Confidential Business Information (CBI) or other 
information whose disclosure is restricted by statute. Do not submit 
information that you consider to be CBI or otherwise protected through 
https://www.regulations.gov or e-mail. The https://www.regulations.gov 
Web site is an ``anonymous access'' system, which means EPA will not 
know your identity or contact information unless you provide it in the 
body of your comment. If you send an e-mail comment directly to EPA 
without going through https://www.regulations.gov, your e-mail address 
will be automatically captured and included as part of the comment that 
is placed in the public docket and made available on the Internet. If 
you submit an electronic comment, EPA recommends that you include your 
name and other contact information in the body of your comment and with 
any disk or CD-ROM you submit. If EPA cannot read your comment due to 
technical difficulties and cannot contact you for clarification, EPA 
may not be able to consider your comment. Electronic files should avoid 
the use of special characters, any form of encryption, and be free of 
any defects or viruses. For additional information about EPA's public 
docket visit the EPA Docket Center homepage at https://www.epa.gov/
epahome/dockets.htm.
    Docket: All documents in the docket are listed in the https://
www.regulations.gov index. Although listed in the index, some 
information is not publicly available, e.g., CBI or other information 
whose disclosure is restricted by statute. Certain other material, such 
as copyrighted material, will be publicly available only in hard copy. 
Publicly available docket materials are available either electronically 
in https://www.regulations.gov or in hard copy at the OEI Docket in the 
EPA Headquarters Docket Center.

    Dated: August 4, 2006.
P.W. Preuss,
Director, National Center for Environmental Assessment.
[FR Doc. E6-13205 Filed 8-10-06; 8:45 am]
BILLING CODE 6560-50-P
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