Government-Owned Inventions; Availability for Licensing, 42859-42860 [E6-12132]

Download as PDF rwilkins on PROD1PC63 with NOTICES Federal Register / Vol. 71, No. 145 / Friday, July 28, 2006 / Notices allotments. This notice merely announces the results of our application of this formula, and therefore does not reach the economic significance threshold of $100 million in any one year. The RFA requires agencies to analyze options for regulatory relief of small businesses. For purposes of the RFA, small entities include small businesses, nonprofit organizations, and government jurisdictions. Most hospitals and most other providers and suppliers are small entities, either by nonprofit status or by having revenues of $6 million to $29 million in any one year. Individuals and States are not included in the definition of a small entity; therefore, this requirement does not apply. In addition, section 1102(b) of the Act requires us to prepare a regulatory impact analysis if a rule may have a significant impact on the operations of a substantial number of small rural hospitals. This analysis must conform to the provisions of section 604 of the RFA. For purposes of section 1102(b) of the Act, we define a small rural hospital as a hospital that is located outside of a Metropolitan Statistical Area and has fewer than 100 beds. The Unfunded Mandates Reform Act of 1995 requires that agencies prepare an assessment of anticipated costs and benefits before publishing any notice that may result in an annual expenditure by State, local, and tribal governments, in the aggregate, or by the private sector, of $120 million or more (adjusted each year for inflation) in any one year. Since participation in the SCHIP program on the part of States is voluntary, any payments and expenditures States make or incur on behalf of the program that are not reimbursed by the Federal government are made voluntarily. This notice will not create an unfunded mandate on States, tribal, or local governments because it merely notifies states of their SCHIP allotment for FY 2006. Therefore, we are not required to perform an assessment of the costs and benefits of this notice. Low-income children will benefit from payments under SCHIP through increased opportunities for health insurance coverage. We believe this notice will have an overall positive impact by informing States, the District of Columbia, and U.S. Territories and Commonwealths of the extent to which they are permitted to expend funds under their child health plans using their FY 2007 allotments. Under Executive Order 13132, we are required to adhere to certain criteria regarding Federalism. We have VerDate Aug<31>2005 17:47 Jul 27, 2006 Jkt 208001 reviewed this notice and determined that it does not significantly affect States’ rights, roles, and responsibilities because it does not set forth any new policies. For these reasons, we are not preparing analyses for either the RFA or section 1102(b) of the Act because we have determined, and we certify, that this notice will not have a significant economic impact on a substantial number of small entities or a significant impact on the operations of a substantial number of small rural hospitals. In accordance with the provisions of Executive Order 12866, this notice was reviewed by the Office of Management and Budget. Authority: (Section 1102 of the Social Security Act (42 U.S.C. 1302)) (Catalog of Federal Domestic Assistance Program No. 93.767, State Children’s Health Insurance Program) Dated: May 17, 2006. Mark B. McClellan, Administrator, Centers for Medicare & Medicaid Services. Dated: May 25, 2006. Michael O. Leavitt, Secretary, Department of Health and Human Services. [FR Doc. E6–12031 Filed 7–27–06; 8:45 am] BILLING CODE 4120–01–C DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Government-Owned Inventions; Availability for Licensing National Institutes of Health, Public Health Service, HHS. ACTION: Notice. AGENCY: SUMMARY: The inventions listed below are owned by an agency of the U.S. Government and are available for licensing in the U.S. in accordance with 35 U.S.C. 207 to achieve expeditious commercialization of results of federally-funded research and development. Foreign patent applications are filed on selected inventions to extend market coverage for companies and may also be available for licensing. ADDRESSES: Licensing information and copies of the U.S. patent applications listed below may be obtained by writing to the indicated licensing contact at the Office of Technology Transfer, National Institutes of Health, 6011 Executive Boulevard, Suite 325, Rockville, Maryland 20852–3804; telephone: 301– 496–7057; fax: 301–402–0220. A signed PO 00000 Frm 00065 Fmt 4703 Sfmt 4703 42859 Confidential Disclosure Agreement will be required to receive copies of the patent applications. On-Demand Protein Microarrays: In Vitro Assembly of Protein Microarrays Description of Technology: Protein microarrays are becoming an indispensable biomedical tool to facilitate rapid high-throughput detection of protein-protein, proteindrug and protein-DNA interactions for large groups of proteins. The novel Protein Microarray of this invention is essentially a DNA microarray that becomes a protein microarray on demand and provides an efficient systematic approach to the study of protein interactions and drug target identification and validation, thereby speeding up the discovery process. The technology allows a large number of proteins to be synthesized and immobilized at their individual site of expression on an ordered array without the need for protein purification. As a result, proteins are ready for subsequent use in binding studies and other analysis. The Protein Microarray is based on high affinity and high specificity of the protein-nucleic acid interaction of the Tus protein and the Ter site of E. coli. The DNA templates are arrayed on the microarray to perform dual function: (1) synthesizing the protein in situ (cell-free protein synthesis) in the array and (2) at the same time capturing the protein it synthesizes by DNA-protein interaction. This method utilizes an expression vector containing a DNA sequence which serves a dual purpose: (a) encoding proteins of interest fused to the Tus protein for in vitro synthesis of the protein and (b) encoding the Ter sequence, which captures the fusion protein through the high affinity interaction with the Tus protein. Applications: (1) Simultaneous analysis of interactions of many proteins with other proteins, antibodies, nucleic acids, lipids, drugs, etc, in a single experiment; (2) Efficient discovery of novel drugs and drug targets. Development Status: The technology is in early stages of development. Inventors: Deb K. Chatterjee, Kalavathy Sitaraman, James L. Hartley, David J. Munroe, Cassio Baptista (NCI). Patent Status: U.S. Patent Application No. 11/252,735 filed 19 Oct 2005 (HHS Reference No. E–244–2005/0-US–01). Licensing Status: Available for nonexclusive and exclusive licensing. Licensing Contact: Cristina Thalhammer-Reyero, Ph.D., M.B.A.; 301–435–4507; thalhamc@mail.nih.gov. Collaborative Research Opportunity: The National Cancer Institute Protein E:\FR\FM\28JYN1.SGM 28JYN1 42860 Federal Register / Vol. 71, No. 145 / Friday, July 28, 2006 / Notices Expression Laboratory is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize in vitro assembly of protein microarrays. Please contact Betty Tong at 301–594–4263 or tongb@mail.nih.gov for more information. Dated: July 24, 2006. Steven M. Ferguson, Director, Division of Technology Development and Transfer, Office of Technology Transfer, National Institutes of Health. [FR Doc. E6–12132 Filed 7–27–06; 8:45 am] BILLING CODE 4140–01–P DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Center for Complementary & Alternative Medicine; Notice of Closed Meeting rwilkins on PROD1PC63 with NOTICES Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. Appendix 2), notice is hereby given of the National Advisory Council for Complementary and Alternative Medicine (NACCAM) meeting. The meeting will be open to the public as indicated below, with attendance limited to space available. Individuals who plan to attend and need special assistance, such as sign language interpretation or other reasonable accommodations, should notify the Contact Person listed below in advance of the meeting. A portion of the meeting will be closed to the public in accordance with the provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The grant applications and/or contract proposals and the discussions could disclose confidential trade secrets or commercial property such as patentable material, and personal information concerning individuals associated with the grant applications and/or contract proposals, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. Name of Committee: National Advisory Council for Complementary and Alternative Medicine. Date: September 8, 2006. Closed: 9 am. to 2 p.m. Agenda: To review and evaluate grant applications and/or proposals. Open: 2 p.m. to 4 p.m. Agenda: Presentations of new research initiatives, and other council related business. VerDate Aug<31>2005 17:47 Jul 27, 2006 Jkt 208001 Place: National Institutes of Health, Neuroscience Building, 6001 Executive Boulevard, Rooms C & D, Rockville, MD 20852. Contact Person: Martin H. Goldrosen, PhD, Executive Secretary, National Center for Complementary and Alternative Medicine, National Institutes of Health, 6707 Democracy Blvd., Suite 401, Bethesda, MD 20892, (301) 594–2014. The public comments session is scheduled from 3:30–4p.m. but could change depending on the actual time spent on each agenda item. Each speaker will be permitted 5 minutes for their presentation. Interested individuals and representatives of organizations are requested to notify Dr. Martin H. Goldrosen, National Center for Complementary and Alternative Medicine, NIH, 6707 Democracy Boulevard, Suite 401, Bethesda, Maryland 20892, 301– 594–2014, Fax: 301–480–9970. Letters of intent to present comments, along with a brief description of the organization represented, should be received no later than 5 p.m. on August 29, 2006. Only one representative of an organization may present oral comments. Any person attending the meeting who does not request an opportunity to speak in advance of the meeting may be considered for oral presentation, if time permits, and at the discretion of the Chairperson. In addition, written comments may be submitted to Dr. Martin H. Goldrosen at the address listed above up to ten calendar days (September 18, 2006) following the meeting. Copies of the meeting agenda and the roster of members will be furnished upon request by contacting Dr. Martin H. Goldrosen, Executive Secretary, NACCAM, National Center for Complementary and Alternative Medicine, National Institutes of Health, 6707 Democracy Boulevard, Suite 401, Bethesda, Maryland 20892, 301–594– 2014, Fax: 301–480–9970, or via e-mail at naccames@mail.nih.gov. In the interest of security, NIH has instituted stringent procedures for entrance into the building by nongovernment employees. Persons without a government I.D. will need to show a photo I.D. and sign-in at the security desk upon entering the building. Dated: July 24, 2006. Anna Snouffer, Acting Director, Office of Federal Advisory Committee Policy. [FR Doc. 06–6548 Filed 7–26–06; 8:45 am] BILLING CODE 4167–01–M DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. Appendix 2), notice is hereby given of the following meeting. The meeting will be closed to the public in accordance with the PO 00000 Frm 00066 Fmt 4703 Sfmt 4703 provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The grant applications and the discussions could disclose confidential trade secrets or commercial property such as patentable material, and personal information concerning individuals associated with the grant applications, the disclosure of which would constitute a clearly unwarranted invasion of personal privacy. Name of Committee: National Heart, Lung, and Blood Institute Special Emphasis Panel, Review of Behavioral Cardiology Program Project Grant. Date: August 15, 2006. Time: 1 p.m. to 5 p.m. Agenda: To review and evaluate grant applications. Place: National Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892. (Telephone Conference Call). Contact Person: Holly Patton, Scientific Review Administrator, Review Branch/ Division of Extramural Affairs, Nation Heart, Lung, and Blood Institute, Two Rockledge Center, 6701 Rockledge Drive Room 7188, Bethesda, MD 20892. (301) 435–0280. pattonh@nhlbi.nih.gov. This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. (Catalogue of Federal Domestic Assistance Program Nos. 93.233, National Center for Sleep Disorders Research; 93.837, Heart and Vascular Diseases Research; 93.838, Lung Diseases Research; 93.839, Blood Diseases and Resources Research, National Institutes of Health, HHS) Dated: July 24, 2006. Anna Snouffer, Acting Director, Office of Federal Advisory Committee Policy. [FR Doc. 06–6544 Filed 7–27–06; 8:45 am] BILLING CODE 4140–01–M DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. Appendix 2), notice is hereby given of the following meeting. The meeting will be closed to the public in accordancd with the provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The grant applications and the discussions could disclose confidential trade secrets or commercial property such as patentable material, and personal information concerning individuals associated with the grant E:\FR\FM\28JYN1.SGM 28JYN1

Agencies

[Federal Register Volume 71, Number 145 (Friday, July 28, 2006)]
[Notices]
[Pages 42859-42860]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: E6-12132]


-----------------------------------------------------------------------

DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Government-Owned Inventions; Availability for Licensing

AGENCY: National Institutes of Health, Public Health Service, HHS.

ACTION: Notice.

-----------------------------------------------------------------------

SUMMARY: The inventions listed below are owned by an agency of the U.S. 
Government and are available for licensing in the U.S. in accordance 
with 35 U.S.C. 207 to achieve expeditious commercialization of results 
of federally-funded research and development. Foreign patent 
applications are filed on selected inventions to extend market coverage 
for companies and may also be available for licensing.

ADDRESSES: Licensing information and copies of the U.S. patent 
applications listed below may be obtained by writing to the indicated 
licensing contact at the Office of Technology Transfer, National 
Institutes of Health, 6011 Executive Boulevard, Suite 325, Rockville, 
Maryland 20852-3804; telephone: 301-496-7057; fax: 301-402-0220. A 
signed Confidential Disclosure Agreement will be required to receive 
copies of the patent applications.

On-Demand Protein Microarrays: In Vitro Assembly of Protein Microarrays

    Description of Technology: Protein microarrays are becoming an 
indispensable biomedical tool to facilitate rapid high-throughput 
detection of protein-protein, protein-drug and protein-DNA interactions 
for large groups of proteins. The novel Protein Microarray of this 
invention is essentially a DNA microarray that becomes a protein 
microarray on demand and provides an efficient systematic approach to 
the study of protein interactions and drug target identification and 
validation, thereby speeding up the discovery process. The technology 
allows a large number of proteins to be synthesized and immobilized at 
their individual site of expression on an ordered array without the 
need for protein purification. As a result, proteins are ready for 
subsequent use in binding studies and other analysis.
    The Protein Microarray is based on high affinity and high 
specificity of the protein-nucleic acid interaction of the Tus protein 
and the Ter site of E. coli. The DNA templates are arrayed on the 
microarray to perform dual function: (1) synthesizing the protein in 
situ (cell-free protein synthesis) in the array and (2) at the same 
time capturing the protein it synthesizes by DNA-protein interaction. 
This method utilizes an expression vector containing a DNA sequence 
which serves a dual purpose: (a) encoding proteins of interest fused to 
the Tus protein for in vitro synthesis of the protein and (b) encoding 
the Ter sequence, which captures the fusion protein through the high 
affinity interaction with the Tus protein.
    Applications: (1) Simultaneous analysis of interactions of many 
proteins with other proteins, antibodies, nucleic acids, lipids, drugs, 
etc, in a single experiment; (2) Efficient discovery of novel drugs and 
drug targets.
    Development Status: The technology is in early stages of 
development.
    Inventors: Deb K. Chatterjee, Kalavathy Sitaraman, James L. 
Hartley, David J. Munroe, Cassio Baptista (NCI).
    Patent Status: U.S. Patent Application No. 11/252,735 filed 19 Oct 
2005 (HHS Reference No. E-244-2005/0-US-01).
    Licensing Status: Available for non-exclusive and exclusive 
licensing.
    Licensing Contact: Cristina Thalhammer-Reyero, Ph.D., M.B.A.; 301-
435-4507; thalhamc@mail.nih.gov.
    Collaborative Research Opportunity: The National Cancer Institute 
Protein

[[Page 42860]]

Expression Laboratory is seeking statements of capability or interest 
from parties interested in collaborative research to further develop, 
evaluate, or commercialize in vitro assembly of protein microarrays. 
Please contact Betty Tong at 301-594-4263 or tongb@mail.nih.gov for 
more information.

    Dated: July 24, 2006.
Steven M. Ferguson,
Director, Division of Technology Development and Transfer, Office of 
Technology Transfer, National Institutes of Health.
 [FR Doc. E6-12132 Filed 7-27-06; 8:45 am]
BILLING CODE 4140-01-P

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